INDICATORS OF THE HEPATOBILIARY SYSTEM FUNCTIONS IN CHRONIC OPISTHORCHIASIS PATIENTS WITH A GENETIC PREDISPOSITION TO THE TYPE 2 DIABETES MELLITUS DEVELOPMENT

To assess the influence of genetic features of metabolic processes on the reactivity to opisthorchiasis invasion, biochemical parameters of the hepatobiliary system functions were studied in chronic opisthorchiasis patients with and without mutant alleles of polymorphisms associated with the type 2 diabetes mellitus. It was found that the presence of mutations in the genes PPARG and TCF7L2 (rs12255372), HHEX, IGF2BP2 and SLC30A8 enhances the opisthorchiasis negative impact on the activity of alpha-amylase and indicators of impaired bile secretion. The presence of a rare allele of the IGF2BP2 gene prevents an increase in GGT activity, and the presence of a rare allele of the CDKAL1 and SLC30A8 genes reduces the degree of increase in glucose concentration in opisthorchiasis. Key words: chronic opisthorchiasis, polymorphisms, type 2 diabetes mellitus, biochemical parameters, disorders of bile secretion.