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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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The Effect of Long-Term Simultaneous Therapy with Salbutamol and Budesonide on Bronchial Reactivity and Serum ECP Level in Asthmatics 沙丁胺醇和布地奈德长期同时治疗对哮喘患者支气管反应性和血清ECP水平的影响
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1996-01-01 DOI: 10.1089/JAM.1996.9.527
Z. Siergiejko, Z. Ziętkowski, S. Chyrek-Borowska
{"title":"The Effect of Long-Term Simultaneous Therapy with Salbutamol and Budesonide on Bronchial Reactivity and Serum ECP Level in Asthmatics","authors":"Z. Siergiejko, Z. Ziętkowski, S. Chyrek-Borowska","doi":"10.1089/JAM.1996.9.527","DOIUrl":"https://doi.org/10.1089/JAM.1996.9.527","url":null,"abstract":"ABSTRACT The effects of 20 weeks of regular application of salbutamol, in comparatively high doses, on asthma symptoms, spirometry, bronchial reactivity, and the serum ECP level in asthmatics, who took inhaled corticosteroids, were studied. The studies were carried out on 20 nonsmoking, mild or moderate, nonallergic patients with stable asthma, treated regularly with inhaled corticosteroids and a β2-agonist if required. After a 1-week run-in period the patients continued the inhalations of corticosteroids and took, on a fixed schedule, 800 μg of salbutamol daily and more on demand. Examinations of the patients and spirometry were performed every 2 weeks. Before and after the treatment, bronchial reactivity to histamine was tested and blood samples for ECP determination were taken. The symptom score, morning and evening PEF, and daily number of β2-agonist doses, taken on demand, were recorded on their diary cards. Small increases in the morning PEF and FEF25–75 (p < 0.05) were observed before the end of th...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"76 1","pages":"527-536"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85729780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Aerosolized Amiloride on Mucociliary Transport Velocity and Transepithelial Potential Difference in Isolated Frog Palate 雾化阿米洛利对离体蛙腭粘膜纤毛运输速度和上皮电位差的影响
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.167
E. Festa, M. Macchione, P. Paiva, P. Saldiva, M. King
{"title":"Effects of Aerosolized Amiloride on Mucociliary Transport Velocity and Transepithelial Potential Difference in Isolated Frog Palate","authors":"E. Festa, M. Macchione, P. Paiva, P. Saldiva, M. King","doi":"10.1089/JAM.1995.8.167","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.167","url":null,"abstract":"ABSTRACT An in vitro dose-response study was performed to determine the effects of aerosolized amiloride on transepithelial potential difference and mucociliary velocity. A preparation of isolated frog palate (Rana sculenta) was used for two groups: one submitted to amiloride nebulization (n = 7) and a control group submitted to vehicle (NaCl 0.45%) nebulization (n = 7). Transepithelial potential difference was measured by means of agar-filled microelectrodes connected to the high input of a grounded electrometer. Mucociliary velocity was determined by monitoring the movement of aluminum disks as tracer particles. Amiloride nebulization caused a significant dose-dependent increase in mucociliary velocity when compared to the control group (p < 0.05). The amiloride also turned the luminal surface more positive, promoting a decrease (in absolute value) in transepithelial potential difference when compared to the control group (p < 0.05). A positive and continuous (quadratic) association between mucociliary ...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"16 1","pages":"167-176"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74352465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Aerosol Inhalation in the Rat Lung Part II: Theoretical Predictions of Particle Deposition Patterns 大鼠肺中的气溶胶吸入第二部分:粒子沉积模式的理论预测
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.21
L. Koblinger, W. Hofmann
{"title":"Aerosol Inhalation in the Rat Lung Part II: Theoretical Predictions of Particle Deposition Patterns","authors":"L. Koblinger, W. Hofmann","doi":"10.1089/JAM.1995.8.21","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.21","url":null,"abstract":"ABSTRACT Theoretical predictions of total, regional and local deposition fractions of inhaled particles are based on the complete stochastic model of the rat lung presented in Part I (Koblinger et al., 1995). Deposition patterns of inhaled particles ranging from 0.01 to 10 μm diameter are computed for two stochastic rat lung models differing only in their respective tracheobronchial morphometries. Deposition fractions based on the two stochastic morphometric models are compared to corresponding results utilizing the deterministic lung model of Yeh et al. (1979) as well as to the available experimental evidence. In contrast to the simulations with the presently used deterministic model of the rat lung and our previous stochastic model of the human lung, the differential distributions of deposited matter throughout the rat airway system are expressed as functions of the airway diameter, which permits a more realistic description of the rather monopodial structure of the rat lung.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"20 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79366519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Clinical Aspects of Nebuliser Therapy 雾化器治疗的临床方面
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.273
M. Muers
{"title":"Clinical Aspects of Nebuliser Therapy","authors":"M. Muers","doi":"10.1089/JAM.1995.8.273","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.273","url":null,"abstract":"ABSTRACT Gas driven nebulisers are very widely used in present clinical medical practice, both in hospital and at home. Their use has expanded appreciably in recent years, but the way in which they are used, both in common diseases and in some of the more novel applications are not necessarily supported by good quality clinical trial data.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"5 1","pages":"273-276"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90431217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aerosolised Drug Administration in the Ventilated Patient: In-Vitro and In-Vivo Correlates 通气患者的雾化给药:体外和体内相关性
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.289
M. O'Doherty, Shl Thomas, C. Page, C. Harvey, D. Treacher
{"title":"Aerosolised Drug Administration in the Ventilated Patient: In-Vitro and In-Vivo Correlates","authors":"M. O'Doherty, Shl Thomas, C. Page, C. Harvey, D. Treacher","doi":"10.1089/JAM.1995.8.289","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.289","url":null,"abstract":"ABSTRACT The use of drugs administered via the airways for the treatment of ventilated patients in an intensive care setting is common. The spectrum of drugs administered this way include bronchodilators, steroids and antimicrobial agents. Despite the administration of these agents directly into a ventilator circuit which communicates directly with the patients lungs, the evidence available suggests that the lung deposition from aqueous aerosols is poor with only 1.2-2.8% of the nebuliser dose reaching the lungs. A variety of factors affect the delivery of drug to the lung: the type of nebuliser used, the nebuliser efficiency, the particle size of the aerosol, the ventilator settings (respiratory rate, tidal volume and inspiratory time) and the position of the nebuliser in the ventilator circuit. A number of these have been explored in-vitro with the results showing that depending on the ventilator settings, the addition of a spacer, the type of nebuliser (e.g. jet or ultrasonic) and the humidification of...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"20 1","pages":"289-292"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80495017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Problems with drug delivery from nebulizers and spacers 雾化器和间隔器给药的问题
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.301
C. O’Callaghan
{"title":"Problems with drug delivery from nebulizers and spacers","authors":"C. O’Callaghan","doi":"10.1089/JAM.1995.8.301","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.301","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"29 1","pages":"301-302"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91318731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Standardisation in Drug Nebulisers: BS7711 Part 3 药物雾化器标准化:BS7711第3部分
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.313
J. Dennis
{"title":"Standardisation in Drug Nebulisers: BS7711 Part 3","authors":"J. Dennis","doi":"10.1089/JAM.1995.8.313","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.313","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"28 1","pages":"313-315"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89822067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Aerosol Inhalation in the Rat Lung Part I: Analysis of the Rat Acinus Morphometry and Construction of a Stochastic Rat Lung Model 气溶胶吸入大鼠肺第一部分:大鼠腺泡形态分析及随机大鼠肺模型的建立
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.7
L. Koblinger, W. Hofmann, R. C. Graham, R. Mercer
{"title":"Aerosol Inhalation in the Rat Lung Part I: Analysis of the Rat Acinus Morphometry and Construction of a Stochastic Rat Lung Model","authors":"L. Koblinger, W. Hofmann, R. C. Graham, R. Mercer","doi":"10.1089/JAM.1995.8.7","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.7","url":null,"abstract":"ABSTRACT Morphometric data of four ventilatory units of the lung of a male Sprague-Dawley rat were statistically analyzed. Because of the rather monopodial structure of the rat lung, airways were classified by their diameters rather than by their generation numbers, as is general practice. The statistical analyses provided information on the distributions of a variety of geometric parameters of a rat acinus and the correlations among them. Together with the previously analyzed tracheobronchial morphometric data they form the basis of a stochastic morphometric model of the whole rat lung. This morphometric model can then be used for Monte Carlo simulations of the transport and deposition of inhaled aerosol particles in the rat lung.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"53 1","pages":"7-19"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88687876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Effect of Age Related Breathing Parameters on the Performance of a New Nebulizer System: An In-Vitro Study 年龄相关呼吸参数对新型雾化器系统性能的影响:体外研究
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.285
M. Knoch, E. Wunderlich
{"title":"Effect of Age Related Breathing Parameters on the Performance of a New Nebulizer System: An In-Vitro Study","authors":"M. Knoch, E. Wunderlich","doi":"10.1089/JAM.1995.8.285","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.285","url":null,"abstract":"ABSTRACT A new continuously operated nebulizer system (PARI LC) has been designed for use in patients from one month of age to adulthood. Two different configurations are available, one with a son silicon face mask for use in babies and infants (three different mask sizes), and one with a mouthpiece with integrated expiratory valve. The nebulizer is based on an open-vent technology in combination with a valve system which enables the entrained air to pass through the nebulizing chamber, thus increasing aerosol output during inspiration. In this study the effect of tidal volume and breathing frequency on the nebulizer efficiency has been investigated by using a breath simulator at fixed 50% inspiration and 50% expiration cycles. Sodium fluoride was used as a tracer and analysed from filters simulating the aerosol to be inhaled by a patient (aerosol delivered) and the amount exhausted to the environment (aerosol wasted). Each configuration of the nebulizer was tested by simulating the relevant breathing con...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"139 1","pages":"285-288"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77519434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Pharmacokinetic Modeling of Systemic Uptake Following Pulmonary Delivery of a Macromolecular Drug in a Sustained Release Formulation 大分子缓释药物经肺给药后全身吸收的药代动力学模型
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1995-01-01 DOI: 10.1089/JAM.1995.8.317
Z. Teitelbaum, D. B. Bennett
{"title":"Pharmacokinetic Modeling of Systemic Uptake Following Pulmonary Delivery of a Macromolecular Drug in a Sustained Release Formulation","authors":"Z. Teitelbaum, D. B. Bennett","doi":"10.1089/JAM.1995.8.317","DOIUrl":"https://doi.org/10.1089/JAM.1995.8.317","url":null,"abstract":"ABSTRACT A pharmacokinetic model was developed to analyze systemic drug levels observed after a controlled release formulation of a macromolecular drug was administered via the lung. In addition to the consideration of classical pharmacokinetic parameters, our four-compartment model addresses issues such as the clearance of intact formulation particles from the lung and the drug's release rate from the formulation into the lung lumen. Using a system-analysis approach, the effect that each of those may have on the resulting plasma drug profiles was assessed, in particular with reference to the potential to generate sustained plasma drug levels. Our analysis indicated that the specifics of the drug's release from the formulation affected those profiles only marginally, while the formulation's residence time in the respiratory tract played a key role in determining the temporal dependence of the plasma drug levels. The implications that these findings may have on the utilization of liposomal formulations for...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"26 1","pages":"317-329"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82255724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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