Journal of Biosciences最新文献_第6页

Sensory modulation of neuropeptide signaling by CASY-1 gates cholinergic transmission at Caenorhabditis elegans neuromuscular junction. CASY-1对秀丽隐杆线虫神经肌肉交界处胆碱能传递的神经肽信号的感觉调节。

IF 2.1 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Navneet Shahi, Shruti Thapliyal, Kavita Babu

{"title":"Sensory modulation of neuropeptide signaling by CASY-1 gates cholinergic transmission at Caenorhabditis elegans neuromuscular junction.","authors":"Navneet Shahi, Shruti Thapliyal, Kavita Babu","doi":"","DOIUrl":"","url":null,"abstract":"The neuromuscular junction (NMJ) is crucial for understanding the fundamentals of synaptic transmission and activity. Various modulators operate within neuronal circuits, from sensory to motor neurons, to influence synaptic transmission at the NMJ. This study sheds light on the regulation of sensory-evoked cholinergic neurotransmission at motor neurons orchestrated by CASY-1, the mammalian calsyntenin orthologue. We report that the increased excitation-inhibition (E-I) ratio at the NMJ in casy-1 mutants is likely due to its interactions with neuromodulators in sensory neurons. We explored the intricate genetic interactions of CASY- 1 with the neuropeptide FLP-21 and its receptor, NPR-1, both of which display simultaneous alterations in cholinergic signaling at the NMJ. Through genetic, pharmacological, and bioimaging-based experiments, we proposed a mechanism by which CASY-1 potentially interacts with the neuropeptide-carrying vesicles to regulate synaptic transmission. The nematode Caenorhabditis elegans serves as an ideal model system for this study, enabling detailed insights into neuromodulatory mechanisms in the neuronal circuit.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparisons between young, aged, and Alzheimer's brains reveal specific expression patterns for a subset of transposons and satellite repeats. 年轻人、老年人和阿尔茨海默病患者大脑之间的比较揭示了转座子和卫星重复序列子集的特定表达模式。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Elif Turan, Büşranur Çeltik, Gökçe Dağlar, Ilayda Kaya, Mert Tu Fekçi, Cihangir YANDıM

{"title":"Comparisons between young, aged, and Alzheimer's brains reveal specific expression patterns for a subset of transposons and satellite repeats.","authors":"Elif Turan, Büşranur Çeltik, Gökçe Dağlar, Ilayda Kaya, Mert Tu Fekçi, Cihangir YANDıM","doi":"","DOIUrl":"","url":null,"abstract":"Recent studies have highlighted the involvement of repeat-derived transcripts in the pathological transcriptome of Alzheimer's disease (AD). However, it remains unclear whether these transcripts arise as a consequence of aging or are directly associated with AD pathology. Particularly, the specific contribution of satellite repeats to this phenomenon has not been systematically investigated. In this study, we profiled the non-coding expression patterns of all repetitive DNA elements - including satellites - across healthy young, healthy aged, and aged AD brain samples. Comparative transcriptome analysis revealed only a single differentially expressed repeat between aged and young brains. In contrast, AD brains exhibited significant expression changes in eight specific repeat elements relative to their healthy aged counterparts. Among these AD-specific repeats, the satellite repeat HSATII showed the highest fold change and a modest increase in histone acetylation levels, suggesting potential regulatory or feedback mechanisms in AD pathology. Weighted Gene Co-Expression Network Analysis (WGCNA) identified modules of co-expressed genes and repeats, revealing a network moderately correlated with the AD phenotype and indicating complex interactions between repeats and genes during disease onset. Collectively, our comprehensive analysis of repeat expression in post-mortem human AD brains demonstrates alterations in transposon and satellite repeat expression patterns that are distinct from agerelated changes.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145389939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why wild herbivores raid crops: Alternative hypotheses and their differential implications for the mitigation of human- wildlife conflict. 为什么野生食草动物袭击农作物：不同的假设及其对缓解人类与野生动物冲突的不同含义。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Sonal Prabhulkar, Milind Watve

{"title":"Why wild herbivores raid crops: Alternative hypotheses and their differential implications for the mitigation of human- wildlife conflict.","authors":"Sonal Prabhulkar, Milind Watve","doi":"","DOIUrl":"","url":null,"abstract":"The devouring of crops by wild herbivores is a major issue in human-wildlife conflict. Although many studies identify the conflict, attempt to estimate the extent of economic loss and its consequences, and suggest some mitigation measures, many fundamental issues remain unaddressed. A number of speculations about the root causes behind the problem have been made, but they have not been treated and tested as alternative hypotheses. In this article, (a) we make a list of alternative hypotheses collected from a wide variety of sources; (b) we evaluate their plausibility, logical integrity and compatibility with existing data; (c) we suggest differential testable predictions; and (d) we discuss their differential implications for mitigation measures. It is important to identify the specific causes of the conflict because the efficacy of mitigation measures crucially depends on the predominant underlying cause. Measures applied without a good understanding of the causal factors might turn out to be ineffective and even counterproductive. Substantial research needs to be focused on differentially testing the predictions of the alternative hypotheses to be able to handle the problem and promote healthy coexistence of wildlife with indigenous people. Although our perceptions of the problem and illustrative examples are in the Indian wildlife context, some of the emerging outcomes will have global importance.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the microscopic gladiator pit: Antibiotics vs resistance. 从微观的角斗士坑：抗生素与耐药性。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Nishad Matange

引用次数: 0

Correction to: Brain dystrophinopathies and cognitive impairment: Pathogenesis, diagnosis, and therapies. 更正：脑营养不良症和认知障碍：发病机制、诊断和治疗。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Aadi Saluja, Kyriloss Gad, Phillipa Iyede, Praveen Parkali, Narendra Chirmule

引用次数: 0

Caenorhabditis elegans germline flux pulls its stem-cell niche cells into shape. 秀丽隐杆线虫的生殖系通量使其干细胞生态位细胞成形。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Priti Agarwal

引用次数: 0

Immune responses in the skin: Not so skinny at all. 皮肤的免疫反应：一点也不瘦。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Dipankar Nandi, Nikita S Ramteke

{"title":"Immune responses in the skin: Not so skinny at all.","authors":"Dipankar Nandi, Nikita S Ramteke","doi":"","DOIUrl":"","url":null,"abstract":"The immune system is our defence network and primarily geared to protect us from pathogens and tumors. This aspect is evident in people who lack or possess a compromised immune system and are, therefore, highly susceptible to infections and development of cancer, as in AIDS patients (Nandi et al. 2020). However, healthy humans possess commensals in the gut and have developed a symbiotic relationship with these microbes. Indeed, we benefit from gut microbes that reside within us due to the production of microbial products such as vitamins, short-chain fatty acids, and other metabolites. As the gut flora changes with disease, information on the changed microbiome can be highly reflective of our health status (Shreiner et al. 2015). Recently, efforts have been directed towards better understanding of host responses towards commensals. While it is true that most of these efforts have focused on the gut, other organs have also been studied such as the respiratory tract and oral cavities. Two new studies have shed light on immune responses in the skin (Bousbaine et al. 2024; Gribonika et al. 2024). Why the skin? In fact, the skin is the largest and most well-exposed organ harboring immune capabilities to deal with several commensals (Belkaid and Segre 2014; Honda et al. 2019; Zhang et al. 2022). Most importantly, bacteria obtained from the skin in healthy humans are coated with antibodies, demonstrating host-directed immune responses (Metze et al. 1991); also, immunodeficient people are susceptible to skin infections (Lehman 2014). However, a detailed understanding of the players involved, and the extent of skin-directed immune responses in dealing with various microbes are lacking. Two recent papers have shed new light on immune responses in the skin utilizing high end flow cytometry, several strains of mutant mice and RNA seq (Bousbaine et al. 2024; Gribonika et al. 2024).","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of histone 3 acetylation and p53 by SIRT1 overexpression in an experimental model of alveolar epithelium damage. 在肺泡上皮损伤实验模型中SIRT1过表达对组蛋白3乙酰化和p53的表观遗传调控。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Liliana Faridi Saavedra-Salazar, Jesús García-Bañuelos, Hugo Christian Monroy-Ramírez, Ana Sandoval-Rodríguez, Marina Galicia-Moreno, Jorge Gutie Rrez-Cuevas, Juan Armendariz-Borunda

{"title":"Epigenetic regulation of histone 3 acetylation and p53 by SIRT1 overexpression in an experimental model of alveolar epithelium damage.","authors":"Liliana Faridi Saavedra-Salazar, Jesús García-Bañuelos, Hugo Christian Monroy-Ramírez, Ana Sandoval-Rodríguez, Marina Galicia-Moreno, Jorge Gutie Rrez-Cuevas, Juan Armendariz-Borunda","doi":"","DOIUrl":"","url":null,"abstract":"Pulmonary fibrosis is a chronic, life-threatening respiratory disease characterized by high incidence and lack of effective treatments. This disease is associated with damage to the alveolar epithelium and heightened proapoptotic activity of p53, attributed to increased acetylation of its Lys381 residue. On the other hand, SIRT1 has been proposed as a therapeutic target for its ability to deacetylate key proteins such as histone 3 (H3), NF-ĸB, and p53, thus modulating cellular processes such as inflammation, apoptosis, differentiation, and oxidative stress, which could improve epithelial damage and fibrogenesis. Because SIRT1 can modulate key molecules related to lung fibrosis, this study examined the effect and localization of SIRT1 overexpression in A549 alveolar epithelial cells after bleomycin-induced injury. Two plasmids were used, one with SIRT1 cDNA and the other with a mutant H363Y catalytic site. SIRT1 expression and localization were analyzed by double immunofluorescence. SIRT1 phosphorylation at serine 47 as well as acetylation of p53 and H3 at lysine 381 and lysine 9, respectively, were also analyzed. Our results indicate that SIRT1 overexpression promotes H3 deacetylation, impacting epithelial-mesenchymal transition (EMT) and preventing pulmonary fibrosis. Additionally, our findings reveal that SIRT1 overexpression boosts its nuclear translocation and phosphorylation, deacetylates p53 and H3 after bleomycin damage, and preserves cell survival. The effect of SIRT1 on p53 and H3 deacetylation supports epigenetic control which may prevent cell death and EMT in pulmonary fibrosis.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145354879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying trials run in India, registered with ClinicalTrials.gov, is not straightforward. 确定在印度进行并在ClinicalTrials.gov上注册的试验并不简单。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Anwesha Dhal Samanta, Jaishree Mendiratta, Gayatri Saberwal

{"title":"Identifying trials run in India, registered with ClinicalTrials.gov, is not straightforward.","authors":"Anwesha Dhal Samanta, Jaishree Mendiratta, Gayatri Saberwal","doi":"","DOIUrl":"","url":null,"abstract":"Clinical trial registries are invaluable resources for many stakeholders. However, these registries often require customized methodologies to identify studies of interest. To determine what steps it would take to catalog every trial that has run in India, in this study, we examined the records held by the registry of the United States, ClinicalTrials.gov. We utilized the Aggregate Analysis of ClinicalTrials.gov database, which draws data from ClinicalTrials.gov. Starting with 458,069 records, a shortlist of 11,439 records of interest was identified that contained the keywords 'India' or 'CTRI', the latter standing for Clinical Trials Registry-India. The Location field indicated that India had been a country of recruitment in 1,416 records. Other, non-obvious fields indicated that 52 records were concerned with trials in India. Among these, 35 cases used confirmatory language, and 17 cases had circumstantial evidence for the studies having run in India. It ought to be easier to unambiguously determine which countries a study has run in. Addressing this challenge is crucial for ensuring the accuracy, completeness, and transparency of clinical trial data, benefiting patients, healthcare providers, researchers, regulators, policymakers, and other stakeholders.","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmaceutical adoption of microphysiological systems in India is contingent on their economics among other aspects. 在印度，微生理系统在制药行业的应用取决于其经济效益和其他方面。

IF 1.7 4区生物学

Journal of Biosciences Pub Date : 2025-01-01

Kasturi Mahadik, Surat Parvatam, Nalam Madhusudhana Rao

引用次数: 0