Journal of Biosciences最新文献_第6页

Germline loss diminishes somatic mitochondria but confers preservation of respiratory function during aging and hypothermia. 生殖系丧失减少了体细胞线粒体，但在衰老和低温期间保留了呼吸功能。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Hye Jin Hwang, Francis R G Amrit, Brandon J Berry, Claudette St Croix, Andrew P Wojtovich, Sruti Shiva, Arjumand Ghazi

引用次数: 0

Role of EhLINE1_ORF1p outside retrotransposition: Downregulation causes growth defects in Entamoeba histolytica. EhLINE1_ORF1p在逆转录外的作用：下调导致溶组织内阿米巴生长缺陷。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Devinder Kaur, Shashi Shekhar Singh, Shraddha Sharma, Sudha Bhattacharya

引用次数: 0

Independent control of functional rewiring after axon injury by let-7 miRNA and insulin/insulin-like growth factor signaling pathways. let-7 miRNA和胰岛素/胰岛素样生长因子信号通路对轴突损伤后功能性重布线的独立控制

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Sruthy Ravivarma, Sibaram Behera, Dipanjan Roy, Anindya Ghosh-Roy

{"title":"Independent control of functional rewiring after axon injury by let-7 miRNA and insulin/insulin-like growth factor signaling pathways.","authors":"Sruthy Ravivarma, Sibaram Behera, Dipanjan Roy, Anindya Ghosh-Roy","doi":"","DOIUrl":"","url":null,"abstract":"The capability of neurons to regenerate after injury becomes poor in adulthood. Previous studies indicated that loss of either let-7 miRNA or components of insulin/insulin-like growth factor signaling (IIS) can overcome age-related decline in axon regeneration in Caenorhabditis elegans. In this study, we wanted to understand the relationship between these two pathways in axon regeneration. We found that the simultaneous removal of let-7 and the gene for insulin receptor daf-2 in parallel increased functional recovery involving posterior touch sensation following axotomy of posterior lateral microtubule (PLM) neurons in adulthood. Conversely, the loss of let-7 could bypass the regeneration block due to the loss of DAF-16, a transcriptional mediator of DAF-2. Similarly, the loss of daf-2 could bypass the requirement of LIN-41, a transcriptional co-factor of the let-7 pathway. Our analysis revealed that these two pathways independently control the targeting of the regenerating axon to the ventral nerve cord (VNC), which leads to functional recovery. The computational analysis of the gene expression data revealed that a large number of genes, their interacting modules, and hub genes under the let-7 and IIS pathways are exclusive in nature. Our study highlights a potential to promote neurite regeneration by harnessing the independent gene expression program involving the let-7 and IIS pathways.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in starch, sucrose, and abscisic acid metabolism under drought stress in contrasting genotypes of chickpea. 不同基因型鹰嘴豆在干旱胁迫下淀粉、蔗糖和脱落酸代谢的变化。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Kinjal Mondal, Romit Seth, Rajeev Rathour, Kamal Dev Sharma

{"title":"Alterations in starch, sucrose, and abscisic acid metabolism under drought stress in contrasting genotypes of chickpea.","authors":"Kinjal Mondal, Romit Seth, Rajeev Rathour, Kamal Dev Sharma","doi":"","DOIUrl":"","url":null,"abstract":"Plants respond to water scarcity by modifying transcription and metabolite accumulation; however, mechanisms leading to drought tolerance/sensitivity in chickpea (Cicer arietinum L.) are poorly understood. To understand the molecular basis of drought tolerance/sensitivity, the carbohydrate content and transcriptional changes in the genes of sugar, starch, abscisic acid (ABA), and gibberellic acid pathways were studied in a drought-tolerant genotype (ICC 8950) and a drought-sensitive genotype (ICC 3776). Droughts disrupted carbohydrate metabolism in ICC 3776, leading to decrease in starch content and increase in sugar content, including sucrose. In ICC 8950, under drought stress, the starch content remained unchanged but sugar levels increased slightly. The reduction in starch content in ICC 3776 resulted from increased degradation rather than decreased synthesis, whereas in ICC 8950, starch anabolism as well as catabolism genes were downregulated, leading to unchanged starch levels. The increase in sucrose content in ICC 3776 under drought stress resulted from lower degradation due to the downregulation of cell wall invertase. The expression of ABA catabolism genes under drought increased in ICC 3776 but decreased in ICC 8950, suggesting increased ABA content in ICC 3776 but not in ICC 8950. This study showed that drought causes a decrease in the starch content and an increase in the sucrose and ABA contents in the drought-sensitive genotype, whereas the drought-tolerant genotype maintains starch and sucrose levels coupled with lower ABA.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in c-Fos protein expression in telencephalic hemispheres of a neotropical fish Piaractus orinoquensis after exposure to a glyphosate-based herbicide. 暴露于草甘膦除草剂后新热带鱼orinoquensis远脑半球c-Fos蛋白表达的变化

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Iveth Caroline Ocampo Rincón, Sergio Conde Ocazionez, Hernán Hurtado Giraldo, Ewing Duque-Díaz, Edwin Gómez Ramírez

{"title":"Changes in c-Fos protein expression in telencephalic hemispheres of a neotropical fish Piaractus orinoquensis after exposure to a glyphosate-based herbicide.","authors":"Iveth Caroline Ocampo Rincón, Sergio Conde Ocazionez, Hernán Hurtado Giraldo, Ewing Duque-Díaz, Edwin Gómez Ramírez","doi":"","DOIUrl":"","url":null,"abstract":"Glyphosate-based herbicides (GBHs) can be found in waterbodies and may affect aquatic populations, resulting in physiological and behavioral impairments. In Colombia, white cachama (Piaractus orinoquensis) are frequently found in areas subjected to glyphosate aerial fumigation. This study aims to investigate changes in c-Fos protein expression in P. orinoquensis telencephalic hemispheres after exposure to 0, 1, 5, and 10 mg/L glyphosate for 30, 60, and 90 min. For this purpose, 5 lm paraffin sections were obtained and used for c-Fos immunodetection. To define the effect of xenobiotics on c-Fos expression, nuclei were taken from the dorsal dorsal (Dd), dorsomedial (Dm), dorsal posterior (Dp), dorsolateral (Dl), ventral (Vv), dorsoventral (Vd), and ventrolateral (Vl) regions of P. orinoquensis telencephalic hemispheres. Except for Dd nuclei, other nuclei showed an initial increase in c-Fos+ cells, followed by a progressive decrease toward values similar to those observed in unexposed individuals. In Dd nuclei, the initial tendency was toward a reduced number of c-Fosexpressing cells, followed by an increase in unexposed values. As changes in the number of cells containing c-Fos can be related to changes in neuronal activity, GBH exposure may potentially affect the fish's behavioral and sensorial performance, resulting in a reduced survival probability in its natural environment.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brassinolide sustains photosynthesis during high-light stress by modulating mitochondrial electron transport and cellular ROS. 油菜素内酯通过调节线粒体电子传递和细胞活性氧来维持强光胁迫下的光合作用。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Kandarpa Mahati, Agepati S Raghavendra, Kollipara Padmasree

{"title":"Brassinolide sustains photosynthesis during high-light stress by modulating mitochondrial electron transport and cellular ROS.","authors":"Kandarpa Mahati, Agepati S Raghavendra, Kollipara Padmasree","doi":"","DOIUrl":"","url":null,"abstract":"Hormones such as abscisic acid and brassinosteroids ameliorate stress tolerance in plants. The present investigation demonstrates the importance of brassinolide, an active form of brassinosteroids, in sustaining photosynthesis under high light (HL). The addition of brassinolide to mesophyll protoplasts activates the mitochondrial electron transport chain (mETC), particularly through an alternative oxidase (AOX) pathway. Brassinolide promotes both respiration and photosynthesis, including PSII activity, under HL. Total respiration was enhanced, but brassinolide caused a differential modulation of the components of mETC. The capacity of the AOX pathway was significantly enhanced, while the capacity of the cytochrome oxidase (COX) pathway was decreased in response to brassinolide under HL. Further, the transcripts of alternative oxidase1A (AOX1A) were elevated more than cytochrome oxidase subunit 15 (COX15), and cellular reactive oxygen species (ROS) were raised marginally upon treatment with brassinolide under HL. Brassinolide enhanced the capacity of the AOX pathway in mETC to ensure an optimal cellular ROS, which in turn sustains photosynthesis. Thus, mETC plays an important role in optimizing photosynthesis under HL stress and highlights the potential of brassinolide in enhancing plant stress tolerance.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of potent inhibitors from traditional rice varieties targeting α-amylase: A computational approach and in vitro validation. 从传统水稻品种中发现α-淀粉酶有效抑制剂：计算方法和体外验证。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Priya Dharshini Veeraragavan, M Karunanithi, Sathya Albert

{"title":"Discovery of potent inhibitors from traditional rice varieties targeting α-amylase: A computational approach and in vitro validation.","authors":"Priya Dharshini Veeraragavan, M Karunanithi, Sathya Albert","doi":"","DOIUrl":"","url":null,"abstract":"Diabetes involves complex metabolic dysregulation and necessitates approaches such as α-amylase inhibition to moderate postprandial glucose spikes and hyperglycemia. Thus, this study scrutinizes the α-amylase inhibitory potential of selected traditional rice varieties (Athur Kichili Samba, Poonkar, Karuppu Kavuni) as well as a modern variety (CO 43) in the cooked condition, using computational approaches alongside in vitro validation. The 156 metabolites obtained from gas chromatography-mass spectrometry analysis, docked with human pancreatic α-amylase (HPA), and based on the binding energies top-five-ranked metabolites were shortlisted (PubChem IDs: 91714169, 13821354, 167795, 2756016, and 3075922). In addition, molecular dynamics simulation was carried out for a timescale of 200 ns to assess protein-ligand complex stability, with parameters such as root mean square deviation, root mean square fluctuation, radius of gyration, solventaccessible surface area, H-bond, and interaction energy. Furthermore, molecular mechanics Poisson- Boltzmann surface area (MM/PBSA) and molecular mechanics generalized Born surface area (MM/GBSA) analyses were performed to validate the selected inhibitors. In vitro studies corroborated inhibitory effectiveness, with Athur Kichili Samba having the highest potency (IC50=4.48 mg/mL), followed by CO 43, Poonkar, and Karuppu Kavuni (IC50=5.12, 6.29, and 11.35 mg/mL). The consistent ranking of antidiabetic functionality observed across both computational and experimental approaches highlights the potential of these traditional rice varieties, suggesting additional clinical investigations to endorse their global consumption.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamate metabolism disruption in Johanson-Blizzard syndrome: Insights from C. elegans ubr-1 model. johnson - blizzard综合征中谷氨酸代谢紊乱：来自秀丽隐杆线虫ubr-1模型的见解。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Yi Li, Shangbang Gao

引用次数: 0

Evolution of body size and selfhood: Size-scaling from selfless reproduction to enhanced self-preservation. 体型和自我的进化：从无私繁殖到增强自我保护的体型缩放。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Douglas S Glazier

{"title":"Evolution of body size and selfhood: Size-scaling from selfless reproduction to enhanced self-preservation.","authors":"Douglas S Glazier","doi":"","DOIUrl":"","url":null,"abstract":"Our knowledge of how and why various biological and ecological traits relate (scale) to body size has grown at a rapid pace. In this exploratory analysis, I aim to further advance our knowledge of biological scaling by arguing that individuality and selfhood increase along a size spectrum from tiny microbes to huge trees and whales, as driven by a gradient of decreasing mortality. According to a proposed size-self spectrum (SSS) model, tiny short-lived organisms are continuously engaged in relatively rapid, all-consuming, selfless reproduction, whereas large long-lived organisms have evolved relatively high levels of individuality and selfpreservation. Grades of individuality in organisms along the SSS are recognized by their levels of development of (a) protective boundaries between their inner and outer environments, (b) autonomy and identity preservation, and (c) self-awareness and regulation. Paradoxically, as increasingly large organisms have evolved increased independence from their external environments, they have also exerted greater per-capita impacts on them. With increasing body size, the prevailing direction of influence of an individual organism's internal versus external environments switches from inward in small 'exocentric' species to outward in large 'endocentric' species. Implications of the SSS model for understanding the nature and environmental impact of humans, who are relatively large organisms, as well as various other controversial biological, ecological, and philosophical issues are discussed.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of Quercus suber L. acorns in natural and semi-natural stands: Morphology characterization, insect attacks, and chemical composition 天然林和半天然林中栎树橡子的比较分析：形态特征、虫害和化学成分

IF 2.9 4区生物学

Journal of Biosciences Pub Date : 2024-09-14 DOI: 10.1007/s12038-024-00470-7

Sabrina Kassouar, Dalila Mecellem, Samia Djellal, Nourelimane Benzitoune

{"title":"Comparative analysis of Quercus suber L. acorns in natural and semi-natural stands: Morphology characterization, insect attacks, and chemical composition","authors":"Sabrina Kassouar, Dalila Mecellem, Samia Djellal, Nourelimane Benzitoune","doi":"10.1007/s12038-024-00470-7","DOIUrl":"https://doi.org/10.1007/s12038-024-00470-7","url":null,"abstract":"The present study aims to investigate the differences between cork oak acorns from natural and semi-natural stands in terms of morphology, insect attack rate, and acorn chemical composition. Moreover, it examines the metabolic responses induced by insect attacks. The results show that acorns from the semi-natural stand in our study are larger than those from the natural stand. In addition, the insect attack rate was higher in the natural stand (8.25%) than in the semi-natural stand (6.25%). Furthermore, acorns in the semi-natural stand exhibit high total flavonoid content (TFC), whereas those in the natural stand are rich in total phenolic content (TPC). In terms of biochemical changes in acorns, the study revealed a remarkably significant difference in TPC, TFC, and antioxidant activity subsequent to infestation by Cydia and Curculio insects. Cydia-infested acorns from the natural stand had higher TPC levels, with a value of 93.96±0.39 mg GAE/g, showing a 17.7% increase over healthy acorns. Acorns from the semi-natural stand attacked by Curculio show the highest TFC with a value of 0.288±0.004 mg EQ/g, showing a 121.5% increase over healthy acorns. Moreover, both DPPH and FRAP methods revealed that antioxidant activity of the acorns from the semi-natural stand attacked by Curculio was more effective. This research is crucial for providing a solid foundation for the selection of high-quality cork oak germplasm resources and exploring the potential valorization of insect-affected acorns in the realms of food and agriculture.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"12 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0