Journal of Cardiovascular Development and Disease最新文献

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ECMO in the Cardiac Catheterization Lab-Patient Selection Is Key.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-31 DOI: 10.3390/jcdd12010012
William Tracy, Brandon E Ferrell, John P Skendelas, Mayuko Uehara, Tadahisa Sugiura
{"title":"ECMO in the Cardiac Catheterization Lab-Patient Selection Is Key.","authors":"William Tracy, Brandon E Ferrell, John P Skendelas, Mayuko Uehara, Tadahisa Sugiura","doi":"10.3390/jcdd12010012","DOIUrl":"10.3390/jcdd12010012","url":null,"abstract":"<p><p>The use of extracorporeal membrane oxygenation (ECMO) has emerged as a rescue intervention for hemodynamically unstable patients and prophylactic intraprocedural hemodynamic support in the cardiac catheterization laboratory. The prompt initiation of ECMO provides immediate hemodynamic support and allows for the completion of bridging and/or life-saving interventions. However, there are no clinical practice guidelines for the use of extracorporeal support in this area. This review examines the role of patient selection and therapeutic intervention for extracorporeal support in the cardiac catheterization laboratory.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and CT Features, Clinical Management, and Decision on Sport Eligibility of Professional Athletes with Congenital Coronary Anomalies: A Case Series Study.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-31 DOI: 10.3390/jcdd12010013
Gianluca Guarnieri, Edoardo Conte, Davide Marchetti, Matteo Schillaci, Eleonora Melotti, Andrea Provera, Marco Doldi, Maria Rosaria Squeo, Antonio Pelliccia, Viviana Maestrini, Daniele Andreini
{"title":"Clinical and CT Features, Clinical Management, and Decision on Sport Eligibility of Professional Athletes with Congenital Coronary Anomalies: A Case Series Study.","authors":"Gianluca Guarnieri, Edoardo Conte, Davide Marchetti, Matteo Schillaci, Eleonora Melotti, Andrea Provera, Marco Doldi, Maria Rosaria Squeo, Antonio Pelliccia, Viviana Maestrini, Daniele Andreini","doi":"10.3390/jcdd12010013","DOIUrl":"10.3390/jcdd12010013","url":null,"abstract":"<p><strong>Background: </strong>Congenital coronary artery anomalies (CAAs) are a significant cause of sudden cardiac death and a key factor in determining athletes' eligibility for competitive sports. Their prevalence varies with diagnostic modalities and may present as asymptomatic or with life-threatening ischemic or arrhythmic events. This case series highlights the diverse manifestations of CAAs and the clinical approaches used to determine sports eligibility.</p><p><strong>Cases description: </strong>Five competitive athletes with different CAAs are presented. These cases include anomalous coronary origins, intramyocardial bridges, and coronary fistulas. Diagnostic tools, including coronary CT angiography (CCTA), cardiac magnetic resonance imaging (CMR), and stress tests, were essential in evaluating these anomalies and determining treatment strategies. In some cases, such as intramyocardial bridges, surgical intervention was necessary, while others required conservative management or exclusion from competitive sports.</p><p><strong>Conclusions: </strong>CAAs require individualized care based on risk stratification through advanced imaging techniques and functional assessment. Surgical interventions are reserved for high-risk anomalies, while others may be managed conservatively. Early detection and tailored management are crucial for ensuring athletes' safety, and ongoing research is needed to optimize long-term outcomes.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raphe-Type Bicuspid Aortic Valve as a Risk Factor for Transcatheter Aortic Valve Replacement Failure: Improving Outcomes Using the LIRA Method and the Medtronic FX Prosthesis.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-30 DOI: 10.3390/jcdd12010011
Francesca Napoli, Barbara Bellini, Vittorio Romano, Greca Zanda, Ciro Vella, Filippo Russo, Luca Angelo Ferri, Marco Bruno Ancona, Paolo Bonfanti, Eustachio Agricola, Antonio Esposito, Matteo Montorfano
{"title":"Raphe-Type Bicuspid Aortic Valve as a Risk Factor for Transcatheter Aortic Valve Replacement Failure: Improving Outcomes Using the LIRA Method and the Medtronic FX Prosthesis.","authors":"Francesca Napoli, Barbara Bellini, Vittorio Romano, Greca Zanda, Ciro Vella, Filippo Russo, Luca Angelo Ferri, Marco Bruno Ancona, Paolo Bonfanti, Eustachio Agricola, Antonio Esposito, Matteo Montorfano","doi":"10.3390/jcdd12010011","DOIUrl":"10.3390/jcdd12010011","url":null,"abstract":"<p><p>Transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis and raphe-type bicuspid aortic valve (BAV) is still associated with poor outcomes in terms of increased risk of paravalvular regurgitation, stroke, and permanent pacemaker implantation. There is no definitive consensus on the optimal sizing method for prosthesis selection in this setting. The LIRA method is a supra-annular tailored sizing method specifically designed for bicuspid anatomy that might increase accuracy of prosthesis choice in BAV patients and improve TAVR outcomes. This is the first report of the combination of the novel LIRA method for prosthesis sizing together with the adoption of the technological improvements introduced by the Evolut FX prosthesis as a useful tool for improving outcomes in this high risk subgroup of patients.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-30 DOI: 10.3390/jcdd12010010
Hagai Yavin, Mark Prasad, Jonathan Gordon, Tolga Aksu, Henry D Huang
{"title":"Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias.","authors":"Hagai Yavin, Mark Prasad, Jonathan Gordon, Tolga Aksu, Henry D Huang","doi":"10.3390/jcdd12010010","DOIUrl":"10.3390/jcdd12010010","url":null,"abstract":"<p><p>Pulsed field ablation (PFA) is a catheter-based procedure that utilizes short high voltage and short-duration electrical field pulses to induce tissue injury. The last decade has yielded significant scientific progress and quickened interest in PFA as an energy modality leading to the emergence of the clinical use of PFA technologies for the treatment of atrial fibrillation. It is generally agreed that more research is needed to improve our biophysical understanding of PFA for clinical cardiac applications as well as its potential as a potential alternative energy source to thermal ablation modalities for the treatment of other arrhythmias. In this review, we discuss the available preclinical and clinical evidence for PFA for atrial fibrillation, developments for ventricular arrhythmia (VA) ablation, and future perspectives.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Advanced Cardiac Imaging in Monitoring Cardiovascular Complications in Patients with Extracardiac Tumors: A Descriptive Review.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-29 DOI: 10.3390/jcdd12010009
Annamaria Tavernese, Valeria Cammalleri, Rocco Mollace, Giorgio Antonelli, Mariagrazia Piscione, Nino Cocco, Myriam Carpenito, Carmelo Dominici, Massimo Federici, Gian Paolo Ussia
{"title":"The Role of Advanced Cardiac Imaging in Monitoring Cardiovascular Complications in Patients with Extracardiac Tumors: A Descriptive Review.","authors":"Annamaria Tavernese, Valeria Cammalleri, Rocco Mollace, Giorgio Antonelli, Mariagrazia Piscione, Nino Cocco, Myriam Carpenito, Carmelo Dominici, Massimo Federici, Gian Paolo Ussia","doi":"10.3390/jcdd12010009","DOIUrl":"10.3390/jcdd12010009","url":null,"abstract":"<p><p>Cardiac involvement in cancer is increasingly important in the diagnosis and follow-up of patients. A thorough cardiovascular evaluation using multimodal imaging is crucial to assess any direct cardiac involvement from oncological disease progression and to determine the cardiovascular risk of patients undergoing oncological therapies. Early detection of cardiac dysfunction, particularly due to cardiotoxicity from chemotherapy or radiotherapy, is essential to establish the disease's overall prognostic impact. Comprehensive cardiovascular imaging should be integral to the clinical management of cancer patients. Echocardiography remains highly effective for assessing cardiac function, including systolic performance and ventricular filling pressures, with speckle-tracking echocardiography offering early insights into chemotoxicity-related myocardial damage. Cardiac computed tomography (CT) provides precise anatomical detail, especially for cardiac involvement due to metastasis or adjacent mediastinal or lung tumors. Coronary assessment is also important for initial risk stratification and monitoring potential coronary artery disease progression after radiotherapy or chemotherapeutic treatment. Finally, cardiac magnetic resonance (CMR) is the gold standard for myocardial tissue characterization, aiding in the differential diagnosis of cardiac masses. CMR's mapping techniques allow for early detection of myocardial inflammation caused by cardiotoxicity. This review explores the applicability of echocardiography, cardiac CT, and CMR in cancer patients with extracardiac tumors.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rate of Perceived Exertion Based on Repetitions in Reserve Versus Percentage of One-Repetition Maximum for Resistance Training Prescription in Cardiac Rehabilitation: A Pilot Study.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-27 DOI: 10.3390/jcdd12010008
Alessandro Gismondi, Ferdinando Iellamo, Giuseppe Caminiti, Barbara Sposato, Emanuele Gregorace, Valentino D'Antoni, Deborah Di Biasio, Sara Vadalà, Alessio Franchini, Annalisa Mancuso, Valentina Morsella, Maurizio Volterrani
{"title":"Rate of Perceived Exertion Based on Repetitions in Reserve Versus Percentage of One-Repetition Maximum for Resistance Training Prescription in Cardiac Rehabilitation: A Pilot Study.","authors":"Alessandro Gismondi, Ferdinando Iellamo, Giuseppe Caminiti, Barbara Sposato, Emanuele Gregorace, Valentino D'Antoni, Deborah Di Biasio, Sara Vadalà, Alessio Franchini, Annalisa Mancuso, Valentina Morsella, Maurizio Volterrani","doi":"10.3390/jcdd12010008","DOIUrl":"10.3390/jcdd12010008","url":null,"abstract":"<p><p>The aims of this study were to assess the efficacy of the rate of perceived exertion (RPE) scale based on the number of repetitions in reserve (RIR) before exhaustion for the prescription of resistance training in cardiac rehabilitation and to compare it to the percentage of estimated one-repetition maximum (1RM) prescription method. Sixteen male patients (age 60 ± 8) with history of coronary artery disease were randomly assigned to two resistance training rehabilitation protocols lasting nine weeks and consisting of three sessions per week, with the same exercise selection, number of sets and repetitions, and rest periods, but different load prescription method (RPE vs. %1RM). Patients' strength was evaluated pre- and post-intervention. Patients in the RPE group showed significant increases in strength across all the exercises of the protocol (leg press 24.25 ± 17.07 kg; chest press 7.25 ± 3.41 kg; seated row 13.88 ± 7.57 kg; leg extension 14.24 ± 4.53 kg; shoulder press 5.75 ± 4.06 kg; lat pulldown 7.50 ± 4.66 kg). Post-intervention between-group analysis showed no differences in strength gains (leg press <i>p</i> = 0.955; chest press <i>p</i> = 0.965; seated row <i>p</i> = 0.763; leg extension <i>p</i> = 0.565; shoulder press <i>p</i> = 0.868; lat pulldown <i>p</i> = 0.780) and trivial effect sizes (ES) for one prescription method over the other (leg press ES = -0.03; chest press ES = 0.00; seated row ES = 0.10; leg extension ES = -0.29; shoulder press ES = 0.18; lat pulldown ES = 0.05). RPE based on RIR seems to be an effective prescription method for resistance training in cardiac rehabilitation, showing similar efficacy to the standardized practice of percentage of 1RM.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Risk Prediction Model for the Assessment of Myocardial Injury in Elderly Patients Undergoing Non-Elective Surgery.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-26 DOI: 10.3390/jcdd12010006
Vedat Cicek, Mert Babaoglu, Faysal Saylik, Samet Yavuz, Ahmet Furkan Mazlum, Mahmut Salih Genc, Hatice Altinisik, Mustafa Oguz, Berke Cenktug Korucu, Mert Ilker Hayiroglu, Tufan Cinar, Ulas Bagci
{"title":"A New Risk Prediction Model for the Assessment of Myocardial Injury in Elderly Patients Undergoing Non-Elective Surgery.","authors":"Vedat Cicek, Mert Babaoglu, Faysal Saylik, Samet Yavuz, Ahmet Furkan Mazlum, Mahmut Salih Genc, Hatice Altinisik, Mustafa Oguz, Berke Cenktug Korucu, Mert Ilker Hayiroglu, Tufan Cinar, Ulas Bagci","doi":"10.3390/jcdd12010006","DOIUrl":"10.3390/jcdd12010006","url":null,"abstract":"<p><p><b>Background:</b> Currently, recommended pre-operative risk assessment models including the revised cardiac risk index (RCRI) are not very effective in predicting postoperative myocardial damage after non-elective surgery, especially for elderly patients. <b>Aims:</b> This study aimed to create a new risk prediction model to assess myocardial injury after non-cardiac surgery (MINS) in elderly patients and compare it with the RCRI, a well-known pre-operative risk prediction model. <b>Materials and Methods:</b> This retrospective study included 370 elderly patients who were over 65 years of age and had non-elective surgery in a tertiary hospital. Each patient underwent detailed physical evaluations before the surgery. The study cohort was divided into two groups: patients who had MINS and those who did not. <b>Results:</b> In total, 13% (48 out of 370 patients) of the patients developed MINS. Multivariable analysis revealed that creatinine, lymphocyte, aortic regurgitation (moderate-severe), stroke, hemoglobin, ejection fraction, and D-dimer were independent determinants of MINS. By using these parameters, a model called \"CLASHED\" was developed to predict postoperative MINS. The ROC analysis comparison demonstrated that the new risk prediction model was significantly superior to the RCRI in predicting MINS in elderly patients undergoing non-elective surgery (AUC: 0.788 vs. AUC: 0.611, <i>p</i> < 0.05). <b>Conclusions:</b> Our study shows that the new risk preoperative model successfully predicts MINS in elderly patients undergoing non-elective surgery. In addition, this new model is found to be superior to the RCRI in predicting MINS.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscular Performance and Blood Pressure After Different Pre-Strength Training Strategies in Recreationally Strength-Trained Women: Cross-Over Trial.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-26 DOI: 10.3390/jcdd12010007
Estêvão Rios Monteiro, Linda S Pescatello, Luis Leitão, Marcelo José Colonna de Miranda, Paulo H Marchetti, Michelle Ribeiro Novaes, Gleisson da Silva Araújo, Victor Gonçalves Corrêa Neto, Jefferson da Silva Novaes
{"title":"Muscular Performance and Blood Pressure After Different Pre-Strength Training Strategies in Recreationally Strength-Trained Women: Cross-Over Trial.","authors":"Estêvão Rios Monteiro, Linda S Pescatello, Luis Leitão, Marcelo José Colonna de Miranda, Paulo H Marchetti, Michelle Ribeiro Novaes, Gleisson da Silva Araújo, Victor Gonçalves Corrêa Neto, Jefferson da Silva Novaes","doi":"10.3390/jcdd12010007","DOIUrl":"10.3390/jcdd12010007","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the acute effects of different pre-ST strategies on muscular performance and blood pressure (BP) responses in recreationally strength-trained women.</p><p><strong>Methods: </strong>Twelve overweight women with normal BP were recruited and performed six experimental protocols in a randomized order: (1) control protocol (CC), where BP was assessed without exercises performed; (2) ST; (3) foam rolling warm-up followed by ST (FR + ST); (4) specific warm-up followed by ST (SW + ST); (5) aerobic exercise followed by ST (AE + ST); and (6) stretching exercises followed by ST (SE + ST). ST consisted of three sets at 80% of 10 repetition maximum with a self-suggested rest interval between sets for bench press, back squat, bench press 45°, front squat, lat pull-down, leg press, shoulder press, and leg extension.</p><p><strong>Results: </strong>All experimental protocol had a lower total training volume, fatigue index, and repetitions performance in relation to ST (<i>p</i> < 0.05). No significant reduction was observed in systolic and diastolic BP for any protocol or exercise, although the effect size magnitudes ranged from trivial to large. Decreases in maximum repetitions, resistance to fatigue, and total training volume were performed before ST as warm-up strategies. However, these strategies indicated a clinical reduction in BP with a large and meaningful magnitude (effect size) in recreationally strength-trained women with normal to elevated BP.</p><p><strong>Conclusions: </strong>The results of this investigation may help to influence decision-making by practitioners who desire to elicit a post-exercise hypotension response in both subjects with normal BP and hypertension.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral Embolic Protection in Patients Undergoing Left Atrial Appendage Closure.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-26 DOI: 10.3390/jcdd12010005
Julia Seeger, Philipp Seppelt, Mario Iturbe-Orbe, David Leistner, Jochen Wöhrle, Michael Joner
{"title":"Cerebral Embolic Protection in Patients Undergoing Left Atrial Appendage Closure.","authors":"Julia Seeger, Philipp Seppelt, Mario Iturbe-Orbe, David Leistner, Jochen Wöhrle, Michael Joner","doi":"10.3390/jcdd12010005","DOIUrl":"10.3390/jcdd12010005","url":null,"abstract":"<p><p>(1) Background: Cerebral magnetic resonance imaging has reported new cerebral ischemic lesions after left atrial appendage (LAA) closure in about one- third of patients. Stroke occurs predominantly periprocedurally. This study evaluated the characteristics of embolized debris captured by the SENTINEL<sup>TM</sup> cerebral embolic protection system in patients undergoing LAA closure; (2) Methods: Sixty filters of 30 consecutive patients undergoing LAA closure with the WATCHMAN FLX<sup>TM</sup> device were collected and captured debris was analyzed by histopathology and histomorphometry. Clinical outcome measures were disabling and non-disabling stroke within 72 h; (3) Results: In most filters, no material was captured. The predominant captured debris was acute or organized thrombi. The most common pattern was acute fibrin-rich thrombus, which was detected in 11/30 (33.3%) patients. Particles of heart tissue were seen in 6/30 (20%) patients, and foreign material was seen in one (3.3%) patient. The number of particles ranged from 0 to 52 per patient with a maximum of 31 in the distal and 21 in the proximal filter. Particle diameter ranged from 131 to 2614 µm. By logistic regression analysis, only protected time remained a multivariable predictor for larger particles (<i>p</i> = 0.039). There was no disabling or non-disabling stroke. Compared to transfemoral aortic valve replacement, the number of particles is only about 1.5%. (4) Conclusion: LAA occlusion with the WATCHMAN FLX<sup>TM</sup> was associated with a very low number of embolized particles captured with the double-filter SENTINEL<sup>TM</sup> embolic protection system and no periprocedural stroke.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac Magnetic Resonance Imaging in Lyme Carditis-A Case Series and Review of Literature.
IF 2.4 4区 医学
Journal of Cardiovascular Development and Disease Pub Date : 2024-12-25 DOI: 10.3390/jcdd12010002
Matthew Kaczynski, Suhani Desai, Brian Osorio, Edward Hulten, Saurabh Agarwal, Michael K Atalay, Yash Patel
{"title":"Cardiac Magnetic Resonance Imaging in Lyme Carditis-A Case Series and Review of Literature.","authors":"Matthew Kaczynski, Suhani Desai, Brian Osorio, Edward Hulten, Saurabh Agarwal, Michael K Atalay, Yash Patel","doi":"10.3390/jcdd12010002","DOIUrl":"10.3390/jcdd12010002","url":null,"abstract":"<p><p>Lyme carditis is an uncommon but potentially fatal manifestation of early disseminated Lyme disease. Timely diagnosis poses a clinical challenge due to the highly variable and non-specific symptomatology that can be easily overlooked, as well as the limited availability of specific and non-invasive diagnostic tests for assessing cardiac involvement. While cardiac magnetic resonance (CMR) imaging is the standard imaging modality for diagnosing various etiologies of cardiomyopathy, its application in Lyme carditis remains understudied. In this study, we present two cases of CMR-proven Lyme carditis and provide a comprehensive review of the existing literature on the use of CMR in this condition.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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