Journal of applied physiology最新文献

{"title":"Evaluating the Effects of Exercise and Phellodendrun Amurense on Cardiac Function in a Prostate Cancer Mouse Model.","authors":"Neha Kumar, Logan R Davis, Gregory J Aune, Paul Rivas, Addanki Kumar, Darpan I Patel","doi":"10.1152/japplphysiol.00039.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00039.2025","url":null,"abstract":"<p><p><b>Introduction:</b> Cytotoxic treatments pose a significant cardiotoxic risk to men with prostate cancer (PCa). Exercise has been found to prevent cardiotoxicities. Previous work from our group has also identified the chemopreventative effects of phellodendron amurense (PhAm). We therefore aimed to compare the effectiveness of exercise ± PhAm on cardiac function in a transgenic PCa mouse model. <b>Methods:</b> A 12-week, 4 arm, randomized controlled study was performed. Twenty-four transgenic adenocarcinoma of the mouse prostate (TRAMP) mice were randomly assigned to either the control, exercise, PhAm or ExPhAm treatment groups. Mice assigned to exercise were given continuous access to a running wheel. PhAm groups consumed a diet enriched with PhAm at 600 mg/kg. Control animals maintained a normal diet and activity. Pre-post echocardiography was performed to measure heart rate, interventricular septum (IVS) thickness, left ventricle (LV) internal diameter, LV volume, ejection fraction (EF), fractional shortening (FS), and left ventricle mass (LVM). <b>Results:</b> Exercise, PhAm and the combination were able to protect against an increase in end diastolic and end systolic LV mass (p=0.003; p=0.006, respectively). Though not significant, the LV/body mass was markedly higher in the exercise group (+4.5%) and combination (+1.1%) compared to the PhAm (-4.2%) and control groups (-10.3%). Exercise and ExPhAm also protected against increases in IVS thickening while an increase was found in both the PhAm and control groups (p<0.05). <b>Conclusion:</b> The results of our study suggest that exercise is the driving factor in promoting cardiac health in PCa and can prevent cardiotoxicities associated with the tumor burden.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative serum LOXL2 levels are elevated in patients with pulmonary hypertension undergoing mitral valve surgery in a prospective observational cohort study.","authors":"Sinead M Nyhan, Mahin Gadkari, Travis Brady, Marta Martinez Yus, Rira Choi, Maria Bauer, Samira Vithani, Joseph Walpole, Allison G Hays, Hamza Aziz, Ahmet Kilic, Michael Robich, James S Gammie, Lakshmi Santhanam, Jochen Steppan","doi":"10.1152/japplphysiol.00287.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00287.2025","url":null,"abstract":"<p><p><b>Objectives:</b> Lysyl oxidase like-2 (LOXL2) is associated with vascular remodeling associated in pulmonary hypertension (PH). This study evaluates the potential of serum LOXL2 levels as a clinical biomarker. <b>Methods:</b> We enrolled 158 patients undergoing mitral valve surgery . Using echocardiographic right ventricular systolic pressures (RVSPs), patients were stratified into those with and without PH pre-operative, post-operative, and post-discharge. Healthy volunteers served as a non51 surgical control. Serum LOXL2 concentrations pre-incision were compared to RVSPs using simple-regression and their relationship to PH using One-Way ANOVA with Tukey-posttest. <b>Results:</b> Serum LOXL2 concentrations were significantly higher in patients with PH compared to patients without PH (2,718 ±5187pg/ml vs. 640 ±1367 g/ml; P=0.0009) and compared to healthy volunteers (283 ±615pg/ml; P=0.04). There was a positive correlation between RVSPs and serum LOXL2 concentrations (p=0.02, r²=0.08). Serum LOXL2 levels positively correlated with intraoperative indices of pulmonary compliance, suggesting that PH in this cohort may primarily represent post-capillary PH. Patients with PH post procedure (and before discharge) had greater pre-procedure serum LOXL2 levels compared to patients without PH (4348 ±8498pg/ml vs. 1281 ±2329pg/ml, P=0.006); as did patients assessed after discharge (1359 ±2693pg/ml vs. 4195 ±6568pg/ml, P=0.009). Patients with persistent PH or new PH, had elevated pre-surgical LOXL2 levels compared to those without PH at both time points (4301 ±7717pg/ml vs. 556.6 ±835.8pg/ml, P= 0.02; 2902 ±5255pg/ml vs. 556.6 ±835.8pg/ml, P=0.03). <b>Conclusions:</b> Serum LOXL2 is elevated in patients with PH. LOXL2 is a potential PH biomarker in patients undergoing mitral valve surgery. This could have implications for follow-up care.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rapid increase in left atrial pressure reduces pulmonary arterial compliance in rats: Insights from pulmonary arterial impedance analysis.","authors":"Masafumi Fukumitsu, Naoshi Hotta, Toru Kawada, Takuya Nishikawa, Keita Saku","doi":"10.1152/japplphysiol.00073.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00073.2025","url":null,"abstract":"<p><p>Pulmonary arterial (PA) impedance is a comprehensive parameter that describes the dynamic properties of pulmonary circulation. PA impedance is estimated using the transfer function that relates PA flow to pressure waveforms. However, both PA flow and pressure may be affected by left atrial (LA) pressure, especially when LA pressure is elevated. This study aimed to evaluate the impact of increased LA pressure on the estimation of PA impedance and its associated parameters. We used eight male Sprague-Dawley rats to measure PA impedance using (1) one-input, one-output (I1O1) analysis that does not consider LA pressure in the calculation, and (2) two-input, one-output (I2O1) analysis that takes into account the potential effect of LA pressure on PA flow and pressure. Under normal physiological conditions, both I1O1 and I2O1 analyses provided accurate estimates of PA impedance with high coherence function. However, when LA pressure was increased by transverse aortic ligation with blood transfusion, I1O1 analysis showed reduced coherence in the low frequency range, whereas I2O1 analysis maintained reasonable estimation of PA impedance. When parameterizing PA impedance estimated by I2O1 analysis, rapid increase in LA pressure was associated with decreased pulmonary arterial compliance (Cp), without affecting peripheral pulmonary resistance (Rp), characteristic impedance of the proximal arteries (Zc) or transmission time from the main trunk to the reflection sites. In conclusion, increase in LA pressure significantly decreases Cp, while Rp and Zc remain unaltered. When estimating PA impedance under conditions of elevated LA pressure, the effect of LA pressure should not be neglected.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leg vascular function with advancing age in men: The impact of physical activity and endurance exercise training.","authors":"Eivind Wang, Matthew J Rossman, Jonathan Groot, Ryan Garten, Catherine L Jarrett, Jan Helgerud, Jan Hoff, Russell S Richardson","doi":"10.1152/japplphysiol.00784.2024","DOIUrl":"https://doi.org/10.1152/japplphysiol.00784.2024","url":null,"abstract":"<p><p>Regular physical activity and endurance exercise training prevent age-related vascular endothelial dysfunction in the arm in men. However, the effects of physical activity and/or endurance exercise training in the legs, which have a greater predisposition for vascular disease, has not been completely elucidated. This study sought to examine the impact of aging, physical activity, and endurance exercise training on leg vascular function in men. Flow-mediated dilation (FMD) of the superficial femoral and popliteal arteries (SFA and PA, respectively) was assessed in a total of 39 men, comprised of 10 young sedentary (Y; 23±2 yrs), 8 older sedentary (OS; 76±8 yrs), 9 older physically active (OA; 71±8 yrs), and 12 older endurance exercise trained (OT) subjects with exceptional aerobic exercise capacity (V̇O_2max) for their age (70±3 yrs, V̇O_2max=53±6 ml·kg^-1·min^-1). FMD was lower in the OS group compared with the Y in the SFA (Y: 4.3±2.1%, OS:1.7±1.0%, p=0.005) and PA (Y: 5.8±2.4% OS: 1.9±1.1%, p<0.05). SFA and PA FMD were not different from OS in the OA group (SFA: 2.8±1.5%; PA: 1.6±1.0%), but were higher than OS in the OT group (SFA: 3.4±2.3%, P=0.043; PA: 4.2±3.0%, P=0.025) and not different from Y. There was evidence of a moderate-strong correlation between SFA (r=0.32, P=0.052) and PA (0.36, p=0.037) FMD and V̇O_2max but not physical activity levels. These findings suggest that habitual physical activity in general, and endurance exercise training in particular, diminish the detrimental effect of aging on lower limb vascular function in men and this may be linked to an augmented V̇O_2max.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-capillary exercise contributions to pulmonary hypertension in adults > 45 years.","authors":"Elizabeth Karvasarski, Joy-Sumin Park, Simone Savaris, Anna Beale, Stephen P Wright, Robert F Bentley, John T Granton, Susanna Mak","doi":"10.1152/japplphysiol.00148.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00148.2025","url":null,"abstract":"<p><p>Clinical differentiation of pre- versus post-capillary pulmonary hypertension can be challenging in older patients with risk factors for both pathophysiologies. The use of exercise pressure-flow relationships during hemodynamic assessment is now recommended when resting pulmonary artery wedge pressure is proximate to a threshold of 15mmHg. In this study we examined relationships between resting pulmonary artery wedge pressure and the balance of pre- and post-capillary contributions to exercise pulmonary hypertension. Patients > 45 years suspected of pre-capillary pulmonary hypertension (n=29, 72 ± 10years, 52% Female) with risk factors for left-heart disease were prospectively recruited to undergo semi-upright cycle-ergometry at time of diagnostic right-heart catheterization. Hemodynamic data, including pressure-flow slopes and contributions of transpulmonary gradient and pulmonary artery wedge pressure to mean pulmonary artery pressure, were analyzed to evaluate pre- and post-capillary contributions, respectively, at rest and during exercise. Exercise pressure-flow slopes indicated 62% with post-capillary contributions to pulmonary hypertension, and 31% with solely pre-capillary contributions. Of patients with pulmonary artery wedge pressure <12mmHg, 67% had post-capillary contributions to exercise pulmonary hypertension. Conversely, 50% of patients with pulmonary artery wedge pressure >15mmHg had pre-capillary contributions to exercise pulmonary hypertension. Exercise-associated increases in pulmonary artery pressures were more strongly associated with pre-capillary contributions regardless of post-capillary contributions or the value of resting pulmonary artery wedge pressure. In conclusion, in this population, post-capillary contributions to exercise pulmonary hypertension were commonly disclosed over a range of resting pulmonary artery wedge pressure, including <12mmHg. The severity of exercise pulmonary hypertension was determined by the pre-capillary contributions.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic neural and cardiovascular responsiveness to involuntary stress-induced crying.","authors":"Jeremy A Bigalke, Jason R Carter","doi":"10.1152/japplphysiol.00419.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00419.2025","url":null,"abstract":"<p><p>Acute and chronic emotional distress is associated with an elevated risk of adverse cardiovascular events in humans. However, our understanding of how complex emotional states impact autonomic and cardiovascular regulation in humans remains limited. The purpose of the present case study was to characterize muscle sympathetic nerve activity (MSNA) and peripheral hemodynamic responses to an involuntary mental stress-related lacrimation (i.e., crying) in a healthy, young female participant (age: 22 years; BMI: 27 kg/m²). Continuous heart rate (HR, electrocardiogram), beat-to-beat blood pressure (finger plethysmography), and MSNA (microneurography) were monitored during a 3-minute resting baseline and subsequent mental arithmetic task during which an unanticipated and involuntary crying was observed after 1 minute of the stress task. Sympathetic and hemodynamic reactivity during the first minute of mental arithmetic were quantified and compared to a retrospective dataset of healthy individuals in whom mental stress reactivity was similarly assessed (31 male, 30 female; age: 21±3 years; BMI: 25±6 kg/m²). Changes in systolic (SBP; Δ3 mmHg) and diastolic (DBP; Δ9 mmHg) blood pressure were comparable to the comparator group (SBP: Δ4±6 mmHg; DBP: Δ5±5 mmHg), while HR reactivity appeared slightly higher (Δ32 beats/min) than the comparator group (Δ22±11 beats/min). In contrast, MSNA burst frequency (BF: Δ22 bursts/min), incidence (BI: Δ20 bursts/100heartbeats), and total area (Δ971%) reactivity was substantially elevated relative to the comparator group (BF: Δ2±7 bursts/min; BI: Δ-3±11 bursts/100heartbeats; total area: Δ132±285%). These findings suggest that involuntary stress-induced crying is associated with substantial sympathetic activation beyond that observed during standard laboratory mental stress, despite modest changes in hemodynamic variables.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women.","authors":"Matthew J McDonald, Sharon D Fears, Samuel Anthony Martin, Brian Shariffi, Todd Lancaster, Jill A Kanaley, Jacqueline K Limberg","doi":"10.1152/japplphysiol.00402.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00402.2025","url":null,"abstract":"<p><p>Acute sleep restriction (4 hours-time in bed) impairs the link between neural activity and cerebral blood flow (<i>i.e.</i>, neurovascular coupling, NVC). Nitric oxide (NO) is an important mechanism in the NVC response. Insufficient sleep increases reactive oxygen species (ROS) and reduces NO bioavailability. Resveratrol, a polyphenol with antioxidant properties, reduces ROS and improves vascular function. We hypothesized NVC following acute sleep restriction would be improved with acute oral resveratrol supplementation. Sixteen adults (8M/8F, 28±7 y, 25±3 kg/m²) completed two morning visits following a night of normal (NS; 449±46 min) or restricted (RS; 243±12 min) sleep. Each visit, middle (MCAv) and posterior (PCAv) cerebral artery velocity (transcranial Doppler ultrasound) were measured prior to and 45 min following oral resveratrol (250 mg) during: 1) a validated visual search paradigm (Where's Waldo), and 2) 5-min carbogen (95% O₂, 5% CO₂) air breathing. The peak cerebral blood velocity response to visual stimulation was reduced following sleep restriction (MCAV: NS 16±7%, RS 11±7%, p=0.017; PCAv: NS 43±13%, RS 32±14%, p=0.017) and restored with resveratrol in the PCA (RS + Resveratrol: 40±17%; p=0.028), but not the MCA (RS + Resveratrol: 9±5%; p=0.391). There was no effect of oral resveratrol on the peak response to visual stimulation following normal sleep. There was no effect of sleep restriction nor oral resveratrol on cerebrovascular response to carbogen air breathing. One night of RS (4 hours-time in bed) impairs NVC and resveratrol mitigates this impairment, particularly in the PCA. These results enhance our mechanistic understanding of sleep-associated impairments in NVC.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high-altitude exposure on skeletal muscle mitochondrial subcellular distribution, ultrastructure and respiration in sea-level residents.","authors":"Camilla Tvede Schytz, Joachim Nielsen, Niels Ortenblad, Anne-Kristine Meinild Lundby, Robert A Jacobs, Carsten Lundby","doi":"10.1152/japplphysiol.00042.2025","DOIUrl":"https://doi.org/10.1152/japplphysiol.00042.2025","url":null,"abstract":"<p><p>The skeletal muscle mitochondrial network, composed of interconnected subsarcolemmal and intermyofibrillar mitochondria, is essential for oxygen-dependent energy transduction. Since high altitude is characterized by tissue hypoxia, this network may adapt by increasing its respiratory efficiency, but little is known about potential adaptations of the mitochondrial network in such an environment. We investigated effects of high-altitude exposure on mitochondrial subcellular distribution, ultrastructure, respiratory control and intrinsic respiratory capacity. Nine healthy and recreationally active sea-level residents (eight males and one female) resided at an altitude of 3454 m with biopsies collected from the vastus lateralis muscle before and after 7 and 28 days at high altitude. Mitochondrial volume per skeletal muscle fiber volume (total fiber mitochondrial volume density) increased after high-altitude exposure, driven by an increase in the intermyofibrillar mitochondrial volume density (n=9). This was, however, accompanied by a decreased cristae surface area per skeletal muscle fiber volume (total fiber cristae density) because of a decline in the cristae surface area per mitochondrial volume (mitochondrial cristae density) (n=7). Despite a reduced total fiber cristae density, mass-specific respiration increased slightly (n=9), and was considerably elevated when normalized to total fiber cristae density (n=7), suggesting intrinsic adjustments. Correcting cristae-specific respiration for an associated cristae-specific leak respiration showed a higher net oxidative phosphorylation capacity meaning an augmented respiratory capacity potentially available for phosphorylation per total fiber cristae density after 7 and 28 days at high altitude (n=7). In conclusion, these findings suggest that high-altitude exposure alters mitochondrial subcellular distribution, ultrastructure and induces intrinsic respiratory adjustments.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of analgesic doses of opioids on cardiorespiratory responses and survival to hemorrhage and trauma in rats.","authors":"Stephanie M Marshall-Lipiec, Kathy L Ryan, Mariam L Calderon, Cassandra M Rodriguez, Brian S Connor, Carmen Hinojosa-Laborde, Harold G Klemcke","doi":"10.1152/japplphysiol.00708.2024","DOIUrl":"10.1152/japplphysiol.00708.2024","url":null,"abstract":"<p><p>Opioids are used for analgesia, but questions persist about their safety after traumatic hemorrhage. We investigated analgesic doses of three opioids (morphine, fentanyl, and sufentanil) on cardiorespiratory responses and survival to moderate or severe (37% or 50% blood volume) hemorrhage after trauma. A conscious hemorrhage model with extremity trauma (fibular fracture + soft tissue injury) was used; mean arterial pressure (MAP) and heart rate (HR) were measured by telemetry, whereas minute volume (MV) was determined by whole body plethysmography. Male rats (<i>n</i> = 10/group) received saline, morphine (2 mg/kg), fentanyl (10 µg/kg), or sufentanil (1 µg/kg) after traumatic hemorrhage. Neither survival times (for 37% hemorrhage: <i>P</i> = 0.209; for 50% hemorrhage: <i>P</i> = 0.88) nor survival percentages (for 37% hemorrhage: <i>P</i> = 0.357; for 50% hemorrhage: <i>P</i> = 1.0) differed among groups. For 37% hemorrhage, MAP of all opioid groups was higher than that in the saline-treated group 10 min post injection. By 75 min post injection, MAP after sufentanil was higher than saline; MAP for other opioids did not differ from saline. HR did not differ across treatments. Opioid injection decreased MV within 10 min but did not vary by treatment subsequently. For 50% hemorrhage, opioid injection did not immediately alter MAP but morphine and sufentanil were lower than saline at ≥75 min post injection, with no treatment effects on HR. Fentanyl produced an immediate (5 min) decrease in MV with no treatment effects thereafter. Opioid effects on cardiorespiratory function were therefore modest and did not alter survival during a 4-h observation period, supporting the judicious use of analgesic doses after traumatic hemorrhage.<b>NEW & NOTEWORTHY</b> Administration of an analgesic dose of either morphine, fentanyl, or sufentanil produced only modest and transient effects on cardiorespiratory function after either moderate (37% blood volume) or severe (50%) hemorrhage in conscious rats with extremity trauma. Under the conditions of these experiments, analgesic doses of these commonly used opioids also did not alter survival after traumatic hemorrhage.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"145-161"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum for Ortiz de Zevallos et al., volume 137, 2024, p. 1649-1658.","authors":"","doi":"10.1152/japplphysiol.00321.2024_COR","DOIUrl":"https://doi.org/10.1152/japplphysiol.00321.2024_COR","url":null,"abstract":"","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":"139 1","pages":"164-166"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}