Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review.

IF 3.7 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI:10.2147/JAA.S504925

Jingya Wang, Kang Yan, Leilei Ma, Xianglei Yan, Zihan Meng, Ji-An Li, Meng Wang, Chenguang Du, Yueyue Yu

引用次数: 0

Abstract

Asthma is a respiratory disease common among all age groups, and there is currently no cure that can be applied, as the patients react differently to the available treatments. Recent studies have shown that the Notch signaling pathway can regulate the dynamic balance between Th1 and Th2 cells, inhibit airway inflammation, reduce airway hyperresponsiveness and remodeling, and promote mesenchymal stem cell (MSCs) homing. This study conducted a comprehensive search of multiple large databases and provided a narrative review of the role of the Notch signaling pathway in asthma.

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Notch信号通路干扰作为可能的哮喘治疗：一个叙述性的回顾。

哮喘是一种在所有年龄组中都很常见的呼吸系统疾病，目前还没有治愈方法，因为患者对现有治疗方法的反应不同。近年来的研究表明，Notch信号通路可以调节Th1和Th2细胞之间的动态平衡，抑制气道炎症，减少气道高反应性和重塑，促进间充质干细胞（mesenchymal stem cell, MSCs）的归巢。本研究对多个大型数据库进行了全面检索，并对Notch信号通路在哮喘中的作用进行了叙述性回顾。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.