Journal of Asthma and Allergy最新文献

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High Serum Allergen-Specific IgE of House Dust Mite in Predicting the Risk of Comorbidity in Children with Allergic Conjunctivitis. 预测过敏性结膜炎患儿合并症风险的高血清屋尘螨过敏原特异性 IgE
IF 3.7 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.2147/JAA.S467671
Xiao-Jiao Tang, Jia-Tong He, Qing Liu, Enmei Liu, Lin Chen
{"title":"High Serum Allergen-Specific IgE of House Dust Mite in Predicting the Risk of Comorbidity in Children with Allergic Conjunctivitis.","authors":"Xiao-Jiao Tang, Jia-Tong He, Qing Liu, Enmei Liu, Lin Chen","doi":"10.2147/JAA.S467671","DOIUrl":"10.2147/JAA.S467671","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the patterns of allergens in allergic conjunctivitis (AC) and the association with allergic comorbidity.</p><p><strong>Methods: </strong>This retrospective cross-sectional study enrolled 2972 children with AC. Clinical data, including sex, age, allergic comorbidities (allergic asthma, allergic rhinitis, and atopic dermatitis), and serum allergen-specific immunoglobulin E (sIgE), were collected from the electronic medical record (EMR). The categorical variables were compared with the chi-square test. The characteristics of allergens in children of different ages and comorbidities were analyzed by trend chi-square. The sensitivity level of HDM associated with AC and comorbidities was assessed by odds ratios (ORs) with 95% confidence intervals of logistic regression analysis.</p><p><strong>Results: </strong>A total of 2972 children (2015 boys and 957 girls) with AC were included in the study. The mean age was 3.78 (0.5~12) years. The most common allergen was house dust mite(HDM) (43.41%). With age, the positive rate for inhaled allergens gradually increased, and the positive rate for ingested allergens decreased. With the number of comorbidities increasing, the positive rates of sensitization were 38.33%, 74.51%, 80.72%, and 89.05%, and the incidence of polysensitization was 44.66%, 56.48%, 59.54%, and 74.59%, respectively. With the increase of HDM-sIgE level, the number of comorbidities and the risk increased gradually.</p><p><strong>Conclusion: </strong>HDM is the most common allergen in AC children of different ages. High levels of HDM-sIgE may be a predictor for allergic comorbidities. Children with polysensitization and high levels of HDM sIgE will be an important target population for future intervention in other allergy-related disease prevention.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"17 ","pages":"601-609"},"PeriodicalIF":3.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key Characteristics of Asthma Patients with COVID-19 Vary Substantially by Age. COVID-19 哮喘患者的主要特征因年龄而有很大不同。
IF 3.7 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-22 eCollection Date: 2024-01-01 DOI: 10.2147/JAA.S456145
Brian K Kirui, Ailiana Santosa, Huiqi Li, Lowie E G W Vanfleteren, Caroline Stridsman, Fredrik Nyberg
{"title":"Key Characteristics of Asthma Patients with COVID-19 Vary Substantially by Age.","authors":"Brian K Kirui, Ailiana Santosa, Huiqi Li, Lowie E G W Vanfleteren, Caroline Stridsman, Fredrik Nyberg","doi":"10.2147/JAA.S456145","DOIUrl":"10.2147/JAA.S456145","url":null,"abstract":"<p><strong>Introduction: </strong>Assessing COVID-19 risk in asthma patients is challenging due to disease heterogeneity and complexity. We hypothesized that potential risk factors for COVID-19 may differ among asthma age groups, hindering important insights when studied together.</p><p><strong>Methods: </strong>We included a population-based cohort of asthma patients from the Swedish National Airway Register (SNAR) and linked to data from several national health registers. COVID-19 outcomes included infection, hospitalization, and death from Jan 2020 until Feb 2021. Asthma patients were grouped by ages 12-17, 18-39, 40-64, and ≥65 years. Characteristics of asthma patients with different COVID-19 outcomes were compared with those in their age-corresponding respective source population.</p><p><strong>Results: </strong>Among 201,140 asthma patients studied, 11.2% were aged 12-17 years, 26.4% 18-39, 37.6% 40-64, and 24.9% ≥65 years. We observed 18,048 (9.0%) COVID-19 infections, 2172 (1.1%) hospitalizations, and 336 (0.2%) COVID-19 deaths. Deaths occurred only among patients aged ≥40. When comparing COVID-19 cases to source asthma populations by age, large differences in potential risk factors emerged, mostly for COVID-19 hospitalizations and deaths. For ages 12-17, these included education, employment, autoimmune, psychiatric, and depressive conditions, and use of short-acting β-agonists (SABA) and inhaled corticosteroids (ICS). In the 18-39 age group, largest differences were for age, marital status, respiratory failure, anxiety, and body mass index. Ages 40-64 displayed notable differences for sex, birth region, cancer, oral corticosteroids, antihistamines, and smoking. For those aged ≥65, largest differences were observed for cardiovascular comorbidities, type 1 diabetes, chronic obstructive pulmonary disease, allergic conditions, and specific asthma treatments (ICS-SABA, ICS-long-acting bronchodilators (LABA)). Asthma control and lung function were important across all age groups.</p><p><strong>Conclusion: </strong>We identify distinct differences in COVID-19-related risk factors among asthma patients of different ages. This information is essential for assessing COVID-19 risk in asthma patients and for tailoring patient care and public health strategies accordingly.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"17 ","pages":"589-600"},"PeriodicalIF":3.7,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11203787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare Resource Utilization Associated with Intermittent Oral Corticosteroid Prescribing Patterns in Asthma. 与哮喘患者间歇性口服皮质类固醇处方模式相关的医疗资源利用。
IF 3.7 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI: 10.2147/JAA.S452305
Trung N Tran, Heath Heatley, Arnaud Bourdin, Andrew Menzies-Gow, David J Jackson, Ekaterina Maslova, Jatin Chapaneri, William Henley, Victoria Carter, Jeffrey Shi Kai Chan, Cono Ariti, John Haughney, David Price
{"title":"Healthcare Resource Utilization Associated with Intermittent Oral Corticosteroid Prescribing Patterns in Asthma.","authors":"Trung N Tran, Heath Heatley, Arnaud Bourdin, Andrew Menzies-Gow, David J Jackson, Ekaterina Maslova, Jatin Chapaneri, William Henley, Victoria Carter, Jeffrey Shi Kai Chan, Cono Ariti, John Haughney, David Price","doi":"10.2147/JAA.S452305","DOIUrl":"10.2147/JAA.S452305","url":null,"abstract":"<p><strong>Purpose: </strong>Oral corticosteroid (OCS) use for asthma is associated with considerable healthcare resource utilization (HCRU) and costs. However, no study has investigated this in relation to patterns of intermittent OCS prescription.</p><p><strong>Methods: </strong>This historical UK cohort study used primary care medical records, linked to Hospital Episode Statistics, from 2008 to 2019, of patients (≥4 years old) with asthma prescribed intermittent OCS. Patients were categorized by OCS prescribing pattern (one-off [single], less frequent [≥90-day gap] and frequent [<90-day gap]) and matched 1:1 (by sex, age and index date) with people never prescribed OCS with/without asthma. HCRU (reported as episodes, except for length of hospital stay [days] and any prescription [records]) and associated costs were compared between intermittent OCS and non-OCS cohorts, and among intermittent OCS prescribing patterns.</p><p><strong>Results: </strong>Of 149,191 eligible patients, 50.3% had one-off, 27.4% less frequent, and 22.3% frequent intermittent OCS prescribing patterns. Annualized non-respiratory HCRU rates were greater in the intermittent OCS versus non-OCS cohorts for GP visits (5.93 vs 4.70 episodes, p < 0.0001), hospital admissions (0.24 vs 0.16 episodes, p < 0.0001), and length of stay (1.87 vs 1.58 days, p < 0.0001). In the intermittent OCS cohort, rates were highest in the frequent prescribing group for GP visits (7.49 episodes; p < 0.0001 vs one-off), length of stay (2.15 days; p < 0.0001) and any prescription including OCS (25.22 prescriptions; p < 0.0001). Mean per-patient non-respiratory related and all-cause HCRU-related costs were higher with intermittent OCS than no OCS (£3902 vs £2722 and £8623 vs £4929, respectively), as were mean annualized costs (£565 vs £313 and £1526 vs £634, respectively). A dose-response relationship existed; HCRU-related costs were highest in the frequent prescribing cohort (p < 0.0001).</p><p><strong>Conclusion: </strong>Intermittent OCS use and more frequent intermittent OCS prescription patterns were associated with increased HCRU and associated costs. Improved asthma management is needed to reduce reliance on intermittent OCS in primary care.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"17 ","pages":"573-587"},"PeriodicalIF":3.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baseline Systemic Oral Corticosteroid Use in Patients with Asthma Initiating Dupilumab Treatment in the Real World: From the RAPID Global Registry. 真实世界中开始使用杜匹单抗治疗的哮喘患者的系统性口服皮质类固醇基线使用情况:来自 RAPID 全球注册。
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.2147/JAA.S451689
Nijra L Lugogo, Enrico Heffler, Vicente Plaza, Ole Hilberg, Changming Xia, Scott Nash, Nami Pandit, Juby A Jacob-Nara, Harry J Sacks, Paul J Rowe, Yamo Deniz, Megan Hardin, Xavier Soler
{"title":"Baseline Systemic Oral Corticosteroid Use in Patients with Asthma Initiating Dupilumab Treatment in the Real World: From the RAPID Global Registry.","authors":"Nijra L Lugogo, Enrico Heffler, Vicente Plaza, Ole Hilberg, Changming Xia, Scott Nash, Nami Pandit, Juby A Jacob-Nara, Harry J Sacks, Paul J Rowe, Yamo Deniz, Megan Hardin, Xavier Soler","doi":"10.2147/JAA.S451689","DOIUrl":"10.2147/JAA.S451689","url":null,"abstract":"","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"17 ","pages":"551-556"},"PeriodicalIF":3.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benralizumab Reduces Respiratory Exacerbations and Oral Glucocorticosteroid Dose in Patients with Severe Asthma and Eosinophilic Granulomatosis with Polyangiitis. 本拉珠单抗可减少重症哮喘和多发性炎性嗜酸性粒细胞增多症患者的呼吸道症状加重和口服糖皮质激素剂量
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.2147/JAA.S461800
Carlo Mümmler, Pontus Mertsch, Michaela Barnikel, Frank Haubner, Ulf Schönermarck, Ulrich Grabmaier, Hendrik Schulze-Koops, Jürgen Behr, Nikolaus Kneidinger, Katrin Milger
{"title":"Benralizumab Reduces Respiratory Exacerbations and Oral Glucocorticosteroid Dose in Patients with Severe Asthma and Eosinophilic Granulomatosis with Polyangiitis.","authors":"Carlo Mümmler, Pontus Mertsch, Michaela Barnikel, Frank Haubner, Ulf Schönermarck, Ulrich Grabmaier, Hendrik Schulze-Koops, Jürgen Behr, Nikolaus Kneidinger, Katrin Milger","doi":"10.2147/JAA.S461800","DOIUrl":"10.2147/JAA.S461800","url":null,"abstract":"<p><strong>Background: </strong>Benralizumab reduces exacerbations and long-term oral glucocorticosteroid (OCS) exposure in patients with severe eosinophilic asthma. In patients with eosinophilic granulomatosis with polyangiitis (EGPA), uncontrolled symptoms and exacerbations of asthma and chronic rhinosinusitis (CRS) are important reasons for continued OCS therapies. We aimed to describe outcomes of patients with severe asthma and EGPA treated with benralizumab in real-life.</p><p><strong>Methods: </strong>We retrospectively analyzed adult patients from the Severe Asthma Unit at LMU Munich diagnosed with severe asthma and EGPA treated with benralizumab, differentiating two groups: Group A, patients with a stable daily OCS dose and diagnosis of EGPA >6 months ago; and Group B, patients treated with high-dose daily OCS due to recent diagnosis of EGPA <6 months ago. We compared outcome parameters at baseline and 12 months after initiation of benralizumab, including respiratory exacerbations, daily OCS dose, and lung function.</p><p><strong>Results: </strong>Group A included 17 patients, all receiving OCS therapy and additional immunosuppressants; 15 patients (88%) continued benralizumab for more than 12 months, demonstrating a significant reduction in daily OCS dose and exacerbations while FEV1 increased. Group B included 9 patients, all with high-dose daily OCS and some receiving cyclophosphamide pulse therapy for life-threatening disease. Benralizumab addition during induction was well tolerated. A total of 7/9 (78%) continued benralizumab for more than 12 months and preserved EGPA remission at the 12-month timepoint.</p><p><strong>Conclusion: </strong>In this real-life cohort of patients with severe asthma and EGPA, benralizumab initiation during remission maintenance reduced respiratory exacerbations and daily OCS dose. Benralizumab initiation during remission induction was associated with a high rate of clinical EGPA remission.</p>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"17 ","pages":"557-572"},"PeriodicalIF":3.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric Analysis of Cough Variant Asthma from 1993 to 2022 1993 年至 2022 年咳嗽变异性哮喘的文献计量分析
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-04 DOI: 10.2147/jaa.s452097
Ziyu Zhu, Jiabao Wu, Wenjun Chen, Fei Luo, Xia Zhao
{"title":"Bibliometric Analysis of Cough Variant Asthma from 1993 to 2022","authors":"Ziyu Zhu, Jiabao Wu, Wenjun Chen, Fei Luo, Xia Zhao","doi":"10.2147/jaa.s452097","DOIUrl":"https://doi.org/10.2147/jaa.s452097","url":null,"abstract":"<strong>Purpose:</strong> Cough variant asthma (CVA) is a chronic inflammatory disease characterized by recurrent coughing, a prevalent cause of chronic cough in children and adults. As a unique form of asthma, researchers have recently become increasingly interested in developing effective diagnostic and treatment methods. Currently, there has been no bibliometric analysis in CVA. Therefore, this study aims to enrich this knowledge network by examining the current development status, research focal points, and emerging trends in this field.<br/><strong>Methods:</strong> Articles and reviews on CVA published between 1993 and 2022 were collected from the Web of Science Core Collection (WoSCC) database. Relevant data from the reports were extracted, and collaborative network analysis was performed using CiteSpace and VOSviewer software.<br/><strong>Results:</strong> 772 articles were included in this study, indicating a significant increase since 2019. The countries with the highest output are China, Japan. The Journal of Asthma and Pulmonary Pharmacology Therapeutics emerged as the most prolific journals in this field. Keyword analysis revealed 22 clusters, highlighting airway inflammation, airway hyperresponsiveness, and eosinophil as the main focus and frontier of research on CVA.<br/><strong>Conclusion:</strong> From the visual analysis results, the research of CVA is still in the development stage, and there is no unified definition of pathogenesis, diagnostic criteria and treatment strategies. Therefore, researchers and teams should actively carry out cross-institutional and cross-regional cooperation, expand cooperation areas, and carry out high-quality clinical research in the future.<br/><br/><strong>Keywords:</strong> Citespace, VOSviewer, keywords, hotspots<br/>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141252837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hematological, Biochemical, and Serum Levels of Allergic Mediators in Individuals with and without Allergic Rhinitis 过敏性鼻炎患者和非过敏性鼻炎患者的血液学、生化和血清过敏介质水平
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-06-04 DOI: 10.2147/jaa.s461295
Miranda Selmonaj Rama, Bernard Tahirbegolli, Mentor Sopjani
{"title":"Hematological, Biochemical, and Serum Levels of Allergic Mediators in Individuals with and without Allergic Rhinitis","authors":"Miranda Selmonaj Rama, Bernard Tahirbegolli, Mentor Sopjani","doi":"10.2147/jaa.s461295","DOIUrl":"https://doi.org/10.2147/jaa.s461295","url":null,"abstract":"<strong>Background:</strong> Allergic rhinitis (AR) is the most prevalent form of non-infectious rhinitis and is characterized by an immune response mediated by immunoglobulin E (IgE).<br/><strong>Aim:</strong> This study aims to compare the levels of biochemical markers and other parameters in individuals with AR, non-allergic rhinitis(n-AR), allergic rhinitis accompanied by symptoms of the lower respiratory tract(AR-SLRT), and healthy controls.<br/><strong>Study Design:</strong> Case control study.<br/><strong>Methods:</strong> Blood samples from the three study groups, AR (<em>n</em> = 22), n-AR (<em>n</em>=20), AR-SLRT group (<em>n</em> = 21), and the control group (n = 18), were analyzed to ascertain the levels of total IgE, specific IgE, periostin, pendrin, vitamin D, thyroid-stimulating hormone (TSH), free triiodothyronine (Ft3), free thyroxine (Ft4), anti-thyroid peroxidase (TPO), and eosinophilic cationic protein (ECP), as well as the leukocyte formula and hemogram.<br/><strong>Results:</strong> The AR and n-AR groups had significantly higher hematocrit values in comparison to the control group(p&lt; 0.05). Further, eosinophil counts were significantly higher in the AR and AR-SLRT groups than in the control group(<em>p</em>&lt; 0.05). Total IgE levels were significantly higher in the AR-SLRT group than in the AR, n-AR, and control groups (<em>p</em>&lt; 0.05). The AR group had higher total IgE values compared to the control group and the n-AR group(<em>p</em>&lt; 0.05). The values of ECP, periostin, pendrin, Ft3, Ft4, TSH, anti-TPO, and vitamin D did not differ significantly between the groups(<em>p</em>&gt; 0.05).<br/><strong>Conclusion:</strong> All the investigated groups did not differ in ECP, periostin, pendrin, Ft3, Ft4, TSH, anti-TPO, or vitamin D parameters. The groups with positive AR and AR-SLRT had higher eosinophil counts than the control group. The group with AR-SLRT had higher total IgE concentrations than the other groups.<br/><br/>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"43 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141252955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on the Mechanism and Application of Acupuncture Therapy for Asthma: A Review 针灸治疗哮喘的机制与应用研究:综述
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-05-29 DOI: 10.2147/jaa.s462262
Fei-xuan Wang, Lu-wei Jin
{"title":"Research on the Mechanism and Application of Acupuncture Therapy for Asthma: A Review","authors":"Fei-xuan Wang, Lu-wei Jin","doi":"10.2147/jaa.s462262","DOIUrl":"https://doi.org/10.2147/jaa.s462262","url":null,"abstract":"<strong>Abstract:</strong> Asthma is a high-risk disease based on airway hyperresponsiveness (AHR). In this review, we found that there are many studies on clinical therapy for asthma that focus on the efficacy of acupuncture therapy and its mechanisms, including the functional connectivity of different brain regions, with the aid of functional magnetic resonance imaging (fMRI), immune responses/cell recognition (innate lymphoid cells and balance of Th1/Th2 and Treg/Th17), intracellular mechanism (autophagy, endoplasmic reticulum stress, and epigenetic alteration), and ligand–receptor/chemical signaling pathway (neurotransmitter, hormone, and small molecules). In this review, we summarized the clinical and experimental evidence for the mechanisms of acupuncture therapy in asthma to offer insights into drug discovery and clinical therapy. Given the paucity of clinical studies on the mechanisms of acupuncture in the treatment of asthma, this review notably included studies based on animal models to investigate the mechanisms of acupuncture in the treatment of asthma.<br/><br/><strong>Keywords:</strong> asthma, acupuncture therapy, acupoint, mechanism, fMRI<br/>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"46 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141167000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient History Is Often Reliable in Cases of Venom-Induced Anaphylaxis: A Retrospective Observational Study 毒液诱发过敏性休克病例中的患者病史通常是可靠的:一项回顾性观察研究
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-05-28 DOI: 10.2147/jaa.s438894
Nina Hein, Conner Callaway, Devin Ford, John C Carlson
{"title":"Patient History Is Often Reliable in Cases of Venom-Induced Anaphylaxis: A Retrospective Observational Study","authors":"Nina Hein, Conner Callaway, Devin Ford, John C Carlson","doi":"10.2147/jaa.s438894","DOIUrl":"https://doi.org/10.2147/jaa.s438894","url":null,"abstract":"<strong>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"44 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Anxiety and Depression on the Level of Asthma Control Among Jordanian Adults with Asthma 焦虑和抑郁对约旦成人哮喘患者哮喘控制水平的影响
IF 3.2 3区 医学
Journal of Asthma and Allergy Pub Date : 2024-05-19 DOI: 10.2147/jaa.s457875
Ola Abu Al Karsaneh, Arwa Al Anber, Sofian Al Shboul, Moath Alrjoub, Omran Ibrahim Almashaqbeh, Mohammad Alqaisi, Rahaf Abuatieh, Suhaib Mohammad Ananzeh, Anas Mousa Hamad, Raneem Almomani, Mohammad Mahmoud Tommalieh
{"title":"Impact of Anxiety and Depression on the Level of Asthma Control Among Jordanian Adults with Asthma","authors":"Ola Abu Al Karsaneh, Arwa Al Anber, Sofian Al Shboul, Moath Alrjoub, Omran Ibrahim Almashaqbeh, Mohammad Alqaisi, Rahaf Abuatieh, Suhaib Mohammad Ananzeh, Anas Mousa Hamad, Raneem Almomani, Mohammad Mahmoud Tommalieh","doi":"10.2147/jaa.s457875","DOIUrl":"https://doi.org/10.2147/jaa.s457875","url":null,"abstract":"<strong>Purpose:</strong> Recent studies imply that psychological factors may actively contribute to the development of asthma. It is generally known that people with asthma frequently suffer from psychological illnesses. This association can make it challenging to reach asthma control. This study aimed to assess the prevalence of depression and anxiety among Jordanian adults with asthma, in addition to the link between asthma control levels and these psychological disorders.<br/><strong>Patients and Methods:</strong> This cross-sectional study included 175 adults with asthma who visited the tertiary asthma clinic in three Jordanian Governmental hospitals. Sociodemographic data was collected directly from the patients who were assessed for their level of depression and anxiety using a self-administered questionnaire, the Hospital Anxiety and Depression Scale (HADS). Also, asthma control was assessed using the Asthma Control Test (ACT). The relation between the different sociodemographic variables and clinical data, particularly depression and anxiety and asthma control level, was assessed.<br/><strong>Results:</strong> Among 175 asthmatic patients, 60.57% had poor disease control, 8% had anxiety alone, 11.43% had depression alone, and 53.14% had anxiety plus depression. Poor asthma control was significantly associated with anxiety and depression (<em>p= 0.044</em>) and low levels of education (<em>p=0.001</em>). Further, a lower level of education was also related to higher levels of anxiety and depression.<br/><strong>Conclusion:</strong> Most of the assessed Jordanian patients with asthma had their disease poorly controlled. Anxiety and depression are common among the studied sample of adults with asthma, and they appear to affect the level of disease control, suggesting the possibility that addressing these psychological conditions could enhance asthma control levels.<br/><br/><strong>Keywords:</strong> Asthma, Asthma control, anxiety, depression, Jordan<br/>","PeriodicalId":15079,"journal":{"name":"Journal of Asthma and Allergy","volume":"25 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141063050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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