Journal of Cardiovascular Development and Disease最新文献

{"title":"Ancel Keys, the Mediterranean Diet, and the Seven Countries Study: A Review.","authors":"Alessandro Menotti, Paolo Emilio Puddu","doi":"10.3390/jcdd12040141","DOIUrl":"https://doi.org/10.3390/jcdd12040141","url":null,"abstract":"<p><p>The identification of the \"Mediterranean Diet\" (MD) by Prof. Ancel Keys is described here, alongside its confirmation through the epidemiological study known as \"The Seven Countries Study of Cardiovascular Diseases\" (SCS). Prof. Keys' intuition on the possible dietary determinants of coronary heart disease (CHD) was derived from several pilot studies conducted in various countries. His impression was that the healthy diet was eaten along the Mediterranean shores of Italy, former Yugoslavia, and Greece, characterized by a large intake of bread, cereals, vegetables, fruit, and olive oil, with a small intake of meat, milk, dairy, and sugar products. The SCS was conducted across 16 cohorts of middle-aged men in seven countries (USA, Finland, the Netherlands, Italy, former Yugoslavia, Greece, and Japan), with assessments of usual eating habits, repeated medical examinations, and long-term follow-up. Analyses by Keys on the data from the first 15 years of follow-up indicated that low intake of saturated fatty acids (SAFA), usually derived from animal foods, was associated with the lower occurrence of and mortality from CHD, confirming the idea that a diet such as the Mediterranean Diet could be healthy. Further analyses by collaborators of the SCS, over a longer follow-up period, included the use of food groups and dietary scores of different types, confirming that cohorts with a Mediterranean Diet had a lower risk and death rate from CHD, whereas the reverse occurred in populations consuming an unhealthy diet.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.","authors":"Nora Bacour, Rutger T Theijsse, Simran Grewal, Robert J M Klautz, Nimrat Grewal","doi":"10.3390/jcdd12040140","DOIUrl":"https://doi.org/10.3390/jcdd12040140","url":null,"abstract":"<p><p>(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing research on racial disparities in the presentation and outcomes of TAAs. (2) Methods: This literature review was conducted using a systematic search strategy to explore racial differences in the presentation and surgical outcomes of patients with TAAs. (3) Results: The findings demonstrated that black patients were younger at presentation and had a higher incidence of ruptured TAAs than non-black patients. Furthermore, compared to non-black patients, black patients had higher rates of cardiac arrhythmia and COPD, as well as comorbidities such as diabetes, hypertension, and renal insufficiency. For black patients undergoing open surgery, the surgical results showed improved 5-year survival rates after repair but higher perioperative mortality rates. All-cause or in-hospital mortality did not significantly differ between the racial groups, according to four studies. (4) Discussion: This review highlights significant racial disparities in TAA presentation and outcomes, underscoring the need for personalized risk stratification models. Standardized racial and ethnic definitions are essential for consistent and reliable research. Future studies should focus on identifying the underlying mechanisms driving racial disparities and on refining risk assessment models to enhance diagnostic and therapeutic strategies, ultimately improving patient outcomes across diverse populations.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary Bypass Time During Surgery for Acute Type A Aortic Dissection and Mid-Term Survival.","authors":"Mikko Uimonen, Christian Olsson, Anders Jeppsson, Arnar Geirsson, Vibeke Hjortdal, Emma C Hansson, Igor Zindovic, Jacob Ede, Jarmo Gunn, Anders Wickbom, Tomas Gudbjartsson, Ari Mennander","doi":"10.3390/jcdd12040139","DOIUrl":"https://doi.org/10.3390/jcdd12040139","url":null,"abstract":"<p><p>We evaluated the association between cardiopulmonary bypass (CPB) time during surgery for acute type A aortic dissection (ATAAD) and mid-term survival. Data of 1122 patients who underwent surgery for ATAAD in eight Nordic centers from January 2005 to December 2014 were retrospectively analyzed. An adjusted logistic regression analysis was performed to investigate the association of incremental 30 min CPB time on 30-day mortality. In addition, the patients were divided into those that underwent surgery with >210 min (n = 369) or <210 min CPB time (n = 605) based on spline analysis and a receiver operating characteristic curve. The restricted mean survival time ratios adjusted for patient characteristics and surgical details between the groups were calculated for survival and aortic reoperation-free survival. The median follow-up time was 2.6 (inter-quartile range 0.9-4.9) years. Incremental CPB time was associated with higher 30-day mortality (OR 1.25 per 30 min, 95% CI 1.15-1.35, <i>p</i> < 0.001). Mid-term survival for all patients was inferior in the >210 min group as compared with the <210 min group (adjusted restricted mean survival time ratio 0.88, 95% confidence interval [CI] 0.81-0.96, <i>p</i> = 0.003). Reoperation-free survival was similar in patients with CPB time > 210 min as compared with <210 min. Prolonged CPB time is associated with higher 30-day mortality and inferior mid-term survival but not with inferior reoperation-free survival after surgical repair of ATAAD.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of Cardiac Complaints in Pediatric and Young Adult Populations During the COVID-19 Pandemic.","authors":"Emily M Ferraro, Madeline I Dorr, Cade M Nylund, Apryl Susi, Elizabeth Hisle-Gorman, Michael Rajnik, Brian N Hughes","doi":"10.3390/jcdd12040138","DOIUrl":"https://doi.org/10.3390/jcdd12040138","url":null,"abstract":"<p><p>The COVID-19 pandemic had a significant impact on the physical and mental health of all age groups. While many studies have evaluated the serious cardiac manifestation associated with multisystem inflammatory syndrome of children, there are less studies evaluating how the COVID-19 pandemic impacted the presentation of less severe symptomatic cardiac manifestations. This large retrospective cross-sectional study examined the impact of the COVID-19 pandemic on the cardiovascular health of patients 1 to 24 years of age by assessing care presentation trends for chest pain, palpitations, and syncope for patients in the military health system. Overall, chest pain had the highest rate of presentation when compared to syncope and palpitations. There was a significant decrease in the rate of incidence for all three cardiac symptoms during the first year of the COVID-19 pandemic compared to the pre-COVID-19 period. When comparing the second year of the COVID-19 pandemic to the pre-COVID-19 period, there was a significant decrease in chest pain and syncope but a slight increase in palpitations. Overall, our results showed that these common cardiac presentations did not greatly increase during the COVID-19 pandemic.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Objective and Subjective Social Isolation and Self-Reported Hypertension in Older Adults.","authors":"Tyrone C Hamler, Ann W Nguyen, Harry Owen Taylor, Weidi Qin, Fei Wang","doi":"10.3390/jcdd12040136","DOIUrl":"https://doi.org/10.3390/jcdd12040136","url":null,"abstract":"<p><p>Hypertension is a major public health concern, especially in older adults, and gender differences are a factor in terms of its prevalence. Social connections benefit health, while social isolation is linked to negative outcomes. Prior studies suggest social isolation and connectedness vary by gender, but few have explored this relationship with hypertension. This study examined gender differences in the association between social isolation and hypertension in older adults using data from the National Survey of American Life (1280 adults aged ≥55). Weighted logistic regressions tested gender differences in objective and subjective social isolation and hypertension. Both men and women who were objectively isolated from family and friends, or only friends, were less likely to have hypertension than those not isolated. However, when accounting for subjective isolation, only isolation from family predicted hypertension. Gender moderated this relationship-men isolated from family and friends had a higher likelihood of hypertension, while no such association was found for women. Findings suggest that preventing objective isolation, particularly from family, may help reduce hypertension risk in older adults. This study highlights the need to further investigate social isolation's impact on health and its underlying mechanisms among older adults in the U.S.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life in Heart Failure Patients: The Effect of Anxiety and Depression (Patient-Caregiver) and Caregivers' Quality of Life.","authors":"Athanasia Tsami, Ioannis Koutelekos, Georgia Gerogianni, Georgios Vasilopoulos, Niki Pavlatou, Antonia Kalogianni, Theodore Kapadochos, Angleliki Stamou, Maria Polikandrioti","doi":"10.3390/jcdd12040137","DOIUrl":"https://doi.org/10.3390/jcdd12040137","url":null,"abstract":"<p><p>Patients with heart failure (HF) and their caregivers are a dyad inextricably linked that exert influence on patients' quality of life (QoL).</p><p><strong>Purpose: </strong>The aim of this study was to explore factors affecting HF patients' QoL. Factors were: (a) HF patients' characteristics, (b) anxiety/depression of the dyad (patient-caregiver) and (c) caregivers' QoL.</p><p><strong>Material and methods: </strong>In this cross-sectional study, we enrolled 340 patients and 340 caregivers. Data collection was performed by the method of an interview using \"The Hospital Anxiety and Depression Scale\", HADS) to assess anxiety and depression (patient-caregiver) as well as the \"Minnesota Living with Heart Failure\" and the \"SF-36 Health Survey (SF-36)\" to assess QoL (patient-caregiver, respectively).</p><p><strong>Results: </strong>From the 340 dyads who comprised the sample, 81.3% and 77.5% of patients experienced anxiety and depression, respectively, while 79.3% and 62.2% of caregivers experienced anxiety and depression, respectively. A statistically significant difference between patients and caregivers was only detected for depression (<i>p</i> = 0.001) and not for anxiety (<i>p</i> = 0.567). Patients with scores in HADS that indicate anxiety and depression had a worse QoL (total, physical, and mental). All subscales of the caregiver's QoL were significantly associated with the patient's QoL (<i>p</i> < 0.001) apart from the physical functioning scale. The correlation coefficients were all negative, indicating that a better caregiver's QoL (higher SF36 scores) is associated with a better patient's QoL (lower Minnesota scores). After controlling for the patient's characteristics, the anxiety and depression of caregivers did not affect the patient's QoL (confounding effect) whereas the patient's anxiety/depression remained significant factors. Patients with anxiety and depression had 5.58 and 6.49 points, respectively, higher QoL score, meaning a worse QoL, compared to those with no anxiety/depression.</p><p><strong>Conclusions: </strong>Evaluating the impact of HF on patients' QoL and anxiety/depression along with their caregivers permits acknowledgment of this dyadic relationship.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Endothelial Progenitor Cells Are Associated with Severe Coronary Artery Disease: Insights from a Clinical Study.","authors":"Ivan Tomić, Ivan Zeljko, Ivica Brizić, Violeta Šoljić, Ivona Ivančić, Monika Tomić, Marina Ćurlin, Domagoj Tomić","doi":"10.3390/jcdd12040132","DOIUrl":"https://doi.org/10.3390/jcdd12040132","url":null,"abstract":"<p><p>Endothelial progenitor cells (EPCs) play a crucial role in vascular repair, and their depletion has been involved in coronary artery disease (CAD) severity. This study examines the relationship between circulating EPC levels and CAD complexity, as quantified by the Syntax Score I. A total of 85 patients undergoing coronary angiography were enrolled, with EPCs quantified using flow cytometry. EPC proportion showed a significant inverse relationship with CAD severity, measured by Syntax Score I. Additionally, we investigated EPC levels in patients presenting with acute coronary syndrome (ACS) and found that EPC depletion was more pronounced in this group compared to non-ACS patients (median EPC count: 0.35 vs. 0.61, <i>p</i> = 0.027). These findings suggest that lower EPC levels are indicative of more severe CAD and ACS, reinforcing their potential as biomarkers for cardiovascular risk stratification, monitoring disease advancement, and identifying patients at risk of adverse events.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere Length and Clonal Hematopoiesis of Indeterminate Potential: A Loop Between Two Key Players in Aortic Valve Disease?","authors":"Ilenia Foffa, Augusto Esposito, Ludovica Simonini, Sergio Berti, Cecilia Vecoli","doi":"10.3390/jcdd12040135","DOIUrl":"https://doi.org/10.3390/jcdd12040135","url":null,"abstract":"<p><p>Aortic valve stenosis (AVS) is the most common valvular heart disease that was considered, for a long time, a passive degenerative disease due to physiological aging. More recently, it has been recognized as an active, modifiable disease in which many cellular processes are involved. Nevertheless, since aging remains the major risk factor for AVS, a field of research has focused on the role of early (biological) aging and its dependent pathways in the initiation and progression of AVS. Telomeres are regions at the ends of chromosomes that are critical for maintaining genome stability in eukaryotic cells. Telomeres are the hallmarks and molecular drivers of aging and age-related degenerative pathologies. Clonal hematopoiesis of indeterminate potential (CHIP), a condition caused by somatic mutations of leukemia-associated genes in individuals without hematologic abnormalities or clonal disorders, has been reported to be associated with aging. CHIP represents a new and independent risk factor in cardiovascular diseases, including AVS. Interestingly, evidence suggests a causal link between telomere biology and CHIP in several pathological disorders. In this review, we discussed the current knowledge of telomere biology and CHIP as possible mechanisms of aortic valve degeneration. We speculated on how a better understanding of the complex relationship between telomere and CHIP might provide great potential for an early diagnosis and for developing novel medical therapies to reduce the constant increasing health burden of AVS.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12027716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endurance Training Exercise Dose in Coronary Artery Disease Rehabilitation.","authors":"Daria Neyroud, Aaron L Baggish","doi":"10.3390/jcdd12040134","DOIUrl":"https://doi.org/10.3390/jcdd12040134","url":null,"abstract":"<p><p>Clinical management of patients with atherosclerotic coronary artery disease (CAD) following acute coronary syndrome includes cardiac rehabilitation. The well-established hallmark of cardiac rehabilitation is structured aerobic exercise training. To date, however, a limited number of studies have directly compared the effects of different doses of exercise on cardiovascular health, leaving uncertainty about the possible differential benefits of different exercise doses for use during cardiac rehabilitation. To address this area of uncertainty, we conducted a literature review and comparative analyses of studies that both compared two or more exercise interventions and assessed pre- and post-intervention peak oxygen consumption (V˙O2PEAK). Results from these analyses suggest that high exercise intensity, even when performed over relatively short duration interventions, appears to yield the most substantial improvements in cardiorespiratory fitness. However, this conclusion is based on the limited number of available studies, underscoring the need for future work examining exercise dose and clinical outcomes in the cardiac rehabilitation setting.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Dependent Risk of Long-Term All-Cause Mortality in Patients Post-Myocardial Infarction and Acute Kidney Injury.","authors":"Keren Skalsky, Mashav Romi, Arthur Shiyovich, Alon Shechter, Tzlil Grinberg, Harel Gilutz, Ygal Plakht","doi":"10.3390/jcdd12040133","DOIUrl":"https://doi.org/10.3390/jcdd12040133","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to investigate the association between acute kidney injury (AKI) and the risk for long-term (up to 10 years) all-cause mortality among elderly compared with younger patients following an acute myocardial infarction (AMI).</p><p><strong>Methods: </strong>This study was a retrospective analysis of the Soroka Acute Myocardial Infarction registry and covered the years 2002 to 2017. It included patients diagnosed with an AMI who had a baseline estimated glomerular filtration rate (eGFR) greater than 60 mL/min/1.73 m² and serum creatinine measurements available during hospitalization. The patients were stratified by age: elderly (aged 65 years or older at admission) and younger. In each stratum, two groups were defined based on the presence of an AKI. The survival approach (Kaplan-Meier survival curves, log-rank test and Cox regressions) was utilized to estimate and compare the probability of long-term (up to 10 years) all-cause mortality in each group.</p><p><strong>Results: </strong>Among the 10,511 eligible patients, which consisted of 6132 younger patients (58.3%) and 4379 elderly (41.7%), an AKI occurred in 15.2% of cases, where the elderly patients experienced a higher incidence than the younger patients (20.9% vs. 11.2%, <i>p</i> < 0.001). The presence of an AKI significantly increased the risk of death in both age groups, with the association being stronger among the younger patients (AdjHR = 1.634, 95% CI: 1.363-1.959, <i>p</i> < 0.001) than among the elderly (AdjHR = 1.278, 95% CI: 1.154-1.415, <i>p</i> < 0.001, <i>p</i>-for-interaction = 0.020).</p><p><strong>Conclusions: </strong>An AKI following an AMI was associated with a high risk for long-term all-cause mortality in both age groups, with a stronger association among younger patients.</p>","PeriodicalId":15197,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"12 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}