Cross-Kingdom Genomic Conservation of Putative Human Sleep-Related Genes: Phylogenomic Evidence From Chlamydomonas reinhardtii

IF 3 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, George C. Abraham, David Warren Spence, Saravana Babu Chidambaram
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引用次数: 0

Abstract

Sleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life-supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, sleep's evolution and adaptive significance continue to be debated. This study explores the evolutionary origins of sleep using Chlamydomonas reinhardtii as a model organism, identifying 112 putative sleep-related genes across species and highlighting the evolutionary conservation of sleep-regulatory pathways. Additionally, discovering uncharacterized proteins with high sequence similarity and significant e-values suggests unexplored roles in sleep regulation, underscoring the potential of C. reinhardtii to reveal new insights into the molecular basis of sleep. This study provides a foundation for identifying previously unknown sleep-associated proteins, particularly within single-celled organisms, which may offer novel perspectives on the biological role of sleep. The study demonstrates that phylogenomic analysis of diverse model organisms can expand our understanding of the evolutionary trajectory of sleep and its fundamental function, paving the way for further research in sleep biology and its health implications. Overall, the fundamental functions of sleep observed in higher animal phyla originated from its primordial activities, demonstrating an evolutionary continuum wherein more specialized tasks were integrated with sleep's essential restorative properties.

假定的人类睡眠相关基因的跨界基因组保护:来自莱茵衣藻的系统基因组证据
从水母到哺乳动物,睡眠是一种广泛存在的进化保守过程,暗示其起源是5亿多年前的一种生命维持机制。尽管其基本目的和机制尚不清楚,但睡眠的进化和适应意义仍在争论中。本研究以莱茵衣藻(Chlamydomonas reinhardtii)为模式生物,探索了睡眠的进化起源,确定了112个跨物种的睡眠相关基因,并强调了睡眠调节途径的进化保护。此外,发现具有高序列相似性和显著e值的未表征蛋白表明在睡眠调节中未被探索的作用,强调了C. reinhardtii揭示睡眠分子基础的新见解的潜力。这项研究为识别以前未知的睡眠相关蛋白,特别是单细胞生物中的睡眠相关蛋白提供了基础,这可能为睡眠的生物学作用提供新的视角。该研究表明,多种模式生物的系统基因组分析可以扩展我们对睡眠进化轨迹及其基本功能的理解,为进一步研究睡眠生物学及其健康意义铺平道路。总的来说,在高等动物门中观察到的睡眠的基本功能起源于其原始活动,证明了一个进化连续体,其中更专门的任务与睡眠的基本恢复特性相结合。
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来源期刊
Journal of cellular biochemistry
Journal of cellular biochemistry 生物-生化与分子生物学
CiteScore
9.90
自引率
0.00%
发文量
164
审稿时长
1 months
期刊介绍: The Journal of Cellular Biochemistry publishes descriptions of original research in which complex cellular, pathogenic, clinical, or animal model systems are studied by biochemical, molecular, genetic, epigenetic or quantitative ultrastructural approaches. Submission of papers reporting genomic, proteomic, bioinformatics and systems biology approaches to identify and characterize parameters of biological control in a cellular context are encouraged. The areas covered include, but are not restricted to, conditions, agents, regulatory networks, or differentiation states that influence structure, cell cycle & growth control, structure-function relationships.
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