Journal of carcinogenesis & mutagenesis最新文献_第6页

Clinical Approaches in Prostate Cancer Therapies 前列腺癌治疗的临床方法

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000327

S. Santos-Filho

{"title":"Clinical Approaches in Prostate Cancer Therapies","authors":"S. Santos-Filho","doi":"10.4172/2157-2518.1000327","DOIUrl":"https://doi.org/10.4172/2157-2518.1000327","url":null,"abstract":"Prostate cancer is the most frequent tumor found in men worldwide and in Brazil and represents their secondleading cause of cancer-related death. Metastatic disease is largely resistant to conventional chemotherapies, and targeted therapies are urgently needed. The PSA (Prostate-Specific Antigen) blood test has been used in various stages of prostate cancer management, including screening and the assessment of future risk of prostate cancer development, detection of recurrent disease after local therapy and in the management of advanced disease. Prostate-Specific Membrane Antigen (PSMA) is a prototypical cell-surface marker of prostate cancer. PSMA is expressed in the neo-vascular of other solid tumours. This work aims to reach the publications of therapies utilized to treat prostatic cancer, mainly the physiotherapy, used to facilitate the life of patients with this disease. PubMed and World-Wide Science databases were used to screening about prostatic cancer therapies and biomarkers. The results showed that cryo-therapy and pelvic floor exercises were useful by physiotherapy to treat prostatic cancer. Chemotherapy showed to be the better treatment for this type of cancer. Though PSMA is a biomarker used in researches in the last 20 years, the PSA levels is still the best biomarker dosed in our days.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"35 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80862943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different IDH Mutation and 1p/19q Codeletion Rates between Astrocytoma, Oligodendrocytoma and Mixed Gliomas 星形细胞瘤、少突胶质细胞瘤和混合胶质瘤中IDH突变和1p/19q编码率的差异

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000316

Jingchi Sun, Zhen Wang, Qiang Liu, Xinyong Huang, Zaihua Xu

{"title":"Different IDH Mutation and 1p/19q Codeletion Rates between Astrocytoma, Oligodendrocytoma and Mixed Gliomas","authors":"Jingchi Sun, Zhen Wang, Qiang Liu, Xinyong Huang, Zaihua Xu","doi":"10.4172/2157-2518.1000316","DOIUrl":"https://doi.org/10.4172/2157-2518.1000316","url":null,"abstract":"Background: The mutations of isocitrate dehydrogenase (IDH-mt) and loss of chromosome 1p and 19q (1p/19q codeleltion) have been used in diagnosis of gliomas, especially in identification of oligodendrocytoma. We have performed and analyzed genetic detections with 3 types of gliomas diagnosed by morphological methods. Methods: The DNA extracted from tumor tissues of 136 patients with astrocytoma, oligodendrogliomas and mixed gliomas were subjected to fluorescence PCR capillary electrophoresis for detection of 1p and 19q codeletion and DNA sequencing for IDH mutations. The results were analyzed by SPSS 22.0 software with chi-square test for significant difference (p<0.05). Results: Among 136 patients, 77 cases (56.6%) were histopathologically diagnosed as astrocytoma (AA, WHO ), 11 (8.0%) as pure oligodendroglial tumors including both low-grade oligodendrogliomas (OA, WHO ) and anaplastic oligodendrogliomas (AOA, WHO ), and 48 (35.4%) as mixed glioma with the features of OA and AA in the same tumor tissue. The genetic detections have shown that 39 cases (28.7%) were with IDH mutations (37 IDH1-mt p.R132H and 2 IDH2-mt), and 47 (34.6%) with 1p/19q co-deletion. The significant differences of the IDH mt (p=0.008) and 1p/19q codeletion (p=0.011) were between 3 pathological types of astrocytoma, oligodendrogliomas and mixed glioms (p=0.008). In three glioma types, the rate of 1p/19q co-deletion was highest in the group of oligodendrogliomas (p=0.040). In 11 patients who were histopathologically diagnosed as oligodendroglioma, only 5 cases meet the WHO criterion that requires the presence of both 1p/19q codeletion and IDH1-mt or IDH2-mt. Conclusion: The rate of IDH mutations and 1p/19q codeletion is significantly different in three groups of gliomas, and highest in oligodendrogliomas. Some cases of oligodendrogliomas with only IDH mutation but without 1p/19q codeletion. Therefore, the genetic detections should be complemented for diagnosis of gliomas.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88959151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in MUC4 Expression in Pancreatic Cancers and Pancreatic Cysts in Egypt. MUC4在埃及胰腺癌和胰腺囊肿中的表达差异

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 Epub Date: 2018-03-26 DOI: 10.4172/2157-2518.1000312

Asserewou Etekpo, Ahmad Alghawalby, Marwa Alghawalby, Amr S Soliman, Ahmed Hablas, Baojiang Chen, Surinder Batra, Ghada A Soliman

{"title":"Differences in MUC4 Expression in Pancreatic Cancers and Pancreatic Cysts in Egypt.","authors":"Asserewou Etekpo, Ahmad Alghawalby, Marwa Alghawalby, Amr S Soliman, Ahmed Hablas, Baojiang Chen, Surinder Batra, Ghada A Soliman","doi":"10.4172/2157-2518.1000312","DOIUrl":"https://doi.org/10.4172/2157-2518.1000312","url":null,"abstract":"Pancreatic cancer is the fourth cause of cancer deaths in the U.S. with most patients diagnosed at advanced stages followed by short survival. Therefore, biomarkers for early detection are urgently needed. Mucin 4 (MUC4) is a mucin protein encoded by the MUC4 gene and identified in the majority of pancreatic cancers. With increasing clinical identification and diagnosis of pancreatic cysts globally and transformation of some cysts into pancreatic cancer, it is important to evaluate if MUC4 is expressed in pancreatic cysts. Immunohistochemistry assays utilizing heat-induced epitope retrieval (HIER) were performed to examine MUC4 protein expression in 44 paraffin-embedded tissues of pancreatic cancers and 20 pancreatic cysts. All patients were diagnosed and operated upon at the Mansoura University Gastrointestinal Surgery Center in Egypt. Clinical, demographic, and survival information were abstracted from the patients' medical records. Logistic regression was performed to predict expression of MUC4 protein in cancer and cysts, by type of cysts. Pancreatic cyst patients were significantly younger than pancreatic cancer patients (Mean age of 28.7 ± 5.25 vs. 54.84 ± 10.60 years) (p=0.0001). Expression of MUC4 was not different between cancers and pancreatic cysts (p=0.16). However, type of pancreatic cysts was predictive of MUC4 expression. Mucinous cystic neoplasms and serous cystadenoma cysts showed significantly higher MUC4 expression than non-specified and pseudocysts (80%, 75%, 25%, and 0% expression for the 4 types of cysts, respectively) (p=0.022). MUC4 expression may be associated with certain types of cysts. Follow-up of pancreatic cyst patients who show MUC4 expression might reveal clues to early detection of pancreatic cancer.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39102889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Nuclear Localisation of Autophagic p62 and Associated Cytoplasmic Beclin-1 and Bcl-2 Expressions in Adenomas and Adenocarcinomas of the Colorectal Regions 结直肠腺瘤和腺癌中自噬p62的核定位及相关细胞质Beclin-1和Bcl-2的表达

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000314

E. Adankwah, K. O. Danquah, Daniel Gyamfi, P. Ossei, E. Asiamah, Ibrahim A. Alsafari, T. Madgwick

{"title":"Nuclear Localisation of Autophagic p62 and Associated Cytoplasmic Beclin-1 and Bcl-2 Expressions in Adenomas and Adenocarcinomas of the Colorectal Regions","authors":"E. Adankwah, K. O. Danquah, Daniel Gyamfi, P. Ossei, E. Asiamah, Ibrahim A. Alsafari, T. Madgwick","doi":"10.4172/2157-2518.1000314","DOIUrl":"https://doi.org/10.4172/2157-2518.1000314","url":null,"abstract":"Background: Autophagy is an important biological process that is involved in cellular homeostasis and survival. Derailment of some cellular autophagic processes affects normal cellular function, resulting in cancers and other disorders. Autophagy related proteins are Beclin-1, a human tumour suppressor, Bcl-2 and p62 have been characterised in most cancers. Particularly, a number of studies have reported a loss of Beclin-1 and up regulation of Bcl-2 and p62 in breast cancers. However, studies regarding the expression of these proteins in colorectal adenomaadenocarcinoma transformation sequence are yet to be described. In this study, we examined the expression patterns of Beclin-1, Bcl-2 and p62 in both colorectal adenomas and adenocarcinomas. Methods: Immunohistochemistry was performed on formalin-fixed paraffin embedded tissue sections from 14 patients with colorectal tumours and the expression patterns were semi-quantitatively evaluated based on the intensity of staining and the percentage of tumour cells stained. Results: Cytoplasmic Beclin-1 and p62 expression patterns ranged from moderate to high in both tubular adenomas and adenocarcinomas as compared to normal colonic mucosa. Cytoplasmic Bcl-2 expression was moderately expressed in tubular adenomas but negative to low expression was observed in the adenocarcinomas. This study also provided, for the first time, nuclear localization of p62 in only the colorectal adenocarcinomas. Conclusion: Beclin-1, Bcl-2 and p62 may be up regulated in the transition of colorectal adenomas to adenocarcinomas.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"57 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90177036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Evolution of Spontaneously Immortalizing Human Mammary Epithelial Cells from a Woman with a Germline STK11 Mutation 携带STK11种系突变的女性乳腺上皮细胞的分子进化

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000322

D. Euhus, D. Bu, M. Considine, L. Cope

引用次数: 0

Optimal Use of Biomarkers in Oncology: Expression of Activation-induced Cytidine Deaminase (AID/AICDA) in Follicular Lymphoma 肿瘤生物标志物的最佳使用:激活诱导胞苷脱氨酶(AID/AICDA)在滤泡性淋巴瘤中的表达

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000317

Y. Yakushijin

引用次数: 0

Patient-Derived Tumor Organoids: A Promising Tool for Personalized Cancer Therapy 患者来源的肿瘤类器官:个性化癌症治疗的一个有前途的工具

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000E124

D. Padmaja, Pratheeshkumar Poyil

引用次数: 0

Safely Chemotherapy Administration in Patient with Small-cell Lung Cancer and End-stage Renal Disease Undergoing Haemodialysis 小细胞肺癌和终末期肾病行血液透析患者的安全化疗给药

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000324

D. Bursac

引用次数: 0

Frequency of HBV among Hepatocellular Carcinoma Patients in Khartoum State, Sudan 苏丹喀土穆州肝细胞癌患者中HBV的频率

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000320

B. M. T. Gorish, Humodi Ahmed Saeed Supervisor

引用次数: 1

Presentations of Clinical, Ultrasonographic and Pathological Features of Nodular Fasciitis from an Established Cytogenetic Viewpoint: Review of the Case Series 从细胞遗传学角度探讨结节性筋膜炎的临床、超声和病理特征:病例回顾

Journal of carcinogenesis & mutagenesis Pub Date : 2018-01-01 DOI: 10.4172/2157-2518.1000326

K. Fujioka

引用次数: 10