Journal of Breast Cancer最新文献

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Radiotherapy Boost to Clinically Positive Internal Mammary Lymph Nodes: An Effective Non-Surgical Alternative? 放疗促进临床阳性内乳淋巴结:一种有效的非手术选择?
IF 2.4 4区 医学
Journal of Breast Cancer Pub Date : 2025-07-08 DOI: 10.4048/jbc.2024.0304
Caglayan Selenge Beduk Esen, Yasin Ozyurek, Sezin Yuce Sari, Melis Gultekin, Gokhan Ozyigit, Ferah Yildiz
{"title":"Radiotherapy Boost to Clinically Positive Internal Mammary Lymph Nodes: An Effective Non-Surgical Alternative?","authors":"Caglayan Selenge Beduk Esen, Yasin Ozyurek, Sezin Yuce Sari, Melis Gultekin, Gokhan Ozyigit, Ferah Yildiz","doi":"10.4048/jbc.2024.0304","DOIUrl":"https://doi.org/10.4048/jbc.2024.0304","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of radiation therapy (RT) boost sequences and doses to internal mammary (IM) lymph nodes (LNs) on oncologic outcomes and toxicity in patients with clinically IMLN-positive breast cancer.</p><p><strong>Methods: </strong>Twenty-six patients with positive IMLNs at diagnosis who were treated between 2013 and 2022 were retrospectively evaluated. After systemic therapy and surgery, RT was applied to the whole breast or chest wall, including the axillary, supraclavicular, and IM lymphatics. An RT boost to the IMLNs was administered either sequentially or as a simultaneous integrated boost (SIB). Treatment outcomes, prognostic factors, and toxicity profiles were analyzed.</p><p><strong>Results: </strong>A complete response (CR) and partial response (PR) in metastatic IMLNs were observed in 17 patients (65.4%) and 5 patients (19.2%) following systemic therapy, respectively. One patient (3.8%) had stable disease, while two patients (7.7%) experienced disease progression in the IMLNs.After a median follow-up of 67 months, regional recurrence, distant metastasis, or both occurred in 1 (3.8%), 1 (3.8%), and 2 (7.7%) patients, respectively. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 86.7% and 76.4%, respectively. The absence of extracapsular extension in axillary LNs was associated with improved OS and DFS. A CR or PR to systemic treatment in IMLNs was associated with improved DFS only. The boost sequence had no significant effect on survival, organ-at-risk doses, or cardiac toxicity.</p><p><strong>Conclusion: </strong>An RT boost to IMLNs without surgical resection provides excellent oncologic outcomes with acceptable toxicity. While the SIB technique reduces the number of treatment fractions, it did not result in superior oncologic outcomes compared to the sequential boost. Further prospective studies are needed to investigate the role of RT boost sequencing to the IMLNs.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "Letter to the Editor: Targeted Inhibition of p21 Promotes the Growth of Breast Cancer Cells and Impairs the Tumor-Killing Effect of the Vaccinia Virus". 回复“致编辑的信:靶向抑制p21促进乳腺癌细胞的生长并削弱牛痘病毒的肿瘤杀伤作用”。
IF 2.4 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-17 DOI: 10.4048/jbc.2025.0128
Muhammad Haris Sultan, Xiaoyuan Jia, Yigang Wang
{"title":"Reply to \"Letter to the Editor: Targeted Inhibition of p21 Promotes the Growth of Breast Cancer Cells and Impairs the Tumor-Killing Effect of the Vaccinia Virus\".","authors":"Muhammad Haris Sultan, Xiaoyuan Jia, Yigang Wang","doi":"10.4048/jbc.2025.0128","DOIUrl":"https://doi.org/10.4048/jbc.2025.0128","url":null,"abstract":"","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Cancer Risk After Hysterectomy: A Health Insurance Database-Based Analysis. 子宫切除术后乳腺癌风险:基于健康保险数据库的分析。
IF 2.4 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-16 DOI: 10.4048/jbc.2025.0031
Yeonjin Shin, Gyuho Nahm, Jiwon Seo, Jin Li Lee, Gwan Hee Han, Sang-Hee Yoon, Ji Hyun Noh, Myounghwan Kim, Jin-Sung Yuk
{"title":"Breast Cancer Risk After Hysterectomy: A Health Insurance Database-Based Analysis.","authors":"Yeonjin Shin, Gyuho Nahm, Jiwon Seo, Jin Li Lee, Gwan Hee Han, Sang-Hee Yoon, Ji Hyun Noh, Myounghwan Kim, Jin-Sung Yuk","doi":"10.4048/jbc.2025.0031","DOIUrl":"https://doi.org/10.4048/jbc.2025.0031","url":null,"abstract":"<p><strong>Purpose: </strong>Despite numerous previous studies, the relationship between hysterectomies and breast cancer risk remains unclear. This study aimed to assess whether hysterectomies are significantly associated with a reduced risk of breast cancer in Korean women using data from the National Health Insurance Service database of South Korea.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of South Korean women aged 40-59 years who underwent hysterectomies for benign reasons or underwent a health check-up between 2003 and 2011. To minimize confounding factors, a 1:1 propensity score matching (PSM) was used to balance the groups based on key covariates. The participants were followed up until December 31, 2020. Stratified Cox proportional hazards regression analysis was performed to assess the association between hysterectomies and breast cancer risk.</p><p><strong>Results: </strong>After 1:1 PSM, 13,148 women were assigned to the hysterectomy or non-hysterectomy groups. Breast cancer occurred in 242 (1.8%) and 233 (1.8%) women in the non-hysterectomy and hysterectomy groups, respectively (<i>p</i> = 0.711). After adjusting for confounders, hysterectomy with or without adnexal surgery was not significantly associated with breast cancer risk (hazard ratio [HR], 0.937; 95% confidence interval [CI], 0.775-1.132 for hysterectomy with/without adnexal surgery; HR, 0.957; 95% CI, 0.779-1.176 for hysterectomy without adnexal surgery; and HR, 0.833; 95% CI, 0.513-1.353 for hysterectomy with adnexal surgery). No significant association was found when analyzing surgical methods or age at natural menopause.</p><p><strong>Conclusion: </strong>Our study found no association between hysterectomies and breast cancer risk, which is consistent with previous studies that reported a null association.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Nomogram Incorporating Intermuscular Adipose Tissue to Predict Chemotherapy Toxicity in Older Adults With Early-Stage Breast Cancer. 结合肌间脂肪组织的Nomogram预测老年早期乳腺癌患者化疗毒性。
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.4048/jbc.2024.0194
Wen-Juan Huang, Han-Bing Xie, Lin Zhao, Rui-Han Zhou, Shurui Wang, Xin Zhang, Rui-Tao Wang, Zexun Duan
{"title":"A Nomogram Incorporating Intermuscular Adipose Tissue to Predict Chemotherapy Toxicity in Older Adults With Early-Stage Breast Cancer.","authors":"Wen-Juan Huang, Han-Bing Xie, Lin Zhao, Rui-Han Zhou, Shurui Wang, Xin Zhang, Rui-Tao Wang, Zexun Duan","doi":"10.4048/jbc.2024.0194","DOIUrl":"10.4048/jbc.2024.0194","url":null,"abstract":"<p><strong>Purpose: </strong>Recent studies have shown that intermuscular adipose tissue (IMAT) is a significant prognostic factor for breast cancer. To date, no clinical studies have investigated whether IMAT can be used to predict chemotherapy toxicity in older adult patients with early-stage breast cancer.</p><p><strong>Methods: </strong>We included 304 patients diagnosed with stage I-III breast cancer between January 2020 and December 2022 in Harbin Medical University Cancer Hospital. All patients were aged ≥ 65 years and treated with neoadjuvant or adjuvant chemotherapy. IMAT within the pectoralis muscle was measured using computed tomography imaging. Logistic regression analysis was used to identify independent predictors of chemotherapy toxicity. A nomogram was built, and the model performance was assessed using accuracy, discrimination, and clinical benefits. The net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to evaluate changes in model performance after the addition of adipose tissue.</p><p><strong>Results: </strong>Of the 304 patients (184 in the training cohort and 120 in the validation cohort), 30.3% developed grade 3-5 chemotherapy toxicities. Three independent predictors were identified in the multivariate analysis: hemoglobin level, IMAT area, and primary prophylaxis with granulocyte colony-stimulating factor. The nomogram demonstrated area under the receiver operating characteristic curve values of 0.708 (95% confidence interval [CI], 0.616-0.801) and 0.751 (95% CI, 0.655-0.846) in the training and validation cohorts, respectively. The nomogram showed good calibration (Hosmer-Lemeshow test, <i>p</i> > 0.05), and incorporating IMAT improved nomogram performance in both cohorts (all NRI and IDI > 0, <i>p</i> < 0.05). Decision curve analysis revealed that the nomogram was clinically useful.</p><p><strong>Conclusion: </strong>A nomogram including IMAT may be useful for predicting the individual probability of chemotherapy toxicity and guiding therapy in older adults with early-stage breast cancer.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":" ","pages":"125-138"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consensus Statement on Robotic Nipple Sparing Mastectomy Expert Panel. 机器人乳头保留乳房切除术专家小组的共识声明。
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.4048/jbc.2025.0030
Jai Min Ryu, Chi Wei Mok, Antonio Toesca, Hung-Wen Lai, Wen-Ling Kuo, Fiona Tsui-Fen Cheng, Seung Yong Song, Jeffrey Johnson, Hyukjai Shin, Hyung Seok Park
{"title":"Consensus Statement on Robotic Nipple Sparing Mastectomy Expert Panel.","authors":"Jai Min Ryu, Chi Wei Mok, Antonio Toesca, Hung-Wen Lai, Wen-Ling Kuo, Fiona Tsui-Fen Cheng, Seung Yong Song, Jeffrey Johnson, Hyukjai Shin, Hyung Seok Park","doi":"10.4048/jbc.2025.0030","DOIUrl":"10.4048/jbc.2025.0030","url":null,"abstract":"<p><strong>Purpose: </strong>Since the last consensus statement on robotic nipple-sparing mastectomy (RNSM) in 2019, this technique has gained popularity, with accumulating evidence supporting its feasibility and patient satisfaction. However, concerns regarding the technical challenges and patient selection persist. This study aimed to provide an updated consensus on RNSM.</p><p><strong>Methods: </strong>An international panel of 10 expert surgeons was convened to develop a consensus covering six domains: indications, contraindications, technical considerations, patient counseling, outcome measures, and training. The panel was asked to vote on statements via two rounds of online surveys and a final in-person meeting at the Global Breast Cancer Conference in conjunction with the International Endoscopic and Robotic Breast Surgery Symposium. Consensus was defined as 80% agreement with each statement.</p><p><strong>Results: </strong>A total of 53 statements with at least 80% agreement were generated after three rounds of voting. Most statements were updated from previous consensus statement. All experts agreed that the consensus statement serves as a set of expert recommendations for the successful and safe practice of robotic mastectomy but are not mandatory actions.</p><p><strong>Conclusion: </strong>Although still evolving, RNSM is a promising technique representing the future of minimally invasive breast surgery. This international consensus statement offers expert recommendations for safe and effective RNSM practices.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":" ","pages":"180-192"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Implication of Subcategorizing T2 Category in Metaplastic Breast Cancer. T2亚分类在转移性乳腺癌中的临床意义。
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 DOI: 10.4048/jbc.2025.0032
Zankai Wu, Qingfeng Yang, Yanting Zhang, Yiping Gong, Jin Hu
{"title":"Clinical Implication of Subcategorizing T2 Category in Metaplastic Breast Cancer.","authors":"Zankai Wu, Qingfeng Yang, Yanting Zhang, Yiping Gong, Jin Hu","doi":"10.4048/jbc.2025.0032","DOIUrl":"10.4048/jbc.2025.0032","url":null,"abstract":"<p><strong>Purpose: </strong>In the tumor, node, metastasis staging system for metaplastic breast cancer (MBC), the T2 category, encompassing a border spectrum of tumor sizes than T1 category, curiously lacks subcategorization.</p><p><strong>Methods: </strong>Using the Surveillance, Epidemiology, and End Results database, data of 767 women diagnosed as T2N0-2 MBC between 2004 and 2016 were analyzed. The optimal tumor size cutoff was determined using X-tile software to facilitate the subclassification of T2 tumors. A comparison of breast cancer-special survival (BCSS) was conducted across three subcategories, with a median follow-up duration of 44 months.</p><p><strong>Results: </strong>Of 767 patients, 136 (17.7%) died. Based on Kaplan-Meier analysis, 30 mm and 40 mm were selected as the cutoff values. Ten-year BCSS rate was 90.2% in patients with breast tumors ≤ 30 mm (T2a), 80.2% in patients with breast tumors ≤ 40 mm (T2b), and 68.2% in patients with breast tumors ≤ 50 mm (T2c) (log-rank <i>p</i> = 0.001). T2b (<i>p</i> = 0.009) and T2c (<i>p</i> < 0.001) subcategory showed worse BCSS than T2a subcategory. By multivariate analysis, T2b (T2a as reference, hazard ratio [HR], 1.610, <i>p</i> = 0.020) and T2c (HR, 1.981, <i>p</i> = 0.002) subcategory were significant independent prognostic factors of BCSS. By subgroup multivariate analysis, patients receiving breast-conserving surgery (BCS) plus radiotherapy (RT) had a better prognosis than that receiving total mastectomy (TM) in T2a stage. However, the prognosis was worse in BCS + RT group than TM group in T2c stage, while there was no difference between two groups in T2b stage.</p><p><strong>Conclusion: </strong>Further stratification within the T2 category could enhance the precision of prognostic predictions and facilitate the customization of adjuvant treatments.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":"28 3","pages":"193-205"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Outcomes of Early Breast Cancer Stratified by Axillary Ultrasound Assessment. 腋窝超声评估早期乳腺癌分层的远期疗效。
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 DOI: 10.4048/jbc.2024.0259
Kwang Hyun Yoon, Suk Jun Lee, Jee Hyun Ahn, Jee Ye Kim, Hyung Seok Park, Seung Il Kim, Seho Park
{"title":"Long-term Outcomes of Early Breast Cancer Stratified by Axillary Ultrasound Assessment.","authors":"Kwang Hyun Yoon, Suk Jun Lee, Jee Hyun Ahn, Jee Ye Kim, Hyung Seok Park, Seung Il Kim, Seho Park","doi":"10.4048/jbc.2024.0259","DOIUrl":"10.4048/jbc.2024.0259","url":null,"abstract":"<p><strong>Purpose: </strong>De-escalation of axillary lymph node (ALN) surgery in early breast cancer is increasingly common. This study aimed to identify patients suitable for this approach by comparing long-term survival based on preoperative axillary ultrasound (AUS).</p><p><strong>Methods: </strong>Patients undergoing surgery at Yonsei University Severance Hospital between January 2010 and December 2017 were categorized into \"no suspicion\" and \"low suspicion\" groups based on AUS findings.</p><p><strong>Results: </strong>Median follow-up duration was 92 months. The 10-year recurrence-free survival (RFS) and overall survival rates for the no suspicion and low suspicion groups were 94.2% and 90.1% (<i>p</i> < 0.001) and 93.1% and 93.0% (<i>p</i> = 0.177), respectively. The 10-year locoregional RFS rates were 96.8% and 96.1% (<i>p</i> = 0.060). Among node-positive patients, 19.9% in the no suspicion group had three or more metastatic ALNs compared with 23.0% in the low suspicion group (<i>p</i> = 0.012). Recurrence was associated with T stage, N stage, histologic grade, Ki-67, and subtype, whereas mortality was linked to age, T stage, N stage, histologic grade, and subtype.</p><p><strong>Conclusion: </strong>The low suspicion and fine-needle aspiration biopsy-negative group had poorer prognostic biomarkers, leading to differences in recurrence but not in overall survival. The preoperative ALN status did not affect survival rates. Even in patients with cT2 and low suspicion of ALN, the rate of three or more metastatic ALNs was low, suggesting that further axillary surgery may not be necessary if two or fewer metastatic lymph nodes are found in the sentinel lymph node.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":"28 3","pages":"158-170"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends and Perspectives in Oncoplastic Breast Surgery: Findings From a Web-Based Survey With the Korean Breast Cancer Society. 乳房肿瘤整形手术的趋势和前景:来自韩国乳腺癌协会网络调查的结果。
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.4048/jbc.2024.0285
Jeeyeon Lee, Byeongju Kang, Ho Yong Park, Sang Yull Kang, Min Kyoon Kim, Hong-Kyu Kim, Sun Young Min, Min-Ki Seong, Tae-Kyung Robyn Yoo, Seokwon Lee, Eun-Shin Lee, Kyung-Hwak Yoon, Eun-Kyu Kim
{"title":"Trends and Perspectives in Oncoplastic Breast Surgery: Findings From a Web-Based Survey With the Korean Breast Cancer Society.","authors":"Jeeyeon Lee, Byeongju Kang, Ho Yong Park, Sang Yull Kang, Min Kyoon Kim, Hong-Kyu Kim, Sun Young Min, Min-Ki Seong, Tae-Kyung Robyn Yoo, Seokwon Lee, Eun-Shin Lee, Kyung-Hwak Yoon, Eun-Kyu Kim","doi":"10.4048/jbc.2024.0285","DOIUrl":"10.4048/jbc.2024.0285","url":null,"abstract":"<p><strong>Purpose: </strong>Oncoplastic breast surgery (OPS) is a crucial component of breast cancer surgery that combines oncological safety with improved cosmetic outcomes. OPS is increasingly being adopted worldwide, although the techniques and concepts vary based on patient demographics and surgeons' expertise. This study aimed to evaluate the evolving OPS concept among Korean breast surgeons and assess the current trends in OPS techniques.</p><p><strong>Methods: </strong>A web-based survey was conducted among members of the Korean Breast Cancer Society and Korean Oncoplastic Breast Surgery Study Group. The questionnaire included seven questions that explored opinions on the scope and practical trends of OPS. Respondents were stratified according to hospital type, position, and age. Data were analyzed to identify trends and differences based on demographic factors.</p><p><strong>Results: </strong>A total of 122 surgeons responded, with a majority (78.7%) working in academic or tertiary hospitals. Most respondents (77.9%) considered OPS to include volume displacement/replacement and implant-based reconstruction, regardless of the resection volume. In addition, 70.5% agreed that robotic or endoscopic surgery fell within the scope of the OPS. Autologous reconstruction after a partial mastectomy is preferred for achieving excellent cosmetic results, particularly among younger surgeons. Notably, 59.0% of the surgeons reported using single- and dual-surgeon strategies.</p><p><strong>Conclusion: </strong>OPS is widely practiced among Korean breast surgeons, with the increasing adoption of advanced techniques such as robotic-assisted and endoscopic surgery. Although preferences differ with the surgeon's age, the concept of OPS has expanded considerably, and a multidisciplinary approach remains critical. Understanding these trends is essential to optimize patient care and improve surgical training programs.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":" ","pages":"171-179"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a Real-Time Artificial Intelligence Ultrasound System With Computer-Aided Detection and Diagnosis for Breast Cancer: A Feasibility Study. 实时人工智能超声系统对乳腺癌计算机辅助检测和诊断的有效性:可行性研究。
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 DOI: 10.4048/jbc.2024.0303
Jeeyeon Lee, Won Hwa Kim, Jaeil Kim, Hye Jung Kim, Joon Suk Moon, Byeongju Kang, Ho Yong Park, Fiona Tsui-Fen Cheng
{"title":"Efficacy of a Real-Time Artificial Intelligence Ultrasound System With Computer-Aided Detection and Diagnosis for Breast Cancer: A Feasibility Study.","authors":"Jeeyeon Lee, Won Hwa Kim, Jaeil Kim, Hye Jung Kim, Joon Suk Moon, Byeongju Kang, Ho Yong Park, Fiona Tsui-Fen Cheng","doi":"10.4048/jbc.2024.0303","DOIUrl":"10.4048/jbc.2024.0303","url":null,"abstract":"<p><p>Existing artificial intelligence (AI) breast ultrasound solutions have limitations owing to their non-real-time detection and server dependency. However, novel real-time AI solutions enable on-device detection and differential diagnosis, aiding immediate decision-making. This study evaluated the feasibility of real-time artificial intelligence-based computer-aided detection/diagnosis (AI-CAD) for breast ultrasound in a clinical setting and assessed its preliminary efficacy in comparison with expert evaluations. A feasibility study was conducted from August to December 2023 at a tertiary medical center in Taiwan using a real-time AI solution (CadAI-B for Breast cancer). AI-CAD runs on a tablet PC and streams the display output from the ultrasound vendor's device via HDMI or DVI. Real-time AI-CAD was evaluated for detection and diagnostic performance based on sensitivity, specificity, and area under the curve (AUC). The analysis included 33 patients with 14 malignancies, 17 benign lesions, and 2 normal cases; 30 (90.9%) underwent biopsy. AI-CAD successfully identified all malignancies in real-time. As AUCs were calculated using the malignancy score and Breast Imaging Reporting and Data System (BI-RADS), the overall diagnostic performances were 0.835 and 0.850, respectively. The per-patient sensitivity and specificity were 100.0% and 52.6%, respectively. The BI-RADS distribution was the same between AI-CAD and experts in malignant cases. In benign cases, AI-CAD categorized nine (50.0%) as C4A or C4B, whereas experts classified 13 (72.2%), indicating the potential to reduce the need for biopsy. Real-time AI-CAD is feasible for supporting detection during breast ultrasound scanning, with potential efficacy in aiding differential diagnosis and reducing the risk of unnecessary biopsies.</p>","PeriodicalId":15206,"journal":{"name":"Journal of Breast Cancer","volume":"28 3","pages":"206-214"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing miR-34a-Loaded HER2-Targeting Exosomes to Improve Breast Cancer Treatment: Insights From an Animal Model. 利用负载mir -34a的her2靶向外泌体改善乳腺癌治疗:来自动物模型的见解
IF 2.2 4区 医学
Journal of Breast Cancer Pub Date : 2025-06-01 Epub Date: 2025-03-14 DOI: 10.4048/jbc.2024.0262
Woo Young Sun, Do-Sang Lee, Jung Hyun Park, Ok-Hee Kim, Ho Joong Choi, Say-June Kim
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