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Parasite immunomodulation and polymorphisms of the immune system. 寄生虫免疫调节和免疫系统的多态性。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-08-05 DOI: 10.1186/jbiol166
Rick M Maizels
{"title":"Parasite immunomodulation and polymorphisms of the immune system.","authors":"Rick M Maizels","doi":"10.1186/jbiol166","DOIUrl":"https://doi.org/10.1186/jbiol166","url":null,"abstract":"<p><p>Parasites are accomplished evaders of host immunity. Their evasion strategies have shaped every facet of the immune system, driving diversity within gene families and immune gene polymorphisms within populations. New studies published recently in BMC Biology and Journal of Experimental Medicine document parasite-associated immunosuppression in natural populations and suggest that host genetic variants favoring resistance to parasites may be detrimental in the absence of infection.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":" ","pages":"62"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40019527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 81
Lateral inhibition and concentration-invariant odor perception. 侧抑制和浓度不变气味感知。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-01-26 DOI: 10.1186/jbiol106
Susy M Kim, Jing W Wang
{"title":"Lateral inhibition and concentration-invariant odor perception.","authors":"Susy M Kim, Jing W Wang","doi":"10.1186/jbiol106","DOIUrl":"10.1186/jbiol106","url":null,"abstract":"<p><p>Sensory identity usually remains constant across a large intensity range. Vertebrates use lateral inhibition to match the sensitivity of retinal ganglion cells to the intensity of light. A new study published in Journal of Biology suggests that lateral inhibition in the Drosophila antennal lobe is similarly required for concentration-invariant perception of odors.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27985679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gene complement of the ancestral bilaterian - was Urbilateria a monster? 祖先双侧龙的基因补充——双侧龙是怪物吗?
Journal of Biology Pub Date : 2009-01-01 DOI: 10.1186/jbiol192
David J Miller, Eldon E Ball
{"title":"The gene complement of the ancestral bilaterian - was Urbilateria a monster?","authors":"David J Miller,&nbsp;Eldon E Ball","doi":"10.1186/jbiol192","DOIUrl":"https://doi.org/10.1186/jbiol192","url":null,"abstract":"<p><p>Expressed sequence tag analyses of the annelid Pomatoceros lamarckii, recently published in BMC Evolutionary Biology, are consistent with less extensive gene loss in the Lophotrochozoa than in the Ecdysozoa, but it would be premature to generalize about patterns of gene loss on the basis of the limited data available.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 10","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28529655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Life and death as a T lymphocyte: from immune protection to HIV pathogenesis. 作为T淋巴细胞的生与死:从免疫保护到HIV发病机制。
Journal of Biology Pub Date : 2009-01-01 DOI: 10.1186/jbiol198
Nienke Vrisekoop, Judith N Mandl, Ronald N Germain
{"title":"Life and death as a T lymphocyte: from immune protection to HIV pathogenesis.","authors":"Nienke Vrisekoop,&nbsp;Judith N Mandl,&nbsp;Ronald N Germain","doi":"10.1186/jbiol198","DOIUrl":"https://doi.org/10.1186/jbiol198","url":null,"abstract":"<p><p>Detailed analysis of T cell dynamics in humans is challenging and mouse models can be important tools for characterizing T cell dynamic processes. In a paper just published in Journal of Biology, Marques et al. suggest that a mouse model with its activated CD4(+) T cells are deleted has relevance for HIV infection.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 10","pages":"91"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28539674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Coordinated gene expression by post-transcriptional regulons in African trypanosomes. 非洲锥虫转录后调控的协调基因表达。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-12-14 DOI: 10.1186/jbiol203
Marc Ouellette, Barbara Papadopoulou
{"title":"Coordinated gene expression by post-transcriptional regulons in African trypanosomes.","authors":"Marc Ouellette,&nbsp;Barbara Papadopoulou","doi":"10.1186/jbiol203","DOIUrl":"https://doi.org/10.1186/jbiol203","url":null,"abstract":"<p><p>The regulation of gene expression in trypanosomes is unique. In the absence of transcriptional control at the level of initiation, a subset of Trypanosoma brucei genes form post-transcriptional regulons in which mRNAs are co-regulated in response to differentiation signals. See research articles http://www.biomedcentral.com/1471-2164/10/427, http://www.biomedcentral.com/1471-2164/10/482 and http://www.biomedcentral.com/1471-2164/10/495.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 11","pages":"100"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28600476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
Sperm dumping as a defense against meiotic drive. 精子倾倒作为对减数分裂驱动的防御。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-01-20 DOI: 10.1186/jbiol109
Tom Price, Zenobia Lewis, Nina Wedell
{"title":"Sperm dumping as a defense against meiotic drive.","authors":"Tom Price,&nbsp;Zenobia Lewis,&nbsp;Nina Wedell","doi":"10.1186/jbiol109","DOIUrl":"https://doi.org/10.1186/jbiol109","url":null,"abstract":"<p><p>Sperm from Drosophila simulans that carry a sex-ratio distorter is preferentially lost from females' sperm-storage organs. This suggests that sperm dumping is a major factor affecting sperm competition in this species, and may have evolved in response to sex-ratio distorters.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27985230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Happy together: genomic insights into the unique Nanoarchaeum/Ignicoccus association. 快乐在一起:对独特的纳米古菌/火苗球菌关联的基因组见解。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-01-23 DOI: 10.1186/jbiol110
Patrick Forterre, Simonetta Gribaldo, Céline Brochier-Armanet
{"title":"Happy together: genomic insights into the unique Nanoarchaeum/Ignicoccus association.","authors":"Patrick Forterre,&nbsp;Simonetta Gribaldo,&nbsp;Céline Brochier-Armanet","doi":"10.1186/jbiol110","DOIUrl":"https://doi.org/10.1186/jbiol110","url":null,"abstract":"<p><p>The complete genome sequence of the crenarchaeon Ignicoccus hospitalis published recently in Genome Biology provides a great leap forward in the dissection of its unique association with another hyperthermophilic archaeon, Nanoarchaeum equitans.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27985675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Genome degeneration affects both extracellular and intracellular bacterial endosymbionts. 基因组退化影响细胞外和细胞内细菌的内共生体。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-04-06 DOI: 10.1186/jbiol129
Heike Feldhaar, Roy Gross
{"title":"Genome degeneration affects both extracellular and intracellular bacterial endosymbionts.","authors":"Heike Feldhaar,&nbsp;Roy Gross","doi":"10.1186/jbiol129","DOIUrl":"https://doi.org/10.1186/jbiol129","url":null,"abstract":"<p><p>The obligate intracellular bacterial endosymbionts of insects are a paradigm for reductive genome evolution. A study published recently in BMC Biology demonstrates that similar evolutionary forces shaping genome structure may also apply to extracellular endosymbionts.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 3","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28243661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria. 重建原核生物转录调控网络:来自放线菌的教训。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-04-15 DOI: 10.1186/jbiol132
Thiago M Venancio, L Aravind
{"title":"Reconstructing prokaryotic transcriptional regulatory networks: lessons from actinobacteria.","authors":"Thiago M Venancio,&nbsp;L Aravind","doi":"10.1186/jbiol132","DOIUrl":"https://doi.org/10.1186/jbiol132","url":null,"abstract":"<p><p>Reconstruction of transcriptional regulatory networks of uncharacterized bacteria is a main challenge for the post-genomic era. Recent studies, including one in BMC Systems Biology, address this problem in the relatively underexplored actinobacteria clade, which includes major pathogenic and economically relevant taxa.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 3","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28243666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Conservation of core gene expression in vertebrate tissues. 脊椎动物组织中核心基因表达的一致性。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-04-16 DOI: 10.1186/jbiol130
Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael J H Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes
{"title":"Conservation of core gene expression in vertebrate tissues.","authors":"Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael J H Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris, Timothy R Hughes","doi":"10.1186/jbiol130","DOIUrl":"10.1186/jbiol130","url":null,"abstract":"<p><strong>Background: </strong>Vertebrates share the same general body plan and organs, possess related sets of genes, and rely on similar physiological mechanisms, yet show great diversity in morphology, habitat and behavior. Alteration of gene regulation is thought to be a major mechanism in phenotypic variation and evolution, but relatively little is known about the broad patterns of conservation in gene expression in non-mammalian vertebrates.</p><p><strong>Results: </strong>We measured expression of all known and predicted genes across twenty tissues in chicken, frog and pufferfish. By combining the results with human and mouse data and considering only ten common tissues, we have found evidence of conserved expression for more than a third of unique orthologous genes. We find that, on average, transcription factor gene expression is neither more nor less conserved than that of other genes. Strikingly, conservation of expression correlates poorly with the amount of conserved nonexonic sequence, even using a sequence alignment technique that accounts for non-collinearity in conserved elements. Many genes show conserved human/fish expression despite having almost no nonexonic conserved primary sequence.</p><p><strong>Conclusions: </strong>There are clearly strong evolutionary constraints on tissue-specific gene expression. A major challenge will be to understand the precise mechanisms by which many gene expression patterns remain similar despite extensive cis-regulatory restructuring.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 3","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28113335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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