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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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Inhalation Flows in Adult Patient Populations, Including Those With Acute Asthma 成人患者的吸入流，包括急性哮喘患者
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.SUPPL_1.S-23
G. Crompton
{"title":"Inhalation Flows in Adult Patient Populations, Including Those With Acute Asthma","authors":"G. Crompton","doi":"10.1089/JAM.1997.10.SUPPL_1.S-23","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.SUPPL_1.S-23","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79904750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A flow cytometric assay of Fc receptor-mediated phagocytosis 流式细胞术检测Fc受体介导的吞噬作用
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.1
W. Schürmann, M. Frampton, G. Schürmann, N. Roberts, J. Nichols, J. Finkelstein, G. Oberdörster, M. Utell
{"title":"A flow cytometric assay of Fc receptor-mediated phagocytosis","authors":"W. Schürmann, M. Frampton, G. Schürmann, N. Roberts, J. Nichols, J. Finkelstein, G. Oberdörster, M. Utell","doi":"10.1089/JAM.1997.10.1","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.1","url":null,"abstract":"ABSTRACT A flow cytometric assay was developed that specifically measures Fc receptor-mediated phagocytosis independent of other phagocytosis-related receptors. Suspensions of rat alveolar macrophages were incubated with fluorescein isothiocyanate (FITC)-labeled polystyrene microspheres and subsequently were analyzed by flow cytometry. Coating of microspheres with bovine serum albumin was used to generate \"neutral\" particles demonstrating low phagocytosis by alveolar macrophages (AMs). AM attachment and uptake of these particles was increased tenfold with IgG opsonization. This increase was abolished completely by blocking of AM Fc receptors with IgG. The quenching effect of ethidium bromide (EB) on FITC fluorescence was used for differentiating attached from internalized particles. The assay was standardized and optimized for use in toxicologic studies.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"1 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72837594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Nebulized Gentamicin in Children with Cystic Fibrosis: Enhancing Antibiotic Lung Deposition by Increasing Flow Rate and Fill Volume 庆大霉素雾化治疗囊性纤维化儿童:通过增加血流速率和填充量来增强抗生素肺沉积
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.331
J. Mallol, C. Robertson, D. J. Cook, Bahitiyar Kaymakci
{"title":"Nebulized Gentamicin in Children with Cystic Fibrosis: Enhancing Antibiotic Lung Deposition by Increasing Flow Rate and Fill Volume","authors":"J. Mallol, C. Robertson, D. J. Cook, Bahitiyar Kaymakci","doi":"10.1089/JAM.1997.10.331","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.331","url":null,"abstract":"ABSTRACT The aim of this study was to determine the influence of altering the nebulizer flow rate and volume fill on intrapulmonary deposition of nebulized gentamicin in adolescents with cystic fibrosis (CF). A single group of individuals inhaled randomly from two nebulization systems in a cross-over fashion. For System A, gentamicin 80 mg labeled with 4 mCi Tc 99m DTPA, diluted to 2 ml were placed in a jet nebulizer (JN) driven by an airflow of 5.5 1/min. For System B, the volume fill was 4 ml and the flow 10 1/min. The mass median diameter (MMD) of aerosol in System A and B was 4.4 m and 3.1 m, respectively. The nebulizer in System B released twice the volume (3.47 ± 0.04 ml) of gentamicin solution compared to System A (1.71 ± 0.03 ml) during similar nebulization time. Intrathoracic deposition was 4.0 ± 2.7% for System A and 7.1 ± 2.8% for System B. Lung deposition in patients inhaling from System A and B was 3.2 ± 1.8% and 6.2 ± 2.1%, respectively (p < 0.05). This study demonstrates that operating cond...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"46 1","pages":"331-340"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88321382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Particle size measurements for the space-chamber metered dose inhaler holding chamber compared with aerochamber and metered dose inhaler alone 与单独的气相室和计量吸入器相比，空间室计量吸入器存放室的颗粒尺寸测量
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.213
W. Finlay, P. Zuberbuhler, M. Mandl
{"title":"Particle size measurements for the space-chamber metered dose inhaler holding chamber compared with aerochamber and metered dose inhaler alone","authors":"W. Finlay, P. Zuberbuhler, M. Mandl","doi":"10.1089/JAM.1997.10.213","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.213","url":null,"abstract":"ABSTRACT The particle size distribution of aerosols inhaled at 28.3 L/min from a new holding chamber, the Space-Chamber (Medical Developments, Melbourne, Australia), is characterized for salbutamol...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"1 1","pages":"213-219"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89275040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
The Fundamentals of Aerosol Dynamics 气溶胶动力学基础
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/jam.1997.10.369
L. Gradoń
{"title":"The Fundamentals of Aerosol Dynamics","authors":"L. Gradoń","doi":"10.1089/jam.1997.10.369","DOIUrl":"https://doi.org/10.1089/jam.1997.10.369","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"149 1","pages":"369-370"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76031273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue Attenuation Corrections in Gamma Scintigraphy 伽玛闪烁成像中的组织衰减校正
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.187
G. Pitcairn, S. Newman
{"title":"Tissue Attenuation Corrections in Gamma Scintigraphy","authors":"G. Pitcairn, S. Newman","doi":"10.1089/JAM.1997.10.187","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.187","url":null,"abstract":"ABSTRACT Gamma scintigraphy may be used to quantify deposition patterns from aerosol inhalers provided that appropriate corrections are made for the attenuation of gamma rays by different body tissues. Tissue attenuation correction factors (ACFs) were determined in a group of 10 healthy volunteers, using four different techniques: measurement of body thickness, transmission scans, a sealed radioactive source, and a perfusion scan. Different combinations of these ACFs were then used to calculate deposition values from data obtained in the same volunteers in a previous study in which the deposition pattern of a drug inhaled from two different asthma inhalers was investigated. In addition, deposition patterns were determined from data that had not been corrected for tissue attenuation. Lung and stomach ACFs were relatively independent of the correction method (means, 1.84–2.16 for the lungs and 3.42–3.81 for the stomach), although ACFs for the oropharynx were more variable (means, 1.41–2.29). There were sign...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"62 1","pages":"187-198"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79979758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 95
Propellant-driven aerosols of DNA plasmids for gene expression in the respiratory tract 推进剂驱动的DNA质粒气溶胶在呼吸道中的基因表达
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.129
Alan R. Brown, S. Chowdhury
{"title":"Propellant-driven aerosols of DNA plasmids for gene expression in the respiratory tract","authors":"Alan R. Brown, S. Chowdhury","doi":"10.1089/JAM.1997.10.129","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.129","url":null,"abstract":"ABSTRACT Delivery of therapeutic DNA molecules to the respiratory tract is of great interest but has been limited to instillation or aerosolization of DNA-coated liposomes or virusvectored genes in aqueous solutions. We have developed propellant-driven aerosols to deliver metered doses of DNA to the respiratory tract. Plasmid DNA was combined with surfactants to suspend it in a propellant. When aerosolized, respirable-sized DNA particles were produced. Aerosols of a β-galactosidase–containing plasmid induced transfection and gene expression in the respiratory epithelial cells of aerosolexposed mice. Metered-dose, propellant-driven aerosols of DNA offer a new approach to delivering therapeutic genes or DNA-based vaccines to the respiratory tract.","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"45 1","pages":"129-146"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86331786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Introduction Standards for In Vitro/In Vivo Measurements of MDIs mdi体外/体内测量标准
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1996-03-01 DOI: 10.1089/JAM.1996.9.SUPPL_1.S-1
M. Dolovich
{"title":"Introduction Standards for In Vitro/In Vivo Measurements of MDIs","authors":"M. Dolovich","doi":"10.1089/JAM.1996.9.SUPPL_1.S-1","DOIUrl":"https://doi.org/10.1089/JAM.1996.9.SUPPL_1.S-1","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89177919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Aerosol Bolus Dispersion and Aerosol-Derived Airway Morphometry: Assessment of Lung Pathology and Response to Therapy, Part 2 气溶胶丸分散和气溶胶衍生的气道形态测定:肺病理评估和对治疗的反应，第2部分
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1996-01-01 DOI: 10.1089/JAM.1996.9.453
J. Blanchard
{"title":"Aerosol Bolus Dispersion and Aerosol-Derived Airway Morphometry: Assessment of Lung Pathology and Response to Therapy, Part 2","authors":"J. Blanchard","doi":"10.1089/JAM.1996.9.453","DOIUrl":"https://doi.org/10.1089/JAM.1996.9.453","url":null,"abstract":"ABSTRACT This review discusses the potential utility of two methods using inhaled aerosol to detect and diagnose lung disease. Part 1, published earlier,(1) focused upon aerosol bolus dispersion, which measures convective gas mixing. Here, Part 2 focuses upon aerosol-derived airway morphometry (ADAM), which assesses the diameters of airways and acini. This method is discussed in terms of its validity, ability to detect known interventions and diseases, and reproducibility (administering and performing this procedure were already discussed(1). With ADAM, airway and acinar diameters are expressed in terms of the effective airway diameter (EAD), which can be measured as a function of volumetric depth in the lungs. Evidence that ADAM is valid is provided by studies showing EAD agrees well with morphometric indices of airway and acinar size, especially once the distribution of aerosol is accounted for, and changes appropriately in response to known interventions and several diseases. Of particular note is the ...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"48 1","pages":"453-476"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79041149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Aerosolized AmBisome Treatment of Pulmonary Cryptococcus neoformans Infection in Mice 雾化AmBisome治疗小鼠肺部新型隐球菌感染
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1996-01-01 DOI: 10.1089/JAM.1996.9.263
B. Gilbert, R. Proffitt
{"title":"Aerosolized AmBisome Treatment of Pulmonary Cryptococcus neoformans Infection in Mice","authors":"B. Gilbert, R. Proffitt","doi":"10.1089/JAM.1996.9.263","DOIUrl":"https://doi.org/10.1089/JAM.1996.9.263","url":null,"abstract":"ABSTRACT AmBisome, a liposomal formulation of amphotericin B (ampB-lip), was tested as an aerosol for delivery to the lungs for the treatment of pulmonary fungal diseases. AmBisome (4.6 mg of ampB/ml) was generated with an AeroTech II (AT) nebulizer, producing an aerosol during 20 of nebulization of 111.3 μg of ampB/L and with a mass median aerodynamic diameter of 1.8 μm. Antifungal activity of AmBisome was not affected by aerosolization. When mice were treated with aerosolized AmBisome(4.5 mg of ampB/ml) every other day for a total of 3 treatments (0.6 mg/kg/20 min), lungs rapidly accumulated ampB. Some hours after aerosolization, there was a gradual loss of drug from the lungs. Multiple treatments led to an accumulation of ampB with a maximum concentration after the third treatment of 43 mg of ampB/gm of lung tissue. AmpB was detected in lung tissue 14 days after treatment (24 mg/g). AmpB was not detected in the blood. The prophylactic and therapeutic efficacy of aerosolized AmBisome in an intranasal Cr...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"295 1","pages":"263-276"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75188866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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