Journal of Asthma and Allergy最新文献

{"title":"Global Ragweed Allergy: Molecular Allergens and Integrated Control Strategies.","authors":"Zi-Lu Cheng, Ting-Ting Ma, Zhong-Shan Gao, Wen-Hua Ming, Mei-Rong Yang, Xue-Yan Wang","doi":"10.2147/JAA.S506897","DOIUrl":"10.2147/JAA.S506897","url":null,"abstract":"<p><p>Originally native to North America, ragweed has become a pervasive invasive species worldwide over the past century, posing a substantial public health risk as a potent allergen. This review explores the key allergens found in common ragweed, assesses global trends in ragweed sensitization, particularly in China, and examines various therapeutic and biological control methods. There are currently 11 identified ragweed allergens, with Amb a 1 and 11 recognized as the primary triggers. Epidemiological data indicate higher rates of sensitization in North America and Europe, with a growing trend observed in China. Ragweed-induced type I hypersensitivity typically presents as seasonal allergic rhinitis, conjunctivitis, and asthma symptoms. Strategies for managing ragweed allergy include allergen avoidance, pharmacotherapy, and allergen immunotherapy (AIT). Biological control using <i>Ophraella communa</i> and <i>Epiblema strenuana</i> effectively limits ragweed proliferation. Accurate allergen identification and personalized treatment can significantly reduce the health burden associated with ragweed. An in-depth understanding of ragweed sensitization patterns and biological control measures is essential for the long-term prevention of ragweed allergies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"403-416"},"PeriodicalIF":3.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Impulse Oscillometry Combined with Fractional Exhaled Nitric Oxide in Monitoring Asthma Control Levels in Children.","authors":"Jie Hu, Yinghong Fan, Ronghua Luo, Qianqian Li, Tao Ai, Li Wang","doi":"10.2147/JAA.S507446","DOIUrl":"10.2147/JAA.S507446","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether Impulse Oscillometry (IOS) could more effectively monitor children with uncontrolled asthma and evaluate small airway function changes, while establishing a prediction model in combination with fractional exhaled nitric oxide (FeNO) to assist in clinical management and treatment of asthmatic children.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on 203 asthmatic children who were followed up in our hospital from August 2023 to August 2024. Patients were divided into controlled asthma group (n=80) and uncontrolled asthma group (n=123). Conventional ventilatory parameters, IOS parameters, FeNO levels, and clinical data were analyzed and compared between the two groups. The optimal prediction model was established through multivariate logistic regression.</p><p><strong>Results: </strong>In the uncontrolled asthma group, the respiratory system impedance at 5 hz (Z5), resistance at 5 hz (R5), the difference between resistance at 5 hz and resistance at 20 hz (R5-R20), resonant frequency (Fres), and FeNO levels were significantly higher compared to the controlled asthma group. The ratio of forced expiratory volume in one second to forced vital capacity (FEV₁/FVC), forced expiratory flow at 50% (FEF50), forced expiratory flow at 75% (FEF75), and maximal mid-expiratory flow (MMEF) were lower in the uncontrolled group (P<0.05). Receiver operating characteristic curve (ROC) analysis demonstrated that Z5, R5, R5-R20, Fres, and FeNO were valuable in asthma diagnosis (P<0.05), with higher sensitivity in monitoring small airway function compared to MMEF. Multivariate logistic regression analysis established the optimal prediction model combining R5+(R5-R20) +FeNO, with an area under curve (AUC) of 0.915 (P<0.05), sensitivity of 0.831, and specificity of 0. 892.</p><p><strong>Conclusion: </strong>Compared to conventional pulmonary function tests, IOS effectively identifies uncontrolled status in asthmatic children, particularly in younger patients, with higher sensitivity to small airway function changes. The model comprising R5+(R5-R20) +FeNO demonstrates clinical value in identifying uncontrolled status in asthmatic children.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"391-402"},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Small Airways Dysfunction and the Bronchodilator Response in Adults With Asthma and Its Risk Factors: A Retrospective Analysis.","authors":"Mohammed A Almeshari, Nowaf Y Alobaidi, James A Stockley, Robert A Stockley, Prasad Nagakumar, Benjamin Paul Sutton, Elizabeth Sapey","doi":"10.2147/JAA.S489893","DOIUrl":"10.2147/JAA.S489893","url":null,"abstract":"<p><strong>Background: </strong>Physiological evidence of small airways dysfunction (SAD) is present in some patients with asthma and is associated with poor disease control. It is unclear if this represents a distinct phenotype of asthma or if it is an early manifestation of the disease. The study aimed to evaluate SAD in asthma and its clinical associations.</p><p><strong>Methods: </strong>A retrospective analysis of routinely collected health data obtained from adults referred for routine spirometric assessment as part of their clinical management. The Maximal Mid-Expiratory Flow (MMEF) z-scores were used to assess the prevalence and association factors for SAD. Pre- and post-bronchodilator data of MMEF and FEV₁ in patients with and without SAD or airflow obstruction (AO) were analysed.</p><p><strong>Results: </strong>A total of 1094 patients were included. 366 (33.5%) had evidence of SAD of whom 261 (71.3%) also had AO. Current smokers were at an increased risk of having SAD (OR: 2.05; 95% CI: 1.43-2.93). 214 patients had Bronchodilator response (BDR) data with 157 (73.4%) demonstrating BDR for MMEF and 121 (56.5%) for FEV₁. SAD at baseline was associated with a significant BDR for FEV₁ (OR of 3.59 (95% CI: 1.77-7.57)) and MMEF (OR of 2.89 (95% CI: 1.41-5.95)). Males were less likely to have a positive BDR for MMEF than females (OR of 0.46; 95% CI: 0.24-0.89).</p><p><strong>Conclusion: </strong>SAD is common in asthma and is related to the presence of AO, cigarette smoking and is associated with increased BDR for both FEV₁ and MMEF. The assessment of SAD in routine clinical practice may help identify airway impairment early for the initiation of targeted therapies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"377-389"},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for the Efficacy of 4-Week Dupilumab Treatment in Atopic Dermatitis Patients.","authors":"Ling Yu, Cheng Lian, Linfeng Li, JianGuo Li, Shoumin Zhang","doi":"10.2147/JAA.S508697","DOIUrl":"10.2147/JAA.S508697","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a common inflammatory disease with heterogeneous clinical features. Certain meaningful phenotypes and clinical features may help better classify AD patients for personalized medicine. To our knowledge, no ideal predictors have been found so far. We aim to investigate clinical predictors for the 4-week efficacy of dupilumab treatment in AD patients in the real world.</p><p><strong>Methods: </strong>Two hundred and thirty-three AD patients treated with dupilumab were enrolled between June 2020 and December 2023. Patients' information, characteristics, and medical history were collected. They were evaluated at the baseline and 4 weeks after dupilumab treatment and divided into groups according to the Investigator's Global Assessment (IGA) and peak pruritus numerical rating scale (PP-NRS) score. Statistical analyses were used to evaluate potential predictors.</p><p><strong>Results: </strong>Age increase, late-onset, erythroderma type, and elevation of total serum IgE level were risk factors for poor response after 4-week treatment. Female, atopic personal or family history, and allergic rhinitis were factors for better response. Multivariate logistic regression analysis showed extrinsic AD had a poor reaction than intrinsic AD (OR=4.792,95% CI 1.460-15.732, <i>p</i>=0.010), so did chronic eczema to acute-subacute eczema (OR=2.386,95% CI 1.247-4.566, <i>p</i>=0.009). Trends to decrease the risk were found for allergic rhinitis (OR=0.315,95% CI 0.202-0.967, <i>p</i>=0.001), and atopic family history (OR=0.442,95% CI 0.159-0.622, <i>p</i>=0.041).</p><p><strong>Conclusion: </strong>Extrinsic AD and chronic lichenoid eczema are risk factors for poor response to 4-week dupilumab treatment, which suggests that AD patients with extrinsic and chronic lichenoid eczema may need more patience for long-term treatment or make other options.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"331-337"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Respiratory Sensitivity Status of Patients in a Hospital in Shanxi Province Before and After the COVID-19 Epidemic.","authors":"Chuanchuan Dong, Fei Hu, Zhen Ma, Xinkai Ma, Lulu Zhang, Yupeng Li, Xianglin Du, Liting Feng, Rujie Huo, Yanqing Xing, Peiqi Li, Yanting Dong, Erjing Cheng, Xinrui Tian, Min Huang","doi":"10.2147/JAA.S497018","DOIUrl":"10.2147/JAA.S497018","url":null,"abstract":"<p><strong>Background: </strong>The lifting of the regional blockade in early December 2022 in Shanxi Province, China, caused an epidemic of Coronavirus disease 2019 (COVID-19). And the high allergy season from July to September each year.</p><p><strong>Purpose: </strong>To investigate the effect of the COVID-19 epidemic on the respiratory sensitivity status of the population, to provide a scientific and effective basis for the prevention, diagnosis, condition assessment, and treatment of allergic respiratory diseases.</p><p><strong>Methods: </strong>We collected 500 outpatient cases from Shanxi Medical University Second Hospital during the period from July to September 2022 and 500 cases during the period from July to September 2023 and divided them into the pre-COVID-19 epidemic group (the 2022 group) and the post-COVID-19 epidemic group (the 2023 group). We conducted statistical analysis on these patients' general conditions, pulmonary function test results, laboratory parameters, and fractional exhaled nitric oxide.</p><p><strong>Results: </strong>Compared with 2022, the number of smokers decreased in 2023 (p = 0.007), while the incidence of respiratory allergic diseases such as bronchial asthma and allergic rhinitis increased (p < 0.05). In 2023, the results of pulmonary function tests showed that the positive rate of bronchial provocation/dilatation tests increased (p < 0.001), and the decline in FEV1 during provocation tests became more significant (p < 0.001). At the same time, laboratory results indicated that the count of eosinophils and the level of immunoglobulin E (IgE) in peripheral blood rose (p < 0.001), suggesting that the respiratory sensitivity of the population after COVID-19 infection might have increased.</p><p><strong>Conclusion: </strong>Research results from Shanxi Province, China, indicate that the COVID-19 epidemic leads to increased respiratory sensitization and the incidence of respiratory allergic diseases. This suggests that we should pay attention to the changes in immune status and respiratory sensitivity among the population after COVID-19 infection, to accurately and timely assess and intervene in patients' conditions.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"339-348"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Protein Classes With Cross-Reactivity and Cross-Sensitization in Furry Animal Allergens: A Component-Resolved Diagnostics Study.","authors":"Jiancai Lu, Huiqing Zhu, Qingqing Yang, Yunjian Xu, Zhifeng Huang, Baoqing Sun","doi":"10.2147/JAA.S505066","DOIUrl":"10.2147/JAA.S505066","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the molecular sensitization patterns of cats, dogs, and horses in patients with cat and/or dog sensitization and the IgE cross-reactivity with other furry animals.</p><p><strong>Methods: </strong>In 95 patients diagnosed with allergic diseases and sensitized to cats and/or dogs (confirmed by specific Immunoglobulin E (sIgE) ≥ 0.35 kU_A/L to crude cat and/or dog dander extracts), sIgE levels of cat components (Fel d 1/2/4), dog components (Can f 1/2/3/5), horse dander (Equ c 1), as well as allergens from cow, guinea pig, mouse, rat, rabbit, and chicken, were measured. Sensitization profiles and cross-reactivity were analyzed. Inhibition tests using serum albumin (SA) and lipocalin proteins were performed.</p><p><strong>Results: </strong>Sensitization rates of crude extracts from other furry animals ranged from 16.8% to 49.5%. A strong positive correlation between cat and dog serum albumin (Fel d 2 and Can f 3) and rabbit epithelium, mouse epithelium, guinea pig epithelium and rat epithelium (rs: 0.66-0.87, all P < 0.05), while the lipocalin family (Fel d 4, Can f 1, Can f 2 and Equ c 1) only had a low to moderate correlation with the epithelial allergens of the above four animals (rs: 0.36-0.65, all P < 0.05). Simultaneous sensitization to SA and these four furry animal allergens accounted for 42.4%. sIgE levels of furry animal extracts were significantly higher in SA-positive groups (all P < 0.05) The results of the inhibition test showed that Fel d 2 and Can f 3 had high inhibition rates of four epithelial allergens, ranging from 66.5% to 91.8% and 75.8% to 91.9%, respectively. When lipocalin family components were used as inhibitors, the sIgE inhibition rates of these furry animal extracts were almost all lower than 50%.</p><p><strong>Conclusion: </strong>SA is the primary driver of cross-sensitization between cats, dogs, and other furry animals, rather than lipocalins.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"363-375"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Microbiota Profiles in Children With and Without Asthma: A Comparative Study.","authors":"Aisha Alamri, Meshal Alhassan, Abdullah K Almutairi, Nithya Jayaseeli, Rebecca P Berg, Christen Rune Stensvold, Lee O'Brien Andersen, Henrik Vedel Nielsen, Suzan A AlKhater","doi":"10.2147/JAA.S498803","DOIUrl":"10.2147/JAA.S498803","url":null,"abstract":"<p><strong>Background: </strong>Asthma is a common chronic respiratory disease that affects children and adults and can have a serious impact on their quality of life. Factors contributing to the development of asthma and related exacerbations are multifactorial, with microbial communities colonizing the airways possibly playing a key role.</p><p><strong>Methods: </strong>The study included asthmatic (79) and healthy children (57) aged 5-16 years. Nasal and throat swabs were collected, and bacterial (16s rRNA) and fungal (18s rRNA) amplicon sequence analysis was performed. Diversity indices and the most abundant microbial genera were estimated accordingly.</p><p><strong>Results: </strong>At the level of the bacteriome in the nasal samples, the asthma group had significantly lower diversity than the control group (p = 0.02). However, the microbiota of the asthma cohort was more evenly distributed, and <i>staphylococci</i> were enriched in the control group. Throat samples collected from the asthma cohort revealed significantly lower diversity (p < 0.0001), with a significant difference in species composition between the two groups (p = 0.005). Enriched bacterial species were different within the asthma subgroups (controlled vs uncontrolled asthma). The fungal microbiome of the nasal and throat samples showed no difference in species richness between the two groups, however, a significant difference in beta diversity (species composition) was detected. The nasal samples from the control group were enriched with <i>Malassezia</i> species, while the asthma cases were enriched with <i>Mucor</i> species. On the other hand, throat specimens of the asthma group were found to be enriched with <i>Candida</i> and <i>Saccharomyces.</i></p><p><strong>Conclusion: </strong>Our findings suggest that asthmatic samples were less diverse than the control samples with certain microbial genera enriching some study groups. Addressing the biomarkers that influence the progression of asthma could lead to improved care for children suffering from severe asthmatic episodes, possibly by including targeted therapies and prevention strategies.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"349-361"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology.","authors":"Shuzhou Deng, Le Ding, Yisong Qian, Xuan Huang","doi":"10.2147/JAA.S490039","DOIUrl":"10.2147/JAA.S490039","url":null,"abstract":"<p><p>Asthma represents a major global health concern, underscoring an imperative for further exploration into its pathogenesis to inform the development of more effective treatment strategies. As a key mechanism for intracellular protein degradation and regulation, the ubiquitin-proteasome system (UPS) plays a crucial but complex and multifaceted role in the pathological process of asthma. This study systematically reviews the functions and mechanisms of E3 ubiquitin ligases and deubiquitinases within the UPS in asthma. The study explores the impact of these mechanisms on the occurrence of inflammation and the alteration of airway hyperresponsiveness by regulating the synthesis and release of inflammatory factors, as well as the proliferation or differentiation of key inflammatory cells. A comprehensive understanding of the pathological mechanism of UPS in asthma will help to provide new theoretical basis and potential drug targets for the precision treatment, which holds great promise for the treatment of asthma in the future.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"307-330"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-Like Peptide 1 Receptor (<i>Glp1r</i>) Deficiency Does Not Appreciably Alter Airway Inflammation or Gut-Lung Microbiome Axis in a Mouse Model of Obese Allergic Airways Disease and Bariatric Surgery.","authors":"Yeon Ji Kim, Victoria M Ihrie, Pixu Shi, Mark D Ihrie, Jack T Womble, Anna Hill Meares, Joshua A Granek, Claudia K Gunsch, Jennifer L Ingram","doi":"10.2147/JAA.S478329","DOIUrl":"10.2147/JAA.S478329","url":null,"abstract":"<p><strong>Purpose: </strong>High body mass index (≥30 kg/m²) is associated with asthma severity, and nearly 40% of asthma patients exhibit obesity. Furthermore, over 40% of patients with obesity and asthma that receive bariatric surgery no longer require asthma medication. Increased levels of glucagon-like peptide 1 (GLP-1) occur after bariatric surgery, and recent studies suggest that GLP-1 receptor (GLP-1R) signaling may regulate the gut microbiome and have anti-inflammatory properties in the lung. Thus, we hypothesized that increased GLP-1R signaling following metabolic surgery in obese and allergen-challenged mice leads to gut/lung microbiome alterations, which together contribute to improved features of allergic airways disease.</p><p><strong>Methods: </strong>Male and female <i>Glp1r</i>-deficient (<i>Glp1r^-/-</i> ) and replete (<i>Glp1r^+/+)</i> mice were administered high fat diet (HFD) to induce obesity with simultaneous intranasal challenge with house dust mite (HDM) allergen to model allergic airway disease with appropriate controls. Mice on HFD received either no surgery, sham surgery, or vertical sleeve gastrectomy (VSG) on week 10 and were sacrificed on week 13. Data were collected with regard to fecal and lung tissue microbiome, lung histology, metabolic markers, and respiratory inflammation.</p><p><strong>Results: </strong>HFD led to metabolic imbalance characterized by lower GLP-1 and higher leptin levels, increased glucose intolerance, and alterations in gut microbiome composition. Prevalence of bacteria associated with short chain fatty acid (SCFA) production, namely <i>Bifidobacterium, Lachnospiraceae UCG-001</i>, and <i>Parasutterella</i>, was reduced in mice fed HFD and positively associated with serum GLP-1 levels. Intranasal HDM exposure induced airway inflammation. While <i>Glp1r^-/-</i> genotype affected fecal microbiome beta diversity metrics, its effect was limited.</p><p><strong>Conclusion: </strong>Herein, GLP-1R deficiency had surprisingly little effect on host gut and lung microbiomes and health, despite recent studies suggesting that GLP-1 receptor agonists are protective against lung inflammation.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"285-305"},"PeriodicalIF":3.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Asthma With Bronchial Hypersecretion: Expression of Mucins and Toll-Like Receptors in Sputum and Blood [Corrigendum].","authors":"","doi":"10.2147/JAA.S523941","DOIUrl":"https://doi.org/10.2147/JAA.S523941","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/JAA.S142200.].</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"18 ","pages":"283-284"},"PeriodicalIF":3.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}