Journal of Analytical Science and Technology最新文献_第5页

Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1 小分子衍生物作为polo样激酶-1的polo-box结构域抑制剂的合成和评价

IF 2.4 4区化学

Journal of Analytical Science and Technology Pub Date : 2023-11-27 DOI: 10.1186/s40543-023-00411-3

Yeo Kyung La, Pethaiah Gunasekaran, Min Su Yim, Gong-Hyeon Lee, Yeon Sil Hwang, Kannan Damodharan, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu

{"title":"Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1","authors":"Yeo Kyung La, Pethaiah Gunasekaran, Min Su Yim, Gong-Hyeon Lee, Yeon Sil Hwang, Kannan Damodharan, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu","doi":"10.1186/s40543-023-00411-3","DOIUrl":"https://doi.org/10.1186/s40543-023-00411-3","url":null,"abstract":"Polo-like kinase 1 (Plk1) is an important mitotic protein. In particular, this protein is highly overexpressed in many types of tumors and has been identified as a potential biomarker for the treatment and diagnosis of tumors. Plk1 is composed of two domains, an N-terminal kinase domain and a C-terminal polo-box domain (PBD). Presently, inhibitors with improved selectivity and specificity for Plk1 are unavailable. Therefore, we aimed to develop an inhibitor targeting the C-terminal PBD present only in Plk1. In this study, three derivatives targeting PBD for Plk1 were designed by protein–protein interactions, which showed high levels of selectivity and specificity for Plk1 PBD, and were evaluated to inhibit tumor cell proliferation through an apoptotic process during tumor cell division. The investigation of the in vitro and in vivo antitumor effects of these inhibitors demonstrated that one of the new small molecules, 1, is a promising anticancer agent. Our findings can provide new insights for the design of novel Plk1 peptide inhibitors in the future.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"59 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138513825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning image segmentation for the reliable porosity measurement of high-capacity Ni-based oxide cathode secondary particles 基于深度学习图像分割的高容量镍基氧化物阴极二次粒子孔隙度可靠测量

IF 2.4 4区化学

Journal of Analytical Science and Technology Pub Date : 2023-11-21 DOI: 10.1186/s40543-023-00407-z

Hee-Beom Lee, Min-Hyoung Jung, Young-Hoon Kim, Eun-Byeol Park, Woo-Sung Jang, Seon-Je Kim, Ki-ju Choi, Ji-young Park, Kee-bum Hwang, Jae-Hyun Shim, Songhun Yoon, Young-Min Kim

{"title":"Deep learning image segmentation for the reliable porosity measurement of high-capacity Ni-based oxide cathode secondary particles","authors":"Hee-Beom Lee, Min-Hyoung Jung, Young-Hoon Kim, Eun-Byeol Park, Woo-Sung Jang, Seon-Je Kim, Ki-ju Choi, Ji-young Park, Kee-bum Hwang, Jae-Hyun Shim, Songhun Yoon, Young-Min Kim","doi":"10.1186/s40543-023-00407-z","DOIUrl":"https://doi.org/10.1186/s40543-023-00407-z","url":null,"abstract":"The optimization of geometrical pore control in high-capacity Ni-based cathode materials is required to enhance the cyclic performance of lithium-ion batteries. Enhanced porosity improves lithium-ion mobility by increasing the electrode–electrolyte contact area and reducing the number of ion diffusion pathways. However, excessive porosity can diminish capacity, thus necessitating optimizing pore distribution to compromise the trade-off relation. Accordingly, a statistically meaningful porosity estimation of electrode materials is required to engineer the local pore distribution inside the electrode particles. Conventional scanning electron microscopy (SEM) image-based porosity measurement can be used for this purpose. However, it is labor-intensive and subjected to human bias for low-contrast pore images, thereby potentially lowering measurement accuracy. To mitigate these difficulties, we propose an automated image segmentation method for the reliable porosity measurement of cathode materials using deep convolutional neural networks specifically trained for the analysis of porous cathode materials. Combined with the preprocessed SEM image datasets, the model trained for 100 epochs exhibits an accuracy of > 97% for feature segmentation with regard to pore detection on the input datasets. This automated method considerably reduces manual effort and human bias related to the digitization of pore features in serial section SEM image datasets used in 3D electron tomography. ","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"56 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138513840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple, sensitive, and label-free miRNA analysis through strand displacement reaction integrating with G-quadruplex-based signal generation 通过链置换反应结合基于g -四重丛的信号生成进行简单、灵敏、无标记的miRNA分析

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-11-13 DOI: 10.1186/s40543-023-00410-4

Hongmin Zhang, Jie Li, Hong Huang, Hao Wang, Sheng Qiu, Gangyi Yang

{"title":"Simple, sensitive, and label-free miRNA analysis through strand displacement reaction integrating with G-quadruplex-based signal generation","authors":"Hongmin Zhang, Jie Li, Hong Huang, Hao Wang, Sheng Qiu, Gangyi Yang","doi":"10.1186/s40543-023-00410-4","DOIUrl":"https://doi.org/10.1186/s40543-023-00410-4","url":null,"abstract":"Abstract MicroRNAs (miRNAs) play a significant role in the pathogenesis of various diseases throughout biological processes, and the accurate detection of miRNA biomarkers holds great potential for early stage disease diagnosis and treatment. In this study, a novel method is developed to detect miRNA-21, a biomarker for drug-induced liver injury, by combining target sequence recycling with G-quadruplex-based signal production. This approach is highly sensitive and does not require the use of labels. The target sequence facilitates the cyclic exposure of G-rich regions in the detection probe by toehold-mediated strand displacement processes, with the aid of the catalytic chain. The G-quadruplex sequences that have been produced subsequently interact with thioflavin T (ThT), resulting in a significant increase in its fluorescence intensity. This enhanced fluorescence is utilized for the purpose of detecting miRNA-21, with a remarkably low detection limit of 4.4 fM. The suggested technique also allows for the very specific identification of the target miRNA-21. Due to its non-label format, excellent selectivity, and sensitivity, this technology presents a straightforward and versatile approach for detecting a wide range of biomarkers in the early phases of illness detection.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"63 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional rolling circle amplification-based sensitive determination and low-speed centrifugation-based isolation of Staphylococcus aureus 基于功能滚环扩增的金黄色葡萄球菌灵敏检测及低速离心分离

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-10-26 DOI: 10.1186/s40543-023-00409-x

Yan Gao, Chaohui Li, Ying Wang, Xue Yu

{"title":"Functional rolling circle amplification-based sensitive determination and low-speed centrifugation-based isolation of Staphylococcus aureus","authors":"Yan Gao, Chaohui Li, Ying Wang, Xue Yu","doi":"10.1186/s40543-023-00409-x","DOIUrl":"https://doi.org/10.1186/s40543-023-00409-x","url":null,"abstract":"Abstract The ability to quickly and accurately analyze Staphylococcus aureus ( S. aureus ) and isolate the bacteria in a simplified setting is crucial for the early identification and treatment of infectious illnesses. Here, we describe the development of a new aptamer-based detection and separation technique that combines Mg 2+ -dependent DNAzyme amplification cascades with catalytic hairpin assembly for enhanced sensitivity. This technique uses a rolling circle amplification procedure to build a detection scaffold with a repetitive functional hairpin structure that, upon identifying S. aureus , can launch a catalytic hairpin assembly-mediated DNAzyme-based cascade signal amplification. This allows S. aureus to be isolated using low-speed centrifugation and simultaneously quantified. The approach has a low limit of detection of 21 cfu/mL and a broad detection range of six orders of magnitude due to the inclusion of the catalytic hairpin assembly for signal amplification. In addition to high sensitivity, the method also demonstrates high selectivity for the identification and isolation of S. aureus , making it a useful instrument for reporting S. aureus infections.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"31 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS UHPLC-MS /MS同时测定大鼠7种胆汁酸，研究伊维菌素对其血浆水平的影响

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-10-16 DOI: 10.1186/s40543-023-00408-y

T. V. Radhakrishna Mullapudi, Punna Rao Ravi, Ganapathi Thipparapu

{"title":"Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS","authors":"T. V. Radhakrishna Mullapudi, Punna Rao Ravi, Ganapathi Thipparapu","doi":"10.1186/s40543-023-00408-y","DOIUrl":"https://doi.org/10.1186/s40543-023-00408-y","url":null,"abstract":"Abstract Bile acids (BAs) are considered to be important diagnostic biomarkers to understand the pathophysiology of hepatobiliary and metabolic diseases. BAs regulate lipid and glucose metabolism by binding to farnesoid X receptor (FXR). To date, there were no reports on the effect of an exogenous FXR modulator, ivermectin (IVM), on the plasma BA profiles in rats. To explore the effect of IVM on plasma BA levels in rat, an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method was developed and validated for simultaneous determination of seven major BAs in rat plasma. The developed method was selective, specific, accurate and precise for the quantification of plasma BAs. Sprague–Dawley rats were orally administered with IVM at a dose of 5 mg/kg once a day for 14 days and the plasma BAs were determined before and after IVM exposure using developed UHPLC–MS/MS method. Once-daily administration of IVM for 14 days resulted in significant reduction in cholic acid and deoxycholic acid levels while glycodeoxycholic acid and taurodeoxycholic acid levels were not affected. Interestingly, tauro-α-muricholic acid and tauro-β-muricholic acid levels were significantly increased. This study revealed that IVM has an important effect on plasma BA profiles in rats. This report provides an analytical methodology that can be applied to investigate the effect of drugs or pathophysiological factors on plasma BA levels.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136114996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of iron-rich hydrochloric acid solutions for uranium, thorium, rare-earth elements and other heavy metals 富铁盐酸溶液对铀、钍、稀土元素和其他重金属的分析

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-10-05 DOI: 10.1186/s40543-023-00405-1

Beena Sunilkumar, M. Krishnakumar, A. A. Patwardhan

{"title":"Analysis of iron-rich hydrochloric acid solutions for uranium, thorium, rare-earth elements and other heavy metals","authors":"Beena Sunilkumar, M. Krishnakumar, A. A. Patwardhan","doi":"10.1186/s40543-023-00405-1","DOIUrl":"https://doi.org/10.1186/s40543-023-00405-1","url":null,"abstract":"Abstract A simple solvent extraction method is described for the separation of trace elements including uranium (U), thorium (Th) and rare-earth elements (REEs) from industrially processed iron-rich hydrochloric acid solutions. Iron (Fe) causes severe spectral interference during the analysis of trace elements using inductively coupled plasma optical emission spectrometer (ICP-OES) and U by light-emitting diode (LED)-based fluorimeter (LEDF). The spectral interferences of Fe on trace elements are studied and documented. Sequential solvent extractions using methyl isobutyl ketone (MIBK) effectively removed the highly interfering Fe from these processed acid solutions, thereby enabling accurate and sensitive determination of Cd, Zn, Pb, Co, Ni, Cr, V, Cu, Sr, Zr, Ti, REEs including radioactive elements like U and Th. Solvent extraction parameters like the number of extractions, aqueous-organic ratio and acidity have been optimized for removal of Fe. The accuracy of the method has been established by analyzing synthetically prepared hydrochloric acid solutions by spiking-recovery method. Ion exchange separation of REEs using Dowex 50 × 8 cation exchange resin has been also studied and reported. The precision obtained has been well within ± 10% RSD for elements having concentration above 10 mg L −1 and ± 15% for elements having concentration below 10 mg L −1 for replicate ( n = 5) measurements.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134975226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence determination of 3-MCPD by combining amino silica nanoparticles with fluorescein isothiocyanate 氨基二氧化硅纳米颗粒与异硫氰酸荧光素联合荧光测定3-MCPD

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-10-02 DOI: 10.1186/s40543-023-00406-0

Ting Xu, Zeng Qingru, Qing Fu, Zhaojie Wang, Xin Liu, Shensheng Xiao, Xiaoming Jiang, Yuepeng Lu, Zhiyong Gong, Yongning Wu, Min Fang

{"title":"Fluorescence determination of 3-MCPD by combining amino silica nanoparticles with fluorescein isothiocyanate","authors":"Ting Xu, Zeng Qingru, Qing Fu, Zhaojie Wang, Xin Liu, Shensheng Xiao, Xiaoming Jiang, Yuepeng Lu, Zhiyong Gong, Yongning Wu, Min Fang","doi":"10.1186/s40543-023-00406-0","DOIUrl":"https://doi.org/10.1186/s40543-023-00406-0","url":null,"abstract":"Abstract Using amino silica modified with fluorescein isothiocyanate (FITC), a quick fluorescence analysis technique is used for the detection of 3-monochloropropane-1,2-diol (3-MCPD). At 100 °C and pH 8.5, FITC-modified amino silica exhibits the lowest fluorescence intensity in the presence of 3-MCPD. This can predominantly be explained mostly explained by 3-MCPD’s capacity to occupy the amino group that FITC normally binds to. The fluorescence intensity of FITC-modified amino silica was greatly quenched by 3-MCPD’s reaction with the amino group under alkaline conditions, and the fluorescence intensity is different at different reaction times, reaction pH, and reaction temperature. The effects of various 3-MCPD concentrations on the optical characteristics of FITC-modified amino silica were also investigated. Fluorescence analysis is used to obtain a linear range from 0.025 to 1.0 mg/L for 3-MCPD detection under optimal experimental conditions, with a detection limit of 0.025 mg/L and a correlation coefficient of 0.9915. The quantity of 3-MCPD in soy sauce was measured under ideal conditions. Using the optimized conditions, the contents of 3-MCPD in soy sauce were determined. These results suggest that this method is sensitive to 3-MCPD and may have a substantial application in the rapid detection of food contaminants particularly, where the quality and safety of food products are of paramount concern.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135828495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary creatinine concentration and urine color as indicators of specimen validity test 尿肌酐浓度和尿色作为标本效度检验的指标

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-09-28 DOI: 10.1186/s40543-023-00397-y

Jaehyeong Park, Nam Hee Kwon, Seon Yeong Kim, Beom Jun Ko, Jin Young Kim

{"title":"Urinary creatinine concentration and urine color as indicators of specimen validity test","authors":"Jaehyeong Park, Nam Hee Kwon, Seon Yeong Kim, Beom Jun Ko, Jin Young Kim","doi":"10.1186/s40543-023-00397-y","DOIUrl":"https://doi.org/10.1186/s40543-023-00397-y","url":null,"abstract":"Abstract In this study, the concentration of urinary creatinine (Cr) and urine color were analyzed, and a correlation obtained, to objectively verify normal urine samples prior to forensic drug testing. Cr was analyzed via a colorimetric method based on the Jaffé reaction using a Cobas C-311 analyzer (Roche SA, Basel, Switzerland; Hitachi, Tokyo, Japan). The Cr concentration for urine specimen validity testing was measured to screen urine samples submitted after dilution or upon the addition of a foreign substance that interferes with drug testing. Urine samples containing < 20 mg/dL of Cr were classified as abnormal. The Korea Standard Color Analysis program was used for urine color analysis and correlations with Cr concentration analyzed. The color and Cr concentration of 271 urine samples were analyzed according to age and sex. The mean ± standard deviation of Cr concentration in males and females was 136.4 ± 66.2 mg/dL and 109.5 ± 71.1 mg/dL, respectively, with a statistically insignificant difference ( p = 0.4554). Furthermore, the participants were categorized into young (19–34 years), middle-aged (35–49 years), and elderly (≥ 50 years) groups to compare Cr concentration; however, no significant difference was found ( p = 0.2143–0.983). Strong variable correlations were identified between Cr and the characteristics of urine color. Despite various factors such as water consumption, health problems, and vitamins, urine color was found applicable for urine specimen validity testing. Future plans include the development of a smartphone camera application for use in urine color analysis to identify abnormal urine samples.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135344596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4-Mercaptobenzoic acid-modified Au@Ag nanoparticle-based colorimetric Cr3+ ions detection in aqueous solution 4-巯基苯甲酸修饰Au@Ag纳米粒子基比色法水溶液中Cr3+离子的检测

4区化学

Journal of Analytical Science and Technology Pub Date : 2023-09-21 DOI: 10.1186/s40543-023-00386-1

Zhikun Zhang, Heng Li, Dongan Guo, Cuixia Hu, Yumin Liu

{"title":"4-Mercaptobenzoic acid-modified Au@Ag nanoparticle-based colorimetric Cr3+ ions detection in aqueous solution","authors":"Zhikun Zhang, Heng Li, Dongan Guo, Cuixia Hu, Yumin Liu","doi":"10.1186/s40543-023-00386-1","DOIUrl":"https://doi.org/10.1186/s40543-023-00386-1","url":null,"abstract":"Abstract Heavy metal ions pose a threat to both ecological balance and human health owing to the non-biodegradable and poisonous characteristics. A simple, convenient and rapid metal ion monitoring plays a significant role for eliminating metal ions pollution. In this work, we prepared 4-mercaptobenzoic acids (4-MBA)-functionalized silver-coated gold nanoparticles (Au@Ag NPs) as colorimetric probes to construct colorimetric Chromium III (Cr 3+ ) ions detection platform. The results showed that 4-MBA-Au@Ag NPs could effectively coordinate with the low-concentration Cr 3+ ions with the group of -COOH, generating the obviously colorimetric reaction. To detection system, the optimal concentration of 4-MBA and pH was 5 μM and 9, respectively. Signal response was found to be proportional to Cr 3+ ions concentration in the range from 10 to 500 μM with a correlation coefficient of 0.993, with UV–Vis and colorimetric detection limits determined as 9 μM and 10 μM, respectively. In addition, the recovery of the system was estimated to be from 88.2 to 112.1%, which was satisfactory for practical analysis of samples. The platform would have great potential applications in many areas.","PeriodicalId":14967,"journal":{"name":"Journal of Analytical Science and Technology","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136235474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of isotope dilution-liquid chromatography tandem mass spectrometry for the accurate determination of vitamin K_1 in spinach and kimchi cabbage 同位素稀释液相色谱-串联质谱法测定菠菜和泡菜中维生素K_1

IF 2.4 4区化学

Journal of Analytical Science and Technology Pub Date : 2023-09-08 DOI: 10.1186/s40543-023-00399-w

Hyeyoung Lee, Joonhee Lee, H. Lee, Byungjoo Kim

引用次数: 0