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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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Drug Delivery to the Lungs V–Inhaled Drug Delivery from Aqueous Based Systems 肺内药物输送v -水基系统的吸入药物输送
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.267
J. Ward
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引用次数: 0
Deposition of Dry Powder Aerosols in Cascade Impactors at Different Flow Rates 不同流速下干粉气溶胶在叶栅冲击器中的沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.181
J. Onyechi, G. P. Martin, C. Marriott, L. Murphy
{"title":"Deposition of Dry Powder Aerosols in Cascade Impactors at Different Flow Rates","authors":"J. Onyechi, G. P. Martin, C. Marriott, L. Murphy","doi":"10.1089/JAM.1994.7.181","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.181","url":null,"abstract":"ABSTRACT A monodisperse aerosol generator (MAGE), has been used to generate calibration aerosols containing stearic acid and Rhodamine B500. The aerosols were used to assess particle deposition cha...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"99 1","pages":"181-184"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79292160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Selective Deposition of Pulsed Charged Aerosols in the Human Lung 脉冲带电气溶胶在人肺中的选择性沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.167
A. Hashish, A. Bailey, T. Williams
{"title":"Selective Deposition of Pulsed Charged Aerosols in the Human Lung","authors":"A. Hashish, A. Bailey, T. Williams","doi":"10.1089/JAM.1994.7.167","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.167","url":null,"abstract":"ABSTRACT The charged, pulsed aerosol technique has the advantage that the inspired aerosol can be delivered efficiently to sites of interest within the lung, and that the exposure time of an airway...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"29 1","pages":"167-171"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90405960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Abstracts from the Aerosol Literature 气溶胶文献摘要
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.303
I. Gonda
{"title":"Abstracts from the Aerosol Literature","authors":"I. Gonda","doi":"10.1089/JAM.1994.7.303","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.303","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"48 1","pages":"303-306"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84303678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aerosols as indices of regional ventilation 气溶胶作为区域通风的指标
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.111
T. O'Riordan, G. Smaldone
{"title":"Aerosols as indices of regional ventilation","authors":"T. O'Riordan, G. Smaldone","doi":"10.1089/JAM.1994.7.111","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.111","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"82 1","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76060691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Radio Labelling of Drugs in a Metered Dose Inhaler (MDI) and Lung Deposition in Human Subjects 计量吸入器(MDI)中药物的无线电标记和人体受试者的肺沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.173
A. Hammermaier, A. Bidlingmaier, J. Waitzinger, R. Stechert, Harald Wenske, H. Jaeger
{"title":"Radio Labelling of Drugs in a Metered Dose Inhaler (MDI) and Lung Deposition in Human Subjects","authors":"A. Hammermaier, A. Bidlingmaier, J. Waitzinger, R. Stechert, Harald Wenske, H. Jaeger","doi":"10.1089/JAM.1994.7.173","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.173","url":null,"abstract":"ABSTRACT The lung deposition (amount and distribution) of drugs from MDIs cannot be quantified using routine pharmacokinetic methods. A growing number of drugs from inhalers has been investigated in recent years using a radiolabel to overcome this difficulty. Fenoterol (Berotec®) and Flunisolide (Inhacort®) both from Boehringer Ingelheim KG are two drugs primarily used by inhalation in the treatment of asthma. These compounds were labelled with 99mTechnetium (Tc) in the MDI. The 99mTc label as observed with a gamma camera was shown to follow the same distribution pattern as the drug particles. Cascade impaction with eight stages resulted in the following distribution 63, 8, 5, 3, 6, 5, 8, and 2 % from Stage 1 to Stage 8. A clinical study with 12 healthy volunteers compared the deposition pattern derived from MDI alone and MDI with spacer. Regions Of Interest (ROIs) were the oropharyngal cavity, esophagus, stomach, and lung (central and peripheral zones). With MDI alone, 73 % of the drug was found in upper...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"57 1","pages":"173-176"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86221339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Text of Plenary Lecture Given by S.T. Holgate 霍尔盖特全体会议演讲全文
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.161
J. Conway, S. Holgate
{"title":"Text of Plenary Lecture Given by S.T. Holgate","authors":"J. Conway, S. Holgate","doi":"10.1089/JAM.1994.7.161","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.161","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"113 1","pages":"161-165"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80532977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Model for the Effect of Inhalation Device Flow Resistance on the Peak Inspiratory Flow Rate and Its Application in Pharmaceutical Testing 吸入装置流动阻力对吸入峰值流速影响的模型及其在药物检测中的应用
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.201
B. Olsson, L. Asking
{"title":"A Model for the Effect of Inhalation Device Flow Resistance on the Peak Inspiratory Flow Rate and Its Application in Pharmaceutical Testing","authors":"B. Olsson, L. Asking","doi":"10.1089/JAM.1994.7.201","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.201","url":null,"abstract":"ABSTRACT An empirical relation between the peak inspiratory flow through a device and the flow resistance of the device has been developed using results from healthy subjects and verified to a limited extent using data from asthmatic patients. The empirical relation can be used to predict the change in peak inspiratory flow resulting from a change in flow resistance. Matching flow rates, representing equal inspiratory force, may thus be calculated for different inhalation devices. The fine particle dose generated by a variety of commercial powder inhalers was tested in-vitro at flow rates representing, for each device, a weak, a medium and a forceful inspiration. It was found that both the level of the fine particle dose and its flow rate dependence varied for the products.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"25 1","pages":"201-204"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83984000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Lung Deposition of Pressurised Terbutaline Sulphate Aerosols Compared by Two Techniques 加压硫酸特布他林气溶胶肺沉积的两种技术比较
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.177
S. Newman, K. Steed, G. Hooper, A. Källén, L. Borgström
{"title":"Lung Deposition of Pressurised Terbutaline Sulphate Aerosols Compared by Two Techniques","authors":"S. Newman, K. Steed, G. Hooper, A. Källén, L. Borgström","doi":"10.1089/JAM.1994.7.177","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.177","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"400 1","pages":"177-179"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80265538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Cellular and Molecular Responses to Inhaled Particles 细胞和分子对吸入颗粒的反应
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.19
D. Shasby, M. Williams
{"title":"Cellular and Molecular Responses to Inhaled Particles","authors":"D. Shasby, M. Williams","doi":"10.1089/JAM.1994.7.19","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.19","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"66 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85512619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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