A Model for the Effect of Inhalation Device Flow Resistance on the Peak Inspiratory Flow Rate and Its Application in Pharmaceutical Testing

B. Olsson, L. Asking
{"title":"A Model for the Effect of Inhalation Device Flow Resistance on the Peak Inspiratory Flow Rate and Its Application in Pharmaceutical Testing","authors":"B. Olsson, L. Asking","doi":"10.1089/JAM.1994.7.201","DOIUrl":null,"url":null,"abstract":"ABSTRACT An empirical relation between the peak inspiratory flow through a device and the flow resistance of the device has been developed using results from healthy subjects and verified to a limited extent using data from asthmatic patients. The empirical relation can be used to predict the change in peak inspiratory flow resulting from a change in flow resistance. Matching flow rates, representing equal inspiratory force, may thus be calculated for different inhalation devices. The fine particle dose generated by a variety of commercial powder inhalers was tested in-vitro at flow rates representing, for each device, a weak, a medium and a forceful inspiration. It was found that both the level of the fine particle dose and its flow rate dependence varied for the products.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"25 1","pages":"201-204"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"26","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/JAM.1994.7.201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 26

Abstract

ABSTRACT An empirical relation between the peak inspiratory flow through a device and the flow resistance of the device has been developed using results from healthy subjects and verified to a limited extent using data from asthmatic patients. The empirical relation can be used to predict the change in peak inspiratory flow resulting from a change in flow resistance. Matching flow rates, representing equal inspiratory force, may thus be calculated for different inhalation devices. The fine particle dose generated by a variety of commercial powder inhalers was tested in-vitro at flow rates representing, for each device, a weak, a medium and a forceful inspiration. It was found that both the level of the fine particle dose and its flow rate dependence varied for the products.
吸入装置流动阻力对吸入峰值流速影响的模型及其在药物检测中的应用
利用健康受试者的结果建立了设备吸气流量峰值与设备流动阻力之间的经验关系,并在有限程度上利用哮喘患者的数据进行了验证。经验关系式可用于预测气流阻力变化引起的吸气峰值流量变化。因此,可以为不同的吸入装置计算表示相等吸气力的匹配流量。由各种商业粉末吸入器产生的细颗粒剂量在体外进行了测试,每种装置的流量分别为弱、中、强吸入。研究发现,产品的细颗粒剂量水平及其流量依赖关系都有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信