{"title":"A Model for the Effect of Inhalation Device Flow Resistance on the Peak Inspiratory Flow Rate and Its Application in Pharmaceutical Testing","authors":"B. Olsson, L. Asking","doi":"10.1089/JAM.1994.7.201","DOIUrl":null,"url":null,"abstract":"ABSTRACT An empirical relation between the peak inspiratory flow through a device and the flow resistance of the device has been developed using results from healthy subjects and verified to a limited extent using data from asthmatic patients. The empirical relation can be used to predict the change in peak inspiratory flow resulting from a change in flow resistance. Matching flow rates, representing equal inspiratory force, may thus be calculated for different inhalation devices. The fine particle dose generated by a variety of commercial powder inhalers was tested in-vitro at flow rates representing, for each device, a weak, a medium and a forceful inspiration. It was found that both the level of the fine particle dose and its flow rate dependence varied for the products.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"25 1","pages":"201-204"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"26","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/JAM.1994.7.201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 26
Abstract
ABSTRACT An empirical relation between the peak inspiratory flow through a device and the flow resistance of the device has been developed using results from healthy subjects and verified to a limited extent using data from asthmatic patients. The empirical relation can be used to predict the change in peak inspiratory flow resulting from a change in flow resistance. Matching flow rates, representing equal inspiratory force, may thus be calculated for different inhalation devices. The fine particle dose generated by a variety of commercial powder inhalers was tested in-vitro at flow rates representing, for each device, a weak, a medium and a forceful inspiration. It was found that both the level of the fine particle dose and its flow rate dependence varied for the products.