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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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Multi-Modality Imaging: The Use of Single Photon Emission Computed Tomography and Magnetic Resonance Imaging to Assess Regional Intra-Pulmonary Deposition of Nebulised Aerosols 多模态成像:使用单光子发射计算机断层扫描和磁共振成像来评估肺内雾状气溶胶的区域沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.293
J. Conway, P. Halson, E. Moore, A. Hashish, A. Bailey, M. Nassim, J. Fleming, S. Holgate
{"title":"Multi-Modality Imaging: The Use of Single Photon Emission Computed Tomography and Magnetic Resonance Imaging to Assess Regional Intra-Pulmonary Deposition of Nebulised Aerosols","authors":"J. Conway, P. Halson, E. Moore, A. Hashish, A. Bailey, M. Nassim, J. Fleming, S. Holgate","doi":"10.1089/JAM.1995.8.293","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.293","url":null,"abstract":"ABSTRACT Single Photon Emission Computed Tomography (SPECT) is now accepted as one method of providing 3-D images of an inhaled radioaerosol. Using SPECT, we have reconstructed 3-D images incorporating an attenuation correction technique utilising aligned Magnetic Resonance Imaging (MRI) of the thorax. This permits threedimensional quantitative analysis of intra-pulmonary deposition by a variety of techniques performed on a RISC workstation. Deposition of nebulised radio-aerosols (99mTc labelled human serum albumin) of 1.5μm MMAD (Optimist, Medic-Aid) and 6.5μm MMAD (Inspiran Bard) has been now been assessed in 12 subjects. All subjects were non-smokers and with no evidence of small airways disease. The aerosols were inhaled at tidal volume in a controlled manner in the erect, seated position. Using a shell analysis (Conway and Holgate 1994) the pattern of deposition for the total mass per shell and for surface density per shell was assessed. SPECT and MRI were found to be more sensitive than planar scint...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"45 1","pages":"293-295"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79383243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Drug Nebuliser Design and Performance: Breath Enhanced Jet Vs. Constant Output Jet Vs. Ultrasonic 药物喷雾器的设计和性能:呼吸增强射流与恒定输出射流与超声波
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.277
J. Dennis
{"title":"Drug Nebuliser Design and Performance: Breath Enhanced Jet Vs. Constant Output Jet Vs. Ultrasonic","authors":"J. Dennis","doi":"10.1089/JAM.1995.8.277","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.277","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"11 1","pages":"277-280"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78987173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
The Effect of Ambient Relative Humidity on Regional Dosages Delivered by a Jet Nebulizer 环境相对湿度对喷射雾化器区域剂量的影响
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.363
R. M. Prokop, W. Finlay, K. Stapleton, P. Zuberbuhler
{"title":"The Effect of Ambient Relative Humidity on Regional Dosages Delivered by a Jet Nebulizer","authors":"R. M. Prokop, W. Finlay, K. Stapleton, P. Zuberbuhler","doi":"10.1089/JAM.1995.8.363","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.363","url":null,"abstract":"ABSTRACT In this study, the output of DeVilbiss Pulmo-Neb® disposable jet nebulizers driven by a DeVilbiss Pulmo-Aide® compressor to nebulize 2.5 ml nebules of 1 mg/ml Ventolin® was measured at five ambient relative humidities ranging from 3% to 95%. It was found that as the humidity was increased from 3% to 95%, the mass median diameter of the aerosol increased by 14% while the concentration of the nebulizer solution at the end of the nebulization period decreased by 19%. Calculations using the procedure of Stapleton, Finlay, and Zuberbuhler (J. Aerosol Med., 7:325-344, 1994) predict that as the ambient relative humidity is increased from 3% to 95%, there is a 100% increase in extrathoracic dosage, a 9% increase in bronchial dosage, and a 63% decrease in pulmonary dosage. The major source of this effect is the hygroscopic shrinkage of the particles as they are inhaled with low humidity ambient air, although there is a minor effect due to changes in initial particle size distribution at different humiditi...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"36 1","pages":"363-372"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86122092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Particle Retention in Airways Estimated by Unbiased Stereology and Photometry 用无偏立体学和光度法估计气道中的颗粒滞留
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.149
M. Geiser, L. Cruz-Orive, U. Waber, V. Hof, P. Gehr
{"title":"Particle Retention in Airways Estimated by Unbiased Stereology and Photometry","authors":"M. Geiser, L. Cruz-Orive, U. Waber, V. Hof, P. Gehr","doi":"10.1089/JAM.1995.8.149","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.149","url":null,"abstract":"ABSTRACT The retention pattern of 6 (μm polystyrene particles at two breathing modes was studied by unbiased stereology in hamster airways (trachea, main bronchi and intrapulmonary conducting airwa...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"11 1","pages":"149-165"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90212795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
The Optimum Size and Shape of Spacer Devices for Inhalational Therapy 吸入治疗中间隔装置的最佳尺寸和形状
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.303
P. Barry, C. O’Callaghan
{"title":"The Optimum Size and Shape of Spacer Devices for Inhalational Therapy","authors":"P. Barry, C. O’Callaghan","doi":"10.1089/JAM.1995.8.303","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.303","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"41 1","pages":"303-305"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90607331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Ultrasonic Nebulisation of Fluids with Different Viscosities and Surface Tensions 不同粘度和表面张力流体的超声雾化
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.281
O. Mccallion, K. Taylor, M. Thomas, A. Taylor
{"title":"Ultrasonic Nebulisation of Fluids with Different Viscosities and Surface Tensions","authors":"O. Mccallion, K. Taylor, M. Thomas, A. Taylor","doi":"10.1089/JAM.1995.8.281","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.281","url":null,"abstract":"ABSTRACT Little information has been published relating the physicochemical properties of nebuliser fluids to the size of ultrasonically generated aerosols. This study addressed this and involved n...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"19 1","pages":"281-284"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88058963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
The Characterization of Dosage Sequences of Self-Dispensing Multi-Dose Dry Powder Inhalers by Spectral Analysis and ARIMA 用光谱分析和ARIMA表征自配多剂量干粉吸入器的剂量序列
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.331
P. Zanen, J. Lammers
{"title":"The Characterization of Dosage Sequences of Self-Dispensing Multi-Dose Dry Powder Inhalers by Spectral Analysis and ARIMA","authors":"P. Zanen, J. Lammers","doi":"10.1089/JAM.1995.8.331","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.331","url":null,"abstract":"ABSTRACT Recently many so called self-dispensing multi-dose dry powder inhalers were designed. Calculation of the average weight, the coefficient of variation of the dosing-sequences are often used to indicate the (in)accuracy of the system. These parameters supply no information with respect to the cause of the inaccuracy. No statistical methods are in use to locate the cause of the inaccuracy. Two techniques, spectral analysis and ARIMA-modelling were used to determine the characteristics of the sequences of two (model) dry powder inhalers. Spectral analysis detects periodic behaviour in sequences, while ARIMA unravels the way a dose interacts with the next one. It was shown that the sequence of the first inhaler is a moving average process, indicating sticking powder in the dosing mechanism itself. The second inhaler showed negative autocorrelation, indicating insufficient supply of powder to the dosing mechanism. Spectral analysis and ARIMA-modelling provide information not obtainable with the present...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"5 1","pages":"331-340"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88358244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Description of Pulmonary Deposition of Radiolabeled Aerosol by Airway Generation Using a Conceptual Three Dimensional Model of Lung Morphology 用肺形态的概念三维模型描述通过气道生成的放射性标记气溶胶的肺沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.297
J. Fleming, M. Nassim, A. Hashish, A. Bailey, J. Conway, S. Holgate, P. Halson, E. Moore, T. Martonen
{"title":"Description of Pulmonary Deposition of Radiolabeled Aerosol by Airway Generation Using a Conceptual Three Dimensional Model of Lung Morphology","authors":"J. Fleming, M. Nassim, A. Hashish, A. Bailey, J. Conway, S. Holgate, P. Halson, E. Moore, T. Martonen","doi":"10.1089/JAM.1995.8.297","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.297","url":null,"abstract":"ABSTRACT Multi-modality medical imaging enables measurement of the three dimensional spatial distribution of a radiolabeled aerosol within the lung (Perring et al, 1994) . A method is described for...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"121 1 1","pages":"341-356"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88762107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 74
Lung Deposition of Salbutamol from the Leiras Metered Dose Powder Inhaler Leiras计量粉末吸入器吸入沙丁胺醇的肺沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.307
G. Pitcairn, T. Lankinen, E. Valkila, S. Newman
{"title":"Lung Deposition of Salbutamol from the Leiras Metered Dose Powder Inhaler","authors":"G. Pitcairn, T. Lankinen, E. Valkila, S. Newman","doi":"10.1089/JAM.1995.8.307","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.307","url":null,"abstract":"ABSTRACT The deposition patterns of salbutamol inhaled from a new metered dose dry powder inhaler (Leiras Oy, Finland) were assessed using gamma scintigraphy. The drug formulation was labelled with the radionuclide 99Tm, and in vitro validation experiments performed with an Andersen Cascade Impactor demonstrated that the radiolabel would act as a marker of in vivo drug distribution. Eleven healthy volunteers took part in the study, inhaling through the device at a mean (SEM) flow rate of 31.2 (3.6) L-mhv1. The mean (SEM) whole lung deposition was 41.6 (1.7) % of the delivered dose, and 23.9 (1.4) % of the metered dose. The drug was distributed fairly evenly throughout the lungs with a mean ratio of peripheral/central deposition of 1.2. It was concluded that drug delivery from the Leiras dry powder inhaler was comparable or superior to that observed for other metered dose powder inhalers.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"33 1","pages":"307-311"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87081442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Salt: Good for What Ails the Airways? 盐:对呼吸道有好处?
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.VII
W. Bennett
{"title":"Salt: Good for What Ails the Airways?","authors":"W. Bennett","doi":"10.1089/JAM.1995.8.VII","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.VII","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82223393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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