Journal of advanced Biomedical and Pharmaceutical Sciences最新文献

{"title":"Evaluating the Effect of Telenursing and Multimedia Self-Care Educational Program on the Level of Existential Anxiety in Patients with COVID-19: A Quasi-Experimental Study","authors":"Asma Khoddami, Elham Imani, Reza Jamhiry, S. Hoseini Teshnizi","doi":"10.18502/jabs.v13i2.13011","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.13011","url":null,"abstract":"Background & Objective: For patients, COVID-19 disease is a reminder of non-existence and death. For this reason, these patients experience existential anxiety. One of the effective factors in the control and treatment of this disease is to educate patients on self-care to reduce the burden of these psychological problems on them. The present study was designed and conducted with the aim of evaluating the effect of self-care educational program using telemedicine and multimedia methods on the level of existential anxiety in COVID-19 patients.Materials & Methods: This study was a quasi-experimental research conducted on 88 COVID-19 patients referred to the comprehensive health service centers of Bandar Abbas, Iran from 2020 to 2021. Th0ey were selected using a convenience sampling method. The samples were randomly assigned to the multimedia (44 patients) and telenursing (44 patients) groups. Patients in both groups received education on self-care during COVID-19 disease for 21 days. The Existence Anxiety Scale was completed before and immediately after the intervention. Data were analyzed with SPSS software version 26. Descriptive statistics, normality test, independent t-test, homogeneity of variance and covariance, univariate and multivariate analysis of covariance were used.Results: The mean score of existential anxiety at the beginning of the study was 90.50± 12.57 and 85.25 ±16.12, respectively, in the telenursing and multimedia groups, and after the intervention, it was 46.88 ± 6.38 and 65.40 ± 9.59, respectively, in the telenursing and multimedia groups. After the intervention, the existential anxiety score was significantly reduced in the telenursing group compared to the multimedia group (p <0.001).Conclusions: Based on the findings of this study, self-care education programs and knowledge about necessary care during COVID-19 illness should be considered for patients in comprehensive health centers, and telenursing should be used for more effective self-care education.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83393682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Updates on Synthetic Strategies of Chalcone Scaffold and their Heterocyclic Derivatives","authors":"Mohamed Amin, M. Shaykoon, Adel A Marzouk, E. Beshr, G. Aburahama","doi":"10.21608/jabps.2023.198509.1184","DOIUrl":"https://doi.org/10.21608/jabps.2023.198509.1184","url":null,"abstract":"Chalcones, α,β-unsaturated ketone linking two aromatic moieties gained noticeable attention in the medicinal chemistry area. Chalcone-scaffold construction has proceeded via verified chemical synthetic strategies, including condensation, coupling, olefination, acylation, reductive annulation, one-pot, and Fries’ rearrangement methods. Specific approaches have assisted chalcone combinations using microwave radiation and ultrasound waves to enhance synthetic conditions and amplify yields. Recently, chalcones have been investigated extensively as core structures in potent bioactive hybrids such as anticancer, antimicrobial, and others. In addition, chalcones serve as parent structures for synthesizing several bioactive heterocyclic derivatives comprising five-membered and six-membered rings. This review will discuss recent applications of chalcones' synthetic strategies, physical and chemical characters, biological activities, and chemical derivatization","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83378080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-HCV potential of the medicinal roots of khella and celery plants","authors":"J. Fahim, S. Ahmed, U. Abdelmohsen, A. Hamed","doi":"10.21608/jabps.2023.201852.1186","DOIUrl":"https://doi.org/10.21608/jabps.2023.201852.1186","url":null,"abstract":".","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75602371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-coated alginate microbeads improve the anti-inflammatory potential of Etodolac: optimization using Box-Behnken design, in-vitro drug release and in-vivo study","authors":"E. Alaa","doi":"10.21608/jabps.2023.191177.1180","DOIUrl":"https://doi.org/10.21608/jabps.2023.191177.1180","url":null,"abstract":"ETODOLAC is a non-steroidal anti-inflammatory drug used for treatment of Rheumatoid arthritis and Osteoarthritis. Its therapeutic effect results from inhibition of both isoforms of cyclo-oxygenase enzyme COX-1 and COX-2. This decreases the synthesis of peripheral prostaglandins (PG) involved in mediating inflammation and this results in a number of undesirable side effects such as GIT complaints. To overcome these side effects and to control the rate of its release, alginate microbeads and chitosan coated alginate microbeads prepared. A Box-Behnken experimental design was employed to produce controlled release Etodolac microbeads by Extrusion/External gelation technique. A three-factors, three levels design within 15 runs was suitable for this research. The independent variables were the drug-polymer ratio, concentration of the cross linker and speed intensity. The influence of these formulation factors was evaluated for entrapment efficiency and in-vitro release of Etodolac from the microbeads at the end of two hours and at the end of eight hours. The microbeads were characterized for their shape and size. Alginate microbeads showed rough surface whilst chitosan coated alginate microbeads showed smooth surface. The microbeads exhibited entrapment efficiency from 61.31% to 97.11% and particle size in the range of 700µm to 900 µm. The release results indicated that the chitosan-coated microbeads displayed a more controlled release than the uncoated microbeads. Selected formulae exhibited a significant anti-inflammatory effect on incited rat paw edema after four hours.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87011275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review","authors":"Ali Elshamsy, Taha Ali, Mohamed Osman, N. El-Koussi","doi":"10.21608/jabps.2023.198467.1183","DOIUrl":"https://doi.org/10.21608/jabps.2023.198467.1183","url":null,"abstract":"Dihydropyrimidines (DHPMs) are a class of nitrogen-containing heterocycles that have attracted considerable interest due to their great significance in organic and medicinal chemistry. In recent years, many biologically active molecules featuring DHPM moiety have been synthesized and biologically evaluated, some of which have served as potential leads for critical unmet pathological conditions such as the antimitotic Monastrol and the antiviral GLS4, which entered clinical trials a few years ago. This review discusses briefly the recent advances in DHPM-based bioactive compounds, their biological activities, and their mechanisms of action, which could provide references for future developments of more potent and selective leads.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80970723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Screening, and In Vitro Evaluation of Antioxidant Activity of Lolium Perenne","authors":"Mahmoud Nagaty Mahrous, E. Attia, Mohamed S. A. Abdelkader, Ashraf Hamed","doi":"10.21608/jabps.2023.198473.1185","DOIUrl":"https://doi.org/10.21608/jabps.2023.198473.1185","url":null,"abstract":"The current study aimed to investigate the preliminary phytochemical screening, quantify the total phenolic (TPC), flavonoidal (TFC) contents and evaluate the antioxidant activities of the total methanol extract (ME) of the aerial parts and its derived fractions of Lolium perenne L. ( L. perenne ). The preliminary phytochemical screening of ME displayed the presence of carbohydrates and/or glycosides, steroids and/or triterpenes, phenolic compounds, proteins and/or amino acids, flavonoids, and quinones. Dichloromethane (DFr) and ethyl acetate (EFr) fractions showed the highest TPC (82.42±2.70 and 70.85±2.27 mg gallic acid equivalent (GAE)/g dried sample), respectively. Also, DFr and EFr displayed the highest TFC (115.65±6.43 and 146.00±1.06 mg rutin equivalent (RE)/g dried sample), respectively. All samples showed variable antioxidant properties. While EFr, followed by DFr, demonstrated the least IC 50 value of 120.04±0.43 and 166.81±0.53 µg/mL, respectively, indicating their high antioxidant potential.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83846366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Frequency of HPV Genotypes 16 and 18 Found in Breast Cancer Patients: Evidence for a More Comprehensive HPV Vaccination Program in Iran","authors":"Mohaddeseh Khalilian, S. Hosseini, Hassan Vahidi Emami, O. Madadgar","doi":"10.18502/jabs.v13i2.12729","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.12729","url":null,"abstract":"Background & Objectives: Papillomaviruses are found in many different types of infections and in a wide range of animals and humans. They can cause health problems, including benign and malignant tumors. In the present study, the association between human papillomavirus (HPV) infection and breast cancer (BC) in Iran was investigated. \u0000Materials & Methods: In this cross-sectional study, the presence of the HPV genome was investigated in BC-suspected tissues for the first time in Qom Province, Iran. A total of 400 samples (including 200 BC-suspected tissue samples and 200 blood samples of women without BC) were collected from women referred to two cancer-specific general hospitals. To determine the presence of the L1 gene of HPV in the collected samples, nested polymerase chain reaction (PCR) was performed. Then, HPV-positive samples were tested by PCR using high-risk specific HPV-16 and 18 primers. \u0000Results: Out of 200 BC-suspected tissue samples, 172 were malignant (in terms of pathology). Based on the nested PCR method, the L1 gene of HPV was detected in 12% (24/200) of the BC-suspected tissue samples and in 1.5% (3/200) of the blood samples from women without BC. The high-risk HPV genotypes (which were the predominant types) were present in 75% of the samples. \u0000Conclusion: The results of the current study show a high frequency of HPV-16 and 18 genotypes in human BC in Iranian women. This is almost certainly due to poor rates of HPV vaccination, and it is strongly recommended that health organizations (such as the World Health Organization [WHO]) ensure adequate coverage of highly effective HPV vaccination in Iran.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77380888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of COVID-19 and Subacute Thyroiditis in Fars, Iran","authors":"Zahra Montaseri, J. Karimi, Ali Ghanbari Asad, B. Pezeshki, Hossein Kargar, Y. Mansoori","doi":"10.18502/jabs.v13i2.12728","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.12728","url":null,"abstract":"Background & Objective: COVID-19 can affect thyroid gland and causes subacute thyroiditis. \u0000Case Presentation: We introduced a 60-year-old woman with an initial symptom of anterior cervical pain without any other constitutional symptoms. Nasopharyngeal and oropharyngeal swabs were detected positive for COVID-19 using RT-PCR assay. According to ultrasonographic, laboratory (lowered TSH, elevated CRP and ESR), and physical findings, subacute thyroiditis was found following the SARS-CoV-2 infection. \u0000Conclusion: As subacute thyroiditis associated with SARS-Cov-2 may be represented without any fever, ruling out this infection in these patients is considerable.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"115 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74195243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Au-doped SnO 2 Nanoparticles Using Teucrium Polium Plant Extract for the Evaluation of Their Physicochemical and Antibacterial Properties","authors":"M. Karimi, E. Sadeghi, M. Zahedifar","doi":"10.18502/jabs.v13i2.12727","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.12727","url":null,"abstract":"Background & Objective: The biological production of nanoparticles (NPs) is a technique that has garnered a lot of interest because it is inexpensive, straightforward, and friendly to the natural environment. This study explores the green synthesis of Au-doped SnO 2 NPs using Teucrium polium plant extract and evaluates their antimicrobial properties in comparison with two commonly used antibiotics. \u0000Materials & Methods: Initially, an extract of Teucrium polium was made using water, and then it was combined with solutions of tin (II) chloride dehydrate [SnCl 2 .2H 2 O] and gold (III) chloride trihydrate [HAuCl 4 .3H 2 O]. The crystal structure was studied using X-ray diffraction (XRD). The form, structure, and grain size of the NPs were analyzed using scanning electron microscope (SEM) and transmission electron microscope (TEM). The synthesized NPs were tested for their antibacterial properties. \u0000Results: The XRD and EDS analyses revealed that the SnO 2 : Au phase formed an average crystallite size of 22 nm and an Au dopant content of around 2%. The SEM and TEM investigations demonstrated that the NPs were formed in a regular and nanoscale manner, with diameters ranging from 25 to 30 nm. MIC and MBC of SnO 2 : Au NPs against the studied bacteria (S.aureus ATCC 43300, P.aeruginosa PAO1) were reported 9.6±0.13- 9.6±0.07 μg/mL and 25.9±11.5- 32.5±11.2 μg/mL. \u0000Conclusion: Green-synthesized NPs exhibit significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, even at low concentrations. The NPs effectively eliminate bacteria and prevent biofilm formation.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89551124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Activity and Wound Healing Properties of Aloe Arborescens Extract: An in Vivo Study","authors":"F. Ghane, Pegah Rasouli, Benafshe Khanjari, A. Yousofi, A. Zarenezhad, Hossein Fattahi, Mahsa Rostami Chijan, A. Ghasemian, B. Miladpour, E. Zarenezhad","doi":"10.18502/jabs.v13i2.12726","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.12726","url":null,"abstract":"Background & Objective: Burn is one of the prominent causes of death around the world, however drug discovery attempts for burn healing has not been entirely successful. Aloe arborescens (A. arborescens), is effective in the burning wounds healing and growth inhibition of bacterial pathogens. Our objective was to assess the wound healing and antibacterial effects of A. arborescens in vivo. \u0000Materials & Methods: Thirty healthy Wistar rat animals were enrolled. The treatment process continued for 21 days and sampling was conducted on days 14 and 21 and the tissue slides were sent to the pathology laboratory for testing. The bactericidal activity of A. arborescens extract was evaluated using the disc diffusion method. \u0000Results: A. arborescens demonstrated a significant effect on the healing of burn wounds. Furthermore, the antibacterial effects of the A. arborescens extract against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) was significantly higher than that against Grampositive (Staphylococcus aureus, Bacillus cereus) bacterial species. \u0000Conclusion: In conclusion, this study indicated that A. arborescens extract had an improving effect on the healing process of third degree burns without toxicity to the tissue.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85966923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}