发布求助
文献互助 智能选刊 最新文献

Journal of Biology最新文献

筛选
英文 中文
SnoPatrol: how many snoRNA genes are there? 有多少个snoRNA基因?
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-01-25 DOI: 10.1186/jbiol211
Paul P Gardner, Alex Bateman, Anthony M Poole
{"title":"SnoPatrol: how many snoRNA genes are there?","authors":"Paul P Gardner,&nbsp;Alex Bateman,&nbsp;Anthony M Poole","doi":"10.1186/jbiol211","DOIUrl":"https://doi.org/10.1186/jbiol211","url":null,"abstract":"<p><p>Small nucleolar RNAs (snoRNAs) are among the most evolutionarily ancient classes of small RNA. Two experimental screens published in BMC Genomics expand the eukaryotic snoRNA catalog, but many more snoRNAs remain to be found.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28686010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Evolution underground: shedding light on the diversification of subterranean insects. 地下进化:揭示地下昆虫的多样化。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-03-11 DOI: 10.1186/jbiol227
Carlos Juan, Brent C Emerson
{"title":"Evolution underground: shedding light on the diversification of subterranean insects.","authors":"Carlos Juan,&nbsp;Brent C Emerson","doi":"10.1186/jbiol227","DOIUrl":"https://doi.org/10.1186/jbiol227","url":null,"abstract":"<p><p>A recent study in BMC Evolutionary Biology has reconstructed the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade, revealing an ancient origin and strong geographic structuring. It seems likely that diversification of this clade in the Oligocene was seeded by an ancestor already adapted to subterranean life.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 3","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28782749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Robust and specific inhibition of microRNAs in Caenorhabditis elegans. 秀丽隐杆线虫中microrna的强大和特异性抑制。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-04-01 DOI: 10.1186/jbiol230
Samrat T Kundu, Frank J Slack
{"title":"Robust and specific inhibition of microRNAs in Caenorhabditis elegans.","authors":"Samrat T Kundu,&nbsp;Frank J Slack","doi":"10.1186/jbiol230","DOIUrl":"https://doi.org/10.1186/jbiol230","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of numerous target genes. Yet, while hundreds of miRNAs have been identified, little is known about their functions. In a recent report published in Silence, Zheng and colleagues demonstrate a technique for robust and specific knockdown of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a powerful tool for the study of regulation and function of miRNAs in vivo.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 3","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28893826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Targeting TNF-alpha for cancer therapy. 靶向tnf - α用于癌症治疗。
Journal of Biology Pub Date : 2009-10-23 DOI: 10.1186/jbiol189
Elizabeth R Burton, Steven K Libutti
{"title":"Targeting TNF-alpha for cancer therapy.","authors":"Elizabeth R Burton,&nbsp;Steven K Libutti","doi":"10.1186/jbiol189","DOIUrl":"https://doi.org/10.1186/jbiol189","url":null,"abstract":"<p><p>As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on the gastric cancer vasculature with the anti-tumor cytokine TNF-alpha, and assesses its potential for gastric cancer therapy.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"85"},"PeriodicalIF":0.0,"publicationDate":"2009-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28463897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
TEs or not TEs? That is the evolutionary question. TEs还是不是TEs?这就是进化的问题。
Journal of Biology Pub Date : 2009-10-23 DOI: 10.1186/jbiol188
Keren Vaknin, Amir Goren, Gil Ast
{"title":"TEs or not TEs? That is the evolutionary question.","authors":"Keren Vaknin,&nbsp;Amir Goren,&nbsp;Gil Ast","doi":"10.1186/jbiol188","DOIUrl":"https://doi.org/10.1186/jbiol188","url":null,"abstract":"<p><p>Transposable elements (TEs) have contributed a wide range of functional sequences to their host genomes. A recent paper in BMC Molecular Biology discusses the creation of new transcripts by transposable element insertion upstream of retrocopies and the involvement of such insertions in tissue-specific post-transcriptional regulation.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2009-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28466212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Molecular machines or pleiomorphic ensembles: signaling complexes revisited. 分子机器或多形性集成:重新审视信号复合体。
Journal of Biology Pub Date : 2009-10-16 DOI: 10.1186/jbiol185
Bruce J Mayer, Michael L Blinov, Leslie M Loew
{"title":"Molecular machines or pleiomorphic ensembles: signaling complexes revisited.","authors":"Bruce J Mayer,&nbsp;Michael L Blinov,&nbsp;Leslie M Loew","doi":"10.1186/jbiol185","DOIUrl":"https://doi.org/10.1186/jbiol185","url":null,"abstract":"<p><p>Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us away from investigating critical issues.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2009-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28441138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 94
Ockham's broom: A new series 奥卡姆的扫帚:一个新的系列
Journal of Biology Pub Date : 2009-10-16 DOI: 10.1186/JBIOL187
M. Robertson
{"title":"Ockham's broom: A new series","authors":"M. Robertson","doi":"10.1186/JBIOL187","DOIUrl":"https://doi.org/10.1186/JBIOL187","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"1 1","pages":"79 - 79"},"PeriodicalIF":0.0,"publicationDate":"2009-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86441855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Decoding the multifaceted HIV-1 virus-host interactome. 解码HIV-1病毒-宿主的多面相互作用组。
Journal of Biology Pub Date : 2009-10-13 DOI: 10.1186/jbiol183
Eric Y Chan, Marcus J Korth, Michael G Katze
{"title":"Decoding the multifaceted HIV-1 virus-host interactome.","authors":"Eric Y Chan,&nbsp;Marcus J Korth,&nbsp;Michael G Katze","doi":"10.1186/jbiol183","DOIUrl":"https://doi.org/10.1186/jbiol183","url":null,"abstract":"<p><p>Recently in BMC Medical Genomics, Tozeren and colleagues have uncovered virus-host interactions by searching for conserved peptide motifs in HIV and human proteins. Their computational model provides a novel perspective in the interpretation of high-throughput data on the HIV-host interactome.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"84"},"PeriodicalIF":0.0,"publicationDate":"2009-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28439914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Adaptation by introgression. 通过渗透来适应。
Journal of Biology Pub Date : 2009-10-13 DOI: 10.1186/jbiol176
Michael L Arnold, Noland H Martin
{"title":"Adaptation by introgression.","authors":"Michael L Arnold,&nbsp;Noland H Martin","doi":"10.1186/jbiol176","DOIUrl":"https://doi.org/10.1186/jbiol176","url":null,"abstract":"<p><p>Both selective and random processes can affect the outcome of natural hybridization. A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals the mosaic nature of introgression, which is probably caused by a combination of selection and demography.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"82"},"PeriodicalIF":0.0,"publicationDate":"2009-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28439913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 101
What are pharmacological chaperones and why are they interesting? 什么是药物伴侣，为什么它们有趣?
Journal of Biology Pub Date : 2009-10-13 DOI: 10.1186/jbiol186
Dagmar Ringe, Gregory A Petsko
{"title":"What are pharmacological chaperones and why are they interesting?","authors":"Dagmar Ringe,&nbsp;Gregory A Petsko","doi":"10.1186/jbiol186","DOIUrl":"https://doi.org/10.1186/jbiol186","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"8 9","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2009-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28439915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 105
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信