Journal of advanced Biomedical and Pharmaceutical Sciences最新文献_第2页

Phytochemical and biological properties of the genus Chorisia: A review 毛苣苔属植物化学和生物学特性研究进展

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.210313.1188

John Fahim, Engy Ibrahim, Mamdouh Samy, Mohamed Kamel

{"title":"Phytochemical and biological properties of the genus Chorisia: A review","authors":"John Fahim, Engy Ibrahim, Mamdouh Samy, Mohamed Kamel","doi":"10.21608/jabps.2023.210313.1188","DOIUrl":"https://doi.org/10.21608/jabps.2023.210313.1188","url":null,"abstract":"Chorisia (syn. Ceiba ) is a genus of approximately 20 species of large, perennial, and deciduous trees within the plant family Bombacaceae, with common geographical distribution throughout the subtropical and tropical regions, especially South America. Besides their well-known ornamental and economic value, members of the genus Chorisia have found applications as medicinal plant species thanks to their assortments of bioactive phytoconstituents. To date, about 273 structurally varied metabolites have been described from different plant parts of Chorisia plants using various chromatographic and spectroscopic techniques, which mainly included flavonoids, anthocyanins, phenolic acids, quinones, terpenoids, and steroids, among others. Moreover, several organic solvent extracts and purified metabolites from Chorisia plants have been tested for their biological potential, such as anti-inflammatory, analgesic, antipyretic, antioxidant, hepatoprotective, antiobesity, cytotoxic, antidiabetic, hypolipidemic, antiulcerogenic, and antimicrobial properties. In of view of that, the current work provides an overview on different phytochemicals reported from the genus Chorisia as well as various biological and toxicological studies conducted so far on these plants, along with future research perspectives that might help expand their phytotherapeutic applications.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135760958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacotherapeutic options for the management of obesity in children 治疗儿童肥胖的药物治疗选择

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.225432.1194

Ahmed Aldhafiri

{"title":"Pharmacotherapeutic options for the management of obesity in children","authors":"Ahmed Aldhafiri","doi":"10.21608/jabps.2023.225432.1194","DOIUrl":"https://doi.org/10.21608/jabps.2023.225432.1194","url":null,"abstract":"Obesity in children has increased dramatically over the past few decades, becoming a major public health concern worldwide. Effective treatments must be implemented to reduce the burdens related to diabetes, cardiovascular disease, and mortality associated with obesity. While lifestyle interventions, such as diet and exercise, are often the first-line treatment for obesity, additional approaches may also be necessary for some individuals. Medications can help individuals achieve significant weight loss targets. This review aims to investigate the potential of pharmacological treatments for managing obesity in children, both currently available and future approaches. This article will discuss utilizing current molecular understanding to develop appropriate pharmacotherapeutic approaches that can lead to improved therapeutic outcomes. This review of anti-obesity drugs evaluates current therapies such as orlistat, which inhibits gastrointestinal lipases and reduces dietary fat absorption. Phentermine suppresses the appetite through the augmentation of norepinephrine levels. Liraglutide is a glucagon-like peptide-1 [GLP-1] receptor agonist that influences appetite regulation and glucose metabolism. Setmelanotide is a synthetic analog of α-melanocyte-stimulating hormone [α-MSH] that acts as a potent melanocortin receptor [MC4R] agonist, which promotes feelings of fullness and reduces appetite. Overall, only a limited number of anti-obesity drugs are approved for children. More research is necessary to evaluate the efficacy and safety of currently available drugs for pediatric obesity. In the future, developing safe and effective pharmacological interventions that target different mechanisms of action for childhood obesity is an important area of research that can potentially improve the health outcomes of millions of children worldwide.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Cannabinoids as Potential Therapeutic Agents for Kidney and Liver Toxicity: A Review" 大麻素作为肾和肝毒性的潜在治疗药物:综述

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.221395.1192

ALI ALALAWI

引用次数: 0

Derivatives contain dimethylaminopyridine as SIRT2 inhibitors: A mini review 衍生物含有二甲氨基吡啶作为SIRT2抑制剂:一个小回顾

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.219233.1191

Mostafa Badran, Samar Abbas, Mikako Fujita, Mohamed Osman

引用次数: 0

Various insulin delivery systems for management of diabetes mellitus 治疗糖尿病的各种胰岛素输送系统

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.216668.1189

Mahmoud EL-Badry, Dina Fathalla, Merna Mansour

引用次数: 0

The main biotargets of indole or 2-oxoindole-based hybrids acting as promising antiproliferative agents 吲哚或2-氧吲哚基杂交体作为有前途的抗增殖剂的主要生物靶点

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.217559.1190

Heba Hassan, Samar Abbas, Eman Beshr, Hend Ezelarab, Taha Ali

{"title":"The main biotargets of indole or 2-oxoindole-based hybrids acting as promising antiproliferative agents","authors":"Heba Hassan, Samar Abbas, Eman Beshr, Hend Ezelarab, Taha Ali","doi":"10.21608/jabps.2023.217559.1190","DOIUrl":"https://doi.org/10.21608/jabps.2023.217559.1190","url":null,"abstract":"Indole moiety is considered a unique core scaffold that can bind with different types of genes and proteins and also has easy synthetic techniques and exclusive chemical characteristics. These characteristics make indole-based scaffolds a prime probe for medicinal chemistry drug research chemists. Hybridization technique utilizing indole moiety could improve the efficacy, combating drug resistance and lowering side-effects of the final compound. Consequently, many indole and 2-oxoindole-based hybrids have been reported recently and entered pre-clinical and clinical studies. But still, more research efforts are essential for a clear understanding of the cancer origin and drug resistance mechanisms in cancer therapy, in addition to getting more achievements in multitargeting drug therapy by developing more potent indole-based scaffolds in the near future. Behind the promising antiproliferative activities of these indole and 2-oxoindole-based hybrids introduced within this review study, there are four main mechanisms which are protein kinases, DNA topoisomerases, histone deacetylase (HDAC), and tubulin polymerization inhibitory activities. Herein, this review will briefly illustrate the newly synthesized indole and 2-oxoindole-based hybrids along with their multiple mechanisms to display their promising antiproliferative activity, which will be a valuable step for more improvement of drug invention and elimination of drug resistance problems’ approaches.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C 埃及慢性丙型肝炎患者的INFL3-INFL4区单核苷酸多态性与纤维化和肝硬化相关

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-10-01 DOI: 10.21608/jabps.2023.233765.1199

Khalid Thabit, Amany Bkeet, Elham Abdelhalem, Abeer Sharaf, Heba Eltahir, Meky Abouzied, Abo Bakr Ahmed

{"title":"Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C","authors":"Khalid Thabit, Amany Bkeet, Elham Abdelhalem, Abeer Sharaf, Heba Eltahir, Meky Abouzied, Abo Bakr Ahmed","doi":"10.21608/jabps.2023.233765.1199","DOIUrl":"https://doi.org/10.21608/jabps.2023.233765.1199","url":null,"abstract":"Genetic variables have a notable and polygenic impact on the incidence and development of hepatic fibrosis and cirrhosis in individuals with chronic hepatitis C (CHC). Genetic polymorphisms in interferon-λ3-interferon-λ4 ( INFL3-INFL4 ) region, rs12979860 and its highly linked disequilibrium polymorphisms (rs368234815 and rs4803217) are linked to liver inflammation and fibrosis progression in CHC individuals from different ethnic groups. For Egyptian patients, no data available about the degree of linkage disequilibrium between these variants and their effect on liver fibrosis. In this study, 99 healthy controls and 176 CHC patients were genotyped for 3 variants in ( INFL3-INFL4 ) region rs12979860, rs4803217, and rs368234815. We found that these variants are highly linked disequilibrium in Egyptian CHC cohort. Moreover, we found that the major alleles of these 3 polymorphisms (rs12979860, rs4803217, and rs368234815) significantly increase the risk of liver fibrosis ( P = 0.015, 0.026, and 0.007 respectively). Additionally, these variants were linked to stage of hepatic fibrosis. This report shows that the 3 linked disequilibrium variants in INFL3-INFL4 region may be valuable foretellers of liver fibrosis and cirrhosis in CHC Egyptian patients.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135760713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Lupus Nephritis Cases with Special Reference to Activity and Chronicity Indices 狼疮性肾炎病例的调查，特别参考活动度和慢性指标

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-06-24 DOI: 10.18502/jabs.v13i2.13010

Khashayar Farshid, F. Noroozinia, M. Pourjabali

{"title":"Investigation of Lupus Nephritis Cases with Special Reference to Activity and Chronicity Indices","authors":"Khashayar Farshid, F. Noroozinia, M. Pourjabali","doi":"10.18502/jabs.v13i2.13010","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.13010","url":null,"abstract":"Background & Objectives: The International Society of Nephrology/ Renal Pathology Society (ISN/RPS) classification is based upon criteria which differentiate acute and chronic phases of Lupus Nephritis. Activity/Chronicity Index grants us a higher insight on the level of pathological lesions and treatment outcome by examining the reversibility of lesions .The present investigation was done in order to highlight the importance of activity and chronicity indices in the course of Lupus Nephritis.Materials & Methods: Seventy-three Kidney biopsy samples of Lupus Nephritis patients were examined. The information was recorded in a check-list and was then statistically analyzed.Results: Lupus Nephritis is importantly age-related, frequency of Lupus Nephritis increases with age until the age of 40 years; 21–40 years being the most frequent among studied patients. A prominent decline was seen after the age of 40. Regardless of age, the occurrence was more frequent in females. Class IV was most frequent in all ages and in both sexes. Both Activity and Chronicity scores were slightly higher in females. Activity Index was higher in ages of 11 to 30 years, whereas Chronicity Index was highest in 41 to 50 years of age. The highest Activity Index was reported in Class IV while the highest Chronicity Index was reported in Class V. The least Activity Index was shown in Class VI while Classes II and I had the lowest Chronicity Index. Endocapillary hypercellularity was the most frequent active lesion and tubular atrophy was the most frequent chronic lesion. It is noteworthy that fibrotic crescents were significantly less common among chronic lesions.Conclusion: Histopathological findings, clinical and para-clinical data could furnish more information on disease process, treatment, quality of life and mortality rate.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79230320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radioprotective Effects of Melatonin on Gamma Radiation- Induced Tissue Damage in Rats 褪黑素对γ射线诱导大鼠组织损伤的防护作用

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-06-24 DOI: 10.18502/jabs.v13i2.13009

Gholam-Reza Bagheri, H. Ghaffari, M. Valizadeh, H. Jahantigh, Marzieh Poursamimi, H. Shahriari, Javad Poursamimi

{"title":"Radioprotective Effects of Melatonin on Gamma Radiation- Induced Tissue Damage in Rats","authors":"Gholam-Reza Bagheri, H. Ghaffari, M. Valizadeh, H. Jahantigh, Marzieh Poursamimi, H. Shahriari, Javad Poursamimi","doi":"10.18502/jabs.v13i2.13009","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.13009","url":null,"abstract":"\u0000 \u0000Background & Objective: Gamma rays are widely used in medicine despite their harmful effects on health. Our study evaluated the protective effects of melatonin on kidney, heart, and liver tissues. \u0000 \u0000Materials & Methods: Seventy-two adult male Wistar rats were categorized into nine groups. Groups 2 and 3 only received whole-body γ-ray irradiation (WBI) (2.0 Gy), no melatonin, interval time (IT) 8hr and 24hr. Groups 4 and 5 received WBI (8.0 Gy, no melatonin, 8hr and 24hr). Groups 6 and 7 received melatonin at 60 minutes (min) before WBI(2.0 Gy). Groups 8 and 9 received melatonin before WBI(8.0 Gy). All the rats were sacrificed 8 or 24 h after the experiments for laboratory and histopathological analysis. Serum levels of Blood Urea Nitrogen(BUN), Creatinine (Cr), Lactate dehydrogenase (LDH), Potassium (K), Gamma-glutamyl Transferase (GGT), Serum Glutamic-Oxaloacetic Transaminase(SGOT), Serum Glutamic-Pyruvic Transaminase(SGPT), Alkaline Phosphatase(ALP), c-reactive protein(CRP), Troponine(TPO) and histological features of liver, heart and kidney tissues were assessed. Statistical analysis was performed by One-Way ANOVA. \u0000 \u0000Results: Our data did not indicate significant differences in BUN, Cr, K, and CRP between groups with or without melatonin treatment (P>0.05); but differences were significant for LDH, GGT, SGOT, SGPT, ALP, and TPO (P<0.05). The results showed that radiation-induced histopathological effects on the liver, heart, and kidneys were mitigated in the groups six to nine. \u0000 \u0000Conclusion: The existence of significant differences in serum levels of LDH, GGT, SGOT, SGPT, ALP, and TPO in groups(6 to 9) and amelioration of the histopathological effects of irradiation on the liver, heart, and kidneys in the groups six to nine showed that the melatonin(100 mg/kg) is able to protect the body in gamma-radiation(2.0 Gy and 8.0 Gy). \u0000 \u0000","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"220 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75891990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphite Furnace Atomic Absorption Spectrometry for Biomonitoring of Blood Lead Level in Quality Control Blood Materials 石墨炉原子吸收光谱法测定质量控制血液材料中血铅含量

Journal of advanced Biomedical and Pharmaceutical Sciences Pub Date : 2023-06-24 DOI: 10.18502/jabs.v13i2.13012

Mehri Aliasgharpour

{"title":"Graphite Furnace Atomic Absorption Spectrometry for Biomonitoring of Blood Lead Level in Quality Control Blood Materials","authors":"Mehri Aliasgharpour","doi":"10.18502/jabs.v13i2.13012","DOIUrl":"https://doi.org/10.18502/jabs.v13i2.13012","url":null,"abstract":"Background & Objective: Lead (Pb) is a major toxicant that has threatened human health for years. There is no safe level of exposure and deposition of a small amount of Pb in the human body has a negative impact on an individual's health. Despite recent reductions in its use, it has caused extensive environmental contamination as well. In the present study,the intralaboratory quality control assessment is reported as an initial step in lead determination by Graphite furnace atomic absorption spectrometry (GFAAS). \u0000Materials & Methods: Varian SpectrAA-220 with partition tube and deuterium background correction was used for the analysis. The evaluation quality control blood material was Seronorm trace elements whole blood (levels I &II). \u0000Results: The lowest method limit of detection was 0.74 μg/dL, and based on the regression analysis, the lowest quantification concentration was 3.00 μg/dL (CV = 4.6 %). In addition, obtained %CV for Seronorm (I) & Seronorm (II) was 7.3% & 5.4% respectively. \u0000Conclusion: In recent years, several diverse technological advancements in blood lead level determination have occurred. At the same time, demands for blood lead (BPb) level determination by GFAAS has been increased by public health in order to identify children exposed to lead in the environment, and by occupational health to reduce excessive exposure in the lead industries. The obtained results indicated that for BPb analysis, the method described by GFAAS is still a reference routine analytical technique that requires less time and no matrix matched standard curve, allowing blood samples to be run against aqueous calibration standards which eliminates the need for standard additions.","PeriodicalId":14861,"journal":{"name":"Journal of advanced Biomedical and Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85164278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0