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Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung最新文献

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What is the GAT 什么是GAT
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 2001-01-01 DOI: 10.1089/08942680152007891
P. Diot, B. Housset
{"title":"What is the GAT","authors":"P. Diot, B. Housset","doi":"10.1089/08942680152007891","DOIUrl":"https://doi.org/10.1089/08942680152007891","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"43 12","pages":"53-53"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72620566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lung-to-systemic exposure ratio (L:S) calculation. 肺-全身暴露比(L:S)计算。
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 2001-01-01 DOI: 10.1089/089426801316970349
Harrison Li
{"title":"Lung-to-systemic exposure ratio (L:S) calculation.","authors":"Harrison Li","doi":"10.1089/089426801316970349","DOIUrl":"https://doi.org/10.1089/089426801316970349","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"2005 22","pages":"377"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91548558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Introduction: Towards Better Delivery of Inhaled Medication 前言:朝着更好的输送吸入药物
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1999-09-01 DOI: 10.1089/JAM.1999.12.SUPPL_1.S-1
J. Agnew
{"title":"Introduction: Towards Better Delivery of Inhaled Medication","authors":"J. Agnew","doi":"10.1089/JAM.1999.12.SUPPL_1.S-1","DOIUrl":"https://doi.org/10.1089/JAM.1999.12.SUPPL_1.S-1","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1999-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77025643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in Predicted Regional Lung Deposition of Salbutamol Sulphate Between 19 Nebulizer Types 19种雾化器类型预测硫酸沙丁胺醇肺区域沉积的差异
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1998-01-01 DOI: 10.1089/JAM.1998.11.65
W. Finlay, K. Stapleton, P. Zuberbuhler
{"title":"Variations in Predicted Regional Lung Deposition of Salbutamol Sulphate Between 19 Nebulizer Types","authors":"W. Finlay, K. Stapleton, P. Zuberbuhler","doi":"10.1089/JAM.1998.11.65","DOIUrl":"https://doi.org/10.1089/JAM.1998.11.65","url":null,"abstract":"ABSTRACT Regional lung dosages are estimated for 19 different nebulizer types, and variations in these dosages within each nebulizer type are given. Experimental methods are used to characterize the aerosols inhaled in vitro (inhalation flow rate = 300 mL/s, tidal volume = 750 mL) from nebulizers filled with 2.5 mL of Ventolin (1 mg/mL of salbutamol sulphate in normal saline) under ambient conditions of 50% ± 3% relative humidity (RH), 22°C ± 1°C. These data are input into a hygroscopic, mathematical lung deposition model to estimate regional lung dosages for a scaled Weibel A lung. The deposition model is a two-way coupled model (i.e., it includes the effects of droplet heat and mass transfer on the surrounding environment and vice versa). As a percentage of normal dose placed in the nebulizer, regional dosages differed significantly between the different nebulizer types (P < 0.01) and varied from 3.1% to 23.4%, 1.6% to 10.6%, 1.6% to 12.8%, and 1.8% to 9.5% for lung, tracheobronchial, alveolar, and extr...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"24 1","pages":"65-80"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81761035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
The Use of Osmometry as a Means of Determining Changes in Drug Concentration During Jet Nebulization 用渗透法测定喷射雾化过程中药物浓度的变化
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1998-01-01 DOI: 10.1089/JAM.1998.11.89
E. Kwong, C. F. MacNeish, D. Meisner, S. Kelemen, E. Vadas, A. Coates
{"title":"The Use of Osmometry as a Means of Determining Changes in Drug Concentration During Jet Nebulization","authors":"E. Kwong, C. F. MacNeish, D. Meisner, S. Kelemen, E. Vadas, A. Coates","doi":"10.1089/JAM.1998.11.89","DOIUrl":"https://doi.org/10.1089/JAM.1998.11.89","url":null,"abstract":"ABSTRACT In the treatment of cystic fibrosis (CF), more and more medications (i.e., aminoglycoside antibiotics, bronchodilators) are being administered by air jet nebulization. Therefore, in order ...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"42 1","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88248470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Factors Influencing the Rate of Drug Output During the Course of Wet Nebulization 湿式雾化过程中影响出药率的因素
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1998-01-01 DOI: 10.1089/JAM.1998.11.101
A. Coates, C. F. MacNeish, L. Lands, A. A. Smountas, D. Meisner, S. Kelemen, E. Vadas
{"title":"Factors Influencing the Rate of Drug Output During the Course of Wet Nebulization","authors":"A. Coates, C. F. MacNeish, L. Lands, A. A. Smountas, D. Meisner, S. Kelemen, E. Vadas","doi":"10.1089/JAM.1998.11.101","DOIUrl":"https://doi.org/10.1089/JAM.1998.11.101","url":null,"abstract":"ABSTRACT Jet nebulization in an unvented nebulizer is a complex phenomenon which includes the physical fracturing of a liquid film into droplets of aerosol and the evaporative losses that accompany the interaction between the nebulizing gas and the nebulizer solution. The process of nebulization continues until a certain minimal residual volume (dead volume) is reached. This dead volume is determined by the loss of the liquid volume of the aerosol and the amount of evaporative losses, the latter partially determined by the relative humidity of the nebulizing gas. Evaporative losses are maximized if the nebulizing gas is free of water vapor and are minimized if it is wet, as is usually the case when room air is compressed but not dried. In order to explain differences in nebulizer output between dry and wet nebulizing gases, a mathematical model was developed that allows the calculation of the total output of drug, the liquid volume of aerosol, and the water loss due to evaporation, all with respect to tim...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"16 1","pages":"101-111"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82348542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
In Vitro Determination of Inhaled Mass and Particle Distribution for Budesonide Nebulizing Suspension 布地奈德雾化混悬液吸入质量和颗粒分布的体外测定
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1998-01-01 DOI: 10.1089/JAM.1998.11.113
G. Smaldone, M. Cruz-Rivera, K. Nikander
{"title":"In Vitro Determination of Inhaled Mass and Particle Distribution for Budesonide Nebulizing Suspension","authors":"G. Smaldone, M. Cruz-Rivera, K. Nikander","doi":"10.1089/JAM.1998.11.113","DOIUrl":"https://doi.org/10.1089/JAM.1998.11.113","url":null,"abstract":"ABSTRACT Nebulized delivery of aerosols to the lung is a complex process dependent on the device, the drug preparation, the patient's breathing pattern and other factors. It is difficult to predict drug delivery in advance and most delivery systems are studied empirically on the bench. To standardize the delivery of aerosolized budesonide suspension, we measured the quantity of drug delivered to the patient mouthpiece using a piston pump as a model of patient breathing and absolute filters. The mass of aerosol at the mouthpiece (the \"inhaled mass\") was determined by high-pressure liquid chromatography (HPLC). The aerodynamic properties of the nebulized budesonide particles were determined by cascade impaction and HPLC. Because the drug is used to treat children, the bench model was based on a \"pediatric\" breathing pattern, that is, a tidal volume of 200 mL, a breathing frequency of 25 per minute, and a duty cycle of 0.5. Twenty-seven nebulizer/compressor combinations were studied. Inhaled mass varied over...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"34 1","pages":"113-125"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90838791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 52
The effect of nasal passage characteristics on particle deposition 鼻道特性对颗粒沉积的影响
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1998-01-01 DOI: 10.1089/JAM.1998.11.27
J. Kesavanathan, R. Bascom, D. Swift
{"title":"The effect of nasal passage characteristics on particle deposition","authors":"J. Kesavanathan, R. Bascom, D. Swift","doi":"10.1089/JAM.1998.11.27","DOIUrl":"https://doi.org/10.1089/JAM.1998.11.27","url":null,"abstract":"ABSTRACT This study determined the effect of nostril dimensions, nasal passage geometry, and nasal resistance (R) on particle deposition efficiency (PDE) in 40 healthy, nonsmoking adults (24 male, 16 female) at a constant flow rate. An aerodynamic particle sizer measured the diameter and concentration of a polydispersed (1−10-μm diameter) aerosol drawn unidirectionally into the nose and out the mouth. For each particle size, the concentration of particles entering the nose (Cin) and leaving the mouth (Cout) was measured. Nasal PDE, defined as (Cin − Cout)/Cin*100, was calculated for bilateral and unilateral flow. A mixed, nonlinear model was used to fit the PDE to two models based on two sets of specifications. The geometric model included particle aerodynamic diameter (da), nostril dimensions, and minimum nasal cross-sectional area (Amin); the resistance model included particle da and R. Left and right nasal passage PDE significantly correlated for 2- to 6-μm diameter particle sizes. The results showed t...","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"32 1","pages":"27-39"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82423437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Can in Vitro Measurements Predict the Lung Deposition of Dry-Powder Inhalers? 体外测量能预测干粉吸入器的肺沉积吗?
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/JAM.1997.10.SUPPL_1.S-13
B. Olsson
{"title":"Can in Vitro Measurements Predict the Lung Deposition of Dry-Powder Inhalers?","authors":"B. Olsson","doi":"10.1089/JAM.1997.10.SUPPL_1.S-13","DOIUrl":"https://doi.org/10.1089/JAM.1997.10.SUPPL_1.S-13","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"AES-23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84595762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Methods in Inhalation Toxicology 方法:吸入毒理学
Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung Pub Date : 1997-01-01 DOI: 10.1089/jam.1997.10.159
W. Beckett
{"title":"Methods in Inhalation Toxicology","authors":"W. Beckett","doi":"10.1089/jam.1997.10.159","DOIUrl":"https://doi.org/10.1089/jam.1997.10.159","url":null,"abstract":"","PeriodicalId":14879,"journal":{"name":"Journal of Aerosol Medicine-deposition Clearance and Effects in The Lung","volume":"292 1","pages":"159-159"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75415880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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