Journal of cellular biochemistry最新文献_第10页

Intrinsic Factors Behind Long COVID: VI. Combined Impact of G3BPs and SARS-CoV-2 Nucleocapsid Protein on the Viral Persistence and Long COVID 长COVID背后的内在因素：VI. g3bp和SARS-CoV-2核衣壳蛋白对病毒持久性和长COVID的联合影响

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-05-25 DOI: 10.1002/jcb.70038

Ahmed Eltayeb, Alberto Rubio-Casillas, Vladimir N. Uversky, Elrashdy M. Redwan

{"title":"Intrinsic Factors Behind Long COVID: VI. Combined Impact of G3BPs and SARS-CoV-2 Nucleocapsid Protein on the Viral Persistence and Long COVID","authors":"Ahmed Eltayeb, Alberto Rubio-Casillas, Vladimir N. Uversky, Elrashdy M. Redwan","doi":"10.1002/jcb.70038","DOIUrl":"https://doi.org/10.1002/jcb.70038","url":null,"abstract":"<div>\u0000 \u0000 The efficient transmission of SARS-CoV-2 caused the COVID-19 pandemic, which affected millions of people around the globe. Despite extensive efforts, specific therapeutic interventions and preventive measures against COVID-19 and its consequences, such as long COVID, have not yet been identified due to the lack of a comprehensive knowledge of the SARS-CoV-2 biology. Therefore, a deeper understanding of the sophisticated strategies employed by SARS-CoV-2 to bypass the host antiviral defense systems is needed. One of these strategies is the inhibition of the Ras GTPase-activating protein-binding protein (GAP SH3-binding protein or G3BP)-dependent host immune response by the SARS-CoV-2 nucleocapsid (N) protein. This inhibition disrupts the formation of stress granules (SGs), which are crucial for antiviral defense. By preventing SG formation, the virus enhances its replication and evades the host's immune response, leading to increased disease severity. Given the involvement of G3BP1 in SG formation and its ability to interact with viral proteins, along with the crucial role of the N protein in the replication of the virus, we hypothesize that these proteins may have a potential role in the pathogenesis of long COVID. Despite the current lack of direct evidence linking these proteins to long COVID, their interactions and functions suggest a possible connection that warrants further investigation.\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Neuregulin 4 Attenuates Podocyte Injury and Proteinuria in Part by Activating AMPK/mTOR-Mediated Autophagy in Mice” 对“神经调节蛋白4通过激活AMPK/ mtor介导的小鼠自噬，部分减轻足细胞损伤和蛋白尿”的更正

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-05-05 DOI: 10.1002/jcb.70034

引用次数: 0

RETRACTION: Downregulation of miR-122 in the Rodent and Human Hepatocellular Carcinomas 撤回：miR-122在啮齿动物和人肝细胞癌中的下调

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-28 DOI: 10.1002/jcb.70023

{"title":"RETRACTION: Downregulation of miR-122 in the Rodent and Human Hepatocellular Carcinomas","authors":"","doi":"10.1002/jcb.70023","DOIUrl":"https://doi.org/10.1002/jcb.70023","url":null,"abstract":"RETRACTION: H. Kutay, S. Bai, J. Datta, T. Motiwala, I. Pogribny, W. Frankel, S. T. Jacob, and K. Ghoshal, “Downregulation of miR-122 in the Rodent and Human Hepatocellular Carcinomas,” Journal of Cellular Biochemistry 99, no. 3 (2006): 671–678. https://doi.org/10.1002/jcb.20982.The above article, published online on 30 June 2006, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. An investigation of alleged research misconduct by The Ohio State University found evidence that false data was included in Figure 4 A by using the 5S RNA Northern blot data for human HCC (tumor (T) and Normal (N) cells) between this article and Figure 2 in another article by many of the same authors (Meng et al. 2007 [https://doi.org/10.1053/j.gastro.2007.05.022]). The investigation confirmed that the 5S RNA data in this article was flipped horizontally as compared to the T/N samples in Meng et al. 2007. An investigation by the publisher also confirmed the evidence of image duplication and manipulation. This retraction has been agreed to because the evidence of image duplication and manipulation compromises the integrity of the study and the conclusions presented in the article. The authors did not respond to the notice regarding the retraction.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Nanos2 Promotes Differentiation of Chicken (Gallus gallus) Embryonic Stem Cells to Male Germ Cells 撤回：Nanos2促进鸡胚胎干细胞向雄性生殖细胞的分化

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-28 DOI: 10.1002/jcb.70024

{"title":"RETRACTION: Nanos2 Promotes Differentiation of Chicken (Gallus gallus) Embryonic Stem Cells to Male Germ Cells","authors":"","doi":"10.1002/jcb.70024","DOIUrl":"https://doi.org/10.1002/jcb.70024","url":null,"abstract":"RETRACTION: W. Zhang, Y. Bi, Y. Wang, D. Li, N. He, M. Wang, J. Jin, Q. Zuo, Y. Zhang, and B. Li, “Nanos2 Promotes Differentiation of Chicken (Gallus gallus) Embryonic Stem Cells to Male Germ Cells,” Journal of Cellular Biochemistry, 119, no. 6 (2018): 4435-4446, https://doi.org/10.1002/jcb.26528.The above article, published online on 16 November 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, it was brought to the journal's attention that Nanos2 has not been identified in Gallus gallus. Further investigation confirmed that the gene examined in the article was actually Nos2, which encodes nitric oxide synthase 2 (NOS2), a protein with different and unrelated functions from those proposed in the study. The corresponding author B. Li stated that she did not directly participate in the experiments conducted for the study and was unaware of its submission. The corresponding author Y. Zhang, on behalf of the remaining co-authors, stated that they mistakenly assumed Nos2, which serves as an alias for Nanos2 in other species, to be homologous to Nanos2 in chickens. This misidentification undermines the study's rationale, methodology, and conclusions. Accordingly, the article is retracted.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Proliferation and Invasion of Colon Cancer Cells Are Suppressed by Knockdown of TOP2A 回归：抑制 TOP2A 可抑制结肠癌细胞的增殖和侵袭

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-25 DOI: 10.1002/jcb.70018

引用次数: 0

RETRACTION: Long Noncoding RNA HOTTIP Alleviates Oxygen-Glucose Deprivation-Induced Neuronal Injury via Modulating MiR-143/Hexokinase 2 Pathway 回归：长非编码 RNA HOTTIP 通过调节 MiR-143/Hexokinase 2 通路缓解氧-葡萄糖剥夺诱导的神经元损伤

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-25 DOI: 10.1002/jcb.70020

引用次数: 0

RETRACTION: Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer 在结肠炎相关结直肠癌小鼠模型中，藏红花素通过Wnt/PI3K途径协同增强5-氟尿嘧啶的抗增殖活性

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-23 DOI: 10.1002/jcb.70015

{"title":"RETRACTION: Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer","authors":"","doi":"10.1002/jcb.70015","DOIUrl":"https://doi.org/10.1002/jcb.70015","url":null,"abstract":"RETRACTION: F. Amerizadeh, N. Rezaei, F. Rahmani, S. M. Hassanian, R. Moradi-Marjaneh, H. Fiuji, N. Boroumand, A. Nosrati-Tirkani, M. Ghayour-Mobarhan, G. A. Ferns, M. Khazaei, and A. Avan, “Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer,” Journal of Cellular Biochemistry 119, no. 12 (2018): 10250-10261, https://doi.org/10.1002/jcb.27367.The above article, published online on August 20, 2018, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Figure 6B was found to contain inappropriate splicing sites and methodological flaws. Additionally, in Figure 5A and 5a, no correlation was observed between samples at low and high magnification. The authors did not provide clarification on these issues or the original data. Accordingly, the article is retracted as the editors have lost confidence in the integrity and accuracy of the whole body of data presented in the article and consider its conclusions invalid. The authors have been informed of the decision of retraction.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Forkhead Box p3 Controls Progression of Oral Lichen Planus by Regulating MicroRNA-146a 缩回：叉头盒p3通过调控MicroRNA-146a调控口腔扁平苔藓的进展

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-23 DOI: 10.1002/jcb.70019

引用次数: 0

Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy 缺乏HSF4通过上调伴侣介导的自噬增加细胞外小泡的分泌

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-10 DOI: 10.1002/jcb.70031

Jingjing Liu, Xuhui Liu, Xiaohang Xie, Wei Si, Yuhang Zhang, Mengjiao Xue, Xuyan Peng, Mingjun Jiang, Shanshan Du, Jingzhi Shao, Yi Mao, Fengyan Zhang, Yanzhong Hu

{"title":"Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy","authors":"Jingjing Liu, Xuhui Liu, Xiaohang Xie, Wei Si, Yuhang Zhang, Mengjiao Xue, Xuyan Peng, Mingjun Jiang, Shanshan Du, Jingzhi Shao, Yi Mao, Fengyan Zhang, Yanzhong Hu","doi":"10.1002/jcb.70031","DOIUrl":"https://doi.org/10.1002/jcb.70031","url":null,"abstract":"<div>\u0000 \u0000 Small extracellular vesicles (SEVs) are membrane-bound vesicles secreted by cells that facilitate intercellular communication. This study reveals how heat shock transcription factor 4 (HSF4) deficiency regulates SEV secretion in lens epithelial cells through chaperone-mediated autophagy (CMA). Compared to mLEC/HA-Hsf4b cells, SEVs secreted by HSF4-deficient mLEC/Hsf4−/− cells showed significantly increased levels of CMA-related proteins (HSP70, HSC70, LAMP2A, and HSP90) and EGFR, while LC3 II levels were reduced. Additionally, EGFR-enriched SEVs activated downstream ERK/AKT signaling pathways, promoting the proliferation and migration of lens epithelial cells and inducing epithelial–mesenchymal transition (EMT). Further inhibition experiments showed that blocking HSP70 and HSP90 with apoptozole and retaspimycin, or silencing LAMP2A with siRNA, reduced SEV secretion in HSF4-deficient cells. Collectively, enhanced CMA activity and increased SEV secretion induced by HSF4 deficiency may represent a potential mechanism underlying congenital cataract development.</div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Structure Insights Into Antioxidant, Anti-Inflammatory, and Computational Investigations: Molecular Docking and Dynamics Studies on Enzyme Inhibitors 分子结构洞察抗氧化，抗炎和计算研究：酶抑制剂的分子对接和动力学研究

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-08 DOI: 10.1002/jcb.70033

Ismail sheriff Parvin, Hamza Serina Banu, Ekambaram Gayathiri, Palanisamy Prakash, Somdatta Y. Chaudhari, Thangaraj Pratheep, Subramanian Deepika Priyadharshini, Muthiah Pugalenthi, Jayapandian Narmathasri

{"title":"Molecular Structure Insights Into Antioxidant, Anti-Inflammatory, and Computational Investigations: Molecular Docking and Dynamics Studies on Enzyme Inhibitors","authors":"Ismail sheriff Parvin, Hamza Serina Banu, Ekambaram Gayathiri, Palanisamy Prakash, Somdatta Y. Chaudhari, Thangaraj Pratheep, Subramanian Deepika Priyadharshini, Muthiah Pugalenthi, Jayapandian Narmathasri","doi":"10.1002/jcb.70033","DOIUrl":"https://doi.org/10.1002/jcb.70033","url":null,"abstract":"<div>\u0000 \u0000 Solanum erianthum D. Don (Solanaceae) species has wide range of usage in treating disease in folk medicine. This study focused on the isolation and characterization of Phytol, βCaryophyllene (βc), and Methoxy - 4- Quercetin (M4Q) from Solanum erianthum leaf and seed fractions. These three compounds were studied for antioxidant activities using DPPH, SOD, and FRAP assays, accompanied by molecular docking, molecular dynamics, and ADMET tools. Our results showed that, Methoxy 4-Quercetin scored good antioxidant potential in the studied assays, with a stable conformation and favorable properties. Docking analysis was used to determine the binding energies of these compounds with different receptor proteins and ligand complexes, as well as their stability, conformation, and binding energy in molecular dynamics. Pharmacokinetic compounds exhibit kinetic values and drug-like characteristics, indicating their biological activity. Competent studies on the compounds using in silico analyses showed that all compounds have notable anti-cardiotoxic and anti-inflammatory effects. Thus, studies on phytocompounds as effective leads to the improvement of anti-inflammatory and anti-cardio agents are necessary for further in vivo studies.\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0