Journal of Advances in Medicine Science最新文献_第5页

Relationship between CYP2E1 Gene Polymorphism and Anti-tuberculosis Drug-induced Liver Injury CYP2E1基因多态性与抗结核药物性肝损伤的关系

Journal of Advances in Medicine Science Pub Date : 2018-11-22 DOI: 10.30564/JAMS.V1I4.289

Donglin Zhu, Yun Xi, Jie-Ming Dong, F. Huang, Changzhi Xu, G. Xiao

{"title":"Relationship between CYP2E1 Gene Polymorphism and Anti-tuberculosis Drug-induced Liver Injury","authors":"Donglin Zhu, Yun Xi, Jie-Ming Dong, F. Huang, Changzhi Xu, G. Xiao","doi":"10.30564/JAMS.V1I4.289","DOIUrl":"https://doi.org/10.30564/JAMS.V1I4.289","url":null,"abstract":" Objective: To investigate the relationship between cytochrome P450 E1 (CYP2E1) gene polymorphisms and susceptibility to anti-tuberculosis drug-induced liver damage (ATDLI) in tuberculosis patients in the Chinese Han nationality. Methods: A retrospective analysis was performed on 360 patients with tuberculosis who had liver damage after tuberculosis treatment (case group) and 360 patients with tuberculosis who did not develop liver injury after treatment (control group). MassARRAY were used to detect CYP2E1 gene polymorphisms. Results: In a total of 8 tagged SNP loci selected, the rs8192773 locus failed to pass the test, and therefore, it is not included in subsequent analysis. At the remaining seven SNP sites, the difference in alleles was not statistically significant between the case group and the control group, suggesting that these sites may not be related to liver damage caused by anti-tuberculosis drugs. Three monomer domains were found in the seven tags SNP loci mentioned above. However, it was found that these haplotypes are not closely related to anti-tuberculosis drug-induced liver damage. Conclusion: The CYP2E1 gene polymorphism in the Chinese Han nationality is not related to the occurrence of anti-tuberculosis drug-induced liver injury.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77612966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequence Analysis of TNFRSF13b, Encoding TACI, in a Patient with Very Early Onset Inflammatory Bowel Disease: a Case Report 编码TACI的TNFRSF13b在极早发性炎症性肠病患者中的序列分析:一个病例报告

Journal of Advances in Medicine Science Pub Date : 2018-11-22 DOI: 10.30564/jams.v1i4.290

Jiaying Shen

{"title":"Sequence Analysis of TNFRSF13b, Encoding TACI, in a Patient with Very Early Onset Inflammatory Bowel Disease: a Case Report","authors":"Jiaying Shen","doi":"10.30564/jams.v1i4.290","DOIUrl":"https://doi.org/10.30564/jams.v1i4.290","url":null,"abstract":"Very early onset inflammatory bowel disease (VEO-IBD), IBD diagnosed before 6 years of age, frequently presents with increased severity, aggressive progression, and often poor response to conventional treatments. Although the cause of IBD is generally considered to be intestinal immune dysfunction induced by polygenic mutations and environment and other factors, VEO-IBD has a stronger genetic susceptibility specifically the neonatal- or infantile-onset IBD. Herein we report compound heterozygous mutations in the tumor necrosis factor receptor superfamily member 13b (TNFRSF13B) gene in a 3-year-old male that was admitted to our hospital with lasted jaundice, repeated fever and diarrhea in May 2014 at 2-month-old. He was diagnosed with VEO-IBD based on clinical, laboratory and histopathological examination. However, he was unresponsive to the conventional therapy, including the nutritional support therapy, antibiotic and immunosuppressive treatment, and surgical release of neonatal intestinal obstruction. Novel compound heterozygous mutations, c.[365G>A];[452C>T](p.[R122Q];[P151L]), were discovered in TNFRSF13B, encoding TACI, for this patient.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84570032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longevity Internal Elixir—Tradition of Yue School in East Sichuan for Warding off Disease, Keeping in Good Health and Cultivating Mind 长寿内药——川东越派的辟病养生养心传统

Journal of Advances in Medicine Science Pub Date : 2018-11-22 DOI: 10.30564/jams.v1i4.292

G. Tan

引用次数: 0

Clinical Application of Percutaneous Transluminal Angioplasty and Stent Implantation in Acute Lower Extremity Deep Venous Thrombosis 经皮腔内血管成形术及支架植入术在急性下肢深静脉血栓中的临床应用

Journal of Advances in Medicine Science Pub Date : 2018-11-22 DOI: 10.30564/JAMS.V1I4.115

Lei Zhang

引用次数: 0

Polysaccharide from Fruits of Physalis Alkekengi L. Enhances Antitumor Efficacy by a DNA Vaccine 酸浆果多糖对DNA疫苗抗肿瘤作用的研究

Journal of Advances in Medicine Science Pub Date : 2018-11-22 DOI: 10.30564/JAMS.V1I4.291

Yun Xi, Donglin Zhu, Jing Huang, Jingping Liu, Hua Li, G. Xiao

引用次数: 0

Association of Genetic Polymorphism of GSTM1 and GSTT1 with the Susceptibility to Antituberculosis Drug-induced Hepatotoxicity in Chinese Population 中国人群GSTM1和GSTT1基因多态性与抗结核药物肝毒性易感性的关系

Journal of Advances in Medicine Science Pub Date : 2018-09-04 DOI: 10.30564/JAMS.V1I3.56

G. Xiao

引用次数: 0

Effect of Detail Nursing Intervention on Headache and Negative Emotion in Patients with Subarachnoid Hemorrhage 细致护理干预对蛛网膜下腔出血患者头痛及负性情绪的影响

Journal of Advances in Medicine Science Pub Date : 2018-09-04 DOI: 10.30564/jams.v1i3.60

Yangyang Zhao, Jingyi Yang, Zhenyao Wang, Yingru Chen

引用次数: 0

Anti-inflammatory Effect of Heat-sensitive Moxibustion via the NF-κB Signaling Pathway on Cerebral Ischemia/Reperfusion Injury in Rats 热敏灸通过NF-κB信号通路对大鼠脑缺血再灌注损伤的抗炎作用

Journal of Advances in Medicine Science Pub Date : 2018-09-04 DOI: 10.30564/jams.v1i3.55

A. Xiaoa, Yisheng Xiaoa, Xin-ping Ouyang, Lin He, Ming-Ren Chen

{"title":"Anti-inflammatory Effect of Heat-sensitive Moxibustion via the NF-κB Signaling Pathway on Cerebral Ischemia/Reperfusion Injury in Rats","authors":"A. Xiaoa, Yisheng Xiaoa, Xin-ping Ouyang, Lin He, Ming-Ren Chen","doi":"10.30564/jams.v1i3.55","DOIUrl":"https://doi.org/10.30564/jams.v1i3.55","url":null,"abstract":"Ischemic stroke is universally acknowledged as a common cause of long-term disability or even death. Suspended moxibustion, an indirect form of moxibustion, is when moxibustion is placed superfcially over the skin without being in contact with it. Some researchers have used this method to treat stroke patients, but strong evidence of its therapeutic effectiveness is lacking.However, the effect of traditional suspended moxibustion has recently been improved with the development of heat-sensitive suspended moxibustion. Our previous studies showed that moxibustion for 35 min provided a more effective treatment strategy than moxibustion for 15 min, and moxibustion by 35 min with tail temperature increase had a better outcome than that without, however,the mechanism underlying the effect is not clear. In this study, we treated the stroke rats with moxibustion by 35min and divided them into non-heat sensitive moxibustion(NHSM) group and heat sensitive moxibustion (HSM) group according to difference in the tail temperature increase, then we compared the effect and investigated the mechanisms between NHSM and HSM. We found that HSM signifcantly decreased tail-ﬂick latency, increased neurological function score, decreased infarct volume, reduced inﬂammatory cells,decreased the expression of inﬂammatory factor ICAM-1 and reduced the expression of NF-κB p65 and p-IKKα/β in rats with focal cerebral ischemia/reperfusion injury. Our experimental fndings revealed that HSM exerted its anti-inﬂammatory and neuroprotective effects from MCAO-induced injury by decreasing the expression of the NF-κB signaling pathway.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79008438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation and Analysis on Constitution and Syndrome Types of HighNormal Blood Pressure People in Hebei Area in the Year of 2017 2017年河北地区高正常血压人群体质及证型调查分析

Journal of Advances in Medicine Science Pub Date : 2018-09-04 DOI: 10.30564/jams.v1i3.57

Qingchen Sun, Xianbing Hou, Hui Zhao, J. Chu, Yanjun Wang

{"title":"Investigation and Analysis on Constitution and Syndrome Types of HighNormal Blood Pressure People in Hebei Area in the Year of 2017","authors":"Qingchen Sun, Xianbing Hou, Hui Zhao, J. Chu, Yanjun Wang","doi":"10.30564/jams.v1i3.57","DOIUrl":"https://doi.org/10.30564/jams.v1i3.57","url":null,"abstract":"Purpose: To investigate the distribution of population and syndrome patterns in high-normal blood pressure people in Hebei area. Methods: A total of 453 people who met the inclusion criteria were investigated using a high-normal blood pressure human mass survey questionnaire. Results: of the 453 constitution types of high-normal blood pressure patients in Hebei area, 184were the constitution of yin-yang harmony, accounting for 40.62% of the total; 73 were the constitution of yang asthenia, accounting for 16.11% of the total; 59 were the constitution of damp-heat, accounting for 13.02% of the total; 52 were the constitution of qi asthenia, accounting for 11.48% of the total; 8 were the allergic constitution, accounting for 1.77% of the total. In addition, of their syndrome types, the syndrome of liver-fre hyperactivity were accounting for 30.24%; the syndrome of excessive phlegm-dampnesswere accounting for 26.71%; the syndrome of yin-defciency and yang-predominance were accounting for 23.18%; the syndrome of defciency of both yin and yang were accounting for 19.87%. Conclusion: Among the high-normal blood pressure people in Hebei area, the proportion of the constitution of yin-yang harmony is the highest, followed by the constitution of yang asthenia, the constitution of damp-heat, and the constitution of qi asthenia, with the lowest percentage being the allergic constitution. In addition, when it comes to the syndrome of them, the proportion of the syndrome of liver-fre hyperactivity is the highest, followed by the syndrome of yin-defciency and yang-predominance, and the lowest is the syndrome of defciency of both yin and yang.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74380009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Nursing Risk Management in Assisted Reproductive Nursing 护理风险管理在辅助生殖护理中的应用

Journal of Advances in Medicine Science Pub Date : 2018-09-04 DOI: 10.30564/jams.v1i3.58

T. Tian, Lingshan Wang

{"title":"Application of Nursing Risk Management in Assisted Reproductive Nursing","authors":"T. Tian, Lingshan Wang","doi":"10.30564/jams.v1i3.58","DOIUrl":"https://doi.org/10.30564/jams.v1i3.58","url":null,"abstract":"Objective: discuss and analyze the application effects of nursing risk management in assisted reproductive nursing.Methodology: this research was carried out by selecting 384 IVF-ET (In-vitro fertilization and embryo transfer) patients admitted bycertain hospital during February 2016 to February 2018 as research objects, who are classifed into general group and research group at random by numbering all randomly, with 192 objects per group for comparing adverse event rate and nursing quality of patients inthese two groups. Result: the adverse event rate of patients in research group is 4.17%, while that in general group is 10.94%, with the adverse event rate in research group lower than that in general group (P ＜ 0.05); the overall scores of nursing quality in research group is (96.37±9.37), while that in general group is (79.34±8.25), with the overall score in research group signifcantly higher than that in general group (P ＜ 0.05); the nursing satisfaction of research group and general group are 95.31% and 84.38% respectively, with the satisfaction in research group signifcantly higher than that in general group (P ＜ 0.05). Conclusion: in assisted reproductive nursing, the application of nursing risk management plays a critical role, which can not only reduce the adverse event rate, but also effectively improve the nursing quality of patients, as well as improve the nursing satisfaction of patients, thus being proven that nursing risk management shall be widely applied in clinical nursing.","PeriodicalId":14958,"journal":{"name":"Journal of Advances in Medicine Science","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81052946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0