Journal of Asia-pacific Entomology最新文献_第10页

Krüppel-homolog 1 is critical for larval metamorphosis in an herbivorous ladybird kr<s:1> ppel-同源物1对草食性瓢虫的幼虫变态至关重要

IF 1.3 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-07-20 DOI: 10.1016/j.aspen.2025.102447

Yi-Kuan Wu, Jia-Qing Yu, Lin Jin, Guo-Qing Li

{"title":"Krüppel-homolog 1 is critical for larval metamorphosis in an herbivorous ladybird","authors":"Yi-Kuan Wu, Jia-Qing Yu, Lin Jin, Guo-Qing Li","doi":"10.1016/j.aspen.2025.102447","DOIUrl":"10.1016/j.aspen.2025.102447","url":null,"abstract":"<div><div>Two transcriptional repressors Krüppel-homolog 1 (Kr-h1) and Hairy have been confirmed mediating juvenile hormone (JH) signaling in Dipterans. To date, nevertheless, whether the two repressors transduce the JH signal has not been explored in any Coleopteran species. Here we found that <em>HvKr-h1</em> exhibited a temporal expression pattern opposite to that of <em>HvHairy</em> in <em>Henosepilachna vigintioctomaculata</em>, an herbivorous ladybird mainly damaging potato. Moreover, <em>HvKr-h1</em> showed opposite expression profiles to that of <em>HvHairy</em> in the larval fore and hindguts. RNA interference (RNAi) against <em>Kr-h1</em> at the second larval instar stage caused premature pupae and adults, and abnormal prepupae. Knockdown of <em>HvKr-h1</em> at the third and fourth (final) larval instar stages led to deformed prepupae and misshapen pupae; the phenotypic defects were more severe when injection of dsRNA at the final instar stage. Moreover, RNAi for <em>HvKr-h1</em> disrupted JH and 20E signaling, indicating by abnormal expression levels of JH signaling pathway genes (<em>Met</em>, <em>Tai</em>, <em>Hairy, Groucho</em>) and upregulated <em>BrC</em> and <em>E93</em>. Conversely, depletion of either <em>HvHairy</em> or <em>HvGroucho</em> did not affect larval developing. Both ds<em>Hairy</em>- or ds<em>Groucho</em>-treated and control larvae exhibited steady weight gain and normal transitions through the third and fourth instars, prepupal, and pupal stages. It appears that Kr-h1, rather than Hairy/Groucho, exerts an anti-metamorphic role during larva developing in <em>H. vigintioctomaculata</em>.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102447"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions to the knowledge of the genus Yunnanebaeus Wittmer, 1996 (Coleoptera, Malachiidae), with descriptions of four new species 对Yunnanebaeus Wittmer属认识的贡献，1996（鞘翅目，孔雀鸟科），附4新种描述

IF 1.3 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-07-15 DOI: 10.1016/j.aspen.2025.102446

Junbo Tong , Sergei E. Tshernyshev , Romain Nattier , Haoyu Liu , Yuxia Yang

引用次数: 0

A systematic review of the East Asian Vidalia Robineau-Desvoidy (Diptera: Tephritidae: Trypetini: Trypetina), with recognition of a new species 东亚褐飞虱属系统综述（双翅目：绢翅虫科：绢翅虫科：绢翅虫科）并发现一新种

IF 1.1 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-06-27 DOI: 10.1016/j.aspen.2025.102436

Ho-Yeon Han, Kyung-Eui Ro

{"title":"A systematic review of the East Asian Vidalia Robineau-Desvoidy (Diptera: Tephritidae: Trypetini: Trypetina), with recognition of a new species","authors":"Ho-Yeon Han, Kyung-Eui Ro","doi":"10.1016/j.aspen.2025.102436","DOIUrl":"10.1016/j.aspen.2025.102436","url":null,"abstract":"<div><div>The East Asian species of the horn-headed tephritid genus <em>Vidalia</em> are systematically reviewed, including <em>V. armifrons</em> (Portschinsky, 1892), <em>V. itoi</em> Han and Ro, sp. nov., and <em>V. satae</em> Ito, 1984. A key, diagnoses, descriptions, photographs of morphological structures (including genitalia), and a 16S rDNA phylogram of 18 genera and 26 species within the tribe Trypetini are provided. The species status of <em>V. armifrons</em> has previously been unclear. However, we were able to distinguish the light-colored <em>V. itoi</em>, sp. nov., from the dark-colored <em>V. armifrons</em> based on the specimens collected from northern South Korea. In addition to differences in coloration, the female aculei exhibit significant interspecific variation. Nevertheless, the two species are indistinguishable based on 16S rDNA sequences, supporting their status as sister species. The dark-colored <em>V. armifrons</em> appears to be distributed in more northern regions (East Siberia, northern China, and Korea), whereas <em>V. itoi</em> has a more southern distribution, extending as far as Japan. Both species coexist in Korea and presumably also in China and Russia, but only <em>V. itoi</em> is found in Japan. Minor differences in flight periods may exist between the two species, likely due to their use of different host plants in northern South Korea. Based on expanded sampling of <em>V. satae</em>, this species is hereby resurrected from synonymy with <em>V. accola</em> (Hardy, 1973) due to significant differences in wing pattern. Furthermore, our 16S rDNA phylogram supports a previously proposed morphological phylogenetic hypothesis: multiple independent, convergent evolutions of male head ornamentation have occurred within the tribe Trypetini, likely driven by intense selection pressure arising from aggressive male butting behavior.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102436"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and expression analysis of olfactory genes from Ephestia elutella (Lepidoptera: Pyralidae) antennal transcriptome elutella（鳞翅目：皮蝇科）嗅觉基因转录组的鉴定与表达分析

IF 1.3 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-08-26 DOI: 10.1016/j.aspen.2025.102460

Guiyao Wang , Yueliang Bai , Hanping Zhou , Yingjie Liu , Taibo Liang , Keke Sun , Yongsheng Wang , Qiang Xu , Jianwei Wang

{"title":"Identification and expression analysis of olfactory genes from Ephestia elutella (Lepidoptera: Pyralidae) antennal transcriptome","authors":"Guiyao Wang , Yueliang Bai , Hanping Zhou , Yingjie Liu , Taibo Liang , Keke Sun , Yongsheng Wang , Qiang Xu , Jianwei Wang","doi":"10.1016/j.aspen.2025.102460","DOIUrl":"10.1016/j.aspen.2025.102460","url":null,"abstract":"<div><div><em>Ephestia elutella</em> (Lepidoptera: Pyralidae) is a globally significant pest of stored products. Its olfactory system is crucial for mating, oviposition, and host location. Despite its importance, the mechanisms underlying odorant recognition in <em>E. elutella</em> are not well understood. Olfactory genes are thought to initiate the process of olfactory signal transduction in insects. In this study, we conducted antennal transcriptome sequencing of <em>E. elutella</em>, identifying 75 genes related to olfaction. This list includes 9 odorant-binding proteins (<em>OBPs</em>), 4 chemosensory proteins (<em>CSPs</em>), 46 olfactory receptors (<em>ORs</em>), 6 ionotropic receptors (<em>IRs</em>), 7 gustatory receptors (<em>GRs</em>), and 3 sensory neuron membrane proteins (<em>SNMPs</em>). Results from quantitative real-time PCR indicated that 7 <em>EeluOBPs</em>, 38 <em>EeluORs</em> and 5 <em>EeluGRs</em> exhibited higher expression levels in male antennae compared to females. These insights lay the groundwork for future research into the chemoreceptive mechanisms of <em>E. elutella</em>.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102460"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repellent activity of nanocrystalline ammonium paratungstate on the German cockroach, Blattella germanica (L.) 仲钨酸铵纳米晶对德国小蠊的驱避作用

IF 1.3 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-08-26 DOI: 10.1016/j.aspen.2025.102468

Ryusei Shimizu , Ikuko Ishikawa , Haruyuki Nakano , Yuuichi Ishikawa , Keiji Nakamura

{"title":"Repellent activity of nanocrystalline ammonium paratungstate on the German cockroach, Blattella germanica (L.)","authors":"Ryusei Shimizu , Ikuko Ishikawa , Haruyuki Nakano , Yuuichi Ishikawa , Keiji Nakamura","doi":"10.1016/j.aspen.2025.102468","DOIUrl":"10.1016/j.aspen.2025.102468","url":null,"abstract":"<div><div>Metal-based nanomaterials’ action as a repellent against the German cockroach, <em>Blattella germanica</em> (Blattodea: Ectobiidae), was examined. After the inner surfaces of black non-transparent rectangular plastic cases were sprayed with colloidal solutions of nanocrystalline ammonium paratungstate or pure water, two black cases were placed as shelters in a large container. Then adult cockroaches were introduced into the container. Cockroaches in shelters were counted 1–3 h later. When using boxes sprayed with 3.0 % colloidal solution and pure water, no cockroach that entered either of the shelters chose the shelter with nanocrystalline ammonium paratungstate. Even with concentrations lower than 3.0 %, fewer cockroaches chose shelters sprayed with the nanomaterial solution over those sprayed with pure water. The repellent effects persisted for 90 days and then decreased gradually. When cockroaches were reared in the container sprayed with the colloidal solution for a week, mortality was only 6 %, which was not different from that of the control experiment. Chemical insecticides in human dwellings pose a risk of human exposure. By contrast, a low impact on human health is expected from the non-volatile nanomaterial used for this study, which shows persistent repellency lasting for several months. Nanocrystalline ammonium paratungstate can be a strong tool when used as part of integrated pest management for cockroaches.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102468"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botanical pesticides as sustainable alternatives for managing lychee fruit borer (Conopomorpha sinensis): Balancing pest control and biodiversity Conservation 植物性农药作为管理荔枝果螟的可持续替代品：害虫控制与生物多样性保护的平衡

IF 1.1 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-06-06 DOI: 10.1016/j.aspen.2025.102430

Tianhang Zuo, Fujing Zheng, Luoluo Wang, Jidong Xian

{"title":"Botanical pesticides as sustainable alternatives for managing lychee fruit borer (Conopomorpha sinensis): Balancing pest control and biodiversity Conservation","authors":"Tianhang Zuo, Fujing Zheng, Luoluo Wang, Jidong Xian","doi":"10.1016/j.aspen.2025.102430","DOIUrl":"10.1016/j.aspen.2025.102430","url":null,"abstract":"<div><div><em>Conopomorpha sinensis</em> Bradley (Lepidoptera: Gracillariidae), commonly known as the lychee fruit borer, is a major pest that severely impacts lychee production, causing significant fruit damage and economic losses. Although chemical pesticides, such as beta-cypermethrin, are effective in controlling this pest, their extensive application raises critical issues, including environmental pollution, pest resistance, and a decline in biodiversity within orchard ecosystems. This study evaluated botanical pesticides as sustainable alternatives to chemical controls. Field trials showed that the combined application of rotenone and azadirachtin provided the highest efficacy—exceeding 80% at multiple time points—and significantly reduced fruit infestation compared to beta-cypermethrin. Furthermore, eco-friendly pest management strategies involving botanical pesticides enhanced arthropod biodiversity, supported natural enemies, and contributed to effective pest regulation, thereby fostering a more balanced and resilient agroecosystem. These findings underscore the benefits of adopting botanical pesticides as a sustainable pest management strategy, offering effective control of <em>C. sinensis</em> while preserving ecological health. This approach provides a promising pathway toward sustainable and environmentally responsible lychee production.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102430"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of Korean Aleochara Gravenhorst subgenus Xenochara Mulsant and Rey (Coleoptera:Staphylinidae:Aleocharinae) with description of a new species 韩国白翅蝗亚属（鞘翅目：葡萄蚜科：白翅蝗科）综述及一新种描述

IF 1.1 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-07-01 DOI: 10.1016/j.aspen.2025.102438

Kee-Jeong Ahn, Joon-Yong Park

引用次数: 0

Distribution and nest occupancy patterns of Oecophylla smaragdina (hymenoptera: formicidae) colonies in Southeast Asian oil palm plantations 东南亚油棕人工林中黄油棕（膜翅目：蚁科）蚁群分布及巢占模式

IF 1.3 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.aspen.2025.102451

Moïse Pierre Exélis , Rosli Ramli , Azarae Hj Idris , Rabha W. Ibrahim , Gemma Maria Clemente-Orta , Camilo Ayra-Pardo , Muhamad Shirwan Abdullah Sani

{"title":"Distribution and nest occupancy patterns of Oecophylla smaragdina (hymenoptera: formicidae) colonies in Southeast Asian oil palm plantations","authors":"Moïse Pierre Exélis , Rosli Ramli , Azarae Hj Idris , Rabha W. Ibrahim , Gemma Maria Clemente-Orta , Camilo Ayra-Pardo , Muhamad Shirwan Abdullah Sani","doi":"10.1016/j.aspen.2025.102451","DOIUrl":"10.1016/j.aspen.2025.102451","url":null,"abstract":"<div><div>The Asian weaver ant (<em>Oecophylla smaragdina</em> F.) is an effective natural predator of key pests affecting economically important crops across Southeast Asia. This study presents a large-scale assessment of its spatial distribution in oil palm plantations (200,000 ha surveys). Geographic coordinates and colony-level data were recorded to investigate spatial structure, the occupation pattern, nesting behaviour, and typology. To distinguish functional nest types (brood versus barracks), 26 samples were analysed using discriminant analysis (DA). The vertical positioning within the palm canopy emerged as a reliable visual indicator (nest morphology, internal content proved insufficient). Brood nests were located at heights averaging 8.0 ± 1.3 m (barracks ± 4.0 m). Colonies exhibited polydomous structure, forming irregular, interconnected spatial patches, with the first documented cases of monodomy observed in shorter palms. The antagonist ant species <em>Odontoponera denticulata</em> is suggested as a potential disruptor vector. Colony age, estimated from the number of nests and occupied palms, was modelled using negative binomial and Poisson distribution. Mature colonies occupied 10–12 palms within an area of 800–2500 m<sup>2</sup>, separated by consistent ant-free buffer zones (∼20 m<sup>2</sup>). Colonisation progressed gradually, with colonies occupying an average of 3–4 palms per year, reaching maturity within 3–4 years. Poisson modelling predictive estimation of colony age based on nesting parameters shows a strong correlation. <em>O. smaragdina</em> colonies’ widespread, stable presence throughout oil palm landscapes underscores the species’ potential as a sustainable biological control agent against the invasive bagworm <em>Metisa plana</em> Walker (Lepidoptera: Psychidae), a major threat to oil palm yields.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102451"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Camelliasaponins A1 and A2 extracted from camellia (Camellia japonica var. japonica) seeds are key antifeedant compounds against the larvae of diamondback moth (Plutella xylostella L.) 从山茶种子中提取的茶花皂苷A1和A2是对小菜蛾幼虫的主要拒食化合物。

IF 1.3 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-08-07 DOI: 10.1016/j.aspen.2025.102453

Ka Hee Cho , Ye Seon Won , Jeong-Yong Cho , Young Cheol Kim

{"title":"Camelliasaponins A1 and A2 extracted from camellia (Camellia japonica var. japonica) seeds are key antifeedant compounds against the larvae of diamondback moth (Plutella xylostella L.)","authors":"Ka Hee Cho , Ye Seon Won , Jeong-Yong Cho , Young Cheol Kim","doi":"10.1016/j.aspen.2025.102453","DOIUrl":"10.1016/j.aspen.2025.102453","url":null,"abstract":"<div><div><em>Plutella xylostella</em> (diamondback moth) is a major pest of cruciferous crops, causing substantial global economic losses. Therefore, this study aims to isolate natural antifeedant compounds from <em>Camellia japonica</em> seeds and evaluate their bioactivity against third-instar larvae of <em>P. xylostella</em>. Among the tested plant extracts, the ethanolic extract of <em>C. japonica</em> seeds exhibited strong antifeedant activity, with a 50 % antifeedant concentration (AFC<sub>50</sub>) of 128 ppm. LC-MS/MS analysis of the extract identified major constituents, including disaccharides (17 %), kaempferol glycosides (12 %), camelliasaponin A1 (10 %), camelliasaponin A2 (11 %), and other triterpenoid glycosides. Subsequent medium-pressure liquid chromatography (MPLC) fractionation of the extract produced five fractions, one of which showed antifeedant activity at 125.0 ppm. This active fraction contained high levels of camelliasaponins A1 (5,031 ± 286 ppm) and A2 (6,053 ± 185 ppm). Authentic camelliasaponin A1 and A2 also showed potent antifeedant activity against <em>P. xylostella</em> larvae, with AFC<sub>50</sub> values of 5.4 ppm and 3.6 ppm, respectively—both lower than that of neem-derived Azadirachtin (AFC<sub>50</sub> = 12.4 ppm). These findings confirm that camelliasaponins A1 and A2 are the principal active antifeedant constituents in <em>C. japonica</em> seed extracts. Overall, the findings highlight the potential of camellia seed extracts for development into environmentally friendly formulations for integrated pest management targeting lepidopteran larvae.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102453"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico molecular docking analysis on acetylcholinesterase (AChE) inhibition activity on Aedes aegypti and Culex quinquefasciatus by β-isocostic acid β-异戊二酸对埃及伊蚊和致倦库蚊乙酰胆碱酯酶抑制活性的硅分子对接分析

IF 1.1 3区农林科学

Journal of Asia-pacific Entomology Pub Date : 2025-09-01 Epub Date: 2025-06-16 DOI: 10.1016/j.aspen.2025.102433

Alex Yagoo , M.C. John Milton , Jelin Vilvest , Antony Stalin

{"title":"In silico molecular docking analysis on acetylcholinesterase (AChE) inhibition activity on Aedes aegypti and Culex quinquefasciatus by β-isocostic acid","authors":"Alex Yagoo , M.C. John Milton , Jelin Vilvest , Antony Stalin","doi":"10.1016/j.aspen.2025.102433","DOIUrl":"10.1016/j.aspen.2025.102433","url":null,"abstract":"<div><div>The increasing prevalence of mosquito-borne diseases poses serious public health and economic threats, further exacerbated by the emergence of insecticide resistance in mosquito populations. Although conventional insecticides are effective, they contribute to environmental degradation and resistance development. This study investigates the insecticidal potential of β-isocostic acid, a plant-derived compound that targets acetylcholinesterase (AChE) to disrupt neurotransmission in <em>Aedes aegypti</em> and <em>Culex quinquefasciatus</em>, two major mosquito vectors. Molecular docking was employed to evaluate and compare the AChE binding affinity and interaction patterns of β-isocostic acid with that of the standard insecticide temephos. Ligand structures were retrieved from PubChem and optimized using ChemDraw and the PRODRG server. Homology models of AChE1 for <em>Ae. aegypti</em> and <em>Cx. quinquefasciatus</em> were constructed based on the crystal structure of an <em>Anopheles gambiae</em> AChE mutant. Docking simulations were performed using AutoDock Tools with a grid-based approach and the Lamarckian Genetic Algorithm. β-Isocostic acid demonstrated strong binding affinity to AChE1 in both species, with binding energies of –8.2 kcal/mol for <em>Ae. aegypti</em> and –8.5 kcal/mol for <em>Cx. quinquefasciatus</em>, values comparable to those of temephos (–8.7 kcal/mol and –9.1 kcal/mol, respectively). These findings suggest that β-isocostic acid may serve as an eco-friendly insecticidal candidate, inhibiting AChE and impairing mosquito function. Given its promising binding profile, β-isocostic acid has potential as a sustainable alternative for mosquito control. Further in vivo studies are warranted to validate its efficacy and safety.</div></div>","PeriodicalId":15094,"journal":{"name":"Journal of Asia-pacific Entomology","volume":"28 3","pages":"Article 102433"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0