Journal of Cancer Prevention & Current Research最新文献_第5页

Testicular liposarcoma: a rare form of testicular cancer 睾丸脂肪肉瘤:一种罕见的睾丸癌

Journal of Cancer Prevention & Current Research Pub Date : 2020-06-05 DOI: 10.15406/JCPCR.2020.11.00428

Chintav Shah, Simeon Jaggenauth, Patrick Pathappillil, Risha Sinha

引用次数: 1

Thyroid, uncommon metastatic site for renal cell carcinoma – practical challenges 甲状腺，罕见的肾细胞癌转移部位-实际的挑战

Journal of Cancer Prevention & Current Research Pub Date : 2020-05-23 DOI: 10.15406/JCPCR.2020.11.00430

R. Pintican, M. Mureşan, A. Chiorean, V. Bintintan, V. Bura, M. Duma

引用次数: 0

The burden of cancer cases attributable to tobacco in India: case of Kerala and Bihar states 印度烟草引起的癌症病例负担:喀拉拉邦和比哈尔邦的案例

Journal of Cancer Prevention & Current Research Pub Date : 2020-05-19 DOI: 10.15406/JCPCR.2020.11.00427

J. Prasad, Arvind Kumar, Rajeshwari A. Biradar

{"title":"The burden of cancer cases attributable to tobacco in India: case of Kerala and Bihar states","authors":"J. Prasad, Arvind Kumar, Rajeshwari A. Biradar","doi":"10.15406/JCPCR.2020.11.00427","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00427","url":null,"abstract":"Background: For effective planning and administrative purpose, a precise estimate of burden due to tobacco and projection figure is essential. There were some studies in India, reporting tobacco-related cancers. However, there is no observable study in India, especially for these backward and forward state, attempting to assess cancers due to tobacco for measuring the geographical variations. Hence, this study tried to highlights geographic variation between one from developed state is as Kerala, and another one is from not so well-developed state as Bihar in India. Materials and methods: Tobacco prevalence, the relative risk of cancer due to tobacco, incidence rates of tobacco-related cancers, and population were obtained respectively from recent five rounds of Nation Sample Survey, our recently published study, reports of Population-Based Cancer Registries, and projections of Registrar General of India. Prasad and Dhar published generalised Population Attributable Risk method (2018) was used to assess cancer due to tobacco and regression method for prediction. Results: The burden of cancer cases due to tobacco was found highest in the state of Bihar (23,679), while in Kerala, it was 5,981 in the year 2015 and increased to 42,244 and 6,646 by 2025 in Bihar and Kerala respectively. Lung cancer is the leading cancer sites followed by mouth and tongue cancers. In Kerala, the proportion of smoking is found to be high and lead to the higher proportions of larynx cancers (61percent) followed by oropharynx (59 percent) and lung cancer (58 percent) and are likely to increase from 2015 to 2025 slightly. In Bihar, around three fourth of mouth cancers cases being due to chewing followed by oesophagus (59 percent), tongue (54 percent) and so on. Conclusion: Present study reports the absolute burden of cancer due to tobacco, Tobacco- Related Cancer as well as a percent change of it for Kerala and Bihar till 2025. It might be helpful to policy planners and administrators in decision making relating to anti-tobacco measures.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"17 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91474734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Is BHCG a good tumor marker for aggressive uterine leiomyosarcoma? case report BHCG是侵袭性子宫平滑肌肉瘤的良好肿瘤标志物吗?病例报告

Journal of Cancer Prevention & Current Research Pub Date : 2020-04-30 DOI: 10.15406/JCPCR.2020.11.00426

Sarah Alrubaish, M. Renaud

引用次数: 0

Small cell lung cancer: a Moroccan retrospective study of 70 cases 小细胞肺癌:摩洛哥70例回顾性研究

Journal of Cancer Prevention & Current Research Pub Date : 2020-04-21 DOI: 10.15406/JCPCR.2020.11.00425

I. Ahalli, K. Messoudi, Raihana Boujarnija, K. Darif, L. Amaadour, K. Oualla, Z. Benbrahim, Samia Arif, N. Mellas

{"title":"Small cell lung cancer: a Moroccan retrospective study of 70 cases","authors":"I. Ahalli, K. Messoudi, Raihana Boujarnija, K. Darif, L. Amaadour, K. Oualla, Z. Benbrahim, Samia Arif, N. Mellas","doi":"10.15406/JCPCR.2020.11.00425","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00425","url":null,"abstract":"Background: Lung cancer is the main cause of cancer-related death worldwide. Small cell lung cancer (SCLC) represents 15-20% of all lung cancers, it is an aggressive neoplasia, with a 5-year mortality of 90% or more. The aim of this study was to evaluate the epidemiological and clinical features, treatment outcome and survival for patients with SCLC treated in medical oncology department during the period from 2010 to 2018. Material and methods: It is a retrospective study including Small cell lung cancer (SCLC) treated in the department of Medical Oncology at Hassan II University hospital in Fes, from January 2010 to December 2018. Collection of data was obtained through computerized records of patients. The survival was analyzed by the Kaplan-Meier method. Results: The mean age was 59 years. Almost all patients were current smokers. The most frequent symptoms on admission were dyspnea, chest pain and hemoptysis. The stages of SCLC were limited disease in 17 (24,3%) and extensive disease in 53 (75,7%) patients. Contra lateral lung was the most common site of metastasis (42.6%) followed by adrenal gland, brain, liver and bone. The median survival was 25.2, 17.2 and 21.3 months for LS, ES and overall patients, respectively. Conclusion: In conclusion, demographic and clinical features of the patients were similar with the literature. We found a better survival than reported in literature.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72595548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An application of matrix eQTL to billions hypothesis testing to identify expression quantitative trait loci in genome wide association studies of inflammatory bowel disease 在炎症性肠病全基因组关联研究中，应用矩阵eQTL进行数十亿假设检验以鉴定表达数量性状位点

Journal of Cancer Prevention & Current Research Pub Date : 2020-04-16 DOI: 10.15406/JCPCR.2020.11.00424

Fahimeh Moradi, Morteza Hajihosseini, Elham Khodayari-Moez, I. Dinu

{"title":"An application of matrix eQTL to billions hypothesis testing to identify expression quantitative trait loci in genome wide association studies of inflammatory bowel disease","authors":"Fahimeh Moradi, Morteza Hajihosseini, Elham Khodayari-Moez, I. Dinu","doi":"10.15406/JCPCR.2020.11.00424","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00424","url":null,"abstract":"Introduction: Genome wide association studies (GWAS) have been widely used in recent years to identify new information on genetic variants which are associated with complex trait in many diseases. Advances in identifying the Single Nucleotide Polymorphisms (SNPs) facilitate the study of etiologies of common disorders including cancers, inflammatory bowel diseases (IBD) and colorectal cancer. Variations in gene expression demonstrate that transcript levels of many RNAs behave as heritable quantitative traits. Studying the genetics of gene expression can provide additional power to the roles of GWAS variants. Expression quantitative trait loci (eQTL) mapping links the genome-wide SNPs with RNA expression. Methods: In this study, we performed expression quantitative trait loci (eQTL) analysis using the Matrix eQTL R package. This technique implements matrix covariance calculation and efficiently runs ANOVA and linear regression analysis for eQTL studies. The statistical test determines the association between SNP and gene expression, where the null hypothesis is no association between genotype and phenotypes. False Discovery Rate (FDR) is used to identify significant cis and trans eQTL and adjust for multiple hypothesis testing. Results: We applied matrix eQTL to a real data set consisting of 730,256 SNP and 33,298 RNA for 173 samples. SNPs with minor allele frequency (MAF) less than 0.05 and those violating the Hardy_Weinberg equilibrium (HWE), were excluded from the study. In this study, 15,408 cis eQTL and 27,562 trans eQTL are identified at a FDR less than 0.05, corresponding to p value thresholds of 8e-5 and 1e-8, respectively. Conclusion: We found out that matrix eQTL is a computationally efficient and user friendly method for analysis of eQTL studies. Our application provides insight into the genomic architecture of gene regulation in inflammatory bowel disease (IBD).","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90417924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retroperitoneal liposarcoma: an unusual case of weight gain despite weight loss measures 腹膜后脂肪肉瘤:一个不寻常的病例体重增加，尽管减肥措施

Journal of Cancer Prevention & Current Research Pub Date : 2020-04-15 DOI: 10.15406/JCPCR.2020.11.00423

Chintav Shah, S. Jaggernauth, V. A. Ayapati, B. o'Brian

引用次数: 0

Senile sebaceous nevus degenerating to a pseudo glandular basal cell carcinoma 老年性皮脂腺痣变性为伪腺性基底细胞癌

Journal of Cancer Prevention & Current Research Pub Date : 2020-03-18 DOI: 10.15406/JCPCR.2020.11.00422

K. Elboukhari, A. Rasso, S. Elloudi, H. Baybay, Z. Douhi, F. Mernissi

{"title":"Senile sebaceous nevus degenerating to a pseudo glandular basal cell carcinoma","authors":"K. Elboukhari, A. Rasso, S. Elloudi, H. Baybay, Z. Douhi, F. Mernissi","doi":"10.15406/JCPCR.2020.11.00422","DOIUrl":"https://doi.org/10.15406/JCPCR.2020.11.00422","url":null,"abstract":"epidermis and dermis, with a triphasic evolution: alopecic patch with underdeveloped adnexal structures. In puberty, the second phase shows a proliferative and veracious plaque. While the third phase is characterized by the occurrence of benign or more rarely invasive tumors in the preexistent plaque. Dermoscopy finds an important place in the characterization of these stages of evolution, and especially in the detection of transformation. 10-20% of sebaceous nevus is transformed into benign or malignant tumors that Abstract Jadassohn nevus is a congenital hamartoma that is characterized by natural evolution in three stages, with a risk of malignancies occurring in the last phase. This benign adnexal tumor often affects the face and scalp. Dermoscopy can provide a major help for detecting transforming tumors. We report the case of a senile sebaceous Nevus which has been diagnosed after the occurrence of Basal cell carcinoma in a 60 years old man. The originality of this observation remains in the rarity of the pseudo glandular basal cell carcinoma that, in the best of our knowledge, has never been reported in underlying nevus sebaceous.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73888872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benign chondroid syringoma of foot: a clinical dilemma 足部良性软骨样注射器瘤:临床困境

Journal of Cancer Prevention & Current Research Pub Date : 2020-03-11 DOI: 10.15406/JCPCR.2020.11.00420

Sonam Sharma, S. Sharma

引用次数: 2

High-grade testicular diffuse B lymphoma, a rare localization: a case report and review of the literature 高度睾丸弥漫性B淋巴瘤，罕见的局部化:1例报告及文献复习

Journal of Cancer Prevention & Current Research Pub Date : 2020-02-19 DOI: 10.15406/JCPCR.2020.11.00419

Z. Youbi, S. Yossi, P. Sesques, H. Jouhadi

引用次数: 0