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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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The Value of Turbuhaler® in Treating Acute Severe Asthma Turbuhaler®治疗急性重症哮喘的价值
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.SUPPL_1.S-27
O. Selroos
{"title":"The Value of Turbuhaler® in Treating Acute Severe Asthma","authors":"O. Selroos","doi":"10.1089/JAM.1997.10.SUPPL_1.S-27","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.SUPPL_1.S-27","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74008623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The demonstration of bronchodilator effects of salbutamol formulated in chlorofluorocarbon and hydrofluoroalkane-134a metered dose inhalation devices on leukotriene D4-Induced pulmonary responses in the guinea pig 氯氟烃和氢氟烷烃-134a计量吸入装置配制的沙丁胺醇对白三烯d4诱导的豚鼠肺反应的支气管扩张效应的论证
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.41
D. Hammerbeck, V. L. Stelzer, M. Nogami-Itoh, R. Miller, K. Takeyama, G. Gullikson
{"title":"The demonstration of bronchodilator effects of salbutamol formulated in chlorofluorocarbon and hydrofluoroalkane-134a metered dose inhalation devices on leukotriene D4-Induced pulmonary responses in the guinea pig","authors":"D. Hammerbeck, V. L. Stelzer, M. Nogami-Itoh, R. Miller, K. Takeyama, G. Gullikson","doi":"10.1089/JAM.1997.10.41","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.41","url":null,"abstract":"ABSTRACT The demonstration of bronchodilator effects of β2-adrenergic agonists delivered by metered dose inhalation (MDI) devices can be useful in the development of new therapies for asthma or assessing the effects of a formulation. MDI formulations of hydrofluoroalkane (HFA)-134a (a chlorofluorocarbon [CFC]-free propellant), salbutamol in the HFA-134a propellant, CFC-P11/P12 propellant, and salbutamol and formoterol in the CFC propellant were evaluated for their ability to reduce leukotriene D4 (LTD4)-induced bronchoconstriction in guinea pigs using the Konzett-Rossler method. LTD4 challenges were made at various times up to 6 hours after MDI treatment. Neither the placebo vehicle propellants nor the drug formulations affected basal airflow. Only the salbutamol/CFC, formoterol/CFC, and salbutamol/HFA MDI formulations inhibited LTD4-induced bronchoconstriction. One actuation of the MDI device containing salbutamol or formoterol in the CFC propellant produced ∼100% inhibition of LTD4-induced effects follo...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"64 1","pages":"41-54"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85036098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of Aerosol Delivery System and Formulation on Nebulized Budesonide Output 喷雾输送系统及配方对布地奈德雾化输出量的影响
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.307
A. Berlinski, J. Waldrep
{"title":"Effect of Aerosol Delivery System and Formulation on Nebulized Budesonide Output","authors":"A. Berlinski, J. Waldrep","doi":"10.1089/JAM.1997.10.307","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.307","url":null,"abstract":"ABSTRACT Inhaled glucocorticoids are the first line drug for the treatment of moderate to severe asthma. Nebulization is the inhalation method recommended for children below age 3. There are conflicting data in the literature regarding the clinical efficiency of nebulized Budesonide in children. We hypothesized that the delivery method and the formulation can dramatically affect the drug output and account in part for these conflicting results. In this study, we compared the aerosol output in the 0.4–5 μm particle size range, the nebulization efficiency, and the aerodynamic profile of aerosolized Budesonide. An ultrasonic nebulizer (UN) and 2 jet nebulizers (JN) (a conventional and an active venturi design, at different flow rates) were studied with liposomal and micronized formulations. All combinations of delivery methods and formulations except UN/liposomes had an aerodynamic profile adequate to deliver Budesonide to the lower airways. Liposomes showed a higher output than the micronized suspension (p ...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"21 1","pages":"307-318"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90352211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Acute Effects of Uridine 5′-Triphosphate on Mucociliary Clearance in Isolated Frog Palate 尿苷5′-三磷酸对离体蛙腭粘膜纤毛清除的急性影响
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.25
E. Festa, E. T. Guimarães, M. Macchione, P. Saldiva, M. King
{"title":"Acute Effects of Uridine 5′-Triphosphate on Mucociliary Clearance in Isolated Frog Palate","authors":"E. Festa, E. T. Guimarães, M. Macchione, P. Saldiva, M. King","doi":"10.1089/JAM.1997.10.25","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.25","url":null,"abstract":"ABSTRACT Mucociliary velocity (MCV), transepithelial potential difference (PD), cilia beat frequency (CBF), mucus collection rate, rheology, and chloride concentration [Cl−] were analyzed in an in vitro study using the freshly isolated frog palate exposed to an aerosol of modified Ringer's injection, followed by uridine 5′-triphosphate (UTP) 10−4 mol/L either alone or immediately preceded by aerosolization of 5 × 10−4 mol/L 4,4′-diisothiocyano-2,2′ stilbenedisulfonate (DIDS), a chloride channel blocker. UTP increased PD and decreased MCV with a positive relationship between the two. UTP promoted the appearance of copious quantities of secretion and increased the collection rate; the computed mucus depth increased by more than sixfold. There was a significant increase in both [Cl−] and wet weight. The increase in PD and chloride secretion led to enhanced transepithelial fluid transport and a decrease in MCV. Rheology and CBF were not affected by UTP, indicating that the main effect was on the interaction b...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"49 1","pages":"25-39"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88672802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Slow Clearance of Different-Sized Particles from Rat Trachea 大鼠气管中不同大小颗粒的缓慢清除
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.55
G. Patrick, C. Stirling
{"title":"Slow Clearance of Different-Sized Particles from Rat Trachea","authors":"G. Patrick, C. Stirling","doi":"10.1089/JAM.1997.10.55","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.55","url":null,"abstract":"ABSTRACT Previous studies have shown that particle clearance from the conducting airways includes a slow component. In humans, there is evidence that the proportion subject to slow clearance depends on particle size. The effect of particle diameter on slow clearance was determined in the trachea of the F-344 rat by comparing 1.4-μm 133BaSO4 particles and 22- to 30-nm 195Au-labeled gold colloid particles. In both cases, clearance over 2 days could be described by the sum of two exponential terms: fast mucociliary clearance and slow clearance. The fraction of particles subject to slow clearance was not significantly different: 29% for 133BaSO4 and 32% for colloidal gold. The half-time for the fast component was also similar in the two cases, but for the slow phase, the half-time was 31 hours for BaSO4 particles and 177 hours for colloidal gold particles. These results differ somewhat from the kinetics of slow clearance in humans for particles of different sizes. Seven days after instillation, there was no s...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"10 1","pages":"55-65"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74526391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Delivery of Nebulized Budesonide Liposomes to the Respiratory Tract of Allergic Sheep 雾化布地奈德脂质体在过敏羊呼吸道的传递
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.117
T. O'Riordan, J. Waldrep, W. Abraham, Yongming Mao, J. Sabater, M. Sielczak, V. Knight
{"title":"Delivery of Nebulized Budesonide Liposomes to the Respiratory Tract of Allergic Sheep","authors":"T. O'Riordan, J. Waldrep, W. Abraham, Yongming Mao, J. Sabater, M. Sielczak, V. Knight","doi":"10.1089/JAM.1997.10.117","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.117","url":null,"abstract":"ABSTRACT Inhaled budesonide has been shown to be an effective therapy for asthma. In a previous study in a sheep model, acute treatment with budesonide delivered by pressurized metered dose inhaler (pMDI) modified the late bronchoconstrictor response to inhaled antigen. In the present study, we utilized the same sheep model to assess whether the delivery of budesonide in a liposome preparation would modify the late asthmatic response and the associated airway hyperresponsiveness that is detectable 24 hours after challenge. In a crossover trial, six conscious intubated sheep were pretreated with 1 mg of budesonide/dilauroyl phosphatidylcholine (DLPC), or DLPC alone, 16 hours and again 1 hour prior to the administration of aerosolized Ascaris suum antigen. Using esophageal and tracheal pressure measurements and plethysmography, specific lung resistance (sRL) was measured over an 8-hour period following administration of the antigen. In addition, airway responsiveness to carbachol (as assessed by potential d...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"29 1","pages":"117-128"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76471803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Bioequivalence for Generic Bronchodilators 通用支气管扩张剂的生物等效性
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.163
W. Adams
{"title":"Bioequivalence for Generic Bronchodilators","authors":"W. Adams","doi":"10.1089/JAM.1997.10.163","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.163","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"8 1","pages":"163-172"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89856128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization on the bench of an amikacin aerosol before clinical studies 临床研究前阿米卡星气雾剂的台架表征
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.221
P. Dequin, F. Delatour, F. Faurisson, C. Valat, E. Lemarié, A. Lepape, P. Diot
{"title":"Characterization on the bench of an amikacin aerosol before clinical studies","authors":"P. Dequin, F. Delatour, F. Faurisson, C. Valat, E. Lemarié, A. Lepape, P. Diot","doi":"10.1089/JAM.1997.10.221","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.221","url":null,"abstract":"ABSTRACT It has been suggested that nebulized antipseudomonas therapy may be of benefit in cystic fibrosis (CF) patients. Amikacin is effective against Pseudomonas aeruginosa and does not contain sulfites. As a prelude to clinical studies that will use gamma camera techniques to quantify amikacin aerosol deposition, we present the characteristics of the amikacin aerosol and demonstrate that labeling it does not change its dynamics. Human serum albumin (HSA) was labeled with 99mTc and was added to an amikacin solution (1 g per 8 mL and 1.5 g per 12 mL). Amikacin mixed with this tracer was charged in an ultrasonic nebulizer (Syst'Am LS; Villeneuve sur Lot, France). Low-resistance filters were connected between the nebulizer mouthpiece and a piston pump. The filters were changed after each 3-minute period during the 18-minute nebulization process. The mass of radiolabeled amikacin collected from each filter was measured by fluorescence polarization immunoassay (FPIA) and estimated from 99mTc countings. Parti...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"98 1","pages":"221-230"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89674530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Adrenergic Beta Agonists and Anticholinergics in Obstructive Lung Diseases 阻塞性肺疾病的肾上腺素能受体激动剂和抗胆碱能药物
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.75
E. Lemarié, P. Diot
{"title":"Adrenergic Beta Agonists and Anticholinergics in Obstructive Lung Diseases","authors":"E. Lemarié, P. Diot","doi":"10.1089/JAM.1997.10.75","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.75","url":null,"abstract":"ABSTRACT Airflow obstruction in chronic obstructive pulmonary disease (COPD) is due to the combination of airway disease and emphysema, may be accompanied by airway reactivity, and may be partially reversible. Aerosol deposition is affected by airway geometry. Deposition patterns in COPD are increasingly abnormal as the forced expiratory volume in 1 second (FEV1) percentage deteriorates. More advanced COPD is characterized by the formation of multiple impactions in the central airways and a marked reduction in peripheral deposition. Vagal innervation is most prominent in the central airways, although beta-adrenergic receptors are more widely distributed in small airways. Anticholinergics and beta agonists are effective bronchodilators in COPD. With large doses of either ipratropium or beta agonists, most studies have demonstrated equivalent bronchodilation in stable COPD. Small, conventional doses of the two agents are additive, and large doses are not. In COPD patients with acute exacerbation, nebulized ...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"32 1","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78984678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Performance Characteristics of pMdi and Turbuhaler Compared in Vitro and in Vivo pMdi和Turbuhaler的体内外性能比较
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.SUPPL_1.S-9
L. Borgström
{"title":"Performance Characteristics of pMdi and Turbuhaler Compared in Vitro and in Vivo","authors":"L. Borgström","doi":"10.1089/JAM.1997.10.SUPPL_1.S-9","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.SUPPL_1.S-9","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"226 ","pages":"912"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91447258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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