Journal of Biosciences最新文献_第7页

Human papillomavirus vaccine: Success and challenges. 人乳头瘤病毒疫苗：成功与挑战。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Chamma Gupta, Karma G Dolma, Mingma L Sherpa, Arundhati Bag, Abhishek Byahut

{"title":"Human papillomavirus vaccine: Success and challenges.","authors":"Chamma Gupta, Karma G Dolma, Mingma L Sherpa, Arundhati Bag, Abhishek Byahut","doi":"","DOIUrl":"","url":null,"abstract":"Persistent infection with high-risk human papillomavirus (HPV) is a major etiological cause of cancers associated with the cervix, anogenital region, vulva, vagina, penis, and oropharynx. Cervarix®, Gardasil®, and Gardsil9® are three approved prophylactic vaccines that can effectively provide protection against HPV infection. However,they only offer protection against a limited number of HPV strains, not all of which can cause cervical cancer (CC). Additionally, they only provide limited therapeutic advantages against HPV infections that have already been established. Thus, developing a therapeutic vaccine is urgently required and is the need of the hour. Unlike normal cells, two of the viral early proteins, E6 and E7, are persistently expressed in tumor cells. This makes these two proteins the prime candidates for therapeutic vaccines that aim to eliminate the infected cells by cytotoxic T-lymphocytes without affecting normal cells. Therapeutic vaccinations are being researched and are under trials, and no such vaccines have yet been authorized. The development of a therapeutic vaccination coupled with currently available prophylactic vaccines is anticipated to significantly lower morbidity and cancer load globally. This review aims to provide a clear understanding of the molecular basis, immunogenicity, effectiveness, and challenges of current prophylactic vaccines and the future scope of implementing therapeutic vaccines against infection caused by HPV.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of EhLINE1_ORF1p outside retrotransposition: Downregulation causes growth defects in Entamoeba histolytica. EhLINE1_ORF1p在逆转录外的作用：下调导致溶组织内阿米巴生长缺陷。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Devinder Kaur, Shashi Shekhar Singh, Shraddha Sharma, Sudha Bhattacharya

引用次数: 0

Effects of sampling methodology on phenology indices: Insights from sites across India and modelling. 抽样方法对物候指数的影响：来自印度各地的见解和建模。

IF 1.9 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Yadugiri V Tiruvaimozhi, Karthik Teegalapalli, Abinand Reddy, Akhil Murali, Aparajita Datta, Aparna Krishnan, Jayashree Ratnam, Mahesh Sankaran, Shasank Ongole, Srinivasan Kasinathan, T R Shankar Raman, Geetha Ramaswami

{"title":"Effects of sampling methodology on phenology indices: Insights from sites across India and modelling.","authors":"Yadugiri V Tiruvaimozhi, Karthik Teegalapalli, Abinand Reddy, Akhil Murali, Aparajita Datta, Aparna Krishnan, Jayashree Ratnam, Mahesh Sankaran, Shasank Ongole, Srinivasan Kasinathan, T R Shankar Raman, Geetha Ramaswami","doi":"","DOIUrl":"","url":null,"abstract":"Plant phenology is the study of the timing and extent of leaf, flower, and fruit production. Phenology data are used to study the drivers of cyclicity and seasonality of plant life-history stages, interactions with organisms such as pollinators, and effects of global change factors. Indices such as the timing of phenological events, and the proportion of individuals in a particular phenophase, seasonality, and synchrony have often been used to summarise plant phenology data. However, these indices have specific utilities and limitations and may be sensitive to sampling methodology, making cross-site comparisons challenging, particularly when data collection methods vary in terms of sample size, observation frequency, and the resolution at which phenophase intensity scores/values are recorded. We used fruiting phenology data from tropical trees across five sites in India to study the effects of sampling methodology on two indices: population-level synchrony (overlap) and seasonality. We supplemented these results with simulations of fast- and slow-changing phenologies to test for the effects of sampling methodology on these indices. We found that the overlap index is sensitive to the resolution of phenophase intensity measurement, with coarser intensity measures leading to overestimation of the overlap index. The seasonality index, on the other hand, was not affected by intensity resolution. Simulations indicated that finer intensity resolution is more important than frequency of observation to accurately estimate population synchrony and seasonality for fast- and slow-changing phenophases. Based on our findings, we provide recommendations for future study designs of tropical tree phenology research, particularly for long-term or cross-site studies.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brassinolide sustains photosynthesis during high-light stress by modulating mitochondrial electron transport and cellular ROS. 油菜素内酯通过调节线粒体电子传递和细胞活性氧来维持强光胁迫下的光合作用。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Kandarpa Mahati, Agepati S Raghavendra, Kollipara Padmasree

{"title":"Brassinolide sustains photosynthesis during high-light stress by modulating mitochondrial electron transport and cellular ROS.","authors":"Kandarpa Mahati, Agepati S Raghavendra, Kollipara Padmasree","doi":"","DOIUrl":"","url":null,"abstract":"Hormones such as abscisic acid and brassinosteroids ameliorate stress tolerance in plants. The present investigation demonstrates the importance of brassinolide, an active form of brassinosteroids, in sustaining photosynthesis under high light (HL). The addition of brassinolide to mesophyll protoplasts activates the mitochondrial electron transport chain (mETC), particularly through an alternative oxidase (AOX) pathway. Brassinolide promotes both respiration and photosynthesis, including PSII activity, under HL. Total respiration was enhanced, but brassinolide caused a differential modulation of the components of mETC. The capacity of the AOX pathway was significantly enhanced, while the capacity of the cytochrome oxidase (COX) pathway was decreased in response to brassinolide under HL. Further, the transcripts of alternative oxidase1A (AOX1A) were elevated more than cytochrome oxidase subunit 15 (COX15), and cellular reactive oxygen species (ROS) were raised marginally upon treatment with brassinolide under HL. Brassinolide enhanced the capacity of the AOX pathway in mETC to ensure an optimal cellular ROS, which in turn sustains photosynthesis. Thus, mETC plays an important role in optimizing photosynthesis under HL stress and highlights the potential of brassinolide in enhancing plant stress tolerance.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in starch, sucrose, and abscisic acid metabolism under drought stress in contrasting genotypes of chickpea. 不同基因型鹰嘴豆在干旱胁迫下淀粉、蔗糖和脱落酸代谢的变化。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Kinjal Mondal, Romit Seth, Rajeev Rathour, Kamal Dev Sharma

{"title":"Alterations in starch, sucrose, and abscisic acid metabolism under drought stress in contrasting genotypes of chickpea.","authors":"Kinjal Mondal, Romit Seth, Rajeev Rathour, Kamal Dev Sharma","doi":"","DOIUrl":"","url":null,"abstract":"Plants respond to water scarcity by modifying transcription and metabolite accumulation; however, mechanisms leading to drought tolerance/sensitivity in chickpea (Cicer arietinum L.) are poorly understood. To understand the molecular basis of drought tolerance/sensitivity, the carbohydrate content and transcriptional changes in the genes of sugar, starch, abscisic acid (ABA), and gibberellic acid pathways were studied in a drought-tolerant genotype (ICC 8950) and a drought-sensitive genotype (ICC 3776). Droughts disrupted carbohydrate metabolism in ICC 3776, leading to decrease in starch content and increase in sugar content, including sucrose. In ICC 8950, under drought stress, the starch content remained unchanged but sugar levels increased slightly. The reduction in starch content in ICC 3776 resulted from increased degradation rather than decreased synthesis, whereas in ICC 8950, starch anabolism as well as catabolism genes were downregulated, leading to unchanged starch levels. The increase in sucrose content in ICC 3776 under drought stress resulted from lower degradation due to the downregulation of cell wall invertase. The expression of ABA catabolism genes under drought increased in ICC 3776 but decreased in ICC 8950, suggesting increased ABA content in ICC 3776 but not in ICC 8950. This study showed that drought causes a decrease in the starch content and an increase in the sucrose and ABA contents in the drought-sensitive genotype, whereas the drought-tolerant genotype maintains starch and sucrose levels coupled with lower ABA.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in c-Fos protein expression in telencephalic hemispheres of a neotropical fish Piaractus orinoquensis after exposure to a glyphosate-based herbicide. 暴露于草甘膦除草剂后新热带鱼orinoquensis远脑半球c-Fos蛋白表达的变化

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Iveth Caroline Ocampo Rincón, Sergio Conde Ocazionez, Hernán Hurtado Giraldo, Ewing Duque-Díaz, Edwin Gómez Ramírez

{"title":"Changes in c-Fos protein expression in telencephalic hemispheres of a neotropical fish Piaractus orinoquensis after exposure to a glyphosate-based herbicide.","authors":"Iveth Caroline Ocampo Rincón, Sergio Conde Ocazionez, Hernán Hurtado Giraldo, Ewing Duque-Díaz, Edwin Gómez Ramírez","doi":"","DOIUrl":"","url":null,"abstract":"Glyphosate-based herbicides (GBHs) can be found in waterbodies and may affect aquatic populations, resulting in physiological and behavioral impairments. In Colombia, white cachama (Piaractus orinoquensis) are frequently found in areas subjected to glyphosate aerial fumigation. This study aims to investigate changes in c-Fos protein expression in P. orinoquensis telencephalic hemispheres after exposure to 0, 1, 5, and 10 mg/L glyphosate for 30, 60, and 90 min. For this purpose, 5 lm paraffin sections were obtained and used for c-Fos immunodetection. To define the effect of xenobiotics on c-Fos expression, nuclei were taken from the dorsal dorsal (Dd), dorsomedial (Dm), dorsal posterior (Dp), dorsolateral (Dl), ventral (Vv), dorsoventral (Vd), and ventrolateral (Vl) regions of P. orinoquensis telencephalic hemispheres. Except for Dd nuclei, other nuclei showed an initial increase in c-Fos+ cells, followed by a progressive decrease toward values similar to those observed in unexposed individuals. In Dd nuclei, the initial tendency was toward a reduced number of c-Fosexpressing cells, followed by an increase in unexposed values. As changes in the number of cells containing c-Fos can be related to changes in neuronal activity, GBH exposure may potentially affect the fish's behavioral and sensorial performance, resulting in a reduced survival probability in its natural environment.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent control of functional rewiring after axon injury by let-7 miRNA and insulin/insulin-like growth factor signaling pathways. let-7 miRNA和胰岛素/胰岛素样生长因子信号通路对轴突损伤后功能性重布线的独立控制

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Sruthy Ravivarma, Sibaram Behera, Dipanjan Roy, Anindya Ghosh-Roy

{"title":"Independent control of functional rewiring after axon injury by let-7 miRNA and insulin/insulin-like growth factor signaling pathways.","authors":"Sruthy Ravivarma, Sibaram Behera, Dipanjan Roy, Anindya Ghosh-Roy","doi":"","DOIUrl":"","url":null,"abstract":"The capability of neurons to regenerate after injury becomes poor in adulthood. Previous studies indicated that loss of either let-7 miRNA or components of insulin/insulin-like growth factor signaling (IIS) can overcome age-related decline in axon regeneration in Caenorhabditis elegans. In this study, we wanted to understand the relationship between these two pathways in axon regeneration. We found that the simultaneous removal of let-7 and the gene for insulin receptor daf-2 in parallel increased functional recovery involving posterior touch sensation following axotomy of posterior lateral microtubule (PLM) neurons in adulthood. Conversely, the loss of let-7 could bypass the regeneration block due to the loss of DAF-16, a transcriptional mediator of DAF-2. Similarly, the loss of daf-2 could bypass the requirement of LIN-41, a transcriptional co-factor of the let-7 pathway. Our analysis revealed that these two pathways independently control the targeting of the regenerating axon to the ventral nerve cord (VNC), which leads to functional recovery. The computational analysis of the gene expression data revealed that a large number of genes, their interacting modules, and hub genes under the let-7 and IIS pathways are exclusive in nature. Our study highlights a potential to promote neurite regeneration by harnessing the independent gene expression program involving the let-7 and IIS pathways.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia. 生殖系丧失减少了体细胞线粒体，但在衰老和低温期间保留了呼吸功能。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Hye Jin Hwang, Francis R G Amrit, Brandon J Berry, Claudette St Croix, Andrew P Wojtovich, Sruti Shiva, Arjumand Ghazi

引用次数: 0

Discovery of potent inhibitors from traditional rice varieties targeting α-amylase: A computational approach and in vitro validation. 从传统水稻品种中发现α-淀粉酶有效抑制剂：计算方法和体外验证。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Priya Dharshini Veeraragavan, M Karunanithi, Sathya Albert

{"title":"Discovery of potent inhibitors from traditional rice varieties targeting α-amylase: A computational approach and in vitro validation.","authors":"Priya Dharshini Veeraragavan, M Karunanithi, Sathya Albert","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes involves complex metabolic dysregulation and necessitates approaches such as α-amylase inhibition to moderate postprandial glucose spikes and hyperglycemia. Thus, this study scrutinizes the α-amylase inhibitory potential of selected traditional rice varieties (Athur Kichili Samba, Poonkar, Karuppu Kavuni) as well as a modern variety (CO 43) in the cooked condition, using computational approaches alongside in vitro validation. The 156 metabolites obtained from gas chromatography-mass spectrometry analysis, docked with human pancreatic α-amylase (HPA), and based on the binding energies top-five-ranked metabolites were shortlisted (PubChem IDs: 91714169, 13821354, 167795, 2756016, and 3075922). In addition, molecular dynamics simulation was carried out for a timescale of 200 ns to assess protein-ligand complex stability, with parameters such as root mean square deviation, root mean square fluctuation, radius of gyration, solventaccessible surface area, H-bond, and interaction energy. Furthermore, molecular mechanics Poisson- Boltzmann surface area (MM/PBSA) and molecular mechanics generalized Born surface area (MM/GBSA) analyses were performed to validate the selected inhibitors. In vitro studies corroborated inhibitory effectiveness, with Athur Kichili Samba having the highest potency (IC50=4.48 mg/mL), followed by CO 43, Poonkar, and Karuppu Kavuni (IC50=5.12, 6.29, and 11.35 mg/mL). The consistent ranking of antidiabetic functionality observed across both computational and experimental approaches highlights the potential of these traditional rice varieties, suggesting additional clinical investigations to endorse their global consumption.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamate metabolism disruption in Johanson-Blizzard syndrome: Insights from C. elegans ubr-1 model. johnson - blizzard综合征中谷氨酸代谢紊乱：来自秀丽隐杆线虫ubr-1模型的见解。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Yi Li, Shangbang Gao

引用次数: 0