Journal of advanced Biomedical and Pharmaceutical Sciences最新文献

A review of phytoconstituents and biological activities of genus Phalaris 法桐属植物成分和生物活性综述

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2024-03-15 DOI: 10.21608/jabps.2024.263056.1212

Eriny Abd-Elmaseh, M. Samy, Mohamed Abdelkader, Mostafa Fouad

引用次数: 0

Solubility enhancement of simvastatin for wound dressing preparation. 提高辛伐他汀在伤口敷料制备中的可溶性。

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2024-03-14 DOI: 10.21608/jabps.2024.254472.1211

Mahmoud A. Hashem, Amal K. Hussein, Hamdy Abdelkader, Mohammed S. Saddik

{"title":"Solubility enhancement of simvastatin for wound dressing preparation.","authors":"Mahmoud A. Hashem, Amal K. Hussein, Hamdy Abdelkader, Mohammed S. Saddik","doi":"10.21608/jabps.2024.254472.1211","DOIUrl":"https://doi.org/10.21608/jabps.2024.254472.1211","url":null,"abstract":"Simvastatin (SMV) is a well-known antihyperlipidemic drug that has demonstrated wound healing effects. However, its clinical application is hindered by poor solubility. Therefore, the objective of this study was to enhance the solubility of simvastatin by utilizing various concentrations of solvents and co-solvents for formulation in selected topical dosage forms. Mixed-solvent systems, namely Buffer-methanol, Buffer-ethanol, and Buffer-dmso, were employed. Additionally, the impact of different polymer concentrations, including carboxymethyl cellulose (CMC), hydroxypropylmethyl cellulose (HPMC), and chitosan (CHT), on drug solubility was investigated. The solubility profile of SMV in 2% w/v polymeric solutions (CMC, HPMC, and CHT) was found to be 73.5, 62.1, and 59.6 µg/mL, respectively. Notably, the use of a 2% w/v chitosan solution resulted in a remarkable 50-fold increase (73.5 µg/mL) in SMV dissolution compared to its aqueous solubility (1.45 µg/mL). This significant enhancement allows for the incorporation of large amounts of the drug in formulations. Our findings indicate that the Chitosan system with ethanol exhibited the highest solubilization effect and demonstrated the necessary characteristics for the preparation and handling of wound dressing films. This suggests a promising approach for the development of topical formulations with improved solubility and potential therapeutic benefits of simvastatin.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binding of curcumin near the GBT440 binding site at the alpha cleft in the sickle cell hemoglobin model [Pdb ID: 1NEJ] 镰状细胞血红蛋白模型中 GBT440 结合位点附近的姜黄素结合 [Pdb ID: 1NEJ]

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2024-03-14 DOI: 10.21608/jabps.2024.247027.1209

Roohallah Yousefi

{"title":"Binding of curcumin near the GBT440 binding site at the alpha cleft in the sickle cell hemoglobin model [Pdb ID: 1NEJ]","authors":"Roohallah Yousefi","doi":"10.21608/jabps.2024.247027.1209","DOIUrl":"https://doi.org/10.21608/jabps.2024.247027.1209","url":null,"abstract":"Introduction: In sickle cell anemia, deoxygenated HbS molecules polymerize into long fibers in deep tissues during hypoxia, leading to erythrocyte sickling and capillary and vessel blockage. We are searching for new ligands, such as gbt440, that can inhibit HbS polymerization. Methods and Materials: We obtained the molecular model of hemoglobin [PDB ID: 1NEJ] from the Protein Data Bank and the molecular models of GBT440 and curcumin from the PubChem database. The physicochemical properties were investigated using SwissADME software, followed by docking to identify protein-ligand binding sites and determine their affinity. Finally, molecular dynamics simulations were conducted to assess the stability of the protein-ligand complex in the alpha-cleft of the hemoglobin tetramer model [PDB ID: 1NEJ]. Results and Discussion: The docking results revealed that curcumin exhibited a higher binding affinity than GBT440 to the nearby binding site of gbt440 in the alpha-cleft of the hemoglobin model. The hydrogen bonding and electrostatic interactions of the 1NEJ-GBT440 complex differed from those of the 1NEJ-curcumin complex. The results of the molecular dynamics simulation showed no significant difference in the flexibility of hemoglobin among the different ligand-hemoglobin complexes. Conclusion: The binding of curcumin to hemoglobin in the alpha cleft may inhibit the transition of hemoglobin to the tense state and stabilize the hemoglobin tetramer model [PDB ID: 1NEJ] in the R2 state. However, further investigation in the laboratory is necessary to confirm this","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly micellar ultra-performance liquid chromatography (UPLC) method for simultaneous determination of non-communicable diseases drugs in bulk powder, spiked human plasma and in individual dosage forms 环保型胶束超高效液相色谱 (UPLC) 法同时测定散装粉末、加标人体血浆和单独剂型中的非传染性疾病药物含量

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2024-03-13 DOI: 10.21608/jabps.2023.248654.1210

Manal Fouad, Noha Rashed, Asmaa Hosameldin

{"title":"Eco-friendly micellar ultra-performance liquid chromatography (UPLC) method for simultaneous determination of non-communicable diseases drugs in bulk powder, spiked human plasma and in individual dosage forms","authors":"Manal Fouad, Noha Rashed, Asmaa Hosameldin","doi":"10.21608/jabps.2023.248654.1210","DOIUrl":"https://doi.org/10.21608/jabps.2023.248654.1210","url":null,"abstract":"Green, simple and accurate micellar UPLC method was established and validated for quantitative determination of glimepiride, pioglitazone HCl, Valsartan and atorvastatin calcium trihydrate in bulk powder, tablets and spiked human plasma. Gradient separation was achieved on Kinetex 1.7µ C 18 100A (2.1-mm × 50-mm) at ambient temperature using ecofriendly gradient mobile phase composed of a mixture of 0.05 M potassium dihydrogen phosphate buffer pH 5.00 (A) with 0.10M sodium dodecyl sulfate and isopropanol (15.00-25.00%) (B) at flow rate of 0.20 mL/minute and UV detection at 230.00 nm using metformin as internal standard. The method was linear in the range of 0.50–25.00 μg/mL. The proposed method was effectively applied for the determination of glimepiride, pioglitazone HCl, valsartan and atorvastatin in bulk powder, pharmaceutical dosage forms and human plasma with good accuracy and precision. The results were compared with those of the reported methods and were found to be in good agreement. The proposed method was validated according to ICH guidelines.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140393111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma 白藜芦醇抑制肝细胞癌的上皮-间质转化

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-12-21 DOI: 10.21608/jabps.2023.233421.1201

Asmaa Bayoumi, Esraa Khalifa, Mohamed Sayed-Ahmed, Marwa Sharaky, M. Nazmy

引用次数: 0

Pharmacognostical studies of the flower, leaf, root, and rhizome used for the identification and authentication of Agapanthus africanus (L.), cultivated in Egypt. 对埃及栽培的非洲芒草（Agapanthus africanus (L.)）的花、叶、根和根茎进行药理研究，用于鉴别和鉴定。

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-12-21 DOI: 10.21608/jabps.2023.232243.1197

N. Younis, A. Gomaa, Alyaa Ibrahim, Samar Y. Desouky

{"title":"Pharmacognostical studies of the flower, leaf, root, and rhizome used for the identification and authentication of Agapanthus africanus (L.), cultivated in Egypt.","authors":"N. Younis, A. Gomaa, Alyaa Ibrahim, Samar Y. Desouky","doi":"10.21608/jabps.2023.232243.1197","DOIUrl":"https://doi.org/10.21608/jabps.2023.232243.1197","url":null,"abstract":"Agapanthus africanus [L.], is a rhizomatous evergreen plant with fleshy roots, linear leaves, and umbellate inflorescence. It is native to southern Africa and commonly named the Nile lily or African lily. Regarding how closely related their morphologies are, the members of the genus Agapanthus have proven challenging to divide into distinct species. Additionally, no documentation was detected for the phytochemical screening, macro and micromorphology of A. africanus up to date. This inspired us to describe the macro and micromorphology of the flower, leaf, root, and rhizome of A. africanus and evaluate its phytoconstituents. This study demonstrated that A. africanus is free from any trichomes and is rich with various forms of calcium oxalate crystals, both these characteristics help to define the plant under investigation. Concomitantly, the fibrous layer of the anther, the papillosed stigma, and the ellipsoid, non-spiny pollen grains, were recorded in the morphology of the flower in this study. The phytochemical screening investigated the presence of saponins, phenolics, and flavonoids as the major constituents of the underground parts of A. africanus . As expected, this resulted in a more precise tool for taxonomical identification and species delimitation of the genus","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyethylene glycol: Properties, applications, and challenges 聚乙二醇：特性、应用和挑战

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-12-21 DOI: 10.21608/jabps.2023.241685.1205

Sherif A. Gaballa, Youssef Naguib, Fatma Mady, Khaled Khaled

{"title":"Polyethylene glycol: Properties, applications, and challenges","authors":"Sherif A. Gaballa, Youssef Naguib, Fatma Mady, Khaled Khaled","doi":"10.21608/jabps.2023.241685.1205","DOIUrl":"https://doi.org/10.21608/jabps.2023.241685.1205","url":null,"abstract":"Polyethylene glycol (PEG) is a versatile polymer with overwhelming properties that enhance its abundant use in different applications. It is widely used in the food industry, various biomedical and pharmaceutical applications, and many daily used products such as cosmetics. In addition, PEGylation, the covalent binding of PEG molecules to nanocarriers, proteins, peptides, or drug molecules, has been designed as a brilliant approach to improve the pharmacokinetics and therapeutic efficacy of PEGylated therapeutics. The extensive application of PEGylation in the drug delivery field is reflected by the increasing number of commercially available PEGylated therapeutics approved through the last two decades and many others are under clinical trials for sooner approval. However, anti-PEG antibodies, both induced after the treatment with PEGylated therapeutics or naturally occurring in healthy individuals, were reported to negatively affect the pharmacokinetics and the therapeutic efficacy of the administered PEGylated therapeutics through the so-called accelerated blood clearance (ABC) phenomenon. Furthermore, hypersensitivity reactions (HSRs) have been reported in several cases following the administration of PEGylated therapeutics or other PEG-containing products. In addition, PEG nonbiodegradability, PEG degradation, and toxicity associated with polymerization reaction residues are remaining challenges. As a result, numerous polymers have been developed and investigated as potential alternatives for PEG in drug delivery and other medical and pharmaceutical applications.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"24 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article 喹唑啉衍生物作为潜在多靶点抗癌药的意义：综述文章

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-12-21 DOI: 10.21608/jabps.2023.234736.1203

Mostafa Mansour, Samar Abbas, Asma AboulMagd, Hamdy Abdel-Rahman, Mohamed Osman

引用次数: 0

Development and characterization of nanostructure lipid carrier for anti-hepatitis-C virus drug 抗丙型肝炎病毒药物纳米脂质载体的开发与表征

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-12-21 DOI: 10.21608/jabps.2023.234602.1202

Mahmoud EL-Badry, Ominia Mahmoud, Dina Fathalla, Gamal EL-Gendy

引用次数: 0

Design, synthesis, and molecular docking of novel urea linked 1,2,3-triazole-benzenesulfonamide hybrid as potential carbonic anhydrase inhibitors 作为潜在碳酸酐酶抑制剂的新型脲联 1,2,3-三唑-苯磺酰胺混合物的设计、合成与分子对接

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-12-21 DOI: 10.21608/jabps.2023.243204.1206

hamada hashem

引用次数: 0