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Apical polarity in three-dimensional culture systems: where to now? 三维培养系统的顶端极性:现在该怎么办?
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-01-21 DOI: 10.1186/jbiol213
Jamie L Inman, Mina J Bissell
{"title":"Apical polarity in three-dimensional culture systems: where to now?","authors":"Jamie L Inman,&nbsp;Mina J Bissell","doi":"10.1186/jbiol213","DOIUrl":"https://doi.org/10.1186/jbiol213","url":null,"abstract":"<p><p>Delineation of the mechanisms that establish and maintain the polarity of epithelial tissues is essential to understanding morphogenesis, tissue specificity and cancer. Three-dimensional culture assays provide a useful platform for dissecting these processes but, as discussed in a recent study in BMC Biology on the culture of mammary gland epithelial cells, multiple parameters that influence the model must be taken into account.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28662263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 62
The mathematics of sexual attraction. 性吸引力的数学。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-03-29 DOI: 10.1186/jbiol233
José A Feijó
{"title":"The mathematics of sexual attraction.","authors":"José A Feijó","doi":"10.1186/jbiol233","DOIUrl":"https://doi.org/10.1186/jbiol233","url":null,"abstract":"<p><p>Pollen tubes follow attractants secreted by the ovules. In a recent paper in BMC Plant Biology, Stewman and colleagues have quantified the parameters of this attraction and used them to calibrate a mathematical model that reproduces the process and enables predictions on the nature of the female attractant and the mechanisms of the male response.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 3","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28891281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant? 有时一个是不够的:脊椎动物含有H2A吗?Z hyper-variant ?
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-01-21 DOI: 10.1186/jbiol214
Monika Mehta, Hyun-Soo Kim, Michael-Christopher Keogh
{"title":"Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?","authors":"Monika Mehta,&nbsp;Hyun-Soo Kim,&nbsp;Michael-Christopher Keogh","doi":"10.1186/jbiol214","DOIUrl":"https://doi.org/10.1186/jbiol214","url":null,"abstract":"<p><p>How much functional specialization can one component histone confer on a single nucleosome? The histone variant H2A.Z seems to be an extreme example. Genome-wide distribution maps show non-random (and evolutionarily conserved) patterns, with localized enrichment or depletion giving a tantalizing suggestion of function. Multiple post-translational modifications on the protein indicate further regulation. An additional layer of complexity has now been uncovered: the vertebrate form is actually encoded by two non-allelic genes that differ by expression pattern and three amino acids.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28662264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Regeneration review reprise. 再生审查，再生产。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-02-16 DOI: 10.1186/jbiol224
Jessica L Whited, Clifford J Tabin
{"title":"Regeneration review reprise.","authors":"Jessica L Whited,&nbsp;Clifford J Tabin","doi":"10.1186/jbiol224","DOIUrl":"https://doi.org/10.1186/jbiol224","url":null,"abstract":"<p><p>There have been notable advances in the scientific understanding of regeneration within the past year alone, including two recently published in BMC Biology. Increasingly, progress in the regeneration field is being inspired by comparisons with stem cell biology and enabled by newly developed techniques that allow simultaneous examination of thousands of genes and proteins.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 2","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28785002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Q&A: what can microfluidics do for stem-cell research? 微流体技术对干细胞研究有什么帮助?
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-02-11 DOI: 10.1186/jbiol220
Marie Csete
{"title":"Q&A: what can microfluidics do for stem-cell research?","authors":"Marie Csete","doi":"10.1186/jbiol220","DOIUrl":"https://doi.org/10.1186/jbiol220","url":null,"abstract":"","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28995670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The water flea Daphnia--a 'new' model system for ecology and evolution? 水蚤——生态学和进化的“新”模式系统?
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-01-13 DOI: 10.1186/jbiol212
Angelika Stollewerk
{"title":"The water flea Daphnia--a 'new' model system for ecology and evolution?","authors":"Angelika Stollewerk","doi":"10.1186/jbiol212","DOIUrl":"https://doi.org/10.1186/jbiol212","url":null,"abstract":"<p><p>Daphnia pulex is the first crustacean to have its genome sequenced. Availability of the genome sequence will have implications for research in aquatic ecology and evolution in particular, as addressed by a series of papers published recently in BMC Evolutionary Biology and BMC Genomics.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 2","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28995671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 94
The THO complex as a key mRNP biogenesis factor in development and cell differentiation. THO复合体在发育和细胞分化过程中是一个关键的mRNP生物发生因子。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-01-28 DOI: 10.1186/jbiol217
Sonia Jimeno, Andrés Aguilera
{"title":"The THO complex as a key mRNP biogenesis factor in development and cell differentiation.","authors":"Sonia Jimeno,&nbsp;Andrés Aguilera","doi":"10.1186/jbiol217","DOIUrl":"https://doi.org/10.1186/jbiol217","url":null,"abstract":"<p><p>The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent to be exported from the nucleus, yet its precise function is unknown. A recent study in BMC Biology on the role of the THOC5 subunit in cell physiology and mouse development provides new clues to the role of the THO complex in cell differentiation.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28781747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Genome of a songbird unveiled. 一种鸣禽的基因组被揭开。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-04-01 DOI: 10.1186/jbiol222
Raphael Pinaud
{"title":"Genome of a songbird unveiled.","authors":"Raphael Pinaud","doi":"10.1186/jbiol222","DOIUrl":"https://doi.org/10.1186/jbiol222","url":null,"abstract":"<p><p>An international collaborative effort has recently uncovered the genome of the zebra finch, a songbird model that has provided unique insights into an array of biological phenomena.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 3","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28893825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Reprogramming of the non-coding transcriptome during brain development. 大脑发育过程中非编码转录组的重编程。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-02-05 DOI: 10.1186/jbiol197
Saba Valadkhan, Timothy W Nilsen
{"title":"Reprogramming of the non-coding transcriptome during brain development.","authors":"Saba Valadkhan,&nbsp;Timothy W Nilsen","doi":"10.1186/jbiol197","DOIUrl":"https://doi.org/10.1186/jbiol197","url":null,"abstract":"<p><p>A recent global analysis of gene expression during the differentiation of neuronal stem cells to neurons and oligodendrocytes indicates a complex pattern of changes in the expression of both protein-coding transcripts and long non-protein-coding RNAs.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28714003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Regulation of metabolism in Caenorhabditis elegans longevity. 秀丽隐杆线虫长寿过程中的代谢调节。
Journal of Biology Pub Date : 2010-01-01 Epub Date: 2010-02-10 DOI: 10.1186/jbiol215
Marco Gallo, Donald L Riddle
{"title":"Regulation of metabolism in Caenorhabditis elegans longevity.","authors":"Marco Gallo,&nbsp;Donald L Riddle","doi":"10.1186/jbiol215","DOIUrl":"https://doi.org/10.1186/jbiol215","url":null,"abstract":"<p><p>The nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC Biology identifying metabolic signatures for longevity suggests that amino-acid pools may be important in longevity.</p>","PeriodicalId":15075,"journal":{"name":"Journal of Biology","volume":"9 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/jbiol215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28714007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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