Journal of Advanced Pharmacy Research最新文献_第10页

Determination of Flucloxacillin-sodium in Binary Mixture with Ampicillin-trihydrate Using Univariate and Multivariate Spectrophotometric Methods: A Comparative Study 单因素与多因素分光光度法测定氟氯西林钠与三水合氨苄西林二元混合物中氟氯西林钠含量的比较研究

Journal of Advanced Pharmacy Research Pub Date : 2018-06-12 DOI: 10.21608/APRH.2018.2362.1047

K. Attia, O. Abdel-Aziz, N. Nasef, G. Mohamed

引用次数: 1

PREPARATION AND EVALUATION OF RAPIDLY DISSOLVING ‎TABLET OF TELMISARTAN 替米沙坦快溶片的制备及评价

Journal of Advanced Pharmacy Research Pub Date : 2018-06-12 DOI: 10.21608/APRH.2018.2848.1050

A. Shatla, M. Osman

{"title":"PREPARATION AND EVALUATION OF RAPIDLY DISSOLVING ‎TABLET OF TELMISARTAN","authors":"A. Shatla, M. Osman","doi":"10.21608/APRH.2018.2848.1050","DOIUrl":"https://doi.org/10.21608/APRH.2018.2848.1050","url":null,"abstract":"Objective: The aim of this work was to enhance the dissolution rate of telmisartan with the goal of developing fast disintegrating tablets (FDTs) with subsequent rapid dissolution for sublingual administration. Methods: Binary solid dispersion systems (SDS) were prepared by solvent evaporation technique for the drug with Gelucire 44/14 (formula A), polyethylene glycol 4000 (PEG4000) (formula B), Pluronic F68 (formula C), hydroxypropyl methylcellulose E5 (HPMC E5) (formula D), and finally by using sodium bicarbonate with the drug in (0.5: 1) ratio (formula E), and (1:1) ratio (formula F). These systems were evaluated for drug dissolution in addition to the physicochemical changes of the drug utilizing FTIR spectroscopy, thermal analysis, and X-ray diffraction. Results: The prepared formulations using sodium bicarbonate significantly enhanced the dissolution rate of the drug compared with those prepared using different types of polymers. The order of enhanced dissolution of the drug in the first 5 min Q5 (%) was: formula E > F > D5, where the % drug dissolved was 88.94 ± 1.31, 84.77 ± 1.1 and72.6 ± 0.81 (mean + SD) for each formula, respectively. Formula E was selected for the formulation of the rapidly dissolving tablet of telmisartan since it showed enhanced dissolution of the drug, more palatable taste in the buccal cavity, relatively inexpensive material and ease of processing compared with a solid dispersion prepared using polymer. Conclusion: Sodium bicarbonate can be utilized in the preparation of telmisartan FDT with fast dissolution rate. Conclusion: sodium bicarbonate can be utilized in the preparation of telmisartan FDT ‎with fast dissolution rate.‎","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80712816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinson's disease: A Review about Pathogenesis, Pharmaceutical Treatment and Experimental Models 帕金森病的发病机制、药物治疗及实验模型研究进展

Journal of Advanced Pharmacy Research Pub Date : 2018-06-12 DOI: 10.21608/APRH.2018.8013

El Sayed, A. Eissa, S. Nofal, Engy Elmorsy

{"title":"Parkinson's disease: A Review about Pathogenesis, Pharmaceutical Treatment and Experimental Models","authors":"El Sayed, A. Eissa, S. Nofal, Engy Elmorsy","doi":"10.21608/APRH.2018.8013","DOIUrl":"https://doi.org/10.21608/APRH.2018.8013","url":null,"abstract":"Parkinson disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer disease, characterized by loss of dopaminergic neurons in substantia nigra pars compacta, accompanied by motor and non-motor symptoms. Idiopathic PD is the most common cause of Parkinsonism (primary Parkinsonism) while, certain medication and different groups of neurological disorder may be causes of secondary Parkinsonism. The presence of intraneuronal proteinaceous cytoplasmic inclusions “Lewy Bodies” and the loss of the nigrostriatal dopaminergic neurons are the main neuropathological hallmarks of PD. However, the etiology of the disease is still undefined; several studies assume that oxidative stress, mitochondrial defects, neuroinflammation, apoptosis and excitotoxicity play vital roles in the pathogenesis and progress of the disease. Experimental models of PD can be induced by several neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6-hydroxydopamine, rotenone and paraquat which produce neuropathological and neurochemical changes that are identical to those seen in PD. The primary drug for PD treatment is L-dopa; however, drug-induced dyskinesia and motor complications restricted its use as long term treatment. Dopamine agonists are alternative options for initial treatment of PD and have been reported to retard the onset of motor complications. Combination of L-dopa with other medications, such ascatechol-O-methyltransferase inhibitors and monoamine oxidase B inhibitors has the ability to alleviate L-dopa-induced motor complications. Anticholinergic drugs can be used to control the symptoms of PD but their cognitive and autonomic side effects make them unsuitable for the elderly.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90115163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INFLUENCE OF COSOLVENTS ON THE ABSORPTIVE CLEARANCE OF KETOTIFEN FUMARATE FROM RABBIT INTESTINE, IN-SITU 共溶剂对兔肠中富马酸酮替芬吸收清除的影响

Journal of Advanced Pharmacy Research Pub Date : 2018-06-12 DOI: 10.21608/APRH.2018.3450.1055

S. El-Gizawy, M. Osman, S. Ibrahim

{"title":"INFLUENCE OF COSOLVENTS ON THE ABSORPTIVE CLEARANCE OF KETOTIFEN FUMARATE FROM RABBIT INTESTINE, IN-SITU","authors":"S. El-Gizawy, M. Osman, S. Ibrahim","doi":"10.21608/APRH.2018.3450.1055","DOIUrl":"https://doi.org/10.21608/APRH.2018.3450.1055","url":null,"abstract":"Objective: Investigate the effect of ethanol, polyethylene glycol 400, propylene glycol, glycerol and sorbitol on the absorptive clearance of ketotifen fumarate in the rabbit. Methods: In-situ intestinal perfusion technique, through and through was used for estimation of membrane transport parameters of ketotifen fumarate from duodenum, jejunum, ileum and ascending colon in the rabbit. These parameters include absorptive clearance per unit length PeA/L (ml/min.cm), percentage fraction absorbed per unit length (% Fa/cm) and anatomical length that required for complete absorption in specific segment (L95%). Results: The absorption was in the order ascending colon> duodenum > jejunum> ileum; where the absorptive clearance normalized to intestinal segment length PeA/L (ml/min.cm) was 0.0071 ± 0.0003, 0.0058 ± 0.0001, 0.0051 ± 0.0001, and 0.0047 ± 0.0001 in each segment respectively. The effect of cosolvents in jejunum was in the order; ethanol 15% >glycerol 30% > propylene glycol (PG40%) > polyethylene glycol400 (PEG-400 40%) >sorbitol 40%, Where the absorptive clearance normalized to intestinal segment length PeA/L (ml/min.cm), mean ± SE was: 0.0142 ±0.0011, 0.0086 ± 0.0002, 0.0075 ± 0.0003, 0.0022 ± 0.0001, and 0.0014 ± 0.0001 for each cosolvents respectively. The same order was obtained in the ascending colon. Conclusion: The enhancing action of the ethanol, propylene glycol and glycerol may be due fluidization of the cell membrane with a subsequent increase in transcellular absorption, while the inhibitory effect of polyethylene glycol and sorbitol could attributed to water secretion, H-bonding formation and reduced thermodynamic activity of drug molecules.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80040463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Simultaneous Determination of Amlodipine and Rosuvastatin in Pharmaceutical Preparations by Square Wave Voltammetry 方波伏安法同时测定制剂中氨氯地平和瑞舒伐他汀的含量

Journal of Advanced Pharmacy Research Pub Date : 2018-06-12 DOI: 10.21608/APRH.2018.3134.1052

B. Yılmaz, Nurullah Yilmaz

{"title":"Simultaneous Determination of Amlodipine and Rosuvastatin in Pharmaceutical Preparations by Square Wave Voltammetry","authors":"B. Yılmaz, Nurullah Yilmaz","doi":"10.21608/APRH.2018.3134.1052","DOIUrl":"https://doi.org/10.21608/APRH.2018.3134.1052","url":null,"abstract":"Objectives: In this work, a new, rapid, simple, precise and specific method has been developed for the simultaneous determination of amlodipine (AML) and rosuvastatin (ROS) in pharmaceutical preparations by square wave voltammetry (SWV). Methods: Electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated using platinum disk electrode. Validation parameters such as specificity, linearity, accuracy, precision, ruggedness, stability, limit of quantification and limit of detection were studied according to the ICH Guidelines. Results: The linearity of this developed method was established in the concentration range of 5-40 μg/mL for AML and ROS, respectively. The precision was less than 1.88 and 1.93%, determined from quality control samples for AML and ROS, and accuracy was within 1.69 and 1.97% in terms of relative error, respectively. The percentage recovery obtained for AML and ROS in pharmaceutical preparations were 99.5 and 100.2%, respectively. Limit of detection and quantification for AML were 0.70 and 2.10 µg/mL, for ROS 0.80 and 2.40 µg/mL, respectively. Conclusion: The developed SWV method can be used for routine analysis of AML and ROS in pharmaceutical preparations.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81793111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product 依折替米在碱性降解产物存在下的密度测定

Journal of Advanced Pharmacy Research Pub Date : 2018-06-12 DOI: 10.21608/APRH.2018.3242.1053

A. Abdel-Fattah, Nasr M. El-Abasawi, Khalid A M Attia, A. A. Abo-serie, S. Morshedy

引用次数: 1