Journal of Advanced Pharmacy Research最新文献

{"title":"Investigation of the Antihyperlipidemic Mechanism of Potential Probiotics","authors":"Fatma E. Salem, Mohamed M. Aboulwafa, Shahenda Mahgoub, Riham M. Shawky, Shima Ali Ibrahim","doi":"10.21608/aprh.2023.193433.1213","DOIUrl":"https://doi.org/10.21608/aprh.2023.193433.1213","url":null,"abstract":"Hypercholesterolemia leads to cardiovascular diseases that are almost the leading cause of death worldwide. The cholesterol-lowering effect of probiotics is getting increased attention especially that the chemical drugs produce several undesirable side effects. Understanding probiotics' potential effects and choosing the right way to use them requires research into the mechanisms through which they control serum cholesterol. Methods: In this study, we used two lactic acid bacteria (LAB) ( Lactococcus lactis ssp. lactis and Pediococcus sp.) that were isolated in a previous work of ours from dairy products and had a high in vitro cholesterol removal activity together with promising antihyperlipidemic effect in vivo . In the laboratory animal experiment conducted on hamsters for studying the antihyperlipidemic effect of probiotics, the livers of the different groups were excised, and the levels of hepatic total cholesterol and Cytochrome P450 Family 7 Subfamily A Member 1 ( CYP7A1) were determined. Statistical analyses were conducted by one-way analysis of variance (ANOVA) then post-hoc test. A probability of p -value < 0.05 was considered statistically significant. Results: Lactococcus lactis ssp. lactis and Pediococcus sp. significantly ( p < 0.05) decreased the hepatic total cholesterol levels by 24.96 % and 35.80 %, respectively and increased hepatic CYP7A1 levels by about 49.60% and 37.84 %, respectively in comparison to the diet-induced hyperlipidemic control group. There was no significant difference between the effect of the two isolates and the reference drug, atorvastatin in the levels of both test parameters. Conclusion: We introduce two potential probiotics with similar effect as atorvastatin on both hepatic total cholesterol and hepatic CYP7A1 levels. Thus, these isolates can act as adjuvant therapy to decrease the atorvastatin dose and consequently its side effects. The possible mechanism for the antihyperlipidemic effect could be through upregulation of hepatic CYP7A1 genes that leads to more bile acid synthesis from cholesterol and consequently decreasing liver cholesterol level.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76204459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heteroresistance: A Gray Side of Antimicrobial Susceptibility Testing","authors":"Alaa Al-Shebiny, Riham M. Shawky, M. Emara","doi":"10.21608/aprh.2023.193384.1212","DOIUrl":"https://doi.org/10.21608/aprh.2023.193384.1212","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76502316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Biofilms: A Current Clinical Dilemma and a Promising Therapeutic Target","authors":"Shaimaa Wahman, Riham M. Shawky, M. Emara","doi":"10.21608/aprh.2023.179064.1203","DOIUrl":"https://doi.org/10.21608/aprh.2023.179064.1203","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82497539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies Adopted to Improve Bioavailability of Glibenclamide: Insights on Novel Delivery Systems","authors":"N. Ahmed, Y. Abo-Zeid, W. Sakran","doi":"10.21608/aprh.2022.168998.1199","DOIUrl":"https://doi.org/10.21608/aprh.2022.168998.1199","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83650985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Sublingual Recombinant Human Insulin Drug Delivery System by Bioinformatics","authors":"M. Kassab","doi":"10.21608/aprh.2022.161468.1192","DOIUrl":"https://doi.org/10.21608/aprh.2022.161468.1192","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88517986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis, and Anti-Cancer Evaluation of some Novel Leucettamine B Analouges","authors":"Aisha Helali, M. Sarg, A. Bayoumi, Fatma Abdul Rahman","doi":"10.21608/aprh.2022.159329.1190","DOIUrl":"https://doi.org/10.21608/aprh.2022.159329.1190","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90335117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Spectrophotometric & Spectrofluorimetric Assay of Silodosin & Solifenacin in their Co-formulated Binary Mixture","authors":"Mona M. Abdel Moneim","doi":"10.21608/aprh.2022.161245.1191","DOIUrl":"https://doi.org/10.21608/aprh.2022.161245.1191","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81825103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common Applications of Black Cumin Seed (Nigella sativa) Oil in Folk Medicine","authors":"Rehab Hosni, Hesham Haffez, Hatem Elkordy","doi":"10.21608/aprh.2022.166251.1196","DOIUrl":"https://doi.org/10.21608/aprh.2022.166251.1196","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89584347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Several Nano Carriers to Improve the Solubility and the Bioavailability of Carvedilol","authors":"D. Mohamed, Wedad Skran, Y. Abo-Zeid","doi":"10.21608/aprh.2022.167884.1198","DOIUrl":"https://doi.org/10.21608/aprh.2022.167884.1198","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76535022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crosstalk between Maternal Life and Fetal Epigenome; A Review Article","authors":"Shahenda Mahgoub, Hadeer Abosalem, Dina M Mahmoud, D. Abdel Mohsen, Zeinab Abd-eltwab","doi":"10.21608/aprh.2022.144865.1181","DOIUrl":"https://doi.org/10.21608/aprh.2022.144865.1181","url":null,"abstract":"Background : It is important to say that maternal lifestyle during gestation could affect embryonic development and health consequences. Objectives : Many endogenous and exogenous factors affect the epigenetics of the germ cells during their division and subsequently affect the embryogenesis. Methods : This systematic review outline various studies that link the different environmental factors and modification in the fetal epigenome. Conclusion : Aberrant fetal epigenome modification subsequently affects the healthy embryonic growth and their contribution to the phenotypic changes and chronic disease development later in life. Study conducted reported an alteration in the gene expression involved in brain development. Nuclear factor one alpha (Nf1a) gene and N-methyl-d-aspartate (Nmda) receptor family were down-regulated in brain hippocampus. These TF regulate the expression of different genes involved in control gliogenesis, cell proliferation and neuronal cells survival 53","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88272116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}