Journal of Biosciences最新文献

{"title":"StaLAENet: A stacked LSTM-nested deep-autoencoder network for identification of antimicrobial resistance of nosocomial pathogens.","authors":"Mousumi Banerjee, Abhishake Lahiri, Sohom Basak, Saptarshi DAS, Subhasis Mukhopadhyay, Rachana Banerjee, Kausik Basak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As various technological innovations are assisting medical science in a considerable way, rendering a significant leap towards 'lab-to-land' delivery, in a similar vein, algorithm development and concomitant framework-based approaches help the field to enrich its patient care. Although antimicrobial drugs revolutionized this particular area, antimicrobial resistance is a pressing global health concern as microbial strains are becoming resistant to conventional antibiotics, undermining the efficacy of these drugs and leading to increased illness and healthcare costs. To tackle this menace, apart from technological innovations such as diagnostic kits, an informatics-based framework approach is the call of the day. Despite the emergence of several computational approaches, they lack in generalization, scope, and scalability. Here, we have developed a novel framework StaLAENet (stacked LSTM-nested deep-autoencoder network) to predict antibiotic-resistant gene drug classes targeting ESKAPE pathogens. This framework comprises two modules: a feature representation module comprising a stacked LSTM-nested deep autoencoder and a classification module that leverages a dense network using latent features. StaLAENet demonstrated an efficient performance - accuracy: 0.938±0.043, specificity: 0.888±0.061, precision: 0.912±0.020, and recall: 0.881±0.021 - for <i>Enterococcus faecium</i> using 4-mer data, with similar results for other organisms using various <i>k</i>-mer data. Comparative analysis confirmed its superiority over existing pipelines. Further, independent evaluation with non-redundant sequences (sourced from another database) and with a metagenomic dataset highlighted its generalizability, robustness, and capability to analyze complex microbial communities. StaLAENet can offer a robust solution for combating AMR, enabling an efficient way of antimicrobial stewardship and patient care.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of mycorrhizal fungal communities to tree species composition and soil properties in the Miombo subtropical dry forest.","authors":"Likulunga Emmanuel Likulunga, Bethan Manley, Mashuta Kalebe, Mokwani Kaluwe, Saasa Ngonda, Kelvin Mwambu, Edwin Lungu, Mupelwa Nalupumbwe, Cyprian Katongo, Stephen Malunga Manchishi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Miombo forests are ecologically and economically important; however, knowledge about mycorrhizal assemblages harboured by these ecosystems and the driving factors is scarce. We investigated the composition and diversity of soil arbuscular and ectomycorrhizal fungi in Miombo National Forest Reserves in Zambia across three sites with different tree species compositions, soil properties, and climatic conditions. Our DNA metabarcoding results identified distinct mycorrhizal fungal communities among the study sites, driven by soil pH, moisture, and nutrient content. Mycorrhizal diversity was highest at sites with low mean annual precipitation. Across all study sites, the variation in mycorrhizal fungal diversity could be explained by soil pH, moisture, and nutrients, while tree species composition contributed little variation. The taxonomic composition and relative abundances of mycorrhizal fungal genera varied among study sites. Our results suggest that changes in tree species composition have the potential to influence mycorrhizal communities in Miombo ecosystems, with implications for ecosystem functions and services.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of low-pH tolerance and chitinase activity between toxigenic and non-toxigenic strains of <i>Vibrio cholerae</i>.","authors":"Vijay Jayaraman, Shafqat Ali Khan, Kumar Perinbam, Isha Rakheja, Abhinav Koyamangalath Vadakkepat, Santosh Kumar Chaudhary, Asheesh Kumar Pandey, Joydeep Mitra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Survival of toxigenic and non-toxigenic strains of <i>Vibrio cholerae</i> involves adaptation to varying pH conditions, a mechanism which is poorly understood. Chitinase activity, which is essential for survival both inside and outside its human host at various pH levels, is not thoroughly profiled. We report on the growth and chitinase activity of two clinical isolates of <i>V. cholerae</i>: VC20, a <i>ctx</i>⁺ strain, and WO5, a <i>ctx</i>^- strain, at different pH. We compared the expression of key genes between these strains. WO5, the non-toxigenic strain, showed robust growth and higher chitinase activity across a wide pH range compared to VC20. WO5 expressed higher <i>omp</i>K and <i>tox</i>T transcripts, implicated in host cell adhesion and virulence, respectively. We propose that lower <i>hap</i>R levels in WO5, in contrast to VC20, are key to its low-pH tolerance. A sequence-based homology search revealed a widespread presence of low-pH adaptation modules - lysine-cadaverine and ornithine-putrescine - in multiple representative species of the <i>Vibrio</i> genus. Further, the loss of a nitrite reductase gene, which confers low-pH tolerance, is specific to <i>V. cholerae</i> and <i>V. mimicus</i>. We propose that <i>hap</i>R expression and other low-pH adaptation factors reported here could be molecular predictors of low-pH tolerance in toxigenic and non-toxigenic <i>V. cholerae</i>.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdependence of cytosolic and mitochondrial calcium dynamics in a hepatocyte cell due to obesity.","authors":"Vedika Mishra, Neeru Adlakha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intentional placement of mitochondria in close proximity to calcium ion (Ca²⁺) release sites enables the quick uptake of cytosolic Ca²⁺ and the close connection of calcium signaling with energy metabolism. Ca²⁺ dynamics have been thoroughly investigated in various cells, including hepatocytes. However, little is known about the interaction between cytosolic and mitochondrial Ca²⁺ dynamics and how it affects adenosine triphosphate (ATP) hydrolysis and nicotinamide adenine dinucleotide (hydrogen) (NADH) production downstream, especially in pathological conditions such as obesity. In this study, we introduce a new reaction-diffusion model of hepatocyte cells that accurately depicts the linked dynamics of mitochondrial and cytosolic Ca²⁺ in both normal and obese states. Important physiological processes, including intracellular buffering, mitochondrial calcium uniporters, Na⁺/Ca²⁺ exchangers, and Ca²⁺ input sources, are integrated into the model. For precise numerical simulations, a combination of the Crank-Nicolson scheme and a linear finite element approach is used. The results show that obese hepatocytes differ significantly from normal cells in terms of calcium signaling, ATP hydrolysis rates, and NADH production. These findings may help guide future experimental and therapeutic research aimed at metabolic liver illnesses and offer fresh insights into how obesity-induced deregulation of calcium dynamics affects cellular energy metabolism.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal circadian rhythm writes immune fate in offspring.","authors":"Manish Grover","doi":"10.1007/s12038-026-00608-9","DOIUrl":"10.1007/s12038-026-00608-9","url":null,"abstract":"&lt;p&gt;&lt;p&gt;An organism's environment is rarely constant. Light, temperature, humidity, food availability, and microbial exposure often fluctuate rhythmically, creating daily patterns that organisms must anticipate and respond to (Paranjpe and Sharma 2005; van der Linden et al. 2010; Thaiss et al. 2014). The ability of biological systems to align physiology with such environmental cycles has fascinated biologists for decades, and circadian regulation is now known to influence diverse processes, including metabolism, behaviour, development, immunity, and stress responses (Fagiani et al. 2022; Poole and Kitchen 2022). Whether environmental rhythms experienced by the mother can influence offspring physiology has only begun to be explored (Yao et al. 2025). In a recent study, Lalsiamthara et al. (2026) provide compelling evidence that infection vulnerability in offspring can be shaped by maternal circadian rhythms. Using Caenorhabditis elegans, the authors first asked whether genetically similar animals differ in a measurable pre-infection state that anticipates later infection outcomes. They focused on irg-5, a PMK-1/p38 MAPK-regulated infection-response reporter (Peterson et al. 2019), and found that animals with high basal irg-5 expression before infection were more susceptible to subsequent Pseudomonas aeruginosa PA14 challenge. Importantly, this high-irg-5 state was not simply a sign of generally poor health, because these animals did not show obvious differences in baseline lifespan, feeding, movement, or pathogen avoidance. The study then asked whether this pre-infection state could be influenced by maternal circadian rhythms. Mothers were exposed to alternating 12 h light/20 C and 12 h dark/15 C cycles, mimicking daily fluctuations that worms may experience in nature. This entrainment did not increase irg-5 expression in the mothers themselves; instead, it rhythmically altered the proportion of offspring entering the high basal irg-5 state. The transgenerational effect of this state was further supported by the observation that high-irg-5 mothers produced more high-irg-5 offspring than low-irg-5 mothers. Consistent with clock-associated regulation, knockdown of nhr-23, a C. elegans homolog of mammalian ROR clock genes (Hiroki and Yoshitane 2024), disrupted this rhythmic oscillation. Together, these experiments connect maternal environmental timing, offspring immune-marker heterogeneity, and infection vulnerability in a single framework. These observations raise mechanistic and evolutionary questions. Mechanistically, what maternal cues are transmitted to offspring: metabolites, small RNAs, chromatin-associated states, or nutrients, and how do they influence basal immune state? Evolutionarily, why might mothers generate heterogeneous offspring states, especially when the high-irg-5 state increases susceptibility to PA14 in this study? One possibility is that this state is not universally maladaptive. Caenorhabditis elegans inhabits transient microbe","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 36","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPE18 protein of Mycobacterium tuberculosis downregulates LPS-induced IgG production by inhibiting nitric oxide synthesis.","authors":"Brahmaji Sontyana, Asma Ahmed, Sangita Mukhopadhyay","doi":"10.1007/s12038-026-00606-x","DOIUrl":"10.1007/s12038-026-00606-x","url":null,"abstract":"<p><p>Mycobacterial PPE18 is a virulence factor. Previous studies have demonstrated that recombinant PPE18 protein (rPPE18) downregulates inflammation-induced nitric oxide synthase (iNOS) and nitric oxide (NO) production. Given its ability to inhibit iNOS, we investigated whether rPPE18 can also affect IgG secretion, which is modulated by NO levels. Mouse splenocytes and purified B cells were stimulated with lipopolysaccharide (LPS) to induce iNOS-mediated NO as well as IgG and IgM production. The addition of rPPE18 to LPS-stimulated cells reduced NO and iNOS at both the transcript and protein levels. This was accompanied by a drop in total secreted IgG, which could be reversed by the addition of SNAP, an NO donor. Importantly, rPPE18 did not affect secreted IgM levels. These data suggest that rPPE18 interferes with NO-dependent antibody class-switching from IgM to IgG. This was further confirmed by significantly reduced transcript levels of activation-induced cytidine deaminase (AID) in rPPE18-treated LPS-stimulated splenocytes. AID is crucial for class-switch recombination and is regulated by NO levels. These data highlight a novel mycobacterial virulence mechanism, in which rPPE18 inhibits IgG secretion and dampens protective humoral immunity, which is a critical component of the host anti-mycobacterial response.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who funds science and its publication? Does it matter?","authors":"Renee M Borges","doi":"10.1007/s12038-026-00613-y","DOIUrl":"10.1007/s12038-026-00613-y","url":null,"abstract":"&lt;p&gt;&lt;p&gt;In recent times, there have been seismic disclosures or revelations that renowned institutions and individuals with hitherto impeccable reputations have received research funds from persons of dubious, if not proven, criminal character. This has led to quiet or not-so-quiet removals, suspensions, and the opening up of investigations into alleged misdeeds. There is a swathe of grey in this finger-pointing game, i.e., guilt by association. A scientist may knowingly or unknowingly accept funds from individuals of dubious reputation, but his/her science is impeccable. How should such science be viewed? Through a jaundiced lens? Would it therefore help if all science, regardless of source of funding, had all its data publicly available, so that a potential verdict of 'guilty by association' could be quashed? In recent years, with the curtailment of government funding for research in many parts of the world, there has also been a need to seek funds from outside government and to tap into private foundations or industry. How might such a shift impact the quality and integrity of science? Is all government-funded/promoted science kosher, while privately-funded research is not? A look back into the past at the infamous Lysenko affair would say otherwise. Furthermore, examples of government-run or -funded trials of drugs and vaccines on unsuspecting members of the 'lower' strata of society or in undeveloped countries are also scattered through history (Jones 1993; Wade 2026). Private industries also have many skeletons in their closet, as evidenced most famously by the suppression of the health effects of tobacco (Grüning et al. 2006), or of pesticides (Baker and Manwell 1988; Martin 2012), or of the ecosystem impacts of genetically modified crops when deployed in inappropriate contexts (Poppy 2000). This therefore implies that neither state- nor private-funded science is potentially free of blemish. Conflict of interest (COI) with the scientific funders is another much misunderstood concept, and the avoidance of COI, whether financial or non-financial in nature (McCartney et al. 2022; Wiersma et al. 2025), needs to be stringently operationalized so that conflicts are not just managed but avoided (McCartney 2025; van Tulleken 2025). In this context, there is also concern about paid Open Access (OA) papers funded by the funders of science (Or 2025); if the scientists are embroiled in a COI, then having much more readership of the results due to OA publication further compromises the equal dissemination of science and the possible spread of misinformation. All of the issues mentioned above are not new, but nevertheless of considerable concern. That many of these concerns need to be operationalized led the International Science Council (ISC) to put out a position paper on Research Funding Transparency in October 2025 (https://council.science/statements/isc-position-on-research-funding-transparency/). The ISC is a conglomeration of the Science Academies ","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 39","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>De novo</i> hybrid genome assembly and analysis of <i>Salmonella enterica</i> serovar Kentucky of Indian origins.","authors":"Dhruv Das, A S Kakatkar, A V S S Narayana Rao, Ravindranath Shashidhar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><i>Salmonella enterica</i> serovar Kentucky has emerged as a global human food-borne pathogen with a known phenotype of multidrug resistance. Whole-genome sequencing of the lab-isolated organism was performed to understand its genomic features using the Illumina platform. The assembled genome, utilizing short reads only, poses gaps that need to be resolved to completely close the genome. To improve the genome assembly, we developed a strategy that utilizes publicly available long reads produced by Nanopore sequencing of a similar strain for <i>de novo</i> hybrid assembly. This approach yielded one completely closed chromosome and three completely closed plasmids. The assembled genome showed the presence of antimicrobial-resistant genes on both chromosome as well as plasmid present in the isolate. Four prophage regions and one CRISPR cluster were also identified on the chromosome. The sequenced isolate of <i>S. enterica</i> serovar Kentucky belongs to sequence type ST198, exhibiting multidrug resistance, including to ciprofloxacin, that causes human non-typhoidal <i>Salmonella</i> infections. This study provides a simple workflow to improve the completeness of assembled genome, in the scenario where long reads of the same isolate are not available for genome assembly.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delta-9-tetrahydrocannabinol delineates D-galactose and aluminium chloride-induced cognitive dysfunction and neurodegeneration in the hippocampus of the Wistar rat model.","authors":"Fatin Nadzirah Zakaria, Mohamad Taufik Hidayat Baharuldin, Che Norma Mat Taib, Hasiah Ab Hamid, Hafizah Abdul Hamid, Samaila Musa Chiroma, Mohamad Aris Mohd Moklas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disorder characterised by neurodegeneration and a decline in cognition and memory. D-galactose (D-gal) and aluminium chloride (AlCl3) have been used to induce cognitive deterioration in rat models that mimic the alterations observed in AD. This study assessed the neurotherapeutic effect of Δ9-tetrahydrocannabinol (Δ9THC) on cognitive abilities, brain morphology, neurogenesis activity and neuropathological markers in Wistar rats induced by D-gal plus AlCl3. Male albino Wistar rats received D-gal (60 mg/kg, intraperitoneally) and AlCl3 (200 mg/kg, orally) daily for 10 weeks. The rats were then treated with increasing concentrations of Δ9THC (0.75, 1.5 and 3.0 mg/kg) for 28 days. Cognitive performance was evaluated using the novel object recognition and modified elevated plus maze tests. Dentate gyrus viable granule cells, neurogenesis markers, amyloid precursor protein and phosphorylated tau (p‑tau Thr231) were assessed histologically and molecularly. Δ9THC treatment improved cognitive performance, prevented granule cell loss in the dentate gyrus, increased neurogenesis-related markers (GFAP+, DCX+, calbindin+ and NeuN immunoreactivity), and reduced amyloid precursor protein and p‑tau Thr231 expression. These findings suggest that Δ9THC possesses promising therapeutic potential against Alzheimer's disease.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational insights into cancer stem cell dynamics and the urokinase plasminogen activation pathway.","authors":"Kumari Neelam Verma, Debabrata Dasgupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study introduces a novel computational model that integrates cancer stem cells (CSCs) and the plasminogen activation system, filling a crucial gap in cancer research. While theoretical models have separately explored CSCs and the plasminogen activation system, no prior computational framework has combined these elements. Our model focuses on the invasion dynamics of CSCs, emphasizing the critical interactions between urokinase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1). We employed reaction-diffusion equations and analyzed the determinant and eigenvalue spectra of the Jacobian matrix of the system to identify instability regions within tumors. The findings revealed that the production and binding of uPA and PAI-1 significantly enhance the invasiveness and motility of CSCs, resulting in more complex and aggressive tumor structures. Our study advances the theoretical understanding of cancer dynamics by integrating these two critical biological processes into a single computational framework. This work builds upon and extends previous models by offering a more comprehensive analysis of tumor growth, with significant implications for optimizing cancer treatment strategies. The insights of the model into the interplay between CSCs and the plasminogen activation system offer a valuable tool for both research and potential clinical applications, paving the way for more targeted and effective therapeutic approaches.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"51 ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}