{"title":"肿瘤生物标志物的最佳使用:激活诱导胞苷脱氨酶(AID/AICDA)在滤泡性淋巴瘤中的表达","authors":"Y. Yakushijin","doi":"10.4172/2157-2518.1000317","DOIUrl":null,"url":null,"abstract":"Follicular lymphoma (FL), which originates in germinal center B-lymphocytes, has been recognized to be a heterogeneous entity in some patients developing progressive or transformed diseases. Secondary genetic events after t(14;18) translocation have been associated with this histological transformation, such as c-myc amplification and/or translocation. Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hyper-mutation and class switch recombination of immunoglobulin genes, and c-myc translocation of the germinal centre derived B-cell lymphoma. The role of AID in FL pathogenesis has not been established. Here we tried to identify the significance of AID associated with c-myc in the progression of FL, and showed that switched-off AID or a low expression of AID after c-myc amplification might correlate to rapidly progressive FL as well as to overall clinical outcomes.","PeriodicalId":15209,"journal":{"name":"Journal of carcinogenesis & mutagenesis","volume":"117 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimal Use of Biomarkers in Oncology: Expression of Activation-induced Cytidine Deaminase (AID/AICDA) in Follicular Lymphoma\",\"authors\":\"Y. Yakushijin\",\"doi\":\"10.4172/2157-2518.1000317\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Follicular lymphoma (FL), which originates in germinal center B-lymphocytes, has been recognized to be a heterogeneous entity in some patients developing progressive or transformed diseases. Secondary genetic events after t(14;18) translocation have been associated with this histological transformation, such as c-myc amplification and/or translocation. Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hyper-mutation and class switch recombination of immunoglobulin genes, and c-myc translocation of the germinal centre derived B-cell lymphoma. The role of AID in FL pathogenesis has not been established. Here we tried to identify the significance of AID associated with c-myc in the progression of FL, and showed that switched-off AID or a low expression of AID after c-myc amplification might correlate to rapidly progressive FL as well as to overall clinical outcomes.\",\"PeriodicalId\":15209,\"journal\":{\"name\":\"Journal of carcinogenesis & mutagenesis\",\"volume\":\"117 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of carcinogenesis & mutagenesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2157-2518.1000317\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of carcinogenesis & mutagenesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2157-2518.1000317","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Optimal Use of Biomarkers in Oncology: Expression of Activation-induced Cytidine Deaminase (AID/AICDA) in Follicular Lymphoma
Follicular lymphoma (FL), which originates in germinal center B-lymphocytes, has been recognized to be a heterogeneous entity in some patients developing progressive or transformed diseases. Secondary genetic events after t(14;18) translocation have been associated with this histological transformation, such as c-myc amplification and/or translocation. Activation-induced cytidine deaminase (AID/AICDA) is required for somatic hyper-mutation and class switch recombination of immunoglobulin genes, and c-myc translocation of the germinal centre derived B-cell lymphoma. The role of AID in FL pathogenesis has not been established. Here we tried to identify the significance of AID associated with c-myc in the progression of FL, and showed that switched-off AID or a low expression of AID after c-myc amplification might correlate to rapidly progressive FL as well as to overall clinical outcomes.
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