Journal of cellular biochemistry最新文献

RETRACTION: Proliferation and Invasion of Colon Cancer Cells Are Suppressed by Knockdown of TOP2A

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-25 DOI: 10.1002/jcb.70018

引用次数: 0

RETRACTION: Long Noncoding RNA HOTTIP Alleviates Oxygen-Glucose Deprivation-Induced Neuronal Injury via Modulating MiR-143/Hexokinase 2 Pathway

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-25 DOI: 10.1002/jcb.70020

引用次数: 0

RETRACTION: Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-23 DOI: 10.1002/jcb.70015

{"title":"RETRACTION: Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer","authors":"","doi":"10.1002/jcb.70015","DOIUrl":"https://doi.org/10.1002/jcb.70015","url":null,"abstract":"RETRACTION: F. Amerizadeh, N. Rezaei, F. Rahmani, S. M. Hassanian, R. Moradi-Marjaneh, H. Fiuji, N. Boroumand, A. Nosrati-Tirkani, M. Ghayour-Mobarhan, G. A. Ferns, M. Khazaei, and A. Avan, “Crocin Synergistically Enhances the Antiproliferative Activity of 5-Flurouracil Through Wnt/PI3K Pathway in a Mouse Model of Colitis-Associated Colorectal Cancer,” Journal of Cellular Biochemistry 119, no. 12 (2018): 10250-10261, https://doi.org/10.1002/jcb.27367.The above article, published online on August 20, 2018, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Figure 6B was found to contain inappropriate splicing sites and methodological flaws. Additionally, in Figure 5A and 5a, no correlation was observed between samples at low and high magnification. The authors did not provide clarification on these issues or the original data. Accordingly, the article is retracted as the editors have lost confidence in the integrity and accuracy of the whole body of data presented in the article and consider its conclusions invalid. The authors have been informed of the decision of retraction.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Forkhead Box p3 Controls Progression of Oral Lichen Planus by Regulating MicroRNA-146a

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-23 DOI: 10.1002/jcb.70019

引用次数: 0

Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-10 DOI: 10.1002/jcb.70031

Jingjing Liu, Xuhui Liu, Xiaohang Xie, Wei Si, Yuhang Zhang, Mengjiao Xue, Xuyan Peng, Mingjun Jiang, Shanshan Du, Jingzhi Shao, Yi Mao, Fengyan Zhang, Yanzhong Hu

{"title":"Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy","authors":"Jingjing Liu, Xuhui Liu, Xiaohang Xie, Wei Si, Yuhang Zhang, Mengjiao Xue, Xuyan Peng, Mingjun Jiang, Shanshan Du, Jingzhi Shao, Yi Mao, Fengyan Zhang, Yanzhong Hu","doi":"10.1002/jcb.70031","DOIUrl":"https://doi.org/10.1002/jcb.70031","url":null,"abstract":"<div>\u0000 \u0000 Small extracellular vesicles (SEVs) are membrane-bound vesicles secreted by cells that facilitate intercellular communication. This study reveals how heat shock transcription factor 4 (HSF4) deficiency regulates SEV secretion in lens epithelial cells through chaperone-mediated autophagy (CMA). Compared to mLEC/HA-Hsf4b cells, SEVs secreted by HSF4-deficient mLEC/Hsf4−/− cells showed significantly increased levels of CMA-related proteins (HSP70, HSC70, LAMP2A, and HSP90) and EGFR, while LC3 II levels were reduced. Additionally, EGFR-enriched SEVs activated downstream ERK/AKT signaling pathways, promoting the proliferation and migration of lens epithelial cells and inducing epithelial–mesenchymal transition (EMT). Further inhibition experiments showed that blocking HSP70 and HSP90 with apoptozole and retaspimycin, or silencing LAMP2A with siRNA, reduced SEV secretion in HSF4-deficient cells. Collectively, enhanced CMA activity and increased SEV secretion induced by HSF4 deficiency may represent a potential mechanism underlying congenital cataract development.</div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Structure Insights Into Antioxidant, Anti-Inflammatory, and Computational Investigations: Molecular Docking and Dynamics Studies on Enzyme Inhibitors

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-08 DOI: 10.1002/jcb.70033

Ismail sheriff Parvin, Hamza Serina Banu, Ekambaram Gayathiri, Palanisamy Prakash, Somdatta Y. Chaudhari, Thangaraj Pratheep, Subramanian Deepika Priyadharshini, Muthiah Pugalenthi, Jayapandian Narmathasri

{"title":"Molecular Structure Insights Into Antioxidant, Anti-Inflammatory, and Computational Investigations: Molecular Docking and Dynamics Studies on Enzyme Inhibitors","authors":"Ismail sheriff Parvin, Hamza Serina Banu, Ekambaram Gayathiri, Palanisamy Prakash, Somdatta Y. Chaudhari, Thangaraj Pratheep, Subramanian Deepika Priyadharshini, Muthiah Pugalenthi, Jayapandian Narmathasri","doi":"10.1002/jcb.70033","DOIUrl":"https://doi.org/10.1002/jcb.70033","url":null,"abstract":"<div>\u0000 \u0000 Solanum erianthum D. Don (Solanaceae) species has wide range of usage in treating disease in folk medicine. This study focused on the isolation and characterization of Phytol, βCaryophyllene (βc), and Methoxy - 4- Quercetin (M4Q) from Solanum erianthum leaf and seed fractions. These three compounds were studied for antioxidant activities using DPPH, SOD, and FRAP assays, accompanied by molecular docking, molecular dynamics, and ADMET tools. Our results showed that, Methoxy 4-Quercetin scored good antioxidant potential in the studied assays, with a stable conformation and favorable properties. Docking analysis was used to determine the binding energies of these compounds with different receptor proteins and ligand complexes, as well as their stability, conformation, and binding energy in molecular dynamics. Pharmacokinetic compounds exhibit kinetic values and drug-like characteristics, indicating their biological activity. Competent studies on the compounds using in silico analyses showed that all compounds have notable anti-cardiotoxic and anti-inflammatory effects. Thus, studies on phytocompounds as effective leads to the improvement of anti-inflammatory and anti-cardio agents are necessary for further in vivo studies.\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Fibronectin Promotes Cervical Cancer Tumorigenesis Through Activating FAK Signaling Pathway

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-03 DOI: 10.1002/jcb.70022

引用次数: 0

RETRACTION: LncRNA SNHG1 Regulates Cerebrovascular Pathologies as a Competing Endogenous RNA Through HIF-1α/VEGF Signaling in Ischemic Stroke

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-03 DOI: 10.1002/jcb.70017

{"title":"RETRACTION: LncRNA SNHG1 Regulates Cerebrovascular Pathologies as a Competing Endogenous RNA Through HIF-1α/VEGF Signaling in Ischemic Stroke","authors":"","doi":"10.1002/jcb.70017","DOIUrl":"https://doi.org/10.1002/jcb.70017","url":null,"abstract":"RETRACTION: L. Zhang, X. Luo, F. Chen, W. Yuan, X. Xiao, X. Zhang, Y. Dong, Y. Zhang, and Y. Liu, “LncRNA SNHG1 Regulates Cerebrovascular Pathologies as a Competing Endogenous RNA Through HIF-1α/VEGF Signaling in Ischemic Stroke, ” Journal of Cellular Biochemistry 119, no. 7 (2018): 5460-5472, https://doi.org/10.1002/jcb.26705.The above article, published online on 27 January 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Image elements within Figures 3 C and 6 F were found to have been published previously by different authors in different scientific contexts. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-04-03 DOI: 10.1002/jcb.70016

{"title":"RETRACTION: Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway","authors":"","doi":"10.1002/jcb.70016","DOIUrl":"https://doi.org/10.1002/jcb.70016","url":null,"abstract":"RETRACTION: P. Chen, S. Xu, and J. Qu, “Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway,” Journal of Cellular Biochemistry 119, no. 1 (2018): 366-377, https://doi.org/10.1002/jcb.26189.The above article, published online on 6 June 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Multiple image elements within Figures 2 A and 4 A were found to have been published previously and/or subsequently by different authors in different scientific contexts. Furthermore, evidence of inappropriate image editing/manipulation were found within Figure 3 C. The authors were invited to comment on these concerns but did not respond. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETRACTION: Characterization of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes

IF 3 3区生物学

Journal of cellular biochemistry Pub Date : 2025-03-31 DOI: 10.1002/jcb.70013

{"title":"RETRACTION: Characterization of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes","authors":"","doi":"10.1002/jcb.70013","DOIUrl":"https://doi.org/10.1002/jcb.70013","url":null,"abstract":"RETRACTION: D. Sheipouri, R. Grant, S. Bustamante, D. Lovejoy, G. J. Guillemin, and N. Braidy, “Characterization of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes,” Journal of Cellular Biochemistry 116, no. 6 (2015): 903-922. https://doi.org/10.1002/jcb.25019.The above article, published online on January 12, 2015, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl, and Wiley Periodicals LLC. The journal received notice from a third party regarding evidence of duplication and image manipulation between the QPRT and KMO panels in Figure 5D as well as the QPRT and KAT-II panels in Figure 5B. The publisher confirmed these duplications. Some authors responded to an inquiry by the publisher but were not able to provide an explanation for the duplicated panels and were not able to provide original data for verification. An initial investigation by the University of New South Wales Conduct & Integrity Office concluded that the immunochemistry data presented in this article had been misrepresented, fabricated and/or falsified and warranted further investigation by an independent research misconduct inquiry panel. The retraction has been agreed to because the evidence of image duplication and manipulation compromises the integrity of the study and the conclusions presented in the article. S.B. and D.L. agree with the retraction. All other authors did not respond to our notice regarding the retraction.","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0