Effect of Aerosol Delivery System and Formulation on Nebulized Budesonide Output

Abstract

ABSTRACT Inhaled glucocorticoids are the first line drug for the treatment of moderate to severe asthma. Nebulization is the inhalation method recommended for children below age 3. There are conflicting data in the literature regarding the clinical efficiency of nebulized Budesonide in children. We hypothesized that the delivery method and the formulation can dramatically affect the drug output and account in part for these conflicting results. In this study, we compared the aerosol output in the 0.4–5 μm particle size range, the nebulization efficiency, and the aerodynamic profile of aerosolized Budesonide. An ultrasonic nebulizer (UN) and 2 jet nebulizers (JN) (a conventional and an active venturi design, at different flow rates) were studied with liposomal and micronized formulations. All combinations of delivery methods and formulations except UN/liposomes had an aerodynamic profile adequate to deliver Budesonide to the lower airways. Liposomes showed a higher output than the micronized suspension (p ...