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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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Grafschafter Kolloquium: Aerosols and Lung IV 《气溶胶与肺》
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.277
med. Dieter Köhler
{"title":"Grafschafter Kolloquium: Aerosols and Lung IV","authors":"med. Dieter Köhler","doi":"10.1089/JAM.1994.7.277","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.277","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"39 1","pages":"277-301"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89396271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nebulized Glucocorticoids in Liposomes: Aerosol Characteristics and Human Dose Estimates 脂质体雾化糖皮质激素:气溶胶特性和人体剂量估计
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.135
J. Waldrep, P. Scherer, G. Hess, Melanie B. Black, V. Knight
{"title":"Nebulized Glucocorticoids in Liposomes: Aerosol Characteristics and Human Dose Estimates","authors":"J. Waldrep, P. Scherer, G. Hess, Melanie B. Black, V. Knight","doi":"10.1089/JAM.1994.7.135","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.135","url":null,"abstract":"ABSTRACT We have developed glucocorticoid (GC)-phosphatidylcholine (PC) liposome formulations for pulmonary administration in small-particle aerosol generated by continuous jet nebulizers from aque...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"7 1","pages":"135-145"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75668496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Factors Affecting In Vitro Testing of Inhalers 影响吸入器体外试验的因素
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1994-01-01 DOI: 10.1089/JAM.1994.7.193
C. Dickens, J. Mcaughey, D. Knight, S. Baker
{"title":"Factors Affecting In Vitro Testing of Inhalers","authors":"C. Dickens, J. Mcaughey, D. Knight, S. Baker","doi":"10.1089/JAM.1994.7.193","DOIUrl":"https://doi.org/10.1089/JAM.1994.7.193","url":null,"abstract":"ABSTRACT By examining data for various inhalers under a range of conditions, we have demonstrated the effect of air flow, humidity, and the shape of an artificial throat, on delivery for a number of different inhaler types. The importance of these effects will be discussed by showing how the achievable flow through an inhaler can be estimated, indicating that standard test conditions of 60 1/min flow may be inappropriate for some inhaler types, and may over estimate their performance.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"5 1","pages":"193-196"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76078785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Particle size distribution for jet nebulizers commonly employed in the pediatric clinical setting 小儿临床常用喷射雾化器的粒径分布
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.213
J. Mallol
{"title":"Particle size distribution for jet nebulizers commonly employed in the pediatric clinical setting","authors":"J. Mallol","doi":"10.1089/JAM.1993.6.213","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.213","url":null,"abstract":"ABSTRACT Two jet nebulizers employed in the pediatric practice were evaluated under usually prescribed operating conditions to determine the particle size distribution of their aerosols. The nebulizers, Hudson Up Draft II (UPD) and Bennett Twin (BT), were operated with different flow rates and volumes of fill, using normal saline (NS) and gentamicin (G) diluted in normal saline. Thus, six nebulization conditions were built. Particle size was measured by laser diffraction. There were wide differences in mass median diameter (MMD), geometric standard deviation (GSD), and percentage of aerosol mass contained in particles less than 5.3 microns (μ), 4 μ, 3 μ and 1.9 μ between the systems. The MMD for UPD nebulizer driven by a flow rate of 5.5L/min and loaded with NS (system A) or G (system E) were not different, 4.4 μ and 4.4 μ, respectively. The MMD for BT nebulizer driven by a flow rate of 5.5L/min and loaded NS (system C) or G (system F) was 7.7 and 8.7 μ, respectively. The percentage of aerosol mass contai...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"23 1","pages":"213-219"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78175202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Aerosol Measurement Principles, Techniques and Applications 气溶胶测量原理、技术和应用
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.317
T. Martonen
{"title":"Aerosol Measurement Principles, Techniques and Applications","authors":"T. Martonen","doi":"10.1089/JAM.1993.6.317","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.317","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"97 1","pages":"317-319"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85762963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Nasal Clearance in Rhesus Monkeys 恒河猴的鼻腔清除率
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.111
R. Wolff, D. Allen, Benjamin Lee Hughes, M. Osier, M. Dorato
{"title":"Nasal Clearance in Rhesus Monkeys","authors":"R. Wolff, D. Allen, Benjamin Lee Hughes, M. Osier, M. Dorato","doi":"10.1089/JAM.1993.6.111","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.111","url":null,"abstract":"ABSTRACT Gamma camera scintigraphy studies were carried out to determine a) anesthetic effects, b) the effect of varying deposition site on nasal clearance and reproducibility. a) Anesthesia effects. Six rhesus monkeys (5-7.5 kg) were studied while anesthetized with 1 ml of ketamine (100 mg/ml) only or with ketamine pretreatment followed by sodium pentobarbital (30 mg/kg). Technetium-99m labeled sulfur colloid solution was deposited in the nose and clearance from the anterior nasal region and turbinate region was measured for 30 minutes using gamma camera scintigraphy. Clearance in monkeys anesthetized with ketamine only was approximately 2-fold faster than in monkeys anesthetized with ketamine plus sodium pentobarbital. These and other studies indicate ketamine anesthesia in monkeys is superior to other anesthetics because clearance is similar to that in conscious man. b) Deposition site effects. Using the ketamine anesthesia regimen, clearance was also measured following deposition in the anterior nasal...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"10 1","pages":"111-119"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84610607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Airway dimensions of dog lungs by aerosols: comparison of bolus and single-breath techniques 通过气溶胶测量狗肺的气道尺寸:单次呼吸和单次呼吸技术的比较
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.151
A. Rahmel, M. Meyer
{"title":"Airway dimensions of dog lungs by aerosols: comparison of bolus and single-breath techniques","authors":"A. Rahmel, M. Meyer","doi":"10.1089/JAM.1993.6.151","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.151","url":null,"abstract":"ABSTRACT Monodisperse aerosols were used to determine airway dimensions as a function of volumetric lung depth in vivo. Two different techniques were compared in anesthetized mechanically ventilated dogs (mean body wt.± SD, 13.6 ± 0.9 kg). Monodisperse di-(2-ethyl-hexyl) sebacate particles (mean aerodynamic diameter±SD, 0.89±0.097 μm) were inhaled as bolus (half-width 8 ml) at 10-85% of the normalized (50% functional residual capacity, FRC) inspired volume (Bolus Technique). Alternatively, the total inspired volume contained the test aerosol, formally representing inspiration of a train of aerosol boluses of infinitesimal small volume (Single-Breath Technique). The particle concentration was continuously recorded at the airway opening by a miniaturized in-line aerosol photometer incorporating a 2 mW laser diode (λ = 820 nm) and a photodiode. The airway diameters determined at a given volumetric lung depth were related to the animal's total lung capacity (TLC) to account for lung volume differences between...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"1 1","pages":"151-164"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74690423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lung deposition of a nacystelyn metered dose inhaler formulation 一种nacystelyn计量吸入器配方的肺沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.37
J. Hardy, M. Everard, M. Coffiner, J. Fossion
{"title":"Lung deposition of a nacystelyn metered dose inhaler formulation","authors":"J. Hardy, M. Everard, M. Coffiner, J. Fossion","doi":"10.1089/JAM.1993.6.37","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.37","url":null,"abstract":"ABSTRACT The lung deposition of a metered dose inhaler formulation of the mucolytic drug nacystelyn has been assessed in six healthy subjects. The drug particles were radiolabelled with technetium ...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"25 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74727331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Probing the Lung with Aerosols: The Next Generation 用气溶胶探测肺部:新一代
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.149
W. Bennett
{"title":"Probing the Lung with Aerosols: The Next Generation","authors":"W. Bennett","doi":"10.1089/JAM.1993.6.149","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.149","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"24 1","pages":"149-150"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82547708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Distribution of Inhaled Aerosols in the Respiratory Tract 吸入气溶胶在呼吸道中的分布
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1993-01-01 DOI: 10.1089/JAM.1993.6.19
T. Sweeney, J. Ultman
{"title":"Distribution of Inhaled Aerosols in the Respiratory Tract","authors":"T. Sweeney, J. Ultman","doi":"10.1089/JAM.1993.6.19","DOIUrl":"https://doi.org/10.1089/JAM.1993.6.19","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"41 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78827996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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