Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Dose-dependent antidiabetic and multiorgan protective effects of Ziziphus abyssinica methanolic extract in streptozotocin-induced diabetic mice","authors":"Tsegay Beyene Weldemariam ,&nbsp;Abebaye Aragaw Leminie ,&nbsp;Wossene Habtu Tadesse ,&nbsp;Worku Gemechu Lemmi ,&nbsp;Samuel Woldekidan Hirpesa ,&nbsp;Rekik Ashebir Muluye ,&nbsp;Abiy Abebe gelagle ,&nbsp;Sofia Yimam Hussen ,&nbsp;Getahun Tsegaye Dibaba ,&nbsp;Beza Tasew Degefu ,&nbsp;Tesfaye Tolessa Dugul","doi":"10.1016/j.jaim.2026.101318","DOIUrl":"10.1016/j.jaim.2026.101318","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a global health challenge, with rising prevalence and significant economic burden, particularly in low- and middle-income countries. Current synthetic antidiabetic drugs, though effective, are associated with adverse effects, prompting interest in plant-based alternatives.</div></div><div><h3>Objectives</h3><div>This study evaluated the antidiabetic potential of <em>Ziziphus abyssinica</em> methanolic extract (ZAE) in streptozotocin (STZ)-induced diabetic mice.</div></div><div><h3>Methods</h3><div>Male Swiss Albino mice were grouped into normal control, diabetic control, glibenclamide (5 mg/kg), and ZAE-treated (200, 400, 600 mg/kg) groups. Parameters were monitored for 28 days.</div></div><div><h3>Results</h3><div>ZAE at 600 mg/kg normalized blood glucose (148.7 ± 11.0 mg/dL vs. normal control group 148.0 ± 3.0 mg/dL, ∗<em>P</em>∗ &gt;0.05), achieving a 66 % reduction (∗<em>P</em> ∗ &lt; 0.001) versus diabetic controls (437.2 ± 43.6 mg/dL). Body weight recovered fully (40.5 ± 1.9 g vs. 41.2 ± 1.2 g, ∗<em>P</em> ∗ &gt;0.05), contrasting with a 25 % loss in diabetic controls (∗<em>P</em>∗ &lt; 0.001).</div><div>Lipid profiles improved, with HDL rising (61.8 ± 3.9 vs. 33 ± 2.4 mg/dL, ∗<em>P</em>∗ = 0.002) and LDL declining (37.5 ± 2.4 vs. 58.8 ± 3.7 mg/dL, ∗<em>P</em>∗ = 0.002). Liver (ALT, AST, ALP) and renal (creatinine, urea) markers normalized (∗<em>P</em>∗ &lt; 0.05).</div><div>Histopathology revealed β-cell preservation (∗<em>P</em>∗ &lt; 0.01) and, specifically at the 600 mg/kg, a marked reduction in hepatic inflammation and renal protection.</div></div><div><h3>Conclusion</h3><div>The 600 mg/kg ZAE demonstrated novel, dose-dependent efficacy not only in glycemic control but also in pancreatic β-cell preservation and multiorgan protection, showing significant benefits in renal and cardiac tissues where glibenclamide was ineffective. These findings suggest the traditional use of <em>Ziziphus abyssinica</em> and highlight the potential of 600 mg/kg regimen to provide concurrent glycemic control and multi-organ protection.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101318"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A recurrent hepatocellular carcinoma with incomplete response to conventional treatments, showing substantial regression and good quality of life by Ayurveda treatment: A case report","authors":"Ranjit G. Nimbalkar ,&nbsp;Gayatri V. Watpade ,&nbsp;Anil T. Pawar ,&nbsp;Amol A. Tagalpallewar ,&nbsp;Akshay M. Baheti ,&nbsp;Manasi R. Nimbalkar","doi":"10.1016/j.jaim.2026.101340","DOIUrl":"10.1016/j.jaim.2026.101340","url":null,"abstract":"<div><div>Hepatocellular carcinoma is a major global health concern with limited treatment options and high recurrence rates. This case study presents a 68-year-old male diagnosed with hepatocellular carcinoma who refused liver transplantation and underwent multiple conventional treatments, including Drug-eluting Bead trans-arterial chemoembolization (DEB TACE), targeted therapy, and radiation therapy. However, due to adverse effects and suspected disease progression, the patient opted to switch to Ayurvedic management. ,It incorporated Ayurvedic formulations, like <em>s</em><em>uvarna</em> <em>malini</em> <em>v</em><em>asant</em><em>a</em>, <em>p</em><em>halatrikadi</em> <em>g</em><em>uggulu</em>, <em>p</em><em>atol</em><em>a</em>, <em>b</em><em>humyamalaki</em>, and <em>b</em><em>hring</em><em>a</em><em>raj</em><em>a</em> to support liver function, enhance immune response, and mitigate tumor progression.</div><div>Over the course of treatment, the patient demonstrated improvements in clinical and biochemical parameters, including a reductions in alpha-fetoprotein and bilirubin levels, clinically improved liver function, enhanced physical strength, and better quality of life. Radiological assessments indicated disease stabilization with no significant metabolic activity. The case highlights the potential of an integrative approach to improve patient outcomes, particularly in those who decline or are unfit for liver transplantation.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101340"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga and the metabolic syndrome: Reconsidering an ancient practice in an age of pharmacological abundance","authors":"Indranill Basu-Ray ,&nbsp;Partha Narayan Dey","doi":"10.1016/j.jaim.2026.101365","DOIUrl":"10.1016/j.jaim.2026.101365","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101365"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geroprotection through modulation of heart rate variability, oxidative enzymes, tissue integrity, and gene expression by an Ayurvedic herbal formulation, Amalaki Rasayana","authors":"Cheryl Rhea Lewis ,&nbsp;Vasudha Devi ,&nbsp;Dinesh Upadhya ,&nbsp;Dhandapani Kuppuswamy ,&nbsp;Rajshekhar Chinta ,&nbsp;Shiny Jasphin ,&nbsp;Souvik Dey ,&nbsp;Neha Choudhari ,&nbsp;Anandan E M","doi":"10.1016/j.jaim.2026.101338","DOIUrl":"10.1016/j.jaim.2026.101338","url":null,"abstract":"<div><h3>Background</h3><div>Aging is a multifactorial process involving cumulative cellular and organ deterioration, largely due to oxidative stress and disrupted homeostasis. These changes lead to increased susceptibility to age-related diseases. Amalaki Rasayana (AR), an ayurvedic formulation from the fruit of <em>Phyllanthus emblica</em>, is traditionally valued for its geroprotective, rejuvenating effects and preventive healthcare. <strong>Objective:</strong> This study scientifically evaluates AR's impact on physiological, biochemical, and molecular markers of aging and functional decline in a rodent model.</div></div><div><h3>Methods</h3><div>Thirty-six, 10 months old, male Fischer rats, (n = 6) were randomized into normal control (NC) and Amalaki Rasayana (AR) -treated groups, and evaluated at the end of 18, 24, and 30 months of age. Comprehensive assessments including, electrocardiography, histopathology, biochemical assays, and molecular analyses were conducted to evaluate cardiac, renal, hepatic, and neural tissue health. Oxidative stress was quantified by measuring superoxide dismutase (SOD) and catalase activity. Tp53 and p21 gene expressions were quantified by qPCR and bioinformatics.</div></div><div><h3>Results</h3><div>Our results demonstrated pronounced age-associated degenerative changes such as neuronal loss, myocardial fibrosis, renal tubule dilation and glomerular fragmentation in NC rats. In contrast, AR-supplementation maintained heart rate variability, preserved antioxidants superoxide dismutase and catalase activities, and mitigated tissue degeneration across multiple organs. AR modulated the expression of Tp53 and p21 in cardiac and neural tissues, suggesting a role in cellular stress response and longevity pathways.</div></div><div><h3>Conclusion</h3><div>Amalaki Rasayana demonstrated potent antioxidant and cytoprotective effects in aging rats, supporting its potential as an adjuvant for healthy aging. These findings highlight AR's promise in attenuating oxidative damage and modulating gene expression, warranting further translational research.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101338"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147995903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated and Ayurveda standalone interventions compared with standalone modern care in Rheumatoid arthritis: Observations from a non-random, parallel group, open label, historical control study","authors":"Sanjeev Rastogi,&nbsp;Krishna Gopal Sharma,&nbsp;Gurmeet Ram","doi":"10.1016/j.jaim.2025.101299","DOIUrl":"10.1016/j.jaim.2025.101299","url":null,"abstract":"<div><h3>Background</h3><div>Rheumatoid arthritis patients frequently visit Ayurveda clinics. Many such patients arrive at Ayurveda clinics after getting a trial of conventional modern medicine and being unsatisfied with the responses. In real world setting, many of these patients prefer to continue modern medicine along with Ayurveda interventions. This patient pool forms a very specific population of RA.</div></div><div><h3>Objective</h3><div>The study was aiming at observing the benefits of adding Ayurveda interventions to ongoing modern medicine or Ayurveda alone intervention in those who preferred to stop modern medicine.</div></div><div><h3>Material and method</h3><div>It was a non-random, single center, parallel group, open label, historical control observational study where the past modern intervention was taken up as the historical control for all those who continued with Ayurveda alone or integrated intervention. The outcome assessment was done on the basis of Swollen Joint count, Tender joint count, VAS score, Patient Global Assessment, ESR and DAS-28. Both intergroup and intragroup comparison of all parameters was done.</div></div><div><h3>Results</h3><div>31 patients who were included in the study (17 in Ayurveda alone group and 14 in integrated management group) were compared for all outcomes within the group and also for inter group. These observations were also compared with historical control. Except historical control, both active intervention groups were found to have statistically significant improvements in pre-post analysis. An intergroup comparison was not able to find any significant difference except for DAS-28 which was found significantly different in three groups.</div></div><div><h3>Conclusion</h3><div>Ayurveda interventions in RA are found to be more effective comparing to modern interventions alone observed through historical control. Integrative management of RA comprising of Ayurveda and modern standard care is only marginally better than Ayurveda alone and is much better than modern alone intervention in RA.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101299"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Gerard Bodeker","doi":"10.1016/j.jaim.2026.101362","DOIUrl":"10.1016/j.jaim.2026.101362","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101362"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An experimental study on the efficacy of Shatapushpa Churna in managing PCOS symptoms in a rat model: An Ayurvedic approach","authors":"Rutuja S. Gaikwad ,&nbsp;Amruta V. Gadade ,&nbsp;Manoj V. Gaikwad ,&nbsp;Vikas D. Dighe","doi":"10.1016/j.jaim.2026.101342","DOIUrl":"10.1016/j.jaim.2026.101342","url":null,"abstract":"<div><h3>Background</h3><div>Polycystic Ovary Syndrome (PCOS) is one of the most prevalent metabolic and reproductive disorders affecting women of reproductive age. It is characterized primarily by menstrual dysfunction and androgen excess, which impact quality of life. PCOS is also associated with various comorbidities, including metabolic syndrome, reproductive abnormalities, psychological stress, and an increased risk of chronic illnesses such as type II diabetes and cardiovascular disease.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the therapeutic potential of <em>Shatapushpa Churna</em> in managing PCOS-like symptoms using a rat PCOS model. The primary focus was on assessing its effects on estrous cyclicity, glucose metabolism, body weight, hormonal profile, and ovarian histomorphology.</div></div><div><h3>Methods</h3><div>A PCOS-like condition was induced in adult female Wistar rats by administering letrozole (2 mg/kg body weight, orally) once daily for 21 days. Model validation was based on irregular estrous cycles, impaired glucose tolerance, increased body weight, and altered hormonal profiles. PCOS-positive rats were then treated for 45 days with Shatapushpa Churna at three graded doses: low (0.62 g/kg b.w.), mid (1.24 g/kg b.w.), and high (1.85 g/kg b.w.). A standard reference group received metformin (300 mg/kg b.w.). Therapeutic outcomes were assessed through estrous cycle monitoring, oral glucose tolerance test (OGTT), serum hormonal assays, and ovarian histopathological examination.</div></div><div><h3>Results</h3><div>Rats treated with <em>Shatapushpa Churna</em> showed significant improvements in reproductive hormone levels and regularity of the estrous cycle. OGTT results indicated improved glycemic control in mid- and high-dose groups, with glucose levels at 30, 60, and 120 min comparable to those of normal controls. Histological analysis of the ovaries revealed a reduction in the number of atretic follicles and a restoration of near-normal ovarian morphology in treated groups compared to the positive control.</div></div><div><h3>Conclusion</h3><div><em>Shatapushpa Churna</em> demonstrated notable efficacy in managing PCOS-like symptoms in letrozole-induced rat models. Its positive impact on hormonal balance, glucose metabolism, and ovarian histomorphology supports its potential as a therapeutic agent for PCOS management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101342"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-proliferative performance of nano-chitosan and nano-silver Moringa oleifera on breast cancer cells through the Wnt signalling pathway","authors":"Hendra Susanto ,&nbsp;Moch Sholeh ,&nbsp;Agustina Tri Endharti ,&nbsp;Sa'diyatul Rizqie Amaliyah Firdaus ,&nbsp;Praseetha Prabhakaran ,&nbsp;Nik Ahmad Nizam Nik Malek ,&nbsp;Adeodatus Yuda Handaya ,&nbsp;Ahmad Taufiq","doi":"10.1016/j.jaim.2026.101324","DOIUrl":"10.1016/j.jaim.2026.101324","url":null,"abstract":"<div><h3>Background</h3><div>The global prevalence of breast cancer has been notably high in recent years. Increased awareness, better screening practices, and access to health services are essential to address this disparity and improve the well-being of women worldwide. <em>Moringa oleifera</em> is one such herbal candidate drug material with potential antioxidant, antibacterial, antiedema, antifungal, antitumor, and anti-cancer properties. Therefore, an innovation is needed to enhance the effectiveness of Moringa extract's compounds using nanoparticles.</div></div><div><h3>Objectives</h3><div>This study used silver nanoparticles and chitosan, which have been extensively studied for their efficacy, especially against breast cancer cells.</div></div><div><h3>Methods</h3><div>An in vitro study of MCF-7 and NIH-3T3 cells compared the effectiveness of both treatments <em>viz.</em> nano-silver (MOA) and nano-chitosan (NCM) using the MTT Assay. Both used IC50 doses based on previous studies. Further molecular (Wnt, TGFβ, and Ki-67 signaling) examination was also performed via RT-qPCR and Immunofluorescence Staining.</div></div><div><h3>Results</h3><div>The treatment effectively alleviated the growth of MCF-7 breast cancer cells. This was confirmed at the molecular level by inhibiting the expression of several genes (Wnt-βcatenin, CyclinD1, Ki-67) that contribute to the proliferation pathway and metastasis signaling genes (Snail and TGFβ).</div></div><div><h3>Conclusions</h3><div>MOA and NCM, as antiproliferative green nanomaterials, have successfully suppressed gene expression in the Wnt signaling pathway. This study's results indicate that both materials are potential drug candidates for breast cancer treatment.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101324"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualization and design of an Ayurveda framework for the diagnosis of Duchenne Muscular Dystrophy: insights from a prospective cohort study","authors":"Somit Kumar ,&nbsp;Raveendran Kannalayam ,&nbsp;Mitravinda Sai Kakarla ,&nbsp;Divya Venugopal ,&nbsp;Lakshmi Bremadesam Raman","doi":"10.1016/j.jaim.2025.101311","DOIUrl":"10.1016/j.jaim.2025.101311","url":null,"abstract":"<div><h3>Background</h3><div>Duchenne Muscular Dystrophy (DMD), an X-linked neuromuscular disorder is caused by dystrophin gene mutations. Ayurveda perceives DMD under <em>adibalapravrittaroga</em> (hereditary anomalies) and <em>janmabalapravrttaroga</em> (congenital anomalies) caused by <em>bijabhagavayava dosha</em> (defects in the subpart of seed) leading to innate <em>vata</em> imbalance progressively damaging the <em>mamsadhatu</em> (muscle tissue)<em>, medadhatu</em> (fatty tissue)<em>,</em> and <em>asthimajjadhatu</em> (bone-bone marrow)<em>,</em> resulting in muscle atrophy and mobility loss.</div></div><div><h3>Objective</h3><div>The framework aims to establish a diagnostic protocol, elucidate the pathogenesis of DMD based on empirical evidence, and differentiate the stages of the disease using Ayurvedic concepts such as <em>dosha, dhatu, mala, agni</em>, and <em>ojas.</em></div></div><div><h3>Methods</h3><div>The framework is based on cross-sectional data prior to intervention in a three-year prospective observational cohort study involving 67 participants with molecularly confirmed DMD not receiving steroid therapy for the past six months and consented. Participants underwent multidisciplinary clinical assessments, including Ayurvedic evaluations of <em>Prakrti</em> (individual constitutional typology)<em>, Sara</em> (predominance of fundamental structural components)<em>, Doshavrddhi-laksana</em> (indicators of <em>Dosha</em> aggravation)<em>,</em> and <em>Rogavastha</em> (disease staging).</div></div><div><h3>Results</h3><div><em>Tridosha prakrti</em> and <em>Mamsa-asthisarah</em> were identified as the most prevalent classes, respectively. The <em>kapha</em> class demonstrated the longest duration of ambulation loss at 3.1 years. Ambulant individuals comprised 47 % in the <em>asthisara</em> class and 27 % in the <em>Mamsa-asthisarah</em> class. <em>Vata dosha</em> exhibited the highest deviation among the <em>doshavrddhi-laksana</em>. Under <em>rogavastha</em>, significant differences between ambulation stages were observed in <em>Sarvagatavata, Asthimajjagatavata,</em> and <em>Ojovisramsa</em>.</div></div><div><h3>Conclusion</h3><div>DMD follows a <em>vata-vyadhi</em> trajectory, with <em>dhatu-</em>specific involvement shaping functional decline. Early <em>mamsavrtavata</em> and persistent <em>medavrtavata</em> emphasize the need for tissue-targeted interventions, while progressive <em>sarvagatavata</em> and <em>asthimajjagatavata</em> drive neuromuscular and skeletal compromise. Advanced <em>ojas</em> disturbances contribute to systemic and cardiopulmonary decompensation. These findings support Ayurvedic strategies focused on <em>dhatu</em> nourishment and <em>ojas</em> restoration and provide a framework for further evidence-based studies.</div></div><div><h3>Trial registration</h3><div>CTRI Reg No: CTRI/2020/07/026906.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 3","pages":"Article 101311"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systems perspective on rare diseases: integrating human phenotype ontology with the Anukta framework of Ayurveda","authors":"Deepika Jangir ,&nbsp;Aditi Joshi ,&nbsp;Saketh Ram Thrigulla ,&nbsp;Abhimanyu Kumar ,&nbsp;Mitali Mukerji","doi":"10.1016/j.jaim.2026.101322","DOIUrl":"10.1016/j.jaim.2026.101322","url":null,"abstract":"<div><div>Rare diseases, though individually uncommon, collectively affect millions and remain among the most underdiagnosed and poorly managed conditions in conventional healthcare. Ayurveda, with its systems approach and emphasis on <em>Dosha</em> imbalance, offers a complementary lens to interpret such unlisted conditions, known as <em>Anukta Vyadhi</em>. Human Phenotype Ontology (HPO) that catalogs 10,610 phenotypes across 12,678 rare diseases can be used to bridge modern phenotype vocabularies and Ayurvedic classifications. This study explores whether integrating the <em>Anukta</em> framework can enable meaningful assessment of rare diseases in Ayurveda clinical settings. A curated list of 140 <em>Nanatmaja Vikara</em> (NV)-<em>Vata</em> (80), <em>Pitta</em> (40), and <em>Kapha</em> (20) was mapped to HPO terms, preserving the semantic context of Ayurvedic descriptions. Noteworthy, 128 of NV phenotypes mapped to 199 HPO terms. Over 7200 rare diseases had representation of <em>Nanatmaja Vikara</em>. <em>Vata</em>-linked features were the most enriched (4786), followed by <em>Pitta</em> (465) and <em>Kapha</em> (240). 1349 of diseases showed dual <em>Dosha</em> involvement and 360 of all three. Seizures, short stature, and ptosis were most prevalent features of nV; gastroesophageal reflux, fever, and abnormal skin blistering of nP; and obesity, lethargy, and pallor of nK. Detailed case interpretation of Steinert Myotonic Dystrophy, Syndromic Diarrhea and Alstrom Syndrome revealed association with <em>Vata-Kapha, Vata-Pitta</em>, and <em>Tridosha</em> features respectively. This integration of <em>Anukta</em> framework with structured ontologies provides a practical pathway for understanding rare diseases for management in Ayurveda clinics and integrative decision-making when biomedical options are limited.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"17 2","pages":"Article 101322"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}