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Reprogramming of the non-coding transcriptome during brain development. 大脑发育过程中非编码转录组的重编程。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-02-05 DOI: 10.1186/jbiol197
Saba Valadkhan, Timothy W Nilsen
{"title":"Reprogramming of the non-coding transcriptome during brain development.","authors":"Saba Valadkhan,&nbsp;Timothy W Nilsen","doi":"10.1186/jbiol197","DOIUrl":"https://doi.org/10.1186/jbiol197","url":null,"abstract":"<p><p>A recent global analysis of gene expression during the differentiation of neuronal stem cells to neurons and oligodendrocytes indicates a complex pattern of changes in the expression of both protein-coding transcripts and long non-protein-coding RNAs.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28714003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Regulation of metabolism in Caenorhabditis elegans longevity. 秀丽隐杆线虫长寿过程中的代谢调节。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-02-10 DOI: 10.1186/jbiol215
Marco Gallo, Donald L Riddle
{"title":"Regulation of metabolism in Caenorhabditis elegans longevity.","authors":"Marco Gallo,&nbsp;Donald L Riddle","doi":"10.1186/jbiol215","DOIUrl":"https://doi.org/10.1186/jbiol215","url":null,"abstract":"<p><p>The nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC Biology identifying metabolic signatures for longevity suggests that amino-acid pools may be important in longevity.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28714007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Robust and specific inhibition of microRNAs in Caenorhabditis elegans. 秀丽隐杆线虫中microrna的强大和特异性抑制。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-04-01 DOI: 10.1186/jbiol230
Samrat T Kundu, Frank J Slack
{"title":"Robust and specific inhibition of microRNAs in Caenorhabditis elegans.","authors":"Samrat T Kundu,&nbsp;Frank J Slack","doi":"10.1186/jbiol230","DOIUrl":"https://doi.org/10.1186/jbiol230","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 3","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28893826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Targeting TNF-alpha for cancer therapy. 靶向tnf - α用于癌症治疗。
Journal of Biology Pub Date : 2009-10-23 DOI: 10.1186/jbiol189
Elizabeth R Burton, Steven K Libutti
{"title":"Targeting TNF-alpha for cancer therapy.","authors":"Elizabeth R Burton,&nbsp;Steven K Libutti","doi":"10.1186/jbiol189","DOIUrl":"https://doi.org/10.1186/jbiol189","url":null,"abstract":"<p><p>As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on the gastric cancer vasculature with the anti-tumor cytokine TNF-alpha, and assesses its potential for gastric cancer therapy.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"85"},"PeriodicalIF":0.0,"publicationDate":"2009-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28463897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
TEs or not TEs? That is the evolutionary question. TEs还是不是TEs?这就是进化的问题。
Journal of Biology Pub Date : 2009-10-23 DOI: 10.1186/jbiol188
Keren Vaknin, Amir Goren, Gil Ast
{"title":"TEs or not TEs? That is the evolutionary question.","authors":"Keren Vaknin,&nbsp;Amir Goren,&nbsp;Gil Ast","doi":"10.1186/jbiol188","DOIUrl":"https://doi.org/10.1186/jbiol188","url":null,"abstract":"<p><p>Transposable elements (TEs) have contributed a wide range of functional sequences to their host genomes. A recent paper in BMC Molecular Biology discusses the creation of new transcripts by transposable element insertion upstream of retrocopies and the involvement of such insertions in tissue-specific post-transcriptional regulation.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2009-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28466212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Molecular machines or pleiomorphic ensembles: signaling complexes revisited. 分子机器或多形性集成：重新审视信号复合体。
Journal of Biology Pub Date : 2009-10-16 DOI: 10.1186/jbiol185
Bruce J Mayer, Michael L Blinov, Leslie M Loew
{"title":"Molecular machines or pleiomorphic ensembles: signaling complexes revisited.","authors":"Bruce J Mayer, Michael L Blinov, Leslie M Loew","doi":"10.1186/jbiol185","DOIUrl":"10.1186/jbiol185","url":null,"abstract":"<p><p>Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us away from investigating critical issues.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2009-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28441138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ockham's broom: A new series 奥卡姆的扫帚:一个新的系列
Journal of Biology Pub Date : 2009-10-16 DOI: 10.1186/JBIOL187
M. Robertson
{"title":"Ockham's broom: A new series","authors":"M. Robertson","doi":"10.1186/JBIOL187","DOIUrl":"https://doi.org/10.1186/JBIOL187","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"1 1","pages":"79 - 79"},"PeriodicalIF":0.0,"publicationDate":"2009-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86441855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Decoding the multifaceted HIV-1 virus-host interactome. 解码HIV-1病毒-宿主的多面相互作用组。
Journal of Biology Pub Date : 2009-10-13 DOI: 10.1186/jbiol183
Eric Y Chan, Marcus J Korth, Michael G Katze
{"title":"Decoding the multifaceted HIV-1 virus-host interactome.","authors":"Eric Y Chan,&nbsp;Marcus J Korth,&nbsp;Michael G Katze","doi":"10.1186/jbiol183","DOIUrl":"https://doi.org/10.1186/jbiol183","url":null,"abstract":"<p><p>Recently in BMC Medical Genomics, Tozeren and colleagues have uncovered virus-host interactions by searching for conserved peptide motifs in HIV and human proteins. Their computational model provides a novel perspective in the interpretation of high-throughput data on the HIV-host interactome.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"84"},"PeriodicalIF":0.0,"publicationDate":"2009-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28439914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Adaptation by introgression. 通过渗透来适应。
Journal of Biology Pub Date : 2009-10-13 DOI: 10.1186/jbiol176
Michael L Arnold, Noland H Martin
{"title":"Adaptation by introgression.","authors":"Michael L Arnold,&nbsp;Noland H Martin","doi":"10.1186/jbiol176","DOIUrl":"https://doi.org/10.1186/jbiol176","url":null,"abstract":"<p><p>Both selective and random processes can affect the outcome of natural hybridization. A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals the mosaic nature of introgression, which is probably caused by a combination of selection and demography.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"82"},"PeriodicalIF":0.0,"publicationDate":"2009-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28439913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 101
What are pharmacological chaperones and why are they interesting? 什么是药物伴侣，为什么它们有趣?
Journal of Biology Pub Date : 2009-10-13 DOI: 10.1186/jbiol186
Dagmar Ringe, Gregory A Petsko
{"title":"What are pharmacological chaperones and why are they interesting?","authors":"Dagmar Ringe,&nbsp;Gregory A Petsko","doi":"10.1186/jbiol186","DOIUrl":"https://doi.org/10.1186/jbiol186","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2009-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28439915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 105
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