Journal of cellular biochemistry最新文献_第2页

EXPRESSION OF CONCERN: Nrf2 Dependent Antiaging Effect of Milk-Derived Bioactive Peptide in Old Fibroblasts. 表达关切：牛奶衍生生物活性肽对老年成纤维细胞的 Nrf2 依赖性抗衰老效应

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1002/jcb.30666

引用次数: 0

FK506 binding protein 51: Its role in the adipose organ and beyond. FK506 结合蛋白 51：它在脂肪器官及其他器官中的作用

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2022-12-11 DOI: 10.1002/jcb.30351

Natalia M Galigniana, Marina C Ruiz, Graciela Piwien-Pilipuk

引用次数: 0

Structural and biochemical insights into FKBP51 as a Hsp90 co-chaperone. 关于 FKBP51 作为 Hsp90 辅伴侣素的结构和生化见解。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2023-02-15 DOI: 10.1002/jcb.30384

Asat Baischew, Sarah Engel, Thomas M Geiger, Martha C Taubert, Felix Hausch

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RETRACTION: Downregulation of Fibroblast Growth Factor 5 Inhibits Cell Growth and Invasion of Human Nonsmall-Cell Lung Cancer Cells. 回归：下调成纤维细胞生长因子 5 可抑制人类非小细胞肺癌细胞的生长和侵袭。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1002/jcb.30673

引用次数: 0

Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease. 正常生理和疾病中 TPR 域免疫亲和素 FKBP51 和 FKBP52 的结构和功能。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2023-04-23 DOI: 10.1002/jcb.30406

Olga B Soto, Christian S Ramirez, Rina Koyani, Isela A Rodriguez-Palomares, Jessica R Dirmeyer, Brian Grajeda, Sourav Roy, Marc B Cox

{"title":"Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease.","authors":"Olga B Soto, Christian S Ramirez, Rina Koyani, Isela A Rodriguez-Palomares, Jessica R Dirmeyer, Brian Grajeda, Sourav Roy, Marc B Cox","doi":"10.1002/jcb.30406","DOIUrl":"10.1002/jcb.30406","url":null,"abstract":"Coordinated cochaperone interactions with Hsp90 and associated client proteins are crucial for a multitude of signaling pathways in normal physiology, as well as in disease settings. Research on the molecular mechanisms regulated by the Hsp90 multiprotein complexes has demonstrated increasingly diverse roles for cochaperones throughout Hsp90-regulated signaling pathways. Thus, the Hsp90-associated cochaperones have emerged as attractive therapeutic targets in a wide variety of disease settings. The tetratricopeptide repeat (TPR)-domain immunophilins FKBP51 and FKBP52 are of special interest among the Hsp90-associated cochaperones given their Hsp90 client protein specificity, ubiquitous expression across tissues, and their increasingly important roles in neuronal signaling, intracellular calcium release, peptide bond isomerization, viral replication, steroid hormone receptor function, and cell proliferation to name a few. This review summarizes the current knowledge of the structure and molecular functions of TPR-domain immunophilins FKBP51 and FKBP52, recent findings implicating these immunophilins in disease, and the therapeutic potential of targeting FKBP51 and FKBP52 for the treatment of disease.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":" ","pages":"e30406"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9755081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The animal and cell models that uncovered FKBP51 as a regulator of glucocorticoid receptor function. 发现 FKBP51 是糖皮质激素受体功能调节器的动物和细胞模型。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2023-01-30 DOI: 10.1002/jcb.30375

Jonathan G Scammell

引用次数: 0

RETRACTION: Trans-Cleaving Hammerhead Ribozyme in Specific Regions Can Improve Knockdown Efficiency In Vivo. 回放：在特定区域反向裂解锤头纹波酶可提高体内敲除效率。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1002/jcb.30677

引用次数: 0

Genetically engineered mouse models of FK506-binding protein 5. FK506 结合蛋白 5 的基因工程小鼠模型。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2023-02-13 DOI: 10.1002/jcb.30374

Niat T Gebru, Shannon E Hill, Laura J Blair

{"title":"Genetically engineered mouse models of FK506-binding protein 5.","authors":"Niat T Gebru, Shannon E Hill, Laura J Blair","doi":"10.1002/jcb.30374","DOIUrl":"10.1002/jcb.30374","url":null,"abstract":"FK506 binding protein 51 (FKBP51) is a molecular chaperone that influences stress response. In addition to having an integral role in the regulation of steroid hormone receptors, including glucocorticoid receptor, FKBP51 has been linked with several biological processes including metabolism and neuronal health. Genetic and epigenetic alterations in the gene that encodes FKBP51, FKBP5, are associated with increased susceptibility to multiple neuropsychiatric disorders, which has fueled much of the research on this protein. Because of the complexity of these processes, animal models have been important in understanding the role of FKBP51. This review examines each of the current mouse models of FKBP5, which include whole animal knockout, conditional knockout, overexpression, and humanized mouse models. The generation of each model and observational details are discussed, including behavioral phenotypes, molecular changes, and electrophysiological alterations basally and following various challenges. While much has been learned through these models, there are still many aspects of FKBP51 biology that remain opaque and future studies are needed to help illuminate these current gaps in knowledge. Overall, FKBP5 continues to be an exciting potential target for stress-related disorders.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":" ","pages":"e30374"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10346775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsically disordered proteins and liquid-liquid phase separation in SARS-CoV-2 interactomes. SARS-CoV-2相互作用组的内在无序蛋白质和液-液相分离。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2023-11-22 DOI: 10.1002/jcb.30502

Lazar M Vasović, Gordana M Pavlović-Lažetić, Jovana J Kovačević, Miloš V Beljanski, Vladimir N Uversky

{"title":"Intrinsically disordered proteins and liquid-liquid phase separation in SARS-CoV-2 interactomes.","authors":"Lazar M Vasović, Gordana M Pavlović-Lažetić, Jovana J Kovačević, Miloš V Beljanski, Vladimir N Uversky","doi":"10.1002/jcb.30502","DOIUrl":"10.1002/jcb.30502","url":null,"abstract":"This paper discusses the properties of proteins and their relations in the interactomes of the selected subsets of SARS-CoV-2 proteome-the membrane protein, nonstructural proteins, and, finally, full proteome. Protein disorder according to several measures, liquid-liquid phase separation probabilities, and protein node degrees in the interaction networks were singled out as the features of interest. Additionally, viral interactomes were combined with the interactome of human lung tissue so as to examine if the new connections in the resulting viral-host interactome are linked to protein disorder. Correlation analysis shows that there is no clear relationship between raw features of interest, whereas there is a positive correlation between the protein disorder and its neighborhood mean disorder. There are also indications that highly connected viral hubs tend to be on average more ordered than proteins with a small number of connections. This is in contrast to previous similar studies conducted on eukaryotic interactomes and possibly raises new questions in research on viral interactomes.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":" ","pages":"e30502"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogeneous nuclear ribonucleoprotein A3 binds to the internal ribosomal entry site of enterovirus A71 and affects virus replication in neural cells. 异质核糖核蛋白 A3 与肠道病毒 A71 的内部核糖体入口位点结合，影响病毒在神经细胞中的复制。

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI: 10.1002/jcb.30575

Jhao-Yin Lin, Jing-Yi Lin, Rei-Lin Kuo, Hsing-I Huang

{"title":"Heterogeneous nuclear ribonucleoprotein A3 binds to the internal ribosomal entry site of enterovirus A71 and affects virus replication in neural cells.","authors":"Jhao-Yin Lin, Jing-Yi Lin, Rei-Lin Kuo, Hsing-I Huang","doi":"10.1002/jcb.30575","DOIUrl":"10.1002/jcb.30575","url":null,"abstract":"Enterovirus A71 (EV-A71) belongs to the genus Enterovirus of the Picornaviridae family and often causes outbreaks in Asia. EV-A71 infection usually causes hand, foot, and mouth disease and can even affect the central nervous system, causing neurological complications or death. The 5'-untranslated region (5'-UTR) of EV-A71 contains an internal ribosome entry site (IRES) that is responsible for the translation of viral proteins. IRES-transacting factors can interact with the EV-A71 5'-UTR to regulate IRES activity. Heterogeneous nuclear ribonucleoprotein (hnRNP) A3 is a member of the hnRNP A/B protein family of RNA-binding proteins and is involved in RNA transport and modification. We found that hnRNP A3 knockdown promoted the replication of EV-A71 in neural calls. Conversely, increasing the expression of hnRNP A3 within cells inhibits the growth of EV-A71. HnRNP A3 can bind to the EV-A71 5'-UTR, and knockdown of hnRNP A3 enhances the luciferase activity of the EV-A71 5'-UTR IRES. The localization of hnRNP A3 shifts from the nucleus to the cytoplasm of infected cells during viral infection. Additionally, EV-A71 infection can increase the protein expression of hnRNP A3, and the protein level is correlated with efficient viral growth. Based on these findings, we concluded that hnRNP A3 plays a negative regulatory role in EV-A71 replication within neural cells.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":" ","pages":"e30575"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0