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Open questions about influenza A (H1N1) 2009. 关于 2009 年甲型 H1N1 流感的开放性问题。
Journal of Biology Pub Date : 2009-01-01 DOI: 10.1186/jbiol182
Miranda Robertson
{"title":"Open questions about influenza A (H1N1) 2009.","authors":"Miranda Robertson","doi":"10.1186/jbiol182","DOIUrl":"10.1186/jbiol182","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"68"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28679240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A circuit supporting concentration-invariant odor perception in Drosophila. 果蝇支持浓度不变气味感知的回路。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-01-26 DOI: 10.1186/jbiol108
Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall
{"title":"A circuit supporting concentration-invariant odor perception in Drosophila.","authors":"Kenta Asahina, Matthieu Louis, Silvia Piccinotti, Leslie B Vosshall","doi":"10.1186/jbiol108","DOIUrl":"10.1186/jbiol108","url":null,"abstract":"<p><strong>Background: </strong>Most odors are perceived to have the same quality over a large concentration range, but the neural mechanisms that permit concentration-invariant olfactory perception are unknown. In larvae of the vinegar fly Drosophila melanogaster, odors are sensed by an array of 25 odorant receptors expressed in 21 olfactory sensory neurons (OSNs). We investigated how subsets of larval OSNs with overlapping but distinct response properties cooperate to mediate perception of a given odorant across a range of concentrations.</p><p><strong>Results: </strong>Using calcium imaging, we found that ethyl butyrate, an ester perceived by humans as fruity, activated three OSNs with response thresholds that varied across three orders of magnitude. Whereas wild-type larvae were strongly attracted by this odor across a 500-fold range of concentration, individuals with only a single functional OSN showed attraction across a narrower concentration range corresponding to the sensitivity of each ethyl butyrate-tuned OSN. To clarify how the information carried by different OSNs is integrated by the olfactory system, we characterized the response properties of local inhibitory interneurons and projection neurons in the antennal lobe. Local interneurons only responded to high ethyl butyrate concentrations upon summed activation of at least two OSNs. Projection neurons showed a reduced response to odors when summed input from two OSNs impinged on the circuit compared to when there was only a single functional OSN.</p><p><strong>Conclusions: </strong>Our results show that increasing odor concentrations induce progressive activation of concentration-tuned olfactory sensory neurons and concomitant recruitment of inhibitory local interneurons. We propose that the interplay of combinatorial OSN input and local interneuron activation allows animals to remain sensitive to odors across a large range of stimulus intensities.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27946612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting the promiscuity of imatinib. 利用伊马替尼的滥交性。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-04-15 DOI: 10.1186/jbiol134
Shun J Lee, Jean Y J Wang
{"title":"Exploiting the promiscuity of imatinib.","authors":"Shun J Lee,&nbsp;Jean Y J Wang","doi":"10.1186/jbiol134","DOIUrl":"https://doi.org/10.1186/jbiol134","url":null,"abstract":"<p><p>The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 A crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 3","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28168490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics. 细菌病原体单核增生李斯特菌:原核生物转录组学中的一个新兴模型。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-12-30 DOI: 10.1186/jbiol202
Pascale Cossart, Cristel Archambaud
{"title":"The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics.","authors":"Pascale Cossart,&nbsp;Cristel Archambaud","doi":"10.1186/jbiol202","DOIUrl":"https://doi.org/10.1186/jbiol202","url":null,"abstract":"<p><p>A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays, an article published in BMC Genomics reports the first use of RNA-seq in Listeria monocytogenes in order to identify genes controlled by sigma B, a transcriptional regulator with a critical role in virulence.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 12","pages":"107"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28629411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Limb regeneration revisited. 重新审视肢体再生。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-01-13 DOI: 10.1186/jbiol105
Jessica L Whited, Clifford J Tabin
{"title":"Limb regeneration revisited.","authors":"Jessica L Whited,&nbsp;Clifford J Tabin","doi":"10.1186/jbiol105","DOIUrl":"https://doi.org/10.1186/jbiol105","url":null,"abstract":"<p><p>The investigation of vertebrate limb regeneration, a favorite topic of early developmental biologists, is enjoying a renaissance thanks to recently developed molecular and genetic tools, as indicated in recent papers in BMC Biology and BMC Developmental Biology. Classical experiments provide a rich context for interpreting modern functional studies.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27957130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Mayr, mathematics and the study of evolution. 迈尔，数学和进化研究。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-02-23 DOI: 10.1186/jbiol117
James F Crow
{"title":"Mayr, mathematics and the study of evolution.","authors":"James F Crow","doi":"10.1186/jbiol117","DOIUrl":"https://doi.org/10.1186/jbiol117","url":null,"abstract":"<p><p>In 1959 Ernst Mayr challenged the relevance of mathematical models to evolutionary studies and was answered by JBS Haldane in a witty and convincing essay. Fifty years on, I conclude that the importance of mathematics has in fact increased and will continue to do so.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 2","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28048335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins. 无序中的联系:非原生相互作用可能支持蛋白质的远程偶联。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-03-13 DOI: 10.1186/jbiol126
Hue Sun Chan, Zhuqing Zhang
{"title":"Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins.","authors":"Hue Sun Chan,&nbsp;Zhuqing Zhang","doi":"10.1186/jbiol126","DOIUrl":"https://doi.org/10.1186/jbiol126","url":null,"abstract":"<p><p>A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 3","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28092154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Dysregulating the regulators. 对监管者的监管失灵。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-08-27 DOI: 10.1186/jbiol175
Miranda Robertson
{"title":"Dysregulating the regulators.","authors":"Miranda Robertson","doi":"10.1186/jbiol175","DOIUrl":"https://doi.org/10.1186/jbiol175","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 7","pages":"60"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28454402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
What we still don't know about AIDS. 我们对艾滋病还不了解的。
Journal of Biology Pub Date : 2009-01-01 DOI: 10.1186/jbiol200
Miranda Robertson
{"title":"What we still don't know about AIDS.","authors":"Miranda Robertson","doi":"10.1186/jbiol200","DOIUrl":"https://doi.org/10.1186/jbiol200","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 10","pages":"87"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28587619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Q&A: systems biology. 问答:系统生物学。
Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-01-26 DOI: 10.1186/jbiol107
James E Ferrell
{"title":"Q&A: systems biology.","authors":"James E Ferrell","doi":"10.1186/jbiol107","DOIUrl":"https://doi.org/10.1186/jbiol107","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":" ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39969294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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