Journal of carcinogenesis & mutagenesis最新文献

Relationships between gut microbiota, red meat consumption and colorectal cancer. 肠道微生物群、食用红肉与结肠直肠癌之间的关系。

Journal of carcinogenesis & mutagenesis Pub Date : 2022-01-01 Epub Date: 2022-05-12

Mahamane Talphi Diakité, Bréhima Diakité, Amadou Koné, Saidou Balam, Djeneba Fofana, Dramane Diallo, Yaya Kassogué, Cheick B Traoré, Bakarou Kamaté, Djibril Ba, Madani Ly, Mamadou Ba, Bourahima Koné, Almoustapha I Maiga, Chad Achenbach, Jane Holl, Robert Murphy, Lifang Hou, Mamoudou Maiga

{"title":"Relationships between gut microbiota, red meat consumption and colorectal cancer.","authors":"Mahamane Talphi Diakité, Bréhima Diakité, Amadou Koné, Saidou Balam, Djeneba Fofana, Dramane Diallo, Yaya Kassogué, Cheick B Traoré, Bakarou Kamaté, Djibril Ba, Madani Ly, Mamadou Ba, Bourahima Koné, Almoustapha I Maiga, Chad Achenbach, Jane Holl, Robert Murphy, Lifang Hou, Mamoudou Maiga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Excessive consumption of red and processed meat has been associated with a higher risk of developing colorectal cancer. There are many attempts to explain the risk of colorectal cancer associated with the consumption of red and processed meat: The temperature cooking of meat such as grilling and smoking contribute to the formation of mutagenic compounds including heterocyclic amines and polycyclic aromatic hydrocarbons.Heme iron in red meat is involved in the formation of N-nitroso compounds and lipid peroxidation products in the digestive tract.Fatty red meat is involved in the production of secondary bile acids by the bacteria of the gut microbiota. Many of the products formed are genotoxic and can cause DNA damage and initiate carcinogenesis of colorectal cancer. Various mechanisms contributing to their genotoxic role have been established in human and animal studies. In addition, there is increasing evidence that compounds formed from red and processed meat interact with the gut microbiota in colorectal cancer pathways. Although several early studies in animals and humans suggest a direct causal role of the gut microbiota in the development of colorectal cancer, the links between diet, gut microbiota, and colonic carcinogenesis are largely associations rather than proven causal relationships. Various biological mechanisms, including inflammation and oxidative stress can lead to DNA damage, gut dysbiosis, and therefore increase the risk of colorectal cancer. Dysbiosis of the gut microbiota may increase the risk of colorectal cancer through dietary component promotion of colonic carcinogenesis. In this paper, we review and update current knowledge about the relationships between red meat consumption, gut microbiota, and colorectal cancer.</p>","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10194058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cemento Ossifying Fibroma: A Pathological Entity 骨水泥骨化纤维瘤:一种病理实体

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.359

S. MohammadShahid, H. Raj, Anil Raj Ks

引用次数: 1

Does the Absence of Down-Regulation of MHC-I in Cancer Cells Necessarily Lead to their Annihilation by Immunologic Attack? 肿瘤细胞中mhc - 1下调缺失是否必然导致其被免疫攻击消灭?

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S6.001

P. Sinha

{"title":"Does the Absence of Down-Regulation of MHC-I in Cancer Cells Necessarily Lead to their Annihilation by Immunologic Attack?","authors":"P. Sinha","doi":"10.35248/2157-2518.21.S6.001","DOIUrl":"https://doi.org/10.35248/2157-2518.21.S6.001","url":null,"abstract":"It has long been known now that MHC-I is down-regulated in several cancers and this has been linked with impaired immune attack against cancer cells. It is obvious then that low MHC-I expression is also linked with poor survival of cancer patients. But, however, through a careful analysis of the prognostic influence of MHC-I expression in colorectal cancer, head and neck squamous cell carcinoma, and biliary tract cancer, I conclude that the percentage of deaths of patients with high MHC-I expression in tumor (due to tumor alone) out of the total number of deaths (due to tumor alone) is not insignificant when compared to the percentage of deaths of cancer patients with low MHC-I expression in tumor. Hence the absence of down-regulation of MHC-I in cancer cells does not necessarily lead to their annihilation by immunologic attack. Stated differently, the down-regulation of MHC-I in cancer cells is not a necessary step in the genesis of cancer. New research needs to be directed at finding the immune evasion mechanism in cancer cells with high MHC-I expression. I finish the paper by speculating on few such mechanisms. Two of the important mechanisms speculated are clonal deletion of T cells (in the thymus) directed against antigens on Cancer Stem Cells, and down-regulation of MHC-II in metastatic cells which arise possibly by the fusion of hematopoietic stem cells and their lineages with tumor cells","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"13 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79265284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FGF2- Mediated Programming of Macrophages: A Novel Target for Cancer Therapy 巨噬细胞FGF2介导的编程:癌症治疗的新靶点

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.362

J. Im, R. Muschel

引用次数: 0

Statistics and Analysis of Cancer Across the World 全球癌症统计与分析

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S18.E002

Elizabeth Grace

引用次数: 0

Impact of Covid 19 on Cancer Covid - 19对癌症的影响

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.E127

J. Maheswari

引用次数: 0

Comparison RNA Expression Level of HER2 (By QRT-PCR) With Protein Expression Level (Immunohistochemistry) and Investigation HER 2 Expression Level with Clinicopathological Features HER2 RNA表达水平(QRT-PCR)与蛋白表达水平(免疫组化)的比较，探讨HER2表达水平与临床病理特征的关系

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S18.003

Samira Shabani, Tayebeh Majidi Zadeh, Ameneh Tavakoli Koudehi, Frouz, E. Mahjoubi

{"title":"Comparison RNA Expression Level of HER2 (By QRT-PCR) With Protein Expression Level (Immunohistochemistry) and Investigation HER 2 Expression Level with Clinicopathological Features","authors":"Samira Shabani, Tayebeh Majidi Zadeh, Ameneh Tavakoli Koudehi, Frouz, E. Mahjoubi","doi":"10.35248/2157-2518.21.S18.003","DOIUrl":"https://doi.org/10.35248/2157-2518.21.S18.003","url":null,"abstract":"Background: Evaluation HER2 (human epidermal growth factor receptor 2) status is considered as a standard practice in breast cancer clinical management. There are different methods for evaluation HER2 status, but currently the routine method for assessment of HER2 status is Immunohistochemistry (IHC) .The aim of the this study was to compare the results obtained by IHC and Quantitative Real Time PCR methods in determination of HER2 status to specify whether QRT- PCR can use as supplementary method in breast cancer or not. Methods: In this regard, 48 fresh tissues from patients with breast tumor were studied. IHC, qRT- PCR technique was done in every speciman. IHC was done with DAKO HercepTest and QRT- PCR method was performed with TaqMan probes and primers in lightcyclerTMsystem (Corbett Real Time Thermal cycler). Results: No Correlations was seen between relative HER2 mRNA expression and IHC HER2 status. Furthermore, the relation between HER2 expression level and patient's age, tumor size, lymph node involvement and tumor grade was not significant. Conclusion: The present results show that the relative mRNA levels of HER2 by using q RT-PCR cannot discriminate between HER2 IHC positive from negative","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"1 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80496628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Distal Pancreatectomy for the Management of Left-Sided Pancreatic Cancer 微创远端胰腺切除术治疗左侧胰腺癌

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S17.003

Y. Kawabata, T. Nishi, Y. Tajima

{"title":"Minimally Invasive Distal Pancreatectomy for the Management of Left-Sided Pancreatic Cancer","authors":"Y. Kawabata, T. Nishi, Y. Tajima","doi":"10.35248/2157-2518.21.S17.003","DOIUrl":"https://doi.org/10.35248/2157-2518.21.S17.003","url":null,"abstract":"Curative surgical resection is considered the most effective treatment option to achieve long–term survival in patients with pancreatic cancer. In performing a Distal Pancreatectomy (DP) for left–sided pancreatic cancer, there are two main approaches to dissection: proceeding from left to right and from right to left. The conventional DP procedure was the Standard Retrograde Pancreatosplenectomy (SRPS), with a left–to–right dissection, and then the radical antegrade Modular Pancreatosplenectomy (RAMPS), with a right–to–left dissection, was developed. A greater number of harvested lymph nodes and an increase in R0 resection have been achieved in RAMPS as compared to SRPS; however, oncological outcomes, including patient survival, are comparable in these procedures. Recently, Minimally Invasive Distal Pancreatectomy (MIDP) using laparoscopy for pancreatic cancer has been advanced. The MIDP also has not been enough to show oncological benefits as compared with an open DP. Additional randomized controlled trials should be conducted to clarify the impacts and benefits of each surgical approach in performing DP for cancer of the body or tail of the pancreas","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"3 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72617942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presentation of an Intertwined Tumor Chain from Diploid over Tetraploid towards the Aneuploid Tumors 从二倍体到四倍体到非整倍体肿瘤的缠绕肿瘤链的呈现

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.363

Rol, Sennerstam, Jan-Olov Strmberg, G. Auer

{"title":"Presentation of an Intertwined Tumor Chain from Diploid over Tetraploid towards the Aneuploid Tumors","authors":"Rol, Sennerstam, Jan-Olov Strmberg, G. Auer","doi":"10.35248/2157-2518.21.12.363","DOIUrl":"https://doi.org/10.35248/2157-2518.21.12.363","url":null,"abstract":"The role of Tetraploidization (TPZ) in tumor progression is not clearly described as an important link from one benign tumor to a more malign tumor. In this report we will intertwine the TPZ in a chain starting with diploid and during a lot of replicative stress parameters and hypoxia under increasing genomic instability losing genetic material and move down to aneuploids tumors. To arrange this connection between DNA (DI) entities we separated all tetraploid tumors in two subgroups (1.8 ≥ DI<2.0) and to (2.0 ≥ DI<2.2), and furthermore, two aneuploid groups divided in (1.2 ≥ DI<1.4) and (1.4 ≥ DI<1.8). This rather simple higher level of resolution has opened a new way to a deeper understanding of ploidy alterations during tumor progression. In total 1253 breast cancer patients divided in five decades were included from age <40 years and up to ≥ 70s. Two connected decades (50 ≥ age<70 years) were included in mammography screening interfering with the data and improved the results. The whole data of DNA- indices in each of the four DI intervals were included within (1.2 ≥ DI<2.2). Furthermore, the genomic instability was analyzed by three increasing levels of Stemline-Scatter Index (SSI): SSI<6, SSI<15 and SSI ≤ 60 rel. units which drives the genomic instability towards higher degree of malignancy.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"2 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78779054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistics of Breast Cancer across Various Countries 各国乳腺癌统计数据

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S18.001

Maegan A. Smith

引用次数: 0