Journal of cellular biochemistry最新文献

{"title":"Ferroptosis in Spinal Cord Injury: Research Progress and Novel Insights","authors":"Shizhe Li,&nbsp;Shutao Gao,&nbsp;Yukun Hu,&nbsp;Guangxu Sun,&nbsp;Jingsheng Feng,&nbsp;Weibin Sheng","doi":"10.1002/jcb.70067","DOIUrl":"https://doi.org/10.1002/jcb.70067","url":null,"abstract":"<div>\u0000 \u0000 <p>Spinal cord injury (SCI) is a severe condition affecting the central nervous system that often leads to varying degrees of motor and sensory impairment. Acute primary SCI is often managed with early surgical intervention; however, secondary SCI generally has a poor prognosis owing to the lack of effective drug therapy, complex pathophysiological processes, and inherent challenges of neural repair. Ferroptosis, a novel form of programmed cell death, is characterised by oxidative damage resulting from iron-mediated accumulation of reactive oxygen species (ROS) and lipid peroxidation (LPO) within cells. This type of cell death is prevalent in various pathological processes. Although research on ferroptosis in SCI is still emerging, some inhibitors (such as target proteins and natural compounds) have shown promising results in preclinical studies. Targeting ferroptosis may be a potential strategy for treating SCI. This paper reviews the current state of research on ferroptosis in SCI by analysing recent literature and proposes future research directions, aiming to provide new insights into SCI treatment.</p></div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RING-Box E3 Ligase Target N-Terminal Lysine 55 to Regulate Turnover of Sp7 Protein","authors":"Abeera Sikandar,&nbsp;Hani Ali,&nbsp;Anabia Javed,&nbsp;Javeed Farooqi,&nbsp;Amjad Javed","doi":"10.1002/jcb.70066","DOIUrl":"10.1002/jcb.70066","url":null,"abstract":"<div>\u0000 \u0000 <p>Specificity protein 7 (Sp7) is essential for osteoblast differentiation and bone formation. In humans, Sp7 gene mutations are associated with skeletal abnormalities, including osteogenesis imperfecta. Ubiquitylation regulates the cellular levels of Sp7 protein. However, the role of the largest class of E3 ubiquitin ligases in the turnover of Sp7 protein remains unknown. Here, we report for the first time that both catalytic subunits of multi-subunit RING-box E3 ligase, Rbx1 and Rbx2, are expressed in the skeletal tissues and during osteoblast differentiation. In situ immunofluorescence and biochemical fractionation revealed that in osteoblasts, Rbx1 and Rbx2 E3 ligase reside in both the cell cytoplasm and nucleus. The coimmunoprecipitation experiment in primary osteoblasts showed that endogenous Rbx1 and Rbx2 E3 ligase form a molecular complex with the Sp7 protein. Both Rbx1 and Rbx2 enzymes target Sp7 protein for ubiquitination. Sp7 protein is degraded by Rbx1 and Rbx2 enzymes in a dose-dependent manner in both osseous and non-osseous cells. Chemical inhibition established the requirement of Rbx1 and Rbx2-mediated ubiquitination and degradation of Sp7 protein by the proteasomal pathway. In-silico analysis identified three evolutionarily conserved lysines, K-55, K-227, and K-229, in the Sp7 protein as potential targets for ubiquitination. A panel of Sp7 deletion and point mutants was generated that established the critical requirement of lysine-55 for Rbx1 and Rbx2-mediated ubiquitination and degradation. Deleting the Rbx2 gene in osteoprogenitors led to a significant accumulation of Sp7 protein, enhanced expression of osteoblast marker genes, and accelerated matrix mineralization.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of New Potential Microtubule Stabilizers via Virtual Screen, Biological Evaluation, and Molecular Dynamics Simulation","authors":"Xiang-Long Chen,&nbsp;Xiu-Yun Shi,&nbsp;Li-Li An,&nbsp;Zhuo Wang,&nbsp;Hai-Rong Yang,&nbsp;Wen Zhang,&nbsp;Mei-Ling Hu,&nbsp;Yuan Li,&nbsp;Sheng Zheng,&nbsp;Hui Zhang","doi":"10.1002/jcb.70065","DOIUrl":"10.1002/jcb.70065","url":null,"abstract":"<div>\u0000 \u0000 <p>Microtubules have become an attractive target for human cancer treatment. Several microtubule stabilizers targeting for taxane site have been widely employed for various tumor treatments in clinic. In this study, to discover novel scaffolds of microtubule stabilizers targeting the taxane site, pharmacophore modeling, molecular docking, and naive Bayes classification models were developed and further applied to screen database with 29,158 compounds. Forty agents were filtered out and considered as potential microtubule stabilizers. The MTT assay showed that hit20 exhibited higher antiproliferative activity against H1299 cell, the IC₅₀ value of which was 16.8 μM. The hit20 conspicuously promoted tubulin polymerization in vitro, and disrupted the intracellular microtubule network of H1299 cells. Moreover, the hit20 caused cells to accumulate at G2/M phase, induced cell apoptosis, and significantly inhibited H1299 cell migration. The results of the molecular dynamics simulation revealed that tubulin-hit20 could form a stable complex, inducing the H6-H7 loop and M-loop regions produce greater fluctuation. The Δ<i>G</i>_bind of tubulin-hit20 was—130.77 kJ/mol, and −156.3 kJ/mol for the tubulin-paclitaxel. In summary, the hit20 is a promising microtubule stabilizer targeting the taxane site and should be further investigated for the development of a novel antitumor agent.</p></div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide Promotes Apoptosis in Malignant Melanoma via PARP1 Inhibition and Mitochondrial Pathway Activation","authors":"Yao Yu,&nbsp;Zhizhan Ni,&nbsp;Bujun Ge,&nbsp;Jinzhe Zhou","doi":"10.1002/jcb.70064","DOIUrl":"https://doi.org/10.1002/jcb.70064","url":null,"abstract":"<div>\u0000 \u0000 <p>Nicotinamide has been reported to promote apoptosis in malignant melanoma cells, however, its mechanism remains unclear. This study aims to predict and analyze the apoptotic targets of nicotinamide in malignant melanoma through network pharmacology and bioinformatics. Experimental validation was conducted to determine whether nicotinamide inhibits PARP1 function and promotes mitochondrial apoptosis in mouse melanoma cells. PARP1 was identified as a key apoptotic target of nicotinamide in malignant melanoma. High PARP1 expression correlated with poor prognosis and was predictive of 1-year survival in melanoma patients. PARP1 was highly expressed in all melanoma subtypes but was not associated with tumor stage or TMB. GSEA revealed three pathways active under low PARP1 expression. Nicotinamide treatment increased apoptosis in B16 melanoma cells, decreased PAR expression, reduced mitochondrial membrane potential, and upregulated mitochondrial apoptotic proteins. GEPIA2 analysis showed that PARP1 is also highly expressed in various other tumors. Nicotinamide promotes apoptosis in mouse melanoma B16 cells, potentially through PARP1 inhibition, thereby mediating the mitochondrial apoptotic pathway in malignant melanoma.</p>\u0000 <p><b>Clinical Trial Number:</b> Not applicable.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Exosomes Derived From Adipose Tissue, Bone Marrow, and Umbilical Cord Blood for Cardioprotection After Myocardial Infarction","authors":"","doi":"10.1002/jcb.70061","DOIUrl":"https://doi.org/10.1002/jcb.70061","url":null,"abstract":"<p><b>RETRACTION:</b> H. Xu, Z. Wang, L. Liu, B. Zhang, and B. Li, “Exosomes Derived From Adipose Tissue, Bone Marrow, and Umbilical Cord Blood for Cardioprotection After Myocardial Infarction,” <i>Journal of Cellular Biochemistry</i> 121, no. 3 (2020): 2089-2102. https://doi.org/10.1002/jcb.27399.</p><p>The above article, published online on 17 November 2019, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. A third party reported to the publisher that several images in the article included panels with overlapping samples. Those overlapping panels are as follows: Figure 1C and 1D have overlapping panels for BMMSC and ADMSC; Figure 2B has an overlapping panel between the Normal and Sham samples; and Figures 4B, 4C, and 4G each have several overlapping panels, several of which included rotated sections. In addition, the third party reported that several images in Figure 4C had been reused from a previously-published article by a different group of authors [Chen et al. 2018 (https://doi.org/10.2147/dddt.s163405)]. An investigation by the publisher confirmed each instance of image duplication and that several of the images had been re-used from the earlier paper. The retraction has been agreed to because the evidence of image duplication and manipulation compromises the integrity of the study and the conclusions presented in the article. The authors did not respond to an inquiry by the publisher.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation of Human Umbilical Cord Mesenchymal Stem Cells Into Pre-Granulosa Cells and Further Maturation","authors":"Cheng Zou,&nbsp;Zelan Yang,&nbsp;Yan Zou,&nbsp;Hanyu Xiao,&nbsp;Yufei Deng,&nbsp;Jin Bai,&nbsp;Liaoqiong Fang,&nbsp;Zhibiao Wang","doi":"10.1002/jcb.70063","DOIUrl":"https://doi.org/10.1002/jcb.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>Mesenchymal stem cells (MSCs) are adult stem cells with the capacity to differentiate into several cell types, including hepatocyte-like cells, neural-like cells, islet-like clusters and so on. However, the differentiation into ovarian-related cells such as ovarian granulosa cells (OGCs) has not been well studied. Here, we established an efficient culture system to differentiate human umbilical cord mesenchymal stem cells (HUCMSCs) into pre-granulosa cells, which can further mature into granulosa-like cells. HUCMSCs were cocultured with hormones (E2, FSH) and cytokines (TGF-β), a simple differentiation method was used to induce morphological changes and positive expression of forkhead transcription factor (<i>FOXL2</i>). In the process of further mature, the cells differentiated into mature granulosa-like cells, expressed mature granulosa cell markers (<i>FSHR</i>, <i>AMHR2</i>, <i>CYP19A1</i>) and likely possesses some granulosa cell hormone secretion capacity. In conclusion, we successfully established an efficient protocol to generate pre-granulosa cells from HUCMSCs that can further differentiate into mature granulosa-like cells, opening a new avenue for the further study of therapies for female reproductive health.</p></div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Advances in Anticancer Properties of Heptamethine Carbocyanine DZ-1 Conjugated to Artesunate: Generation of Reactive Oxygen Species","authors":"Badrinath Narayanasamy,&nbsp;Sarah Helmueller,&nbsp;Yi Zhang,&nbsp;Yong J. Lee","doi":"10.1002/jcb.70062","DOIUrl":"https://doi.org/10.1002/jcb.70062","url":null,"abstract":"<div>\u0000 \u0000 <p>Heptamethine cyanine dyes and anticancer agents based conjugates are being developed for enhanced targeting and killing of cancer cells. DZ-1 dye conjugated agents induced cytotoxicity and mechanism of action have been shown in previous studies. In this study, a conjugated form of DZ-1 and artesunate (DZ-1-ART) was used to evaluate its cytotoxicity and elucidate the mechanism of actions in various cancer cell lines. Cells survival assays indicated dose-dependent cytotoxic activities of DZ-1-ART in HCT116, BxPC-3, and OVCAR-3 cell lines. Immunoblotting and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay confirmed involvement of apoptosis in DZ-1-ART-induced cytotoxicity. To elucidate the anticancer mechanism of the action of DZ-1-ART, MitoTracker and JC-1 assay were used. The results showed that translocation of DZ-1-ART in the mitochondria was followed by disruption of mitochondrial outer membrane potential. Dichlorofluorescin diacetate assay confirmed the generation of reactive oxygen species (ROS) in DZ-1-ART treated cancer cells. An antioxidant, N-acetyl cysteine treatment with DZ-1-ART showed reduction in cell death as well as suppression of ROS generation. When compared to HCT116 wild-type cells, Bak and Bax-deficient HCT116 cells also showed similar levels of cytotoxicity of DZ-1-ART. Taken together, this study's results reported that DZ-1-ART could induce mitochondria-mediated, ROS-generated, and Bak and Bax-independent apoptosis in cancer cells.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches","authors":"Eduarda Moreira Barreto,&nbsp;Gabriel Rodrigues Coutinho Pereira,&nbsp;Isadora de Salles Arêas,&nbsp;Júlia Mendes Fortes,&nbsp;Alessandra da Silva Domingos,&nbsp;Lucio Mendes Cabral,&nbsp;Carlos Rangel Rodrigues,&nbsp;Alessandra Mendonça Teles de Souza,&nbsp;Barbara de Azevedo Abrahim-Vieira","doi":"10.1002/jcb.70060","DOIUrl":"https://doi.org/10.1002/jcb.70060","url":null,"abstract":"<p>Leishmaniasis is a neglected tropical disease with a significant global health burden, particularly in developing countries, where it accounts for approximately 1.6 million new infections annually. Current therapeutic options are limited by severe adverse effects, toxicity, and drug resistance, highlighting the urgent need for novel treatment strategies. Arginase from <i>Leishmania</i> spp. (<i>Lam</i>ARG) has been identified as a promising therapeutic target due to its pivotal role in parasite survival and proliferation. Drug repurposing offers a strategic advantage by accelerating the identification of new therapeutics with established safety profiles, as demonstrated by repurposed agents such as miltefosine, amphotericin B, and paromomycin. This study aimed to identify FDA-approved drugs with inhibitory potential against <i>Lam</i>ARG, leveraging structure- and ligand-based computational approaches. A three-dimensional model of <i>Lam</i>ARG was constructed through comparative modeling, followed by the compilation of known inhibitors from the literature. Molecular docking analyzed their binding interactions, generating pharmacophore hypotheses. These models were validated and applied for virtual screening of FDA-approved compounds from the e-Drug 3D database. Hits identified through pharmacophore-based screening were further evaluated using molecular docking and molecular dynamics simulations to elucidate their binding modes and stability within the catalytic site of <i>Lam</i>ARG. Our findings indicate that Dabigatran exhibits strong binding affinity and key interactions within the active site of <i>Lam</i>ARG, suggesting its potential as a viable therapeutic candidate. With strong binding affinity, oral bioavailability, and a well-established safety profile, Dabigatran emerges as a promising repurposed drug against cutaneous leishmaniasis, offering a novel, patient-friendly therapeutic option to overcome treatment limitations and resistance challenges.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: A Shared Comparison of Diabetes Mellitus and Neurodegenerative Disorders","authors":"","doi":"10.1002/jcb.70040","DOIUrl":"https://doi.org/10.1002/jcb.70040","url":null,"abstract":"<p><b>RETRACTION:</b> M. Morsi, A. Maher, O. Aboelmagd, D. Johar, and L. Bernstein, “A Shared Comparison of Diabetes Mellitus and Neurodegenerative Disorders,” <i>Journal of Cellular Biochemistry</i> 119, no. 2 (2018): 1249–1256, https://doi.org/10.1002/jcb.26261.</p><p>The above article, published online on 25 September 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed upon due to an editorial error, which led to the duplicate publication of the same article. Since the article published later in time contains further revisions and additional co-authors, the authors wished to keep this version for the scholarly record [1]. The publisher and the authors regret this error.</p><p>Reference</p><p>[1] M. Morsi, F. Kobeissy, S. Magdeldin, A. Maher, O. Aboelmagd, D. Johar, and L. Bernstein, “A Shared Comparison of Diabetes Mellitus and Neurodegenerative Disorders,” <i>Journal of Cellular Biochemistry</i> 120, no. 9 (2019): 14318–14325, https://doi.org/10.1002/jcb.28094.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Findings on Post-COVID Cardiovascular Risk: Transcriptional Regulation and Gene Expression Patterns","authors":"Vikash Sharma,&nbsp;Jitender Singh,&nbsp;Ashish Kumar,&nbsp;Vikas Jogpal,&nbsp;Md. Sayeed Akhtar,&nbsp;Khalid Orayj,&nbsp;Sadaf Farooqui,&nbsp;Abida Khan,&nbsp;Gunjan Sharma,&nbsp;Arun K. Sharma","doi":"10.1002/jcb.70059","DOIUrl":"https://doi.org/10.1002/jcb.70059","url":null,"abstract":"<div>\u0000 \u0000 <p>Survivors of COVID-19 are facing a new vulnerability of encountering post-COVID complications, including cardiovascular diseases (CVDs). Despite the increasing prevalence of CVDs, post-COVID-induced cardiac abnormalities significantly escalate mortality and morbidity. However, some recent studies have begun to elucidate complex pathological signaling pathways in these conditions, further investigation is required to distinguish key genetic and proteomic regulators in post-COVID states precisely. Gene Expression Omnibus (GEO) databases were used to investigate gene expression profiles in post-COVID-19 patients. The selected data set underwent normalization and PCA using prcomp and limma to visualize the correlation and patterns. Differentially expressed genes (DEGs) were identified to evaluate their role in molecular functions, and biological processes by Gene Ontology and KEGG analysis. Moreover, transcriptional regulators of selected DEGs were identified using the TRUST database. The comprehensive consequences from post-COVID patients revealed unique DEGs (five downregulated and two upregulated). Transcriptional factors (TFs) like ATRX, GATA1, and KLF4 have been identified as key regulators of HBA2 gene expression, which could encode crucial components of adult hemoglobin and cardiac functionality in post-COVID conditions. Moreover, immunoregulators NF-κB1 and SLA2 affect inflammatory cascades through the downregulation of the CD69 gene, which may be considered a promising pathway highlighting target sites for ameliorating CVDs in the post-COVID states. The present investigation revealed the promising TFs and DEGs, based on their persuasive biological function, that need to be validated for developing competent health interventions to mitigate the associated cardiac complications at the primary stage in post-COVID incidents.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}