Journal of Cardiac Failure最新文献

{"title":"Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction: One Step Closer to Therapeutic Targets?","authors":"MANOJ S. AMBALAVANAN MD, NICOLE C. SCHULTE MS, PA-C, VISHAL N. RAO MD, MPH","doi":"10.1016/j.cardfail.2026.03.032","DOIUrl":"10.1016/j.cardfail.2026.03.032","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1727-1729"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of a Medical Career: Intersections and Adaptation","authors":"Randall C. Starling MD, MPH, FACC, FAHA, FHFSA, FESC, FRCP (London)","doi":"10.1016/j.cardfail.2026.09.002","DOIUrl":"10.1016/j.cardfail.2026.09.002","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1687-1688"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure Hospitalization in Randomized Trials of Tricuspid Valve Transcatheter Edge-to-Edge Repair: A Harmonized Estimand Analysis of Reconstructed Time-to-Event Data.","authors":"Aref A Bin Abdulhak, Mirvat Alasnag, Poghni Peri-Okonny","doi":"10.1016/j.cardfail.2026.09.035","DOIUrl":"https://doi.org/10.1016/j.cardfail.2026.09.035","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":" ","pages":""},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Outcomes of Atrial Fibrillation and Systolic Dysfunction in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy: A Multicenter Study","authors":"OLIVES NGUYEN MD, MA, JACK WIEDRICK MS, MA, DANIELE MASSERA MD, ELIZABETH ADLESTEIN MD, SUMAR FREJAT MD, MATTEO CASTRICHINI MD, SAID ALSIDAWI MD, JOHN R. GIUDICESSI MD, PhD, JEFFREY B. GESKE MD, RICHARD T. CARRICK MD, JOSE MADRAZO MD, NICOLE DELLISE DNP, MARK A. ZENKER MD, THOMAS A. BOYLE MD, NOSHEEN REZA MD, ANJALI TIKU OWENS MD, DAVID S. FRANKEL, PRABHJOT HUNDAL MD, JAMIL TAJIK MD, PATRYCJA GALAZKA MD, AHMAD MASRI MD, MS","doi":"10.1016/j.cardfail.2026.02.035","DOIUrl":"10.1016/j.cardfail.2026.02.035","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1826-1832"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease-Modifying Therapies in Transthyretin Amyloid Cardiomyopathy: What Have We Achieved?","authors":"MICHEL G. KHOURI MD, JOHANA FAJARDO DNP, MORGAN LEWIS RN, BSN, ALEXANDER H. GUNN MD","doi":"10.1016/j.cardfail.2026.01.011","DOIUrl":"10.1016/j.cardfail.2026.01.011","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1751-1753"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Care Access and Affordability for Patients With Heart Failure in Medicare Advantage vs Traditional Medicare","authors":"ANDREW S. OSERAN MD, MBA, MSc,&nbsp;ANJALI BHATLA MD, MBA,&nbsp;ARCHANA TALE MS,&nbsp;BASSEL M. SHANAB BA,&nbsp;JOSE FIGUEROA MD, MPH,&nbsp;RISHI K. WADHERA MD, MPP, MPhil","doi":"10.1016/j.cardfail.2025.11.493","DOIUrl":"10.1016/j.cardfail.2025.11.493","url":null,"abstract":"<div><h3>Background</h3><div>Adults with heart failure—the majority of whom are covered by Medicare—often face barriers to accessing affordable medical care and prescription medications. Medicare Advantage (MA), the private plan alternative to traditional Medicare (TM), has expanded rapidly and now covers millions of individuals with heart failure nationwide. Therefore, understanding whether access and affordability to health care differ for patients with heart failure who have coverage from MA vs TM is critically important.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study of Medicare beneficiaries with heart failure using the Medicare Current Beneficiary Survey 2018−2022.</div></div><div><h3>Results</h3><div>The study population included 1487 respondents with heart failure, corresponding to a weighted national total of 5,875,323 beneficiaries (44.4% MA, 55.6% TM). Measures of access to medical care and prescription medications were largely similar between MA vs TM beneficiaries with heart failure. However, MA beneficiaries with heart failure reported greater difficulty affording health care, including being more likely to delay care due to costs (14.1% vs 8.5%, adjusted difference [AD], 5.32 percentage points [pp]; 95% CI, 0.57pp−10.08pp) and to skip doses of medications to make them last longer (9.6% vs 6.7%; AD, 5.74pp; 95% CI, 0.90pp−10.58pp) compared with their counterparts in TM. In addition, MA beneficiaries with heart failure were less satisfied with the overall quality of their medical care (46.4% vs 56.6%; AD, −10.60pp; 95% CI, −120.71pp to −0.48pp), but more satisfied with their prescription medication coverage across three of the four measures.</div></div><div><h3>Conclusions</h3><div>In this nationally representative study of Medicare beneficiaries with heart failure, those enrolled in MA reported more trouble affording both medical care and prescription medications and were overall less satisfied with their care compared with those in TM. As enrollment in MA grows, policy efforts should focus on ensuring care is affordable for patients with heart failure.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1704-1711"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Structure of Care Coordination in Heart Failure Care Transitions: A Mixed-Method Network Analysis of Clinical Notes","authors":"SIJIA WEI PhD, RN, PHN,&nbsp;ELEANOR S. MCCONNELL PhD, RN,&nbsp;KIRSTEN N. CORAZZINI PhD,&nbsp;JAMES MOODY PhD,&nbsp;WEI PAN PhD,&nbsp;JEFFREY A. LINDER MD, MPH,&nbsp;BRADI B. GRANGER PhD, MSN, RN","doi":"10.1016/j.cardfail.2025.12.008","DOIUrl":"10.1016/j.cardfail.2025.12.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with heart failure, especially those with lower socioeconomic position, are vulnerable to adverse outcomes of care fragmentation. Care coordination mitigates care fragmentation; however, a comprehensive assessment of relationships among all relevant clinicians that enable it is lacking. This explanatory sequential mixed-methods study explores how patients’ clinician network characteristics relate to their social context and clinical outcomes following heart failure care transitions.</div></div><div><h3>Methods</h3><div>We conducted a bipartite social network analysis to describe clinician networks for 1269 patients first hospitalized with heart failure in a southeastern US health system. Networks were constructed using electronic health record notes 1 year before, during, and 1 year after the index hospitalization (January 2015–February 2020). We then used stratified purposive sampling to select 11 adults with diverse socioeconomic positions but similar illness severity and comorbidity. For these patients, we conducted qualitative chart reviews of their clinical notes. Each patient’s clinician network size, density, and centrality were integrated with qualitative findings to explore clinician networks’ relationship to patients’ social context and outcomes.</div></div><div><h3>Results</h3><div>Patients with higher socioeconomic positions used fewer acute care services and lived longer. Their clinicians, particularly outpatient clinicians, tended to have denser and more centrally located team networks before the index hospitalization that persisted after the index hospitalization. Their telephone notes indicated more regular and reciprocal communication patterns between patients and clinicians.</div></div><div><h3>Conclusions</h3><div>Early involvement and better communication among clinician networks with greater density and centrality may help to explain better care transition outcomes observed among patients with higher socioeconomic positions.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1730-1738"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should Network Structure Be Considered in Care Coordination of Heart Failure Transitions?","authors":"KRISTEN SETHARES PhD, RN, CNE, FAHA, FHFSA, FAAN,&nbsp;MICHELLE WHYTE PhD, RN","doi":"10.1016/j.cardfail.2026.03.015","DOIUrl":"10.1016/j.cardfail.2026.03.015","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1739-1741"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HFSA President's Message: Building a National Resource for the Future of Heart Failure Care","authors":"","doi":"10.1016/j.cardfail.2026.09.003","DOIUrl":"10.1016/j.cardfail.2026.09.003","url":null,"abstract":"","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1859-1860"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149175065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid-Specific Medication in Transthyretin Amyloid Cardiomyopathy: A Systematic Review and Meta-Analysis of Cardiovascular Outcome trials","authors":"MAXIMILIAN AUTHERITH MD,&nbsp;LAURENZ HAUPTMANN MD,&nbsp;SOPHIA KOSCHATKO MD,&nbsp;CHARLOTTE JANTSCH MD,&nbsp;CHRISTINA KRONBERGER MD,&nbsp;MICHAEL POLEDNICZEK MD,&nbsp;KSENIYA HALAVINA MD,&nbsp;CAGLAYAN DEMIREL MD, PhD,&nbsp;ROBIN RISTL PhD,&nbsp;FRANZ DUCA MD, PhD,&nbsp;ANDREAS KAMMERLANDER MD, PhD,&nbsp;MAZEN HANNA MD,&nbsp;MARIANNA FONTANA MD, PhD,&nbsp;MATHEW MAURER MD,&nbsp;PHILIPP E. BARTKO MD, PhD,&nbsp;CHRISTIAN NITSCHE MD, PhD","doi":"10.1016/j.cardfail.2025.08.002","DOIUrl":"10.1016/j.cardfail.2025.08.002","url":null,"abstract":"<div><h3>Background</h3><div>The introduction of disease-specific medication has revolutionized the management of transthyretin-associated cardiomyopathy (ATTR-CM). However, dedicated trials included different patient populations, primary endpoints, and follow-up periods, rendering study comparison challenging. This systematic review and meta-analysis aimed to harmonize data from all phase 3 placebo-controlled drug trials in ATTR-CM to elucidate the magnitude and timing of treatment efficacy of ATTR-specific medication.</div></div><div><h3>Methods</h3><div>We searched PubMed and Embase for trials published up to February 23, 2025 (PROSPERO: CRD42025645376). Efficacy outcomes included all-cause death, cardiovascular (CV) events, change in 6-minute walk distance, N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, and Kansas City Cardiomyopathy Questionnaire Overall Score. Outcome metrics were pooled across trials using inverse-variance weighting and a random-effects model.</div></div><div><h3>Results</h3><div>We included data from 4 identified trials (ATTR-ACT, ATTRibute, APOLLO-B, and HELIOS-B) and 2086 patients. Baseline risk profiles differed substantially, highlighted by a decrease in NT-proBNP and estimated glomerular filtration rate levels from earlier to later trials, likely resulting in different death rates of the respective placebo groups. At 12 months, ATTR-specific medication showed a trend toward less decline in 6-minute walk distance (least squares mean difference: 12.9 meters; 95% confidence interval [CI] −4.1 to 29.8) and was associated with a significantly blunted decline in Kansas City Cardiomyopathy Questionnaire Overall Score (least squares mean difference: 4.7 points; 95% CI 2.3−7.0) and NT-proBNP (geometric mean fold ratio 0.80; 95% CI 0.74−0.85) compared with placebo. These effects are consolidated with continued treatment. At 12-months, ATTR-specific medication did not improve all-cause mortality (OR 1.00; 95% CI 0.69−1.44) compared with placebo. Conversely, over the maximum follow-up period and at 30 months, respectively, ATTR-specific medication reduced the risk of all-cause mortality by 28% (HR 0.72; 95% CI 0.59−0.87) and for CV events by 42% (OR 0.58; 95%CI 0.47−0.73).</div></div><div><h3>Conclusions</h3><div>ATTR-specific medication exhibits early salutary effects on blood biomarkers, functional capacity and quality of life. These effects translate into reductions in CV events and all-cause mortality after continued treatment.</div></div>","PeriodicalId":15204,"journal":{"name":"Journal of Cardiac Failure","volume":"32 10","pages":"Pages 1742-1750"},"PeriodicalIF":9.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}