Journal of carcinogenesis & mutagenesis最新文献_第2页

Novel Therapy with Hybrid Liposomes for Orthotopic Graft Mouse Models of Glioblastoma 用杂交脂质体治疗小鼠胶质母细胞瘤模型

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.360

Keiji Kuwabara, H. Ichihara, Y. Matsumoto

引用次数: 0

Incongruent Biology of Redistributed Chemokine Action in Carcinogenesis 致癌过程中再分布趋化因子作用的不一致生物学

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S19.002

L. Agius

引用次数: 0

Trehalose Liposomes Inhibit the Growth of Glioblastoma Cell In vitro and In vivo 海藻糖脂质体对胶质母细胞瘤细胞生长的体内外抑制作用

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.364

Keiji Kuwabara, H. Ichihara, Y. Matsumoto

引用次数: 0

Current Genetic Advances in NAFLD/NASH: Related Hepatocellular Carcinoma Along with Characteristic Clinical Manifestation NAFLD/NASH的遗传学进展:相关肝细胞癌及特征性临床表现

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S17.001

K. Fujioka

{"title":"Current Genetic Advances in NAFLD/NASH: Related Hepatocellular Carcinoma Along with Characteristic Clinical Manifestation","authors":"K. Fujioka","doi":"10.35248/2157-2518.21.S17.001","DOIUrl":"https://doi.org/10.35248/2157-2518.21.S17.001","url":null,"abstract":"Non-Alcoholic Fatty Liver Disease (NAFLD) is the common liver disease worldwide because of the increasing rates in parallel to obesity and Type 2 Diabetes Mellitus (T2DM). Mechanically, lipid accumulation and insulin resistance serve as the first hit, second hit is considered as inflammation and fibrosis in NAFLD. NAFLD is attributed to liverrelated morbidity and mortality, there is also growing evidence that NAFLD is a multisystem disease and is associated with hepatic (hepatocellular carcinoma: HCC) and extrahepatic (Cardiovascular Disease: CVD, Coronary Artery Disease: CAD, and Chronic Kidney Disease: CKD) diseases. The author previously suggested that an association between chronic liver disease (NAFLD/NASH and chronic hepatitis C virus infection: HCV infection) and systemic atherosclerosis may be present due to the presence of the inflammation as a common pathway. In this article, the current genetic advances of NAFLD/NASH-related HCC including PNPLA3, TM6SF2, GCKR, MBOAT7, HSD17B13, and the combined effect of these variants along with characteristic clinical manifestation have been reviewed. NAFLDs clinically predispose to occur non-cirrhotic NAFLD-HCC. The study of polygenic risk scores may be attributed to the stratification of the risk of the NAFLD/NASH-related HCC in the near feature. On the basis of the characteristic clinical and genetic evidences, the author suggests that the risk stratification of the medium/high risk in NAFLD-related HCC, especially non-cirrhotic HCC may contribute to the prevention, prediction, and surveillance.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"44 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87534087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of Bromine, Calcium, Chlorine, Iodine, Potassium, Magnesium, Manganese, and Sodium Content in the Thyroid Adenomas using Neutron Activation Analysis 用中子活化分析法评价甲状腺腺瘤中溴、钙、氯、碘、钾、镁、锰和钠的含量

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.366

V. Zaichick

引用次数: 4

Comparative Quality Evaluation of Different Brands of Clopidogrel Tablet Available in Bangladesh 孟加拉国不同品牌氯吡格雷片剂质量比较评价

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.365

Naimur Rehman

{"title":"Comparative Quality Evaluation of Different Brands of Clopidogrel Tablet Available in Bangladesh","authors":"Naimur Rehman","doi":"10.35248/2157-2518.21.12.365","DOIUrl":"https://doi.org/10.35248/2157-2518.21.12.365","url":null,"abstract":"This study aims to assess the quality parameters of Clopidogrel tablets from different manufacturers available in the Bangladeshi market. Clopidogrel is a potent antiplatelet and antithrombotic drug. Clopidogrel has been approved and marketed globally with the primary indication being to reduce atherosclerotic events in patients with several comorbid conditions due to stroke, myocardial infarction and cardiovascular disease. The aim and the objective of our present study are to evaluate the quality parameters of some marketed Clopidogrel tablet and to compare the parameters among them. To assess the quality, three different marketed Clopidogrel 75 mg tablet are selected and invitro dissolution test, potency, disintegration time are carried out. Other general quality parameters of these tablets like weight variation, hardness, friability are also determined according to established protocols. All the brands comply the requirements of United State Pharmacopoeia as they show acceptable weight variation range. Friability of all brands is less than 1%. No significant differences are found in disintegration time as they disintegrate within 15 minutes. In case of dissolution profile all brands show better dissolution time as they release more than 75% of drug in 45 minutes. The hardness of one brand is within the range 40-60N. The limitation of the potency must be within 95- 105%. All three brands meet this specification. This study suggests that most commercially available Clopidogrel tablets in Bangladesh maintain the quality and comply with the USP specifications which are essential for better therapeutic activity of this antiplatelet drug.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"12 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86626060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calm Therapy in Managing Cancer Treatment 冷静疗法管理癌症治疗

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S18.002

R. Solomon

引用次数: 0

Exosomes and Cancer: The Bio Informational Reprogramming Therapy for Malignant Cells 外泌体与癌症:恶性细胞的生物信息重编程治疗

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.358

Michael J. González, P. Biava, Alondra P Toro, J. Olalde, J. R. Mir, A. Massari

引用次数: 0

A Brief Note on Cancer Immunology 癌症免疫学简介

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.S18.E001

J. George

引用次数: 0

The Role of Side Population Cells and Hypoxia in Resistance to Chemotherapy in Astrocytoma Cell Lines 侧群细胞和缺氧在星形细胞瘤细胞耐化疗中的作用

Journal of carcinogenesis & mutagenesis Pub Date : 2021-01-01 DOI: 10.35248/2157-2518.21.12.361

J. Balbuena, J. Castresana, J. Petriz

{"title":"The Role of Side Population Cells and Hypoxia in Resistance to Chemotherapy in Astrocytoma Cell Lines","authors":"J. Balbuena, J. Castresana, J. Petriz","doi":"10.35248/2157-2518.21.12.361","DOIUrl":"https://doi.org/10.35248/2157-2518.21.12.361","url":null,"abstract":"The objective of this work focuses on determining whether there are tumor cells with the Side Population phenotype in cell lines derived from astrocytomas, and if they are sensitive to hypoxia conditions and to the combination of temozolomide with inhibitors of sonic hedgehog pathway (cyclopamine) and of MGMT (O6 -benzylguanine). Cytometry studies were performed to separate the SP cell fraction in all cell lines. The proportion of SP cells was directly proportional to the degree of malignancy of the astrocytoma. The cells showed characteristics of tumor stem cells, such as a greater capacity for self-renewal, and constituted an independent or partially overlapping population with the population of CD133+ cancer stem cells. SP cells were highly resistant to temozolomide, while tumor cells that did not display tumor stem cell properties appeared to be more sensitive. The sonic hedgehog pathway caused resistance to temozolomide, but its inhibition with cyclopamine increased the cytotoxic effects of temozolomide, preferentially in populations not enriched for tumor stem cells of the Side Population. Chemoresistance was often independent of MGMT expression. O6 -benzylguanine was not always capable of increasing the sensitivity to temozolomide in tumor stem cells of the Side Population and in hypoxia. ABCG2 was the transporter predominantly expressed in tumor stem cell populations of the Side Population in high-grade astrocytomas, whereas MDR1 expressed more in non-tumor stem cell populations, and in tumor cells in lower-grade astrocytomas. ABCG2 might be responsible for acquired resistance during treatment with temozolomide.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"40 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86382314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0