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Sclerodermiform basal cell carcinoma: rare form in a young patient 硬皮样基底细胞癌:罕见的年轻患者
Journal of Cancer Prevention & Current Research Pub Date : 2019-11-06 DOI: 10.15406/jcpcr.2019.10.00406
I. Assenhaji, M. Bennani, J. Ziani, S. Elloudi, H. Baybay, F. Mernissi
{"title":"Sclerodermiform basal cell carcinoma: rare form in a young patient","authors":"I. Assenhaji, M. Bennani, J. Ziani, S. Elloudi, H. Baybay, F. Mernissi","doi":"10.15406/jcpcr.2019.10.00406","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00406","url":null,"abstract":"We report the cases of one 34-year-old, phototype 3, the delay of consultation was 4 years, and the factors risk was mainly sun exposure, the symptoms leading to consultation were ulceration. The clinical examination found sclerodermiform plaque, poorly limited, and erosion at the forehead. The dermoscopy revealed telangiectasia and vascularization in tree trunks, as well as ulceration. The rest of the somatic examination was normal. The diagnosis of basal cell carcinoma scleroderma was confirmed by histology. Surgical excision with margins was performed (Figure 1 & 2).","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"453 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72629166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming of doxorubicin resistance in breast cancer cells by cationic peptides 阳离子多肽克服乳腺癌细胞对阿霉素的耐药性
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-30 DOI: 10.15406/jcpcr.2019.10.00405
Anna A Lushnikova, Anastasia V Onyan, Anna A Rudakova, Alexandr V Kostarev, Kseniya V Kozhikhova, Sergey M Andreev, Natalya I Moiseeva, Mariya A Baryshnikova
{"title":"Overcoming of doxorubicin resistance in breast cancer cells by cationic peptides","authors":"Anna A Lushnikova, Anastasia V Onyan, Anna A Rudakova, Alexandr V Kostarev, Kseniya V Kozhikhova, Sergey M Andreev, Natalya I Moiseeva, Mariya A Baryshnikova","doi":"10.15406/jcpcr.2019.10.00405","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00405","url":null,"abstract":"Drug resistance in tumor cells is one of the obstacles for effective cancer chemotherapy. Novel strategies for therapy of multi-drug resistant tumors include the combinations of doxorubicin with microRNA.1 Metformin2 and other prodrugs. Various molecular constructions are used to codeliver doxorubicin +metformin followed by release metformin to enhance Dox cytotoxicity through attenuating hypoxic stress and inhibition of HIF1α/Pgp expression. Small molecular inhibitors of oncoproteins and essential cell pathways are considered now as promising therapeutic agents.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82243664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dental provider vaccination recommendations, a parent accepted strategy for disease prevention 牙科医生建议接种疫苗，是家长接受的疾病预防策略
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-28 DOI: 10.15406/jcpcr.2019.10.00404
Lisa A Waiwaiole, Michelle L Henninger, Daniel J Pihlstrom, Michael C Leo, David M Mosen, Allison L Naleway
{"title":"Dental provider vaccination recommendations, a parent accepted strategy for disease prevention","authors":"Lisa A Waiwaiole, Michelle L Henninger, Daniel J Pihlstrom, Michael C Leo, David M Mosen, Allison L Naleway","doi":"10.15406/jcpcr.2019.10.00404","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00404","url":null,"abstract":"Recommended vaccines for adolescents between the ages of 11-17 years in the United States (U.S.) are tetanus-diphtheriaacellular pertussis (Tdap), meningococcal conjugate (MCV4), human papillomavirus (HPV), and seasonal influenza (flu). While U.S. vaccine coverage rates for Tdap and MCV4 approach Healthy People target goals of 80%, coverage rates are 43% for HPV1 and 49% for flu.2 The American Academy of Paediatrics cites the need for improvement in vaccination rates.3 A model suggests that increasing HPV vaccine coverage to 80% for 13 birth cohorts of U.S. girls 12 and under could avoid 53,300 lifetime cervical cancer cases.4 Given that most flu-associated pediatric deaths are in children who were not vaccinated, estimates show that vaccination could reduce risk of death by 50% for children in high-risk categories and two-thirds for children with no high-risk conditions.5 With pertussis disease rates increasing,6 increased vaccination coverage could prevent death and disease. Renewed strategies are needed to address low vaccination rates.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86270717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electro-therapies for sarcomas 电疗法治疗肉瘤
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-25 DOI: 10.15406/jcpcr.2019.10.00403
R. Sundararajan, S. Poompavai, G. Sree, S. Madhivanan, S. Prabakaran, I. Camarillo
{"title":"Electro-therapies for sarcomas","authors":"R. Sundararajan, S. Poompavai, G. Sree, S. Madhivanan, S. Prabakaran, I. Camarillo","doi":"10.15406/jcpcr.2019.10.00403","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00403","url":null,"abstract":"Sarcomas are cancers of the bones and soft tissues.1,2 They are generally divided into soft tissue sarcomas (STS) and bone sarcomas based on their different mesenchymal origins and anatomical locations. They develop from cells that maintain the structure or cushion other organs in our bodies, including bone, cartilage, muscle, fat, and tendons. The different types of sarcomas are: a) Primary bone sarcomas, including Chondrosarcoma, Ewing Sarcoma, and Osteosarcoma. The various soft tissue sarcomas are: Angiosarcoma, Gastrointestinal Stromal Tumors (GIST), Kaposi Sarcoma, Leiomyosarcoma, Liposarcoma, Synovial Sarcoma, Undifferentiated Pleomorphic Sarcoma, Desmoid Fibromatosis and Pigmented Villonodular Synovitis.2 They are uncommon and make up only 1 percent of all adult cancers.1 However, in children and young adults of up to 30years age, its occurrence is higher; up to 3/100,000 happen and especially Ewing Sarcoma is experienced by teens. Since sarcomas are transported by blood, their spread is quicker and often secondaries are possible, compared to other cancers, such as carcinomas. About 80 percent of sarcomas begin in the body’s soft tissues (cartilage, muscle, fat, and tendons). The other 20 percent arise in the bones. Medical news today1 indicates that 60% of sarcoma starts in an arm or leg, 30% in abdomen or torso and 10% in neck or head. The greatest numbers of bone tumors are metastatic and spread to lung, colon, or breast. Figure 1 shows different types of sarcomas including angiosarcoma, osteosarcoma, Ewing sarcoma, Chondrosarcoma, etc.3","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88585931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Abscopal effect in head and neck cancer: a unicorn summoned once every eon? 头颈癌的异象效应:每千年召唤一次独角兽?
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-18 DOI: 10.15406/jcpcr.2019.10.00402
Efstathios Kamperis, C. Kodona, K. Markou, Vasileios, Giannouzakos
{"title":"Abscopal effect in head and neck cancer: a unicorn summoned once every eon?","authors":"Efstathios Kamperis, C. Kodona, K. Markou, Vasileios, Giannouzakos","doi":"10.15406/jcpcr.2019.10.00402","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00402","url":null,"abstract":"Abscopal effect is the reduction of tumor lesions located outside the irradiation field, assuming no other active systemic cytotoxic is administered concurrently. The term was first coined by Mole and etymologically is derived from the Latin prefix “ab” which means “position away from” and the word “scopos” which means “target”.2 Hence, abscopal effect is an “effect away from the target”. It is noteworthy that Mole used the term to describe radiation effects to normal organs, not tumors. In specific, he noticed that thyroid depression would appear only when sufficient volume of the abdomen was irradiated. Although the term was introduced in the middle of the 20th century, the first clinical case is often attributed to McCulloch who, in 1908, irradiated the regional lymph nodes of a patient with locally advanced unresectable laryngeal cancer achieving complete remission.3","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"86 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72568215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Anesthetic management of anaplastic thyroid carcinoma 甲状腺间变性癌的麻醉治疗
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-11 DOI: 10.15406/jcpcr.2019.10.00401
Barbabosa Balanzario MA, Vázquez Roque P, Cortes Aceves HO, Puente Solorio A
{"title":"Anesthetic management of anaplastic thyroid carcinoma","authors":"Barbabosa Balanzario MA, Vázquez Roque P, Cortes Aceves HO, Puente Solorio A","doi":"10.15406/jcpcr.2019.10.00401","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00401","url":null,"abstract":"examination, the patient is shown with a volume increase in the neck with a neck circumference of 66 centimeters, the largest limited oral opening, a chest x-ray is performed presenting retrosternal goitre with displacement and narrowness of the airway to the left. Therefore, computed tomography is taken, revealing narrowness of the larynx of 7.4x17.09 mm corroborated in the reconstruction of the airway (Figure 2–5), so it was scheduled by general surgery for a thyroidectomy plus tracheostomy.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86741717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on PARP inhibitor therapy for solid tumors PARP抑制剂治疗实体瘤的最新进展
Journal of Cancer Prevention & Current Research Pub Date : 2019-10-03 DOI: 10.15406/jcpcr.2019.10.00400
S. Bayraktar, S. Glück, H. Darling
{"title":"Update on PARP inhibitor therapy for solid tumors","authors":"S. Bayraktar, S. Glück, H. Darling","doi":"10.15406/jcpcr.2019.10.00400","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00400","url":null,"abstract":"There are different types of DNA defects caused by chemicals and environmental factors which include single-strand break (SSB), mismatch repair (MMR), and double-strand break (DSB).1 Polyadenosine diphosphate [ADP] ribose polymerase-1 (PARP1) and -2 (PARP2) enzymes2 are responsible for repair of most of the SSB. After they detect the defective site, they bind to the DNA damage site and recruit a set proteins to repair the break.3,4 When those proteins are recruited to the damaged site, the PARP-DNA interaction becomes unstable so that DNA repair can proceed.5 If the SSB are not repaired, they are converted to DSB.6 In that situation, another repair mechanism called homologous recombination (HR) will play a role. This mechanism is well represented in PARP1 knockout mice that SSB could not be repaired, but HR repair and non-homologous end joining (NHEJ) pathways were able to repair the formed DSB (Figure 1). HR is slower than NHEJ, but it is more accurate.7","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85768646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Metanephric stromal tumor, a rare pediatric renal neoplasm in Iranian children 后肾间质瘤，一种罕见的伊朗儿童肾脏肿瘤
Journal of Cancer Prevention & Current Research Pub Date : 2019-08-28 DOI: 10.15406/jcpcr.2019.10.00398
B. Abdolkarimi, B. Khodadadi, Kamran Sabzyan
{"title":"Metanephric stromal tumor, a rare pediatric renal neoplasm in Iranian children","authors":"B. Abdolkarimi, B. Khodadadi, Kamran Sabzyan","doi":"10.15406/jcpcr.2019.10.00398","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00398","url":null,"abstract":"Stromal tumors comprise less than 20% of the pediatric renal neoplasms.1 Metanephric stromal tumor (MST) is a very rare pediatric renal mass most occurring during infancy and childhood. Surgical excision of the lesion alone is curative in most patients.2 The correct diagnosis of this benign tumor is important because it saves the patient from side effects of unnecessary chemotherapy or radiation therapy. The most presentation of MST is an abdominal mass. In this report, a MST presented with an asymptomatic mass during vesicourethral reflux (VUR) follow up in a 3 y-old girl.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84606371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of dental professionals in managing HPV infection and oral cancer 牙科专业人员在管理HPV感染和口腔癌中的作用
Journal of Cancer Prevention & Current Research Pub Date : 2019-08-21 DOI: 10.15406/jcpcr.2019.10.00397
A. Hakeem, F. Catalanotto
{"title":"The role of dental professionals in managing HPV infection and oral cancer","authors":"A. Hakeem, F. Catalanotto","doi":"10.15406/jcpcr.2019.10.00397","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00397","url":null,"abstract":"Introduction: A dramatic increase in the number of cases of head and neck cancers in the U.S. Oropharyngeal cancers (OPCs) have been found to be linked to strains of high-risk human papillomavirus infections. 1 The purpose of this paper is to review recent updates on the spread of the Human Papilloma Virus (HPV) infection and the increase of oral cancer, as well as the potential roles of dental professionals in the prevention of HPV infection and oral cancer. Also, to help guide dental professionals about their important role in prevention and patient counselling related to HPV infection and oral cancer. Methods: The literature review was conducted via the examination of 110 scholarly articles, which were published between 2010 and 2019. For these articles, inclusion and exclusion criteria were applied, which resulted in the selection of 41 sources relevant to the issue. Inclusion criteria were articles related to oral cancer prevalence (epidemiology), HPV, the role of dental professionals, risky sexual practices, HPV vaccine, barriers, and recommendations. For exclusion criteria, articles which were completed outside the United States and Canada, in languages other than English, or were only partially available, were avoided. Additionally, technical articles and articles which precede more recent ones on the same topic were eliminated. Conclusion: Dental professionals are encouraged to be part of this prevention effort against HPV infection.","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78165642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Impact of volumetric imaging (CBCT) in defining PTV margins in the treatment of carcinoma cervix 体积成像(CBCT)在确定PTV边缘治疗宫颈癌的影响
Journal of Cancer Prevention & Current Research Pub Date : 2019-08-12 DOI: 10.15406/jcpcr.2019.10.00396
S. Sehgal, A. Anand, R. Munjal, A. Bansal
{"title":"Impact of volumetric imaging (CBCT) in defining PTV margins in the treatment of carcinoma cervix","authors":"S. Sehgal, A. Anand, R. Munjal, A. Bansal","doi":"10.15406/jcpcr.2019.10.00396","DOIUrl":"https://doi.org/10.15406/jcpcr.2019.10.00396","url":null,"abstract":"Carcinoma cervix presently poses a major burden on India’s health care system. The incidence of these tumors is on an increasing trend worldwide. There will be 18.1 million new cases and 9.6 million cancer deaths worldwide in 2018. Globally, cervical cancer ranks fourth for both incidence and mortality. However, in India every year 96,922 new cases of cervical cancer are diagnosed and amongst them 60,078 die from the disease.1","PeriodicalId":15185,"journal":{"name":"Journal of Cancer Prevention & Current Research","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83246257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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