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Glyphosate, a cancer generator? – mini review 草甘膦致癌?-迷你回顾
Journal of Cancer Prevention & Current Research Pub Date : 2020-02-05 DOI: 10.15406/JCPCR.2020.11.00418
H. Anis
{"title":"Glyphosate, a cancer generator? – mini review","authors":"H. Anis","doi":"10.15406/JCPCR.2020.11.00418","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00418","url":null,"abstract":"The potential carcinogenic properties of glyphosate are the subject of widespread scientific debate. The US Environmental Protection Agency said in a 2017 draft risk assessment that the herbicide “is not likely to be carcinogenic to humans, while the “European Food Safety Authority”2 maintains a similar stance. In 2015, however, the World Health Organization’s International Agency for Research on Cancer classified glyphosate as “probably carcinogenic to humans”.1 Moreover, the chemical has triggered multiple lawsuits from people who believe that exposure to the herbicide caused their Non-Hodgkin’s Lymphoma.3","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76641809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influences impacting the attitudes of parents towards the HPV vaccine 影响家长对HPV疫苗态度的因素
Journal of Cancer Prevention & Current Research Pub Date : 2020-01-21 DOI: 10.15406/JCPCR.2020.11.00416
Kate Lawless, P. Murphy, L. Marignol, C. Poole
{"title":"Influences impacting the attitudes of parents towards the HPV vaccine","authors":"Kate Lawless, P. Murphy, L. Marignol, C. Poole","doi":"10.15406/JCPCR.2020.11.00416","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00416","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"139 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2020-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80406262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neuroendocrine tumor of appendix presenting as appendicitis 阑尾神经内分泌肿瘤，表现为阑尾炎
Journal of Cancer Prevention & Current Research Pub Date : 2020-01-15 DOI: 10.15406/JCPCR.2020.11.00415
Chintav Shah, Jay Patolia, S. Jaggernauth, Nirav Nagarsheth
{"title":"Neuroendocrine tumor of appendix presenting as appendicitis","authors":"Chintav Shah, Jay Patolia, S. Jaggernauth, Nirav Nagarsheth","doi":"10.15406/JCPCR.2020.11.00415","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00415","url":null,"abstract":"This was 34yr old male with no PMH was in his usual state of health at work loading a truck where he experienced a fall resulting in persistent RLQ pain. He had a CT scan of the abdomen and pelvis performed that was normal with a non visualised appendix. Patient was seen by surgery who suggested an appendectomy however the patient wasn’t ready for it and wanted to try antibiotics. He was placed on ciprofloxacin and metronidazole. His symptoms worsened therefore he returned to the emergency room and was admitted. He underwent a laparoscopic appendectomy with no visible tumor seen at the time of the surgery.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"161 1","pages":"4-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86389688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenocarcinoma of the bladder: case report 膀胱腺癌1例
Journal of Cancer Prevention & Current Research Pub Date : 2020-01-06 DOI: 10.15406/JCPCR.2020.11.00414
Chintav Shah, Jay Patolia, S. Jaggernauth, Nirav Nagarsheth
{"title":"Adenocarcinoma of the bladder: case report","authors":"Chintav Shah, Jay Patolia, S. Jaggernauth, Nirav Nagarsheth","doi":"10.15406/JCPCR.2020.11.00414","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00414","url":null,"abstract":"Primary adenocarcinoma of the bladder is derived from the urothelium of the bladder. Patient present in the sixth to seventh decade of life with male predominance.2 The most common symptom on presentation is hematuria but they can also present as bladder irritation symptoms.2 Adult vesicle exostrophy and persistent Urachal remnants are also a risk factor for adenocarcinoma.3 The diagnosis of primary adenocarcinoma can only be made once the secondary causes has been ruled which mainly involves colorectal, endometrial and cervical.2","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85152693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Novel NBQ-48 as marker of hypoxic cells in 2D and 3D colon cancer cells. 新型NBQ-48作为2D和3D结肠癌细胞缺氧细胞的标记物。
Journal of Cancer Prevention & Current Research Pub Date : 2020-01-01 Epub Date: 2020-01-23 DOI: 10.15406/jcpcr.2020.11.00417
Beatriz Zayas, Vivian Lebron, Christian Vélez, Osvaldo Cox
{"title":"Novel NBQ-48 as marker of hypoxic cells in 2D and 3D colon cancer cells.","authors":"Beatriz Zayas,&nbsp;Vivian Lebron,&nbsp;Christian Vélez,&nbsp;Osvaldo Cox","doi":"10.15406/jcpcr.2020.11.00417","DOIUrl":"https://doi.org/10.15406/jcpcr.2020.11.00417","url":null,"abstract":"<p><p>This study presents the applicability of a novel nitro-substituted heterocyclic compound NBQ48, member of the family of compounds identified as 3 nitrobenzazolo[3, 2-a] quinolinium chloride salts (NBQS) as a screening tool to identify hypoxic tumor cells. The applicability was tested on COLO 205 colon cancer cells 2D and 3D cultures treated with NBQ48 to assess the formation of a bio-reduction fluorescent metabolite under hypoxic conditions in contrast, to those under aerobic environment. Hypoxic environment was created applying a controlled hypoxic gas chamber. Prior to testing the applicability of NBQ48 as a hypoxic fluorescent marker, cytotoxic studies where performed to identify a low-toxicity dose at 24 hours under aerobic and hypoxic environments that would allow the bio-reduction process with little toxicity. The differences in fluorescence emission after treatment was measured by fluorometer and fluorescence microscopy. Results indicated that cell treatments up to 24 hours with NBQ48 under aerobic environment did not reach an IC50 dose in COLO205 cells, however under hypoxic environment the IC50 reached at 100μM. The significant fluorescence increment after 24 and 48 hrs in 2D and 3D cultures treated with NBQ48 (75uM) at hypoxic in contrast to aerobic environments clearly demonstrated the need of a low oxygen content for the bio-reduction of the parent NBQ48. This study confirms the applicability of NBQ48 as markers for hypoxia in metabolically active 2D and 3D cultures. This hydrophilic hypoxic marker could additionally aid researchers in testing hypoxia activated pro-drugs for therapeutic applications in cancer as well as on other diseases where cellular hypoxia is a significant risk factor.</p>","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"11 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/e6/nihms-1750639.PMC8580369.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39613643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Metastatic malignant melanoma: a case report 转移性恶性黑色素瘤1例报告
Journal of Cancer Prevention & Current Research Pub Date : 2019-12-23 DOI: 10.15406/jcpcr.2019.10.00413
Chintav Shah, Jay Patolia, S. Jaggernauth, J. Kimbel
{"title":"Metastatic malignant melanoma: a case report","authors":"Chintav Shah, Jay Patolia, S. Jaggernauth, J. Kimbel","doi":"10.15406/jcpcr.2019.10.00413","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00413","url":null,"abstract":"The incidence of melanoma has been increasing although the cancer of the other sites is decreasing.3 Malignant melanoma are derived from the melanocytes.1Skin is the most common site of occurrence however other organs like eye, oral and nasal mucosa, anorectal mucosa and CNS tend to occur.1 It is the 5th most common cancer in men.5 The 5-year survival rate is only 15% for distant metastasis, improved only slightly from 12% in the past decade.5 70% of all cutaneous melanomas have CDKN2A mutations.5 Mutations in N-RAS and BRAF, the proteins involved in MAPK pathway were found in 20% and 60% cases respectively.5 The most commonly seen BRAF mutation is a substitution of valine with glutamate (V600E).5 The most common sites of melanoma are legs in women and back in men.1Macroscopic locoregional lymph node metastasis reduces fiveyear survival to 43%. Patients who had locoregional metastasis had a better survival rate than those with metastasis to viscera.1 Sentinel lymph node status remains an important prognostic factor for survival of patients with melanoma.1","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87296223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using prostatic fluid levels of rubidium and zinc concentration multiplication in non-invasive and highly accurate screening for prostate cancer 利用前列腺液中铷和锌的浓度倍增在非侵入性和高度准确的前列腺癌筛查中的应用
Journal of Cancer Prevention & Current Research Pub Date : 2019-11-17 DOI: 10.15406/jcpcr.2019.10.00409
V. Zaichick
{"title":"Using prostatic fluid levels of rubidium and zinc concentration multiplication in non-invasive and highly accurate screening for prostate cancer","authors":"V. Zaichick","doi":"10.15406/jcpcr.2019.10.00409","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00409","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77451643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A FLASH back to radiotherapy’s past and then fast forward to the future 一闪回到放射治疗的过去，然后快进到未来
Journal of Cancer Prevention & Current Research Pub Date : 2019-11-13 DOI: 10.15406/jcpcr.2019.10.00407
E. Kamperis, C. Kodona, V. Giannouzakos
{"title":"A FLASH back to radiotherapy’s past and then fast forward to the future","authors":"E. Kamperis, C. Kodona, V. Giannouzakos","doi":"10.15406/jcpcr.2019.10.00407","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00407","url":null,"abstract":"","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85696635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Sclerodermiform basal cell carcinoma: rare form in a young patient 硬皮样基底细胞癌:罕见的年轻患者
Journal of Cancer Prevention & Current Research Pub Date : 2019-11-06 DOI: 10.15406/jcpcr.2019.10.00406
I. Assenhaji, M. Bennani, J. Ziani, S. Elloudi, H. Baybay, F. Mernissi
{"title":"Sclerodermiform basal cell carcinoma: rare form in a young patient","authors":"I. Assenhaji, M. Bennani, J. Ziani, S. Elloudi, H. Baybay, F. Mernissi","doi":"10.15406/jcpcr.2019.10.00406","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00406","url":null,"abstract":"We report the cases of one 34-year-old, phototype 3, the delay of consultation was 4 years, and the factors risk was mainly sun exposure, the symptoms leading to consultation were ulceration. The clinical examination found sclerodermiform plaque, poorly limited, and erosion at the forehead. The dermoscopy revealed telangiectasia and vascularization in tree trunks, as well as ulceration. The rest of the somatic examination was normal. The diagnosis of basal cell carcinoma scleroderma was confirmed by histology. Surgical excision with margins was performed (Figure 1 & 2).","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"453 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72629166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming of doxorubicin resistance in breast cancer cells by cationic peptides 阳离子多肽克服乳腺癌细胞对阿霉素的耐药性
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-30 DOI: 10.15406/jcpcr.2019.10.00405
Anna A Lushnikova, Anastasia V Onyan, Anna A Rudakova, Alexandr V Kostarev, Kseniya V Kozhikhova, Sergey M Andreev, Natalya I Moiseeva, Mariya A Baryshnikova
{"title":"Overcoming of doxorubicin resistance in breast cancer cells by cationic peptides","authors":"Anna A Lushnikova, Anastasia V Onyan, Anna A Rudakova, Alexandr V Kostarev, Kseniya V Kozhikhova, Sergey M Andreev, Natalya I Moiseeva, Mariya A Baryshnikova","doi":"10.15406/jcpcr.2019.10.00405","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00405","url":null,"abstract":"Drug resistance in tumor cells is one of the obstacles for effective cancer chemotherapy. Novel strategies for therapy of multi-drug resistant tumors include the combinations of doxorubicin with microRNA.1 Metformin2 and other prodrugs. Various molecular constructions are used to codeliver doxorubicin +metformin followed by release metformin to enhance Dox cytotoxicity through attenuating hypoxic stress and inhibition of HIF1α/Pgp expression. Small molecular inhibitors of oncoproteins and essential cell pathways are considered now as promising therapeutic agents.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82243664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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