Journal of Advanced Pharmacy Research最新文献

{"title":"Current Practice in Weekly Pillbox Preparation and Perceived Added Value of Future Collaboration between Community Pharmacists and Home Care Nurses in Belgium","authors":"Robin Crunenberg, Olivier Ethgen, Claire Simon","doi":"10.21608/aprh.2023.222438.1228","DOIUrl":"https://doi.org/10.21608/aprh.2023.222438.1228","url":null,"abstract":"pharmacist-nurse","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136247208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico ADME Prediction and Molecular Docking of 1,2,3-Triazole-based Compounds Against Human Aromatase Cytochrome P450","authors":"Ola Nosseir, Yasmin Syam, Alaa Hashim, Radwan El-Haggar, Manal Anwar, Wafaa Zaghary","doi":"10.21608/aprh.2023.225722.1231","DOIUrl":"https://doi.org/10.21608/aprh.2023.225722.1231","url":null,"abstract":"Objective: Inhibition of the human aromatase cytochrome P450 enzyme has been emphasized as being an efficient mechanism for reducing high estrogen levels in the treatment of breast cancer. Methods: Molecular docking and in silico ADME predictions were performed for a set of 1,2,3-triazole-based compounds aiming for the discovery of new therapeutics targeting the human aromatase cytochrome P450 enzyme. Results: The results showed that compounds 1-3 are capable of binding to the enzyme active site, while compounds 4-8 and 9-11 are capable of binding to the potential allosteric sites 1 and 2 of the enzyme, respectively. Furthermore, all compounds 1-7 and 9-11 were predicted to be orally bioavailable, and compounds 1-3 , 9 , and 11 were anticipated to be blood-brain barrier permeants. Conclusion: Most of the designed compounds possessed relatively good binding affinities to the human placental aromatase cytochrome P450 enzyme and promising in silico ADME-related properties for further optimization towards developing novel human aromatase inhibitors.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136247237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential and Molecular Docking Perspective of Six Medicinal Plants against the Human SIRT-6 Protein Implicated in Type-2 Diabetes.","authors":"Ishola Abeeb Akinwumi, Barakat Ishola, Riswat Musbau, Aishat Abubakar, Adefolarin Owojuyigbe","doi":"10.21608/aprh.2023.222618.1226","DOIUrl":"https://doi.org/10.21608/aprh.2023.222618.1226","url":null,"abstract":"Despite the vast array of approved anti-diabetic drugs and the fact that these medications are often associated with other serious side effects like cardiovascular disease, weight gain, liver disorders, and countless others, the prevalence of Type-2 diabetes is soaring. Through in silico analysis, our study seeks to elucidate the anti-diabetic potential of six (6) medicinal plants Buchholzia coriacea, Vernonia amygdalina, Mimosa pudica, Momordica charantia, Bergenia ciliate, and Mangifera indica. Methods: Twenty-nine (29) bioactive compounds were selected from the six plants. Metformin and Miglitol are used as the control drug in this study. PubChem, an online server, was used to get the 3D structure of the bioactive compounds and the control drugs. The protein data bank was used to retrieve the crystal structure of the SIRT6 protein. The SwissADME online server was used for the Drug-likeness of the bioactive compounds and the control drugs. AutoDock was used for the molecular docking of compounds that passed the drug-likeness with the SIRT6 active site. The protein-ligand complexes were analyzed using a protein-ligand interaction profiler and proteins plus web server. The Molinspiration online server was used to predict compound bioactivity. The ADMETlab webserver was used to determine the ligands' ADMET properties. Results: The drug-likeness screening of the twenty-nine compounds and the control drugs revealed that twenty-five compounds have zero or one violation of Lipinski's rule of five. Metformin and Miglitol have zero violations. The docking analysis revealed that twenty out of the twenty-five compounds docked against the protein target have better binding affinity than the control drugs. Catechin, Luteolin, Chlorogenic acid, and Mimopudine have an excellent binding affinity of -8.4 kcal/mol -7.8 kcal/mol, -7.7 kcal/mol, and -7.5 kcal/mol, respectively. In contrast, Metformin and Miglitol have binding scores of -4.8 and -5.1 kcal/mol, respectively. Conclusions: Therefore, the greater binding affinity of the twenty compounds compared to the control drugs suggests that these compounds possess anti-diabetic properties with good interaction with the SIRT6 protein. However, this research needs further validation with molecular dynamics studies and in-vitro and in-vivo evaluation.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136247143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TITLE: Modernized management and formulation of nanovesicular drug delivery systems for treatment of keratitis","authors":"Reem Ragaey, Samar M. Abouelatta, Aya Elfouly","doi":"10.21608/aprh.2023.217709.1220","DOIUrl":"https://doi.org/10.21608/aprh.2023.217709.1220","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83231543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenolic profiling and analgesic activity of Citrullus lanatus var. citroides fruit","authors":"Heba T. Khazaal, Reham Bassyoni, M. Bishr, E. El-Sayed, R. E. El Dib, H. Soliman","doi":"10.21608/aprh.2023.217966.1221","DOIUrl":"https://doi.org/10.21608/aprh.2023.217966.1221","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73714146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superbug Arsenal: Antimicrobial Resistance in Hospital and Wastewater Environments","authors":"Ahmed Ahmed, Ahmed Saleh, Michael M. Kamal, Mennatallah M. Abdelrahman, Salma Abou Elhassan, R. Khalel, A. Elbehery","doi":"10.21608/aprh.2023.200708.1215","DOIUrl":"https://doi.org/10.21608/aprh.2023.200708.1215","url":null,"abstract":"Background : Antimicrobial resistance (AMR) is a serious problem with growing threats to the health situation of societies. AMR is particularly important in hospital environments and is a major cause of death in nosocomial (hospital-acquired) infections. Similarly, wastewater is a hotspot for AMR with high bacterial diversity and stress exerted by pollutants, such as antibiotics and heavy metals. Objectives : We sought to get a better insight of AMR in these two environments. Methods : In 30 high-throughput sequenced metagenomes from both environments, we assessed AMR using the open reading frames, called from the assembled contigs, via Resistance Gene Identifier. Taxonomy of the sequences for which AMR could be detected was also determined. Results : Taxonomy generally agreed between both environments for the most abundant families, namely, Enterobacteriaceae, Moraxellaceae, and Pseudomonadaceae. However, for other less abundant families, each environment showed unique distribution. On the genus level, Moraxellaceae and Pseudomonadaceae were mainly dominated by Acinetobacter and Pseudomonas , respectively, which are notorious superbugs. Assessment of AMR identified 1,652 AMR genes belonging to 156 gene families. Tetracycline occupied the top of the list of drug classes for which resistance was detected in both environments, followed by fluoroquinolones in hospital samples and macrolides in wastewater samples. Top resistance mechanisms detected in both environments were efflux pumps and antibiotic inactivation. Accordingly, gene families manifested this pattern of resistance mechanisms with the top three gene families being Resistance-Nodulation-Division (RND) efflux pumps, Major Facilitator Superfamily (MFS) efflux pumps, and OXA-beta-lactamases. Conclusions : Taken together, we shed light on AMR in two particularly important environments, emphasizing the significance of wastewater as a reservoir of resistance.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90087058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, In-vitro Antimalarial Activity and In silico Molecular Docking Study of Amino Chalcone Derivatives from 1-(2-aminophenyl)-3-(4- substituted-phenyl) prop-2-en-1-one and Dihydroquinolone Derivatives","authors":"A. Mulula, Abdeldjalil Bouzina, Joachim Nsomue, Hugues Mambu, Milka Tshingamb, A. Zaki","doi":"10.21608/aprh.2023.207345.1217","DOIUrl":"https://doi.org/10.21608/aprh.2023.207345.1217","url":null,"abstract":"Background: Malaria is one of the major global health problems in developing countries and faced to the increased resistance of Plasmodium falciparum against existing malarial agents, it is important to look for new antimalarial compounds that will be active in multiple stage of Plasmodium falciparum's life cycle. Objective: The goal of this work was to synthesize Amino Chalcone derivatives and Dihydroquinolone derivatives, then evaluate their antimalarial activity by standard computational and biological methods. Methods: These amino chalcones were synthesized by the ClaisenSchmidt condensation and by intramolecular cyclization of substituted amino chalcones for the Dihydroquinolones derivatives. Their structures have been determined by NMR (H and C). The in-vitro antimalarial assays were carried out by using the maturation test of trophozoites into schizonts. The molecular docking of these compounds was performed by AutoDock vina program using Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) (PDB ID 1J3I) as target protein. Results: All synthesized amino chalcones and dihydroquinolone derivatives were active against Fresh clinical isolates of Plasmodium falciparum with a range of EC50 ranging from 1.56 to 25μg/mL. However, the 2phenyl-2, 3-dihydroquinolin-4-(1H)-one (DHQ 2) and 2(4-methoxyphenyl)-2, 3-dihydroquinolin-4-(1H)-one (DHQ 4) showed excellent antimalarial activity with IC50 of 3.125 and 1.56 μg/mL, respectively. Whereas the IC50 of Chloroquine use as reference was 1.56μg/mL. Based on absorption, distribution, metabolism and excretion (ADME) properties, all synthetized compounds satisfied the Lipinski rule. Conclusion: The results suggest that these synthesized compounds (DHQ 2 and DHQ 4), could be used, after in vivo and clinical tests, like antimalarial supplement or even replace current drug therapies.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79507111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-Silver Nanoparticles: A Versatile Conjugate for Biotechnological Advancements","authors":"S. Faisal, Ahmed M. Hamed, Riham M. Shawky, M. Emara","doi":"10.21608/aprh.2023.218891.1222","DOIUrl":"https://doi.org/10.21608/aprh.2023.218891.1222","url":null,"abstract":"conjugates show promise for water purification, as they can effectively remove pollutants and disinfect water due to the antimicrobial properties of silver nanoparticles. Chitosan's ability to form gels and membranes further facilitates their use in filtration systems for wastewater treatment and environmental remediation. In conclusion, the conjugation of chitosan with silver nanoparticles represents a promising avenue in nano technology. This conjugate offers versatile applications in biomedicine and environmental remediation, leveraging the synergistic properties of both components. Further research and development are required to optimize the synthesis techniques, understand the mechanisms of action, and assess the long-term effects to ensure safe and effective utilization of chitosan-silver nanoparticle conjugates in various industries.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87169912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Potential of the ATP-Binding Cassette (ABC) Transporter Antigen as a Vaccine Candidate Against","authors":"Salma Abdallah, Mervat A. Kassem, Nelly M. Mohamed, M. Bahey-El-Din","doi":"10.21608/aprh.2023.177396.1202","DOIUrl":"https://doi.org/10.21608/aprh.2023.177396.1202","url":null,"abstract":"Objectives: The emerging multidrug-resistant strains of Acinetobacter baumannii and the limited available treatment options, have led the World Health Organization to enlist this pathogen among the microorganisms with critical priority demanding the development of novel treatment alternatives. This study aimed at exploring, for the first time, the potential of an efflux-related protein, the ATP-binding cassette (ABC) transporter substrate-binding protein, as a vaccine candidate against A. baumannii infections. The ABC transporter substrate-binding protein is known to play a role in the iron acquisition pathway of A. baumannii . It utilizes the energy released from the hydrolysis of ATP in the transportation of the iron-bound siderophore across the plasma membrane into the cell. Methods: In this work, the ABC transporter substrate-binding protein was expressed in Escherichia coli after cloning its respective gene into pQE31 plasmid vector. The protein was purified using metal affinity chromatography. The purified antigen was administered to mice in combination with Bacillus Calmette–Guérin (BCG) and alum nanoparticles as adjuvants. Immunological parameters were assessed, and protection was tested following bacterial challenge in a murine infection model. Results: Two weeks after the last immunization dose, serum samples were tested for antigen-specific IgG antibody response which was extremely significant in immunized mice when compared with negative control mice. Following challenge of mice with A. baumannii , only a short-lived protection lasting for 24 hours was obtained. Conclusion: The diversity of the virulence factors exhibited by A. baumannii including several iron acquisition mechanisms might necessitate the design of a multi-component vaccine to elicit effective protection. Furthermore, the immunization regimen, the used adjuvant, and the route of administration are critical factors which are worthy of further investigation to fulfill complete long-lasting protection.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80773228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public Health Interest of Vaccination Through Community Pharmacies: A Literature Review","authors":"Robin Crunenberg, Pauline Hody, O. Ethgen, Louis Hody, B. Delille","doi":"10.21608/aprh.2023.189159.1210","DOIUrl":"https://doi.org/10.21608/aprh.2023.189159.1210","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86521589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}