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Journal of Cardiovascular Disease Research最新文献

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Recent Improvements in in vitro Angiogenesis Assays 体外血管生成试验的最新进展
Journal of Cardiovascular Disease Research Pub Date : 2020-01-09 DOI: 10.5530/jcdr.2019.4.22
K. Kang
{"title":"Recent Improvements in in vitro Angiogenesis Assays","authors":"K. Kang","doi":"10.5530/jcdr.2019.4.22","DOIUrl":"https://doi.org/10.5530/jcdr.2019.4.22","url":null,"abstract":"Blood vessel formation, a highly organized sequence of cellular events, is initiated with activation of endothelial cells (ECs) followed by proliferation, sprouting, migration, tube formation, and maturation. Two fundamental processes of blood vessel formation are vasculogenesis and angiogenesis. Vasculogenesis refers to the de novo process of new vessel formation by migration and differentiation of endothelial progenitors into endothelial cells (ECs), whereas angiogenesis refers to the extension of pre-existing blood vessels through EC sprouting and subsequent stabilization by pericytes1,2. Angiogenesis plays an important role in not only embryonic development but also adult reproductive function and wound healing3. Furthermore, abnormal angiogenesis is associated with many pathological conditions such as diabetic retinopathy, rheumatoid arthritis, and tumor progression. Thus, exploring key molecular mechanisms of angiogenesis has become one of the most important biomedical research areas because drugs to control angiogenesis hold great promise in overcoming vascular malformation-associated diseases, especially cancer4.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"10 1","pages":"92-96"},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43000339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-Relationships of Cholesterol With Cardiac Factors for Heart Patients 心脏病患者胆固醇与心脏因素的相互关系
Journal of Cardiovascular Disease Research Pub Date : 2020-01-09 DOI: 10.5530/jcdr.2019.4.23
Jinseog Kim, R. Das, Youngjo Lee, S. Mukherjee, H. An, S. K. Medda
{"title":"Inter-Relationships of Cholesterol With Cardiac Factors for Heart Patients","authors":"Jinseog Kim, R. Das, Youngjo Lee, S. Mukherjee, H. An, S. K. Medda","doi":"10.5530/jcdr.2019.4.23","DOIUrl":"https://doi.org/10.5530/jcdr.2019.4.23","url":null,"abstract":"Objectives: The role of Cholesterol and its relationship with some cardiac risk factors for heart patients are examined in the \u0000current report using both Cholesterol level and two cardiac factors modeling. \u0000Materials and methods: A real data set of 303 heart patients with 14 study characters are considered in the report. Statistical \u0000joint generalized linear models (JGLMs) are considered using both Gamma & Log-normal distributions. \u0000Results: It is observed from Cholesterol level modeling that Cholesterol level is higher for female heart patients (P=0.0013) than \u0000male, or at older ages (P=0.0012) than younger. It is higher for the patients with high maximum heart rate (P=0.0877), or having \u0000resting electrocardiographic at normal level (P=0.0107), or with thalassemia at reversal defect (P=0.0466) and at fixed defect \u0000(P=0.0940) than at normal. It is also higher for the patients having heart disease diagnosis (angiographic disease status) value 0 \u0000(meaning less than 50% diameter narrowing) (P=0.0515) than others. Variance of Cholesterol level is higher for female patients \u0000(P=0.0265) than male, and it increases as ST depression induced by exercise relative to rest (Oldpeak) (P=0.0095) increases. \u0000From maximum heart rate modeling, it is noted that maximum heart rate increases as the Cholesterol level (P=0.0325) increases. \u0000In addition, variance of maximum heart rate decreases as the Cholesterol level (P=0.0058) increases. Also from resting blood \u0000pressure modeling, it is observed that mean resting blood pressure increases as the Cholesterol level increases, where it is a \u0000confounder in the model. \u0000Conclusions: Cholesterol levels should be examined regularly at older ages, along with the maximum heart rate achieved, \u0000thalassemia status, and resting blood pressure for both male and female heart patients.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"10 1","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46580331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hepatic Subcapsular Hematoma after Dual Antiplatelet Therapy using Ticagrelor 替卡格雷双重抗血小板治疗后肝包膜下血肿
Journal of Cardiovascular Disease Research Pub Date : 2020-01-09 DOI: 10.5530/jcdr.2019.4.24
Y. Song, Sang-Hoon Seol, Jino Park, Seunghwan Kim, Dong-Kie Kim, Ki-Hun Kim, D. Kim
{"title":"Hepatic Subcapsular Hematoma after Dual Antiplatelet Therapy using Ticagrelor","authors":"Y. Song, Sang-Hoon Seol, Jino Park, Seunghwan Kim, Dong-Kie Kim, Ki-Hun Kim, D. Kim","doi":"10.5530/jcdr.2019.4.24","DOIUrl":"https://doi.org/10.5530/jcdr.2019.4.24","url":null,"abstract":"Subcapsular liver hematoma is a rare life-threatening complication that may occur due to several causes such as coagulation disorder, neoplasm, pregnancy, trauma, and iatrogenic etiologies. However, the etiopathogenesis of spontaneous hematoma is still unclear. This condition is defined as an accumulation of blood between Glisson’s capsule and the liver parenchyma. Patients who undergo coronary intervention are vulnerable in terms of bleeding complication due to use of dual antiplatelet therapy (DAPT). Herein, we report a case of subacute hepatic subcapsular hematoma that occurred after percutaneous coronary intervention; the patient was receiving DAPT that included ticagrelor.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"10 1","pages":"101-103"},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43705937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Serum Lactate-A Prognostic Marker of Early Post-Operative Outcome After Off Pump Coronary Artery Bypass Surgery: A Propensity Matched Study 血清乳酸是非体外循环冠状动脉搭桥术后早期术后结果的预后标志物：一项倾向匹配研究
Journal of Cardiovascular Disease Research Pub Date : 2020-01-09 DOI: 10.5530/jcdr.2019.4.21
Ganesh Kumar K. Ammannaya, P. Mishra, J. Khandekar
{"title":"Serum Lactate-A Prognostic Marker of Early Post-Operative Outcome After Off Pump Coronary Artery Bypass Surgery: A Propensity Matched Study","authors":"Ganesh Kumar K. Ammannaya, P. Mishra, J. Khandekar","doi":"10.5530/jcdr.2019.4.21","DOIUrl":"https://doi.org/10.5530/jcdr.2019.4.21","url":null,"abstract":"Hyperlactatemia is a well-documented marker of systemic hypoperfusion, tissue hypoxia and circulatory failure in the postoperative period following cardiac surgery1. Lactic acidosis after cardiopulmonary bypass (CPB) is indicative of low cardiac output syndrome (LCOS) and is significantly associated with poor prognosis and mortality2. Incomplete revascularization in coronary artery bypass graft (CABG) surgery, insufficient myocardial protection, and coagulation disorders are factors that affect hyperlactatemia3.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"10 1","pages":"87-91"},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47569105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of Prognostic Factors in Outcome of Bowel Anastomosis 肠吻合术预后因素的评价
Journal of Cardiovascular Disease Research Pub Date : 2020-01-01 DOI: 10.31838/jcdr.2020.11.03.02
Ajinkya N. Puppal, A. Kshirsagar
{"title":"Evaluation of Prognostic Factors in Outcome of Bowel Anastomosis","authors":"Ajinkya N. Puppal, A. Kshirsagar","doi":"10.31838/jcdr.2020.11.03.02","DOIUrl":"https://doi.org/10.31838/jcdr.2020.11.03.02","url":null,"abstract":"Serum albumin can serve as a simple and economical prognosticator of outcome in bowel anastomosis and henceforth, can help in surgeon’s choice making as well as clarifying the risk to the patient. A prospective study was carried out to evaluate the risk factors which effect the result of bowel anastomosis. The objective of the study was to recognize the risk factors for anastomotic leak and study the rate of early complications and mortality of intestinal anastomosis. Study included 50 patients undergoing resection and anastomosis for various indications, both emergency and elective from the 1st December of 2016 to 30th June of 2018, at Krishna Institute of Medical Sciences who satisfied inclusion criteria. Patients with intra-abdominal sepsis, anemia, old age and patients treated with perioperative corticosteroids for pulmonary disease carry a substantial risk for anastomotic dehiscence and in these patients it is advised that anastomoses must be protected by a diverting stoma.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"11 1","pages":"06-09"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69628215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Successfully Treated Iatrogenic Left Main Coronary Artery Dissection: A Catastrophic Complication 成功治疗的医源性左主干冠状动脉夹层:一个灾难性的并发症
Journal of Cardiovascular Disease Research Pub Date : 2020-01-01 DOI: 10.5530/JCDR.2020.11.06
Natraj Setty Hs, S. Shankar, Santhosh Jadav, M. C. Yeriswamy, R. Murthy, J. Kharge, Babu Reddy, B. Srinivas, T. Raghu, R. Patil, Sathwic Raj, C. Manjunath
{"title":"A Successfully Treated Iatrogenic Left Main Coronary Artery Dissection: A Catastrophic Complication","authors":"Natraj Setty Hs, S. Shankar, Santhosh Jadav, M. C. Yeriswamy, R. Murthy, J. Kharge, Babu Reddy, B. Srinivas, T. Raghu, R. Patil, Sathwic Raj, C. Manjunath","doi":"10.5530/JCDR.2020.11.06","DOIUrl":"https://doi.org/10.5530/JCDR.2020.11.06","url":null,"abstract":"","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"95 20 Supplement 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71058641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiogenesis in the Ovarian Corpus luteum 卵巢黄体血管生成
Journal of Cardiovascular Disease Research Pub Date : 2020-01-01 DOI: 10.5530/JCDR.2020.11.07
Sang-Hee Lee, Seunghyung Lee
{"title":"Angiogenesis in the Ovarian Corpus luteum","authors":"Sang-Hee Lee, Seunghyung Lee","doi":"10.5530/JCDR.2020.11.07","DOIUrl":"https://doi.org/10.5530/JCDR.2020.11.07","url":null,"abstract":"","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71058530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiometabolic Risk Factors and Pregnancy Outcomes: A Systematic Review 心脏代谢危险因素与妊娠结局的系统评价
Journal of Cardiovascular Disease Research Pub Date : 2019-10-10 DOI: 10.5530/jcdr.2019.3.18
Maitrayee Mitra, Arnab Ghosh
{"title":"Cardiometabolic Risk Factors and Pregnancy Outcomes: A Systematic Review","authors":"Maitrayee Mitra, Arnab Ghosh","doi":"10.5530/jcdr.2019.3.18","DOIUrl":"https://doi.org/10.5530/jcdr.2019.3.18","url":null,"abstract":"With the headway of pregnancy, a rapid metabolic shift occurs to ensure the persistent supply of nutrients to the foetus from mother. During early pregnancy, increased insulin secretion increases the implementation of peripheral glucose, decreases the level fasting plasma glucose, enhances the glycogen storage in tissue and fat and deceases the lyposis. During this time increased accumulation of body fat is found which quickly breaks down in late pregnancy for fetal development1.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45145876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ambient Air Pollution: A Major Modifiable Cardiovascular Risk Factor in the UAE? 环境空气污染:阿联酋一个主要的可改变的心血管危险因素?
Journal of Cardiovascular Disease Research Pub Date : 2019-10-10 DOI: 10.5530/jcdr.2019.3.20
A. Bhagavathula, A. Shehab
{"title":"Ambient Air Pollution: A Major Modifiable Cardiovascular Risk Factor in the UAE?","authors":"A. Bhagavathula, A. Shehab","doi":"10.5530/jcdr.2019.3.20","DOIUrl":"https://doi.org/10.5530/jcdr.2019.3.20","url":null,"abstract":"With an increase in ambient air levels and change in anthropogenic emission of greenhouse gases have a variety of adverse effects on health, including cardiac health. Globally, cardiovascular disease (CVD) is one of the leading causes of death worldwide, with an estimated 17.9 million (31%) of people die every year1. In the United Arab Emirates (UAE), CVD is also a significant cause of mortality accounted for 37.1% in 20162. In particular, ischemic heart diseases (25%) and stroke (24%) accounts for around 50% of all premature deaths directly or indirectly from air pollution3. With rapid urbanization in UAE, results in higher air pollution from fossil fuel-powered electricity and increases the risk of heart diseases. It is also estimated that population-weight average of PM2.5 (vehicular emissions) in UAE was more than three times greater (63.9 μg/m3) than global population-weight mean of 20 μg/m3 4.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49032440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Diabetes Mellitus on Interventional Outcome in Patients with Non-ST-Myocardial Infarction 糖尿病对非ST段心肌梗死患者介入治疗效果的影响
Journal of Cardiovascular Disease Research Pub Date : 2019-10-10 DOI: 10.5530/jcdr.2019.3.19
H. Abomandour, H. Radwan
{"title":"Effects of Diabetes Mellitus on Interventional Outcome in Patients with Non-ST-Myocardial Infarction","authors":"H. Abomandour, H. Radwan","doi":"10.5530/jcdr.2019.3.19","DOIUrl":"https://doi.org/10.5530/jcdr.2019.3.19","url":null,"abstract":"The relationship between diabetes mellitus and a higher incidence of coronary artery disease is clinically established. Diabetic patients with acute coronary syndrome appeared to have worse prognosis than nondiabetic patients1. During hospitalization of diabetic and non-diabetic patients with Non-ST elevation myocardial infarction, the incidence of heart failure was twice in diabetic versus nondiabetic ones2.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45376167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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