Medical Parasitology and Parasitic Diseases最新文献

{"title":"INDICATORS OF THE HEPATOBILIARY SYSTEM FUNCTIONS IN CHRONIC OPISTHORCHIASIS PATIENTS WITH A GENETIC PREDISPOSITION TO THE TYPE 2 DIABETES MELLITUS DEVELOPMENT","authors":"I. Bakshtanovskaya, K. B. Stepanova, A. Ozerova, T. F. Stepanova, E. A. Zmatrakova","doi":"10.33092/0025-8326mp2023.1.3-9","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.3-9","url":null,"abstract":"To assess the influence of genetic features of metabolic processes on the reactivity to opisthorchiasis invasion, biochemical parameters of the hepatobiliary system functions were studied in chronic opisthorchiasis patients with and without mutant alleles of polymorphisms associated with the type 2 diabetes mellitus. It was found that the presence of mutations in the genes PPARG and TCF7L2 (rs12255372), HHEX, IGF2BP2 and SLC30A8 enhances the opisthorchiasis negative impact on the activity of alpha-amylase and indicators of impaired bile secretion. The presence of a rare allele of the IGF2BP2 gene prevents an increase in GGT activity, and the presence of a rare allele of the CDKAL1 and SLC30A8 genes reduces the degree of increase in glucose concentration in opisthorchiasis. Key words: chronic opisthorchiasis, polymorphisms, type 2 diabetes mellitus, biochemical parameters, disorders of bile secretion.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134445154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYASES, PSEUDOMYASES AND TRANSITIONAL CARRIER IN THE PRACTICE OF LABORATORY DIAGNOSIS","authors":"L. V. Fedyanina, M. Maksimova, N. S. Fomina, S.A. Rozmaritsa, K. Fetisova","doi":"10.33092/0025-8326mp2023.1.49-55","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.49-55","url":null,"abstract":"The problem of differential diagnosis of myiasis and transient carriage is discussed from the point of view of doctors of clinical diagnostic laboratories. Several cases of unusual, controversial and exotic imported myiasis are described. Key words: Laboratory diagnostics, myiasis, pseudomyiasis, transient carriage, fly larvae, Cordilobia spp., Dermatobia spp., Drosophila spp.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":" 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113949815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF OPISTHORCHIS FELINEUS EXOMETABOLITES IN STRUCTURAL TRANSFORMATION OF HOST TISSUES","authors":"E. D. Khadieva, S. Lazarev, S. Kulikova, R. Uruzbaev, S. A. Orlov, I.E. Rusakov, A. Plotnikova, L. Kalenova, E. Morozov, V. Bychkov","doi":"10.33092/0025-8326mp2023.1.10-17","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.10-17","url":null,"abstract":"The article presents the results of studying the role of Opisthorchis felineus metabolites in the development of pathology in various hosts. It has been established that exometabolites initiate granulomatosis, sclerotic processes and act as a predictor of cardiomyocyte damage in hypereosinophilic syndrome. Key words: opisthorchis, exometabolites, granulomatosis, sclerosis, secretom, hypereosinophilic syndrome.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122038492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF THE MECHANISMS OF DETOXIFICATION OF PROINSECTICIDES IN THE GERMAN COCKROACH BLATTELLA GERMANICA","authors":"O. Eremina, V. V. Olifer, T. A. Davlianidze","doi":"10.33092/0025-8326mp2023.1.33-39","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.33-39","url":null,"abstract":"The data on the observed detoxification process of the proinsecticides indoxacarb and chlorfenapyr in the body of the German cockroach, Blattella germanica of several laboratory strains are presented. Different resistance ratios to indoxacarb of M10 (16.7×), DM (45.8×) and MAG (10.4×) strains, and chlorfenapyr (6.7×, 2.0×, 1.7×, respectively) against the background of high resistance to cypermethrin (92–833×), fipronil (46–192×), tolerance to chlorpyrifos (5.0–50×) and thiamethoxam (3.5–10×). The insecticidal activity of indoxacarb and chlorfenapyr was studied with desynchronized application of synergists PPB, TBTP, DEM - inhibitors of insect enzyme systems and an inhibitor of ABC transporters verapamil. The antagonistic action of synergists indicates the difficulty of converting proinsecticides into a toxic metabolite. In the M10 strain, PPB and TBTP significantly suppressed the activity of chlorfenapyr, while in DM and MAG strains, activity of chlorfenapyr suppressed only under the action of TBTP. For the DM strain most resistant to indoxacarb, the use of TBTP and DEM reduces resistance by 2.8 and 2.4 times, respectively. Verapamil has a statistically significant effect on susceptibility to chlorfenapyr only in S-NIID and DM strains, and to indoxacarb in MAG and DM strains. Key words: indoxacarb, chlorfenapyr, German cockroach, resistanc.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122044438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARASITIC SYSTEM OF SCRUB TYPHUS: CHIGGER MITES (ACARIFORMES, TROMBICULIDAE) AS VECTORS AND RESERVIOURS OF INFECTION IN SOUTH EAST ASIA","authors":"A. A. Antonovskaia, Y. Lopatina","doi":"10.33092/0025-8326mp2023.1.40-48","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.40-48","url":null,"abstract":"This review is dedicated to chigger mites (Trombiculidae) as vectors and reservoirs of infection in scrub typhus foci in South East Asia. Here we review biology, infection rates in natural and anthropurgic foci of scrub typhus. Vector competence of chigger mite species were summarized. Key words: scrub typhus, Orientia tsutsugamushi, Trombiculidae, vectors.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125840790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WORK EXPERIENCE OF AN ENTOMOLOGIST IN THE SYSTEM OF SANITARY AND EPIDEMIOLOGICAL SERVICE","authors":"E. P. Gerik","doi":"10.33092/0025-8326mp2023.1.56-62","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.56-62","url":null,"abstract":"The main issues of medical entomology are considered, in the solution of which the author of the article, who has worked in the sanitary service of the Voronezh region for 50 years, participated. Key words: blood-sucking arthropods, malaria, natural focal infections.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131962396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE PREVALANCE OF PARASITIC DISEASES AND MIXED INVASIONS IN CHILDREN IN THE KYRGYZ REPUBLIC","authors":"Mambet kyzy Gulinа, K. M. Raimkulov, O. Kuttubaev","doi":"10.33092/0025-8326mp2023.1.24-32","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.24-32","url":null,"abstract":"This article presents the results of a study of sanitary epidemiological surveillance (SES) among preschool and school-age children conducted in the pilot districts of Osh, Naryn, Jalal-Abad and Batken regions of the Kyrgyz Republic (KR) in the period from 2015 to 2021 and describes the relevance of combined parasitic diseases, in particular helminthiasis, the problematic issues of epidemiological features of the combination of helminthiasis with a large range of parasitic diseases to assess the true picture of the prevalence of parasitic diseases in children. SES for parasitic diseases is a system for collecting biomaterials (stool) of children using preservatives and taking scrapings from the anus, laboratory analysis to determine the types of parasites and the dissemination of epidemiological information on the prevalence of parasitic diseases and children with mixed infestations, necessary for planning, implementing and monitoring preventive programs. 39398 children of school and preschool age up to 14 years were examined. Preschool children accounted for 36.3 % and schoolchildren below 14 years years old 63.6 % of the total number of surveyed. During the analyzed period, the total infection rate of children below 14 in the republic amounted to 10.9 % of the total number of examined, of which 5.7 % are girls and 5.2 % are boys. Key words: parasites, mixed invasion, intestinal parasitocenosis, mixed invasion, invasion, SES.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134039185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF CLINICAL MANIFESTATIONS, DIAGNOSIS AND TREATMENT IN PATIENTS WITH OPISTHORCHIASIS IN THE KRASNOYARSK REGION","authors":"E. Zorina, L. Mudrova, M. Zorin","doi":"10.33092/0025-8326mp2023.1.18-23","DOIUrl":"https://doi.org/10.33092/0025-8326mp2023.1.18-23","url":null,"abstract":"Despite the progress made in the diagnosis and treatment of opisthorchiasis, this problem remains more than relevant and significant in the Russian Federation and requires a comprehensive system of approaches to combat it. The paper reflects the situation with opisthorchiasis in one of the regions of the Krasnoyarsk Territory, where it occurs most often, identifies the clinical manifestations of this disease in the specified region, identifies the features of diagnosis and treatment in specific situations, as well as measures to prevent this disease. Key words: opisthorchiasis, analysis of clinical cases, features of diagnosis, treatment, region.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129566798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF HUMAN ECHINOCOCCOSIS IN THE LOWER VOLGA REGION","authors":"V. A. Irdeeva, R. S. Arakelyan, N. I. Latyshevskaya, G. A. Yamanova, N. S. Malysheva, A. Akhmineeva, L.P. Rurua, N. V. Levchenko, I.I. Lychagina, YA.V. Mikhaylova","doi":"10.33092/0025-8326mp2022.4.38-46","DOIUrl":"https://doi.org/10.33092/0025-8326mp2022.4.38-46","url":null,"abstract":"The clinical and epidemiological situation of human echinococcosis in the Lower Volga region is studied and analyzed on the example of the Volgograd region. During the analyzed period, 77 cases of human echinococcosis were registered in the Volgograd region. The clinical diagnosis of “Echinococcosis” was made on the basis of data from laboratory blood tests by ELISA, data from radiation tests, anamnesis and the clinical picture of the disease. Hydatid disease was observed in individuals of different ages, most often meeting in the adult population of the Volgograd region – 92,2 % (71 people). In most cases, cases, cases of typical hydatid disease (liver, lung/lungs) – 96,1 % (74 people). The cases of combined echinococcosis (liver and lung, liver and spleen) were observed in 3,9 % of (3 people). Cases of echinococcosis is a rare localization (abdominal cavity and internal organs) were 1,3 % (1 person). The complaints of the patients were different: pain at the site of localization of the parasite – a 43,4 % (23 patients), weakness was 28,3 % (15 people), discomfort in the place of localization of the parasite, shortness of breath and heaviness in the epigastric region and 3,8 % (for 2 people). After establishing the clinical diagnosis was given treatment: surgical – 67,5 % (52 people) – excision of the parasitic cyst and/or laparoscopic surgery depending on the location and outpatient is 32,5 % (25 people). As a result, the following results were obtained: the number of cases of human echinococcosis is steadily increasing every year, as evidenced by the above indicators; the disease is registered mainly in the adult population, whose professional activities in one way or another affected contact with dogs; in the clinical picture of the disease, complaints of pain at the location of the parasite and general weakness prevailed; the duration of the disease was from several days to 1 month; In the diagnosis of echinococcosis, combined diagnostic methods, coupled with the data of the clinical picture and epidemiological history, play an undoubted role. Key words: echinococcus, liver damage, parasitic lesion, laparoscopic surgery, ELISA, computed tomography, pain in the epigastric region.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122007883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF POLYOXIDONIUM ON THE IMMUNOMORPHOLOGICAL CHARACTERISTICS OF THE SPLEEN AND THE DISTRIBUTION OF LARVAE OF TRICHINELLA SPIRALIS (OWEN, 1835) IN THE MUSCLES OF WHITE MICE WITH EXPERIMENTAL TRICHINOSIS","authors":"O. Zhdanova, O. V. Rudneva, A. Uspensky, N. S. Malysheva","doi":"10.33092/0025-8326mp2022.4.47-56","DOIUrl":"https://doi.org/10.33092/0025-8326mp2022.4.47-56","url":null,"abstract":"The study of the reaction of the organs of the immune system to the introduction of immunomodulators in parasitosis is extremely relevant. Previous studies have studied the role of lymphoid tissue associated with the intestine in trichinosis, in this study special attention is paid to the organ of immunogenesis, which plays an important role in the formation of humoral and cellular immunity – the spleen. The aim of the research was to study morphological changes in the structure of lymphoid tissue associated with the intestine and spleen in trichinosis and against the background of immunocorrection of the invasive process with polyoxidonium. Key words: immunomodulator, red pulp, white pulp, lymphoid tissue.","PeriodicalId":152020,"journal":{"name":"Medical Parasitology and Parasitic Diseases","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131069487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}