Journal of cellular biochemistry最新文献

{"title":"Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and Therapeutic Implications","authors":"Min Tang,&nbsp;Ikram Outissint,&nbsp;Yijing Chen,&nbsp;Xun Gong","doi":"10.1002/jcb.70056","DOIUrl":"https://doi.org/10.1002/jcb.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>Mitophagy, a selective autophagic process, is critical for maintaining mitochondrial quality and cellular homeostasis. It plays a dual role, facilitating cell survival by removing damaged mitochondria or contributing to programmed cell death in certain conditions. Dysregulation of mitophagy is implicated in various diseases, including neurodegenerative disorders, metabolic syndromes, cardiovascular diseases, and cancers. This review examines the key regulatory mechanisms of mitophagy, focusing on pathways such as the PINK1-Parkin, BNIP3/NIX, and FUNDC1 pathways, alongside emerging modulators. Notably, mitophagy is frequently associated with various cell death pathways, such as apoptosis, necroptosis, ferroptosis, and pyroptosis. Primarily, mitophagy functions as a protective mechanism rather than a direct trigger of cell death. It may be connected to cell death when its capacity is overwhelmed rather than actively promoting the process. For instance, impaired mitophagy exacerbates neurodegeneration in Parkinson's and Alzheimer's diseases, while its activation protects against ischemic injury in cardiovascular diseases. In cancer, mitophagy is paradoxical, as it either inhibits tumor growth or promotes survival under stress. Therapeutic interventions targeting mitophagy, including small-molecule modulators, show promise in preclinical studies; however, they require further clinical validation. Advancements in imaging techniques, single-cell omics, and high-throughput screenings are anticipated to deepen our understanding of mitophagy dynamics and therapeutic potential. This review highlights mitophagy as a pivotal target for treating diseases associated with mitochondrial dysfunction, providing insights into innovative therapeutic strategies.</p>\u0000 </div>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Study of the Mechanisms of Crocetin-Induced Differentiation and Apoptosis in Human Acute Promyelocytic Leukemia Cells","authors":"","doi":"10.1002/jcb.70057","DOIUrl":"https://doi.org/10.1002/jcb.70057","url":null,"abstract":"<p><b>RETRACTION:</b> M. Moradzadeh, A. Ghorbani, S. Erfanian, et al., “Study of the Mechanisms of Crocetin-Induced Differentiation and Apoptosis in Human Acute Promyelocytic Leukemia Cells,” <i>Journal of Cellular Biochemistry</i> 120, no. 2 (2019): 1943–1957, https://doi.org/10.1002/jcb.27489.</p><p>The above article, published online on September 11, 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed upon following an investigation into concerns raised by a third party. The investigation revealed that the two panels, Crocetin 100 µM—NB4 cells and Crocetin 100 µM—HL60 cells, presented in Figure 4a, are identical. Furthermore, the flow cytometry plots showing ATRA 10 µM—Primary APL cells and Crocetin 100 µM—Primary APL cells in Figure 4b have been published in another article, representing different experimental conditions. Additionally, panels in Figure 6a showing Control Primary APL cells and ATRA 1 µM Primary APL cells, as well as β-actin bands and Acetyl-H3K4 bands in Figure 8c, have been found duplicated in another article. The manuscripts with these duplicates were co-authored by one of the co-authors of this article. The authors collaborated with the investigation and provided some supporting data, but this was deemed insufficient. Consequently, the editors consider the results and conclusions of this article to be unreliable. The author, H. R. Sadeghnia, agrees that a retraction is the appropriate and responsible course of action.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Heparan Sulfate Proteoglycans as Trastuzumab Targets in Anoikis-Resistant Endothelial Cells”","authors":"","doi":"10.1002/jcb.70051","DOIUrl":"https://doi.org/10.1002/jcb.70051","url":null,"abstract":"<p>J. O. S. Onyeisi, P. Castanho de Almeida Pernambuco Filho, S. de Araujo Lopes, H. B. Nader, and C. C. Lopes, “Heparan Sulfate Proteoglycans as Trastuzumab Targets in Anoikis-Resistant Endothelial Cells,” <i>Journal of Cellular Biochemistry</i> 120, no. 8 2019: 13826–13840. https://doi.org/10.1002/jcb.28656.</p><p>Following the publication of this article, the authors identified errors in Figures 2A and 3A. Specifically, in each figure, one panel was inadvertently duplicated, replacing another panel that should have been included. These duplications occurred due to a technical error during the final stages of image assembly and were unfortunately not detected before publication.</p><p>Upon discovering the issue, the authors conducted a thorough review of the original image data and have provided the corrected versions of Figures 2A and 3A below. The corrected figures accurately reflect the intended experimental conditions.</p><p>The authors confirm that these errors do not compromise the integrity of the underlying data, nor do they affect the results or conclusions of the study.</p><p>We sincerely regret any confusion or inconvenience this may have caused and reaffirm our commitment to upholding the highest standards of scientific accuracy and transparency. We appreciate the editorial team's attention to this matter and remain available to provide any further clarification or supporting documentation as needed.</p><p><b>Author contribution statement</b></p><p>J. O. S. Onyeisi – Investigation, Data Acquisition, Writing – Original Draft</p><p>P. Castanho de Almeida Pernambuco Filho – Methodology, Analysis</p><p>S. de Araujo Lopes – Data Acquisition, Analysis</p><p>H. B. Nader – Supervision</p><p>C. C. Lopes – Writing – Review &amp; Editing, Supervision</p><p><b>Corrected</b> Figure 2A<b>:</b></p><p><b>Corrected</b> Figure 3A<b>:</b></p><p>The authors sincerely apologize for these errors and any confusion it may have caused. We remain committed to maintaining the highest standards of scientific integrity and transparency.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Citronellal Prevents Endothelial Dysfunction and Atherosclerosis in Rats”","authors":"","doi":"10.1002/jcb.70054","DOIUrl":"https://doi.org/10.1002/jcb.70054","url":null,"abstract":"<p>Jun-xiu Lu, Chao Guo, Wen-sheng Ou, Yun Jing, Hui-fang Niu, Ping Song, Quan-zhi Li, Zhan Liu, Jian Xu, Peng Li, Mo-li Zhu, Ya-ling Yin, “Citronellal Prevents Endothelial Dysfunction and Atherosclerosis in Rats,” <i>Journal of Cellular Biochemistry</i> 120, no. 3 (2019); 3790–3800.</p><p>In Figure 2, the representative images of Figure 2A have weak typicality.</p><p>Replaced Figure 2.</p><p>We apologize for this error.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Inhibition of Transforming Growth Factor-β (TGF-β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer","authors":"","doi":"10.1002/jcb.70053","DOIUrl":"https://doi.org/10.1002/jcb.70053","url":null,"abstract":"<p><b>EXPRESSION OF CONCERN</b>: A. A. Bokhari, V. Syed, “Inhibition of Transforming Growth Factor-β (TGF-β) Signaling by <i>Scutellaria baicalensis</i> and <i>Fritillaria cirrhosa</i> Extracts in Endometrial Cancer,” <i>Journal of Cellular Biochemistry</i> 116, no. 8 (2015): 1797–1805, https://doi.org/10.1002/jcb.25138.</p><p>This Expression of Concern is for the above article, published online on June 10, 2015 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC.</p><p>The Expression of Concern has been published due to concerns raised by a third party regarding duplicated Western blot bands between the Figure 5 Slug and Figure 6 Integrin β3 subpanels. A subsequent investigation by the journal team identified further inconsistencies regarding duplication of the β-actin control bands in Figures 1A and 3A,B. The authors were informed about the concerns but they remained unresponsive. In the absence of a satisfactory explanation and/or the original raw data, the journal team could not verify the authenticity of these figures and could not exclude that these concerns affect the conclusions of the article. Therefore, the journal has decided to issue an Expression of Concern to inform and alert the readers.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Transcription Factor TFII-I Causes Transcriptional Upregulation of GRP78 Synthesis in Prostate Cancer Cells","authors":"","doi":"10.1002/jcb.70045","DOIUrl":"https://doi.org/10.1002/jcb.70045","url":null,"abstract":"<p><b>RETRACTION</b>: U. K. Misra, F. Wang, and S. V. Pizzo, “Transcription Factor TFII-I Causes Transcriptional Upregulation of GRP78 Synthesis in Prostate Cancer Cells,” <i>Journal of Cellular Biochemistry</i> 106, no. 3 (2009): 381-389, https://doi.org/10.1002/jcb.22016.</p><p>The above article, published online on 18 December 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, duplication of image elements has been detected between Figures 1A and 3, and within Figure 3. In all instances, these image elements have been used to represent different experimental conditions. An institutional review confirmed the validity of the concerns. Accordingly, the article is retracted as the editors have lost trust in the accuracy and integrity of the whole body of data and consider the conclusions of the article invalid. The authors have been informed of the decision of retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Epac1-Induced Cellular Proliferation in Prostate Cancer Cells Is Mediated by B-Raf/ERK and mTOR Signaling Cascades","authors":"","doi":"10.1002/jcb.70046","DOIUrl":"https://doi.org/10.1002/jcb.70046","url":null,"abstract":"<p><b>RETRACTION</b>: U. K. Misra and S. V. Pizzo, “Epac1-Induced Cellular Proliferation in Prostate Cancer Cells Is Mediated by B-Raf/ERK and mTOR Signaling Cascades,” <i>Journal of Cellular Biochemistry</i> 108, no. 4 (2009): 998–1011, https://doi.org/10.1002/jcb.22333.</p><p>The above article, published online on 1 September 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, duplication of image elements has been detected between Figures 2A and 4B, between Figure 3B and 3D, and between Figures 3B and 4C. In all instances, these image elements have been used to represent different experimental conditions. An institutional review confirmed the validity of the concerns. Accordingly, the article is retracted as the editors have lost trust in the accuracy and integrity of the whole body of data and consider the conclusions of the article invalid. The authors have been informed of the decision of retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Upregulation of mTORC2 Activation by the Selective Agonist of EPAC, 8-CPT-2Me-cAMP, in Prostate Cancer Cells: Assembly of a Multiprotein Signaling Complex","authors":"","doi":"10.1002/jcb.70048","DOIUrl":"https://doi.org/10.1002/jcb.70048","url":null,"abstract":"<p><b>RETRACTION:</b> U. K. Misra and S. V. Pizzo, “Upregulation of mTORC2 Activation by the Selective Agonist of EPAC, 8-CPT-2Me-cAMP, in Prostate Cancer Cells: Assembly of a Multiprotein Signaling Complex,” <i>Journal of Cellular Biochemistry</i> 113, no. 5 (2011): 1488–1500, https://doi.org/10.1002/jcb.24018.</p><p>The above article, published online on 15 December 2011 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, duplication of image elements has been detected between Figures 4C and 7B, between Figure 7A and 7B, and within Figure 6C. An institutional review confirmed the validity of the concerns. Accordingly, the article is retracted as the editors have lost trust in the accuracy and integrity of the whole body of data and consider the conclusions of the article invalid. The authors have been informed of the decision of retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Activation of Akt/PDK Signaling in Macrophages Upon Binding of Receptor-Recognized Forms of α2-Macroglobulin to Its Cellular Receptor: Effect of Silencing the CREB Gene","authors":"","doi":"10.1002/jcb.70044","DOIUrl":"https://doi.org/10.1002/jcb.70044","url":null,"abstract":"<p><b>RETRACTION</b>: U. K. Misra, and S. V. Pizzo, “Activation of Akt/PDK Signaling in Macrophages Upon Binding of Receptor-Recognized Forms of α2-Macroglobulin to Its Cellular Receptor: Effect of Silencing the CREB Gene,” <i>Journal of Cellular Biochemistry</i> 93, no. 5 (2004): 1020–1032, https://doi.org/10.1002/jcb.20233.</p><p>The above article, published online on 9 September 2004 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, duplication of image elements has been detected between Figures 2A and 5A, within Figure 3 and between Figures 3 and 4B, and between Figures 4A and 6. In all instances, these image elements have been used to represent different experimental conditions. An institutional review confirmed the validity of the concerns. Accordingly, the article is retracted as the editors have lost trust in the accuracy and integrity of the whole body of data and consider the conclusions of the article invalid. The authors have been informed of the decision of retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Loss of Cell Surface TFII-I Promotes Apoptosis in Prostate Cancer Cells Stimulated With Activated α2-Macroglobulin*","authors":"","doi":"10.1002/jcb.70047","DOIUrl":"https://doi.org/10.1002/jcb.70047","url":null,"abstract":"<p><b>RETRACTION:</b> U. K. Misra, Y. M. Mowery, G. Gawdi, and S. V. Pizzo, “Loss of Cell Surface TFII-I Promotes Apoptosis in Prostate Cancer Cells Stimulated With Activated α2-Macroglobulin*,” <i>Journal of Cellular Biochemistry</i> 112, no. 6 (2011): 1685–1695, https://doi.org/10.1002/jcb.23083</p><p>The above article, published online on 24 February 2011 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, duplication of image elements has been detected between Figures 1A and 3, and within Figure 3. In all instances, these image elements have been used to represent different experimental conditions. An institutional review confirmed the validity of the concerns. Accordingly, the article is retracted as the editors have lost trust in the accuracy and integrity of the whole body of data and consider the conclusions of the article invalid. The authors have been informed of the decision of retraction.</p>","PeriodicalId":15219,"journal":{"name":"Journal of cellular biochemistry","volume":"126 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcb.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}