Journal of Anaesthesiology, Clinical Pharmacology最新文献

{"title":"Airway management of a Crouzon syndromic child with mid face distractor in situ for redo osteotomy.","authors":"Kruthika Sree Manoharan, Sunil Rajan, Jerry Paul, Lakshmi Kumar","doi":"10.4103/joacp.joacp_37_24","DOIUrl":"10.4103/joacp.joacp_37_24","url":null,"abstract":"","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"544-545"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic management of neuroblastoma excision in child with Kinsbourne syndrome.","authors":"Nitika Goel, Nivedita, Indu Mohini Sen, Jai Kumar Mahajan","doi":"10.4103/joacp.joacp_208_24","DOIUrl":"10.4103/joacp.joacp_208_24","url":null,"abstract":"","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"554-555"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sugammadex versus neostigmine reversal on lung aeration score after operative fixation of cervical spine: A prospective, double blinded, randomised control trial.","authors":"Sumit R Chowdhury, Ashish Bindra, Gyaninder P Singh, Charu Mahajan, Maroof A Khan","doi":"10.4103/joacp.joacp_513_24","DOIUrl":"10.4103/joacp.joacp_513_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Traumatic cervical spine injury (tCSI) is associated with an increased risk of postoperative pulmonary complications (POPC) after surgical fixation. Sugammadex provides superior neuromuscular recovery; however, its effectiveness in reducing POPC in tCSI remains unclear. The primary outcome of this study was the ultrasonographic lung aeration score (LAS) at 24 hours after surgery. Secondary outcomes included extubation success in the operation theatre, POPC, length of intensive care unit stay, duration of mechanical ventilation, need for tracheostomy, hospital stay after surgery, and in-hospital mortality.</p><p><strong>Material and methods: </strong>In this prospective, double-blinded, randomised control trial, 75 patients undergoing elective fixation of tCSI were randomly allocated to either the neostigmine (N) group (<i>n</i> = 37) or sugammadex (S) group (n = 38) for neuromuscular blockade (NMB) reversal. A <i>P</i> value less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>There was no significant difference in LAS at 24 hours between groups [median (range) LAS: 2 (0-18) in the N group, 2 (0-19) in the S group] (<i>P</i> = 0.632) or in any other secondary outcomes. The incidence of POPC was 27.03% in the N group and 26.32% in the S group (<i>P</i> = 0.944) Exploratory analysis did not find any difference in outcomes based on the level [high (C1-C4) vs. low (C5-C7)] or severity [American Spinal Injury Association (ASIA) impairment scale: A, B vs. C, D, E] of spinal injury (<i>P</i> > 0.05). A LAS of 4 at 24 h predicted the development of POPC within 7 days with 80% sensitivity and 87.27% specificity (area under the receiver operator characteristics curve: 0.9032).</p><p><strong>Conclusion: </strong>In tCSI, NMB reversal using either sugammadex or neostigmine resulted in comparable LAS at 24 h postoperatively following cervical spine fixation. Additionally, a LAS of 4 was found to be a strong predictor of POPC within a 7-day follow-up period.</p>","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"523-531"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral sacral erector spinae plane block for lower limb surgery in children.","authors":"Vikram Chandra, Chandni Sinha, Amarjeet Kumar, Shagufta Naaz","doi":"10.4103/joacp.joacp_156_24","DOIUrl":"10.4103/joacp.joacp_156_24","url":null,"abstract":"","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"545-547"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic management of chronic thromboembolic pulmonary hypertension for surgical pulmonary thromboendarterectomy: A narrative review.","authors":"Sambhunath Das, K G Krithika","doi":"10.4103/joacp.joacp_362_24","DOIUrl":"10.4103/joacp.joacp_362_24","url":null,"abstract":"<p><p>Chronic thromboembolic pulmonary hypertension (CTEPH) is caused due to the total or partial occlusion of the pulmonary vasculature due to organized thrombus, leading to severe pulmonary hypertension and eventually right heart failure, which makes anesthetic management very challenging. Pulmonary endarterectomy (PTE) is the treatment of choice for patients with operable CTEPH. The objective of the present review is to examine the preoperative evaluation, anesthesia technique, and postoperative management in the intensive care unit (ICU) of patients with CTEPH after PTE. We identified published journal articles in the last 25 years from PubMed and Google Scholar databases with the keywords \"chronic thromboembolic pulmonary hypertension,\"\" anesthetic management of pulmonary thrombo-endarterectomy,\" and \"perioperative management of CTEPH.\" One hundred fifty-three articles were reviewed, out of which 30 articles were retrieved finally. Based on the articles reviewed, we inferred that a balanced anesthesia technique should be carefully chosen to avoid hemodynamic collapse. Transesophageal echocardiography (TEE) is used to assess biventricular function, peak pulmonary artery pressure, the severity of tricuspid regurgitation, location and extent of thrombus, and guide pulmonary artery catheter insertion. Deep hypothermic circulatory arrest (DHCA) is utilized to perform a complete endarterectomy into segmental and subsegmental arterial branches. This narrative review article highlights the role of anesthesiologists in preoperative evaluation, intraoperative TEE guidance, anesthetic management, and postoperative management of complications such as reperfusion pulmonary edema, residual pulmonary hypertension, intrapulmonary hemorrhage, and the consequences of DHCA in patients with CTEPH undergoing surgical PTE. Future research is required to study the effects of DHCA and free radical injuryon postoperative complications and its prevention.</p>","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"418-426"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of dual versus single subsartorial block for postoperative analgesia after total knee arthroplasty - A randomized, double-blind study.","authors":"Devyani Desai, Neha Shah, Kanchan Choube","doi":"10.4103/joacp.joacp_206_24","DOIUrl":"10.4103/joacp.joacp_206_24","url":null,"abstract":"<p><strong>Background and aims: </strong>This study compared the dual sub-sartorial block (DSB), which allegedly includes all pain generators of the anterior and posterior compartments of the knee joint, to the routinely used single sub-sartorial bock (SSB), in terms of analgesic efficacy and preservation of motor strength after unilateral total knee arthroplasty (TKA).</p><p><strong>Material and methods: </strong>Sixty patients aged 18-80 years and ASA grade I-III undergoing unilateral TKA were randomised to two groups postoperatively to receive DSB or SSB. Patients in group DSB received distal femoral triangle block (15 ml) + proximal adductor canal block (20 ml), while group SSB received only proximal adductor canal block (20 ml). Primarily, the changes in pain intensity and pain control in terms of static and dynamic visual analogue score (VAS) with the duration of analgesia and cumulative dose requirement of rescue analgesic in the first 24 hours postoperatively were studied. Secondary outcomes were the postoperative degree of motor blockade, the ability of early ambulation, patient satisfaction and complications. Statistical analysis was done using the student <i>t</i>-test and Chi-square test using MedCalc version 12.4.3.0.</p><p><strong>Result: </strong>At all time intervals, the static and dynamic VAS scores were lower in the patients with the DSB group (<i>P</i> < 0.001) with longer duration of postoperative analgesia (14.96 ± 5.05 vs 6.03 ± 1.73 hours, <i>P</i> < 0.0001) and less requirement of total parenteral analgesic (1.06 ± 0.37 vs 2 ± 0.52, <i>P</i> < 0.0001) in first 24 hours postoperatively. A shorter time was required to finish the Timed Up and Go test for patients belonging to the DSB group (53.48 ± 4.06 vs 66.16 ± 6.23 seconds, <i>P</i> < 0.0001) in comparison to group SSB.</p><p><strong>Conclusion: </strong>DSB provided better pain control with a longer duration of analgesia and required fewer doses of parenteral analgesics in the first 24 hours postoperatively after TKA, as opposed to SSB. Neither block had incidences of motor weakness and other complications.</p>","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"470-477"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of efficacy of suprascapular nerve block using local anaesthetic and two different doses of steroid in cervical radicular pain.","authors":"Naveen Malhotra, Rishabh Anand, Amit Kumar, Neha Sinha, Vaishali Phogat, N Charan","doi":"10.4103/joacp.joacp_284_24","DOIUrl":"10.4103/joacp.joacp_284_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Neck pain resulting from various cervical spine disorders ranks second among the leading cause of musculoskeletal disorders. This prospective study was conducted to compare the efficacy of suprascapular nerve block (SSNB) using a local anaesthetic and two different doses of dexamethasone in patients with cervical radicular pain.</p><p><strong>Material and methods: </strong>Forty participants were randomised into Group I (n = 20), in which patients received a SSNB with 6 ml of a drug solution comprising 0.25% bupivacaine (4 ml) and 8 mg of dexamethasone (2 ml), and Group II (n = 20), in which patients received SSNB with 6 ml of a drug solution comprising 0.25% bupivacaine (4 ml), 4 mg of dexamethasone (1 ml), and normal saline (1 ml). Patients were followed for a period of six months. The numeric rating scale (NRS), patient global impression of change (PGIC), need for repeat injections, and side effects were compared between the two groups.</p><p><strong>Results: </strong>NRS and PGIC scores were found to be comparable between the two groups at all time intervals (<i>P</i> > 0.05). There was no significant difference amongst the two groups in terms of the number of repeat injections (<i>P</i> > 0.05). None of the patients reported any serious side effects.</p><p><strong>Conclusions: </strong>A SSNB with a local anaesthetic and either 8 mg or 4 mg of dexamethasone is an equally effective technique for managing patients with cervical radicular pain. Hence, a SSNB with 4 mg of dexamethasone can be utilised to reduce the steroid dose without compromising the efficacy and safety of the treatment in patients with cervical radicular pain.</p>","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"491-495"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fake it till you make it? AI hallucinations and ethical dilemmas in Anesthesia research and practice.","authors":"M Ashwin, Sukriti Jha, Ganga Prasad, Subodh Kumar","doi":"10.4103/joacp.joacp_56_25","DOIUrl":"10.4103/joacp.joacp_56_25","url":null,"abstract":"","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"381-383"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of ABO-incompatible kidney transplant: Anesthetic considerations and management.","authors":"Srinivasan Ramachandran, Senthil Kumaran Sundaram, Savitri Velayudhan","doi":"10.4103/joacp.joacp_262_24","DOIUrl":"10.4103/joacp.joacp_262_24","url":null,"abstract":"","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"552-553"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study.","authors":"Kajal Shrestha, Priyanka Gupta, Mridul Dhar","doi":"10.4103/joacp.joacp_484_24","DOIUrl":"10.4103/joacp.joacp_484_24","url":null,"abstract":"<p><strong>Background and aims: </strong>Intravenous magnesium sulfate is known to reduce hemodynamic response of laryngoscopy and intubation. However, it is associated with some systemic side effects. We compared the efficacy of nebulized and intravenous magnesium sulfate pretreatment on attenuation of hemodynamic response during tracheal intubation.</p><p><strong>Material and methods: </strong>Sixty-six American Society of Anesthesiologists classification I-II patients aged 18-65 were randomly assigned to two groups: Group IV, which received 30 mg/kg of intravenous magnesium sulfate, and Group IN, which received the same dose via nebulization. Intubation was performed by an experienced anesthesiologist who was blinded to group allocation. The primary outcomes were heart rate (HR) and mean arterial pressure (MAP) during laryngoscopy and intubation. Secondary outcomes included propofol consumption for anesthesia induction, time to achieve a train-of-four (TOF) ratio of 0 after vecuronium administration, and any adverse effects.</p><p><strong>Results: </strong>Both groups showed similar attenuation of hemodynamic responses during laryngoscopy and intubation (HR: <i>P</i> =0.139, MAP: <i>P</i> =0.40). Propofol consumption (mg) was comparable between the groups (113.64 in Group IN vs. 113.79 in Group IV, <i>P</i> = 0.629). However, the time (seconds) to achieve a TOF ratio of 0 was significantly shorter in Group IV compared to Group IN (228.33 vs. 247.09, <i>P</i> = 0.035).</p><p><strong>Conclusion: </strong>Nebulized magnesium sulfate was as effective as intravenous magnesium sulfate in reducing hemodynamic changes during intubation, offering a noninvasive alternative for managing this response.</p>","PeriodicalId":14946,"journal":{"name":"Journal of Anaesthesiology, Clinical Pharmacology","volume":"41 3","pages":"538-542"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}