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The effects of lipids on channel function. 脂质对通道功能的影响。
Journal of Biology Pub Date : 2009-10-06 DOI: 10.1186/jbiol178
Anthony G Lee
{"title":"The effects of lipids on channel function.","authors":"Anthony G Lee","doi":"10.1186/jbiol178","DOIUrl":"https://doi.org/10.1186/jbiol178","url":null,"abstract":"<p><p>Anionic lipids affect the function of many channels, including connexins, as shown in a recent report in BMC Biology. These effects might follow from direct binding of the anionic lipids to the channels.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"86"},"PeriodicalIF":0.0,"publicationDate":"2009-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28426800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Nursing some sense out of Myc. 让我恢复理智。
Journal of Biology Pub Date : 2009-09-28 DOI: 10.1186/jbiol181
Nicole M Sodir, Gerard I Evan
{"title":"Nursing some sense out of Myc.","authors":"Nicole M Sodir,&nbsp;Gerard I Evan","doi":"10.1186/jbiol181","DOIUrl":"https://doi.org/10.1186/jbiol181","url":null,"abstract":"<p><p>Data recently published in BMC Biology provide insights into the normal physiological function of c-myc in the development and regeneration of the mammary gland and indicate a key role in epithelial cell proliferation, elaboration of ductal alveoli, and the biosynthetic capacity and milk production of the mature organ.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":" ","pages":"77"},"PeriodicalIF":0.0,"publicationDate":"2009-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40056223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Physical forces in myelination and repair: a question of balance? 髓鞘形成和修复中的物理力量:平衡的问题?
Journal of Biology Pub Date : 2009-09-25 DOI: 10.1186/jbiol169
Nina G Bauer, Charles ffrench-Constant
{"title":"Physical forces in myelination and repair: a question of balance?","authors":"Nina G Bauer,&nbsp;Charles ffrench-Constant","doi":"10.1186/jbiol169","DOIUrl":"https://doi.org/10.1186/jbiol169","url":null,"abstract":"<p><p>A recent report in BMC Cell Biology examines how the balance of extracellular forces and intracellular contractions regulate the shape changes required for oligodendrocyte myelination. A failure of remyelination such as seen in multiple sclerosis could be caused by loss of this balance.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":" ","pages":"78"},"PeriodicalIF":0.0,"publicationDate":"2009-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40056222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Deciphering the genetic code of morphogenesis using functional genomics. 利用功能基因组学破译形态发生的遗传密码。
Journal of Biology Pub Date : 2009-09-22 DOI: 10.1186/jbiol180
Athea Vichas, Jennifer A Zallen
{"title":"Deciphering the genetic code of morphogenesis using functional genomics.","authors":"Athea Vichas,&nbsp;Jennifer A Zallen","doi":"10.1186/jbiol180","DOIUrl":"https://doi.org/10.1186/jbiol180","url":null,"abstract":"<p><p>A fundamental goal of developmental biology is to define the molecular mechanisms that control cell behavior during morphogenesis. A recent study in BMC Biology combines gene expression profiling, bioinformatics and functional analysis to identify genes that shape the Drosophila embryo.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":" ","pages":"76"},"PeriodicalIF":0.0,"publicationDate":"2009-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40048824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The 'stem cell' concept: is it holding us back? “干细胞”概念:它阻碍了我们的发展吗?
Journal of Biology Pub Date : 2009-09-21 DOI: 10.1186/jbiol177
Arthur D Lander
{"title":"The 'stem cell' concept: is it holding us back?","authors":"Arthur D Lander","doi":"10.1186/jbiol177","DOIUrl":"https://doi.org/10.1186/jbiol177","url":null,"abstract":"<p><p>Developmental biology, regenerative medicine and cancer biology are increasingly occupied with the molecular characterization of stem cells. Yet recent work adds to a growing body of literature suggesting that 'stemness' cannot be reduced to the molecular features of cell types, and is instead an emergent property of cell lineages under feedback control.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"70"},"PeriodicalIF":0.0,"publicationDate":"2009-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28413515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 79
Motifs from the deep. 来自深海的主题。
Journal of Biology Pub Date : 2009-09-02 DOI: 10.1186/jbiol174
Tony W Hwang, Vlad Codrea, Andrew D Ellington
{"title":"Motifs from the deep.","authors":"Tony W Hwang,&nbsp;Vlad Codrea,&nbsp;Andrew D Ellington","doi":"10.1186/jbiol174","DOIUrl":"https://doi.org/10.1186/jbiol174","url":null,"abstract":"<p><p>Because of the increasing recognition of the importance of non-coding RNAs in gene regulation, there is considerable interest in identifying RNA motifs in genomic data. In a recent report in BMC Genomics, Breaker and colleagues describe a new algorithm for identifying functional noncoding RNAs in metagenomic sequences of marine organisms, a strategy that may be particularly effective for discovering new and unique riboswitches.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"72"},"PeriodicalIF":0.0,"publicationDate":"2009-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28386712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complementary pathways in mammalian female sex determination. 哺乳动物雌性性别决定的互补途径。
Journal of Biology Pub Date : 2009-09-02 DOI: 10.1186/jbiol173
Serge Nef, Jean-Dominique Vassalli
{"title":"Complementary pathways in mammalian female sex determination.","authors":"Serge Nef,&nbsp;Jean-Dominique Vassalli","doi":"10.1186/jbiol173","DOIUrl":"https://doi.org/10.1186/jbiol173","url":null,"abstract":"<p><p>In mammals, the sex of the embryo is determined by the fate of the gonad. Recent papers, including one in BMC Developmental Biology, shed light on the molecular regulation of ovarian development and suggest that the R-spondin1/Wnt4/beta-catenin pathway and the Foxl2 transcription factor act in a complementary manner to promote ovarian fate and to repress testicular development.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"74"},"PeriodicalIF":0.0,"publicationDate":"2009-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28386711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme. 绝缘子作为染色体内和染色体间相互作用的介质:一个共同的进化主题。
Journal of Biology Pub Date : 2009-08-27 DOI: 10.1186/jbiol165
Chin-Tong Ong, Victor G Corces
{"title":"Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme.","authors":"Chin-Tong Ong,&nbsp;Victor G Corces","doi":"10.1186/jbiol165","DOIUrl":"https://doi.org/10.1186/jbiol165","url":null,"abstract":"<p><p>Insulator elements mediate intra- and inter-chromosomal interactions. The insulator protein CCCTC-binding factor (CTCF) is important for insulator function in several animals but a report in BMC Molecular Biology shows that Caenorhabditis elegans, yeast and plants lack CTCF. Alternative proteins may have a similar function in these organisms.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2009-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28451737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
The absolute pitch mind continues to reveal itself. 绝对音高思维不断显露出来。
Journal of Biology Pub Date : 2009-08-27 DOI: 10.1186/jbiol171
Patrick Bermudez, Robert J Zatorre
{"title":"The absolute pitch mind continues to reveal itself.","authors":"Patrick Bermudez,&nbsp;Robert J Zatorre","doi":"10.1186/jbiol171","DOIUrl":"https://doi.org/10.1186/jbiol171","url":null,"abstract":"<p><p>Absolute pitch has proved useful as an alternative perspective from which to investigate various cognitive faculties. A new functional magnetic resonance imaging study published recently in BMC Neuroscience adds new data to the ongoing debate concerning the neural underpinnings of this unusual ability.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"75"},"PeriodicalIF":0.0,"publicationDate":"2009-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28451738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
The complex genetic basis of simple behavior. 简单行为的复杂遗传基础。
Journal of Biology Pub Date : 2009-08-27 DOI: 10.1186/jbiol172
Anna J Jasinska, Nelson B Freimer
{"title":"The complex genetic basis of simple behavior.","authors":"Anna J Jasinska,&nbsp;Nelson B Freimer","doi":"10.1186/jbiol172","DOIUrl":"https://doi.org/10.1186/jbiol172","url":null,"abstract":"<p><p>Genetic approaches to dissecting complex traits in animal models increasingly use transcript levels as a molecular phenotype and as validation for predictions of gene function. A recent study in BMC Biology using these approaches shows the complexity of the genetic contribution to aggressive behavior in Drosophila.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 8","pages":"71"},"PeriodicalIF":0.0,"publicationDate":"2009-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28451739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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