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Hormonal and Metabolic Status of Male Rats with Metabolic Syndrome Model Induced by Interruption of Breastfeeding in the Early Postnatal Period 产后早期中断母乳喂养诱导的代谢综合征模型雄性大鼠的激素和代谢状况
Journal Biomed Pub Date : 2022-10-17 DOI: 10.33647/2074-5982-18-3-67-71
A. Shpakov, V. Bondareva, K. Derkach
{"title":"Hormonal and Metabolic Status of Male Rats with Metabolic Syndrome Model Induced by Interruption of Breastfeeding in the Early Postnatal Period","authors":"A. Shpakov, V. Bondareva, K. Derkach","doi":"10.33647/2074-5982-18-3-67-71","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-67-71","url":null,"abstract":"A short-term deprivation of rat pups from breastfeeding in the early postnatal period leads to MS at the age of 4-6 months. However, this neonatal MS model requires optimization and a detailed study into the metabolic and hormonal parameters of adult animals. The aim of the work was to study these parameters in adult male rats deprived of breast milk at the age of 19-21 days, which was achieved by treating lactating females with bromocriptine. Adult male rats showed an increased body weight and adipose tissue, impaired glucose tolerance, insulin resistance, and hyperleptinemia. These animals had reduced levels of testosterone, free thyroxine, and total triiodothyronine, with an increase in the thyroid-stimulating hormone. Thus, a short-term deprivation of breastfeeding in adult rats leads to the development of MS and endocrine dysregulations.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86351929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of Changes in Acetylcholinesterase Activity in the Brain and Bood of Rats During Pharmacological Correction of Seizures Caused by Carbamate 氨基甲酸酯致癫痫药物纠正过程中大鼠脑和血乙酰胆碱酯酶活性的动态变化
Journal Biomed Pub Date : 2022-10-17 DOI: 10.33647/2074-5982-18-3-27-31
A. S. Melekhova, L. G. Kubarskaya, A. Petrov, A. Bespalov, A. B. Verveda, A. V. Belskaya, M. Melnikova
{"title":"Dynamics of Changes in Acetylcholinesterase Activity in the Brain and Bood of Rats During Pharmacological Correction of Seizures Caused by Carbamate","authors":"A. S. Melekhova, L. G. Kubarskaya, A. Petrov, A. Bespalov, A. B. Verveda, A. V. Belskaya, M. Melnikova","doi":"10.33647/2074-5982-18-3-27-31","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-27-31","url":null,"abstract":"To simulate a convulsive syndrome, phenylcarbamate was administered intraperitoneally at a dose of 1 mg/kg. Valproic acid aminoester (43 mg/kg), caramiphene (50 mg/kg), and diferidine (2 mg/kg) were investigated as potential anticonvulsant drugs. Blood and brain tissue for the determination of acetylcholinesterase (AСhE) were taken at 10, 30, 60 minutes, 6 and 24 hours after administration of the xenobiotic. In case of poisoning with reversible inhibitors of AChE and accumulation of acetylcholine in the CNS synapses (due to inhibition of AChE activity), only the initial manifestations of convulsive activity are caused, and other mechanisms not associated with AChE inhibition are responsible for the processes of further maintenance and recurrence of seizures.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76258044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels 胰岛素原c肽改善胰岛素水平正常但不升高的2型糖尿病大鼠的代谢和激素参数
Journal Biomed Pub Date : 2022-10-17 DOI: 10.33647/2074-5982-18-3-90-94
K. Derkach, V. Bondareva, N. E. Basova, A. Shpakov
{"title":"Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels","authors":"K. Derkach, V. Bondareva, N. E. Basova, A. Shpakov","doi":"10.33647/2074-5982-18-3-90-94","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-90-94","url":null,"abstract":"In type 2 diabetes mellitus (DM2), the impaired functions of the brain insulin system are associated with the weakened insulin transport through the blood-brain barrier due to insulin resistance. Insulin deficiency in the brain can be corrected by intranasal administration of insulin (II), whose effect may be enhanced by intranasal administration of C-peptide (ICP). In this work, we study the effect of treating hyperinsulinemic and normoinsulinemic DM2 rats with ICP (36 µg/rat/day), II (20 µg/rat/day) and ICP+II on metabolic and hormonal parameters. In normoinsulinemic DM2, ICP attenuated thyroid hormone deficiency and enhanced the restorative effects of II on glucose, insulin, and leptin sensitivity. In hyperinsulinemic DM2, ICP was ineffective, and its combination with II weakened the restorative effects of II. Thus, ICP and its combination with II are effective in restoring metabolic and hormonal parameters in normoinsulinemic, but not hyperinsulinemic, DM2.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87970044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis 修饰释放肽提取物在纠正光不同步中的抗氧化作用
Journal Biomed Pub Date : 2022-10-17 DOI: 10.33647/2074-5982-18-3-50-57
A. V. Sharabanov, E. G. Batotsyrenova, V. Kashuro, M. T. Gasanov, Yu. V. Komov
{"title":"Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis","authors":"A. V. Sharabanov, E. G. Batotsyrenova, V. Kashuro, M. T. Gasanov, Yu. V. Komov","doi":"10.33647/2074-5982-18-3-50-57","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-50-57","url":null,"abstract":"This research was aimed at creating novel domestic medical preparations with a modified release of active peptide substances obtained from renewable sources of biological materials. These preparations can be used for the purposes of pharmacological correction of desynchronosis by the action of biologically active substances on the processes of lipid peroxidation and antioxidant protection of cells in order to increase the body's resistance to the negative effects of various stress factors. The conducted studies have confirmed the efficacy of modified-release peptide extracts when correcting the body's oxidative status in various types of desynchronosis.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73084463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Disorders in the Functional State of the Central Nervous System, Intestinal Peristalsis and Microbiocenosis in Experimental Barbiturate Poisoning 实验性巴比妥酸盐中毒的中枢神经系统功能状态紊乱、肠蠕动和微生物病
Journal Biomed Pub Date : 2022-10-17 DOI: 10.33647/2074-5982-18-3-45-49
N. S. Tropskaya, E. Kislyakova, I. G. Vilkova, Yu. V. Gurman, O. S. Kislitsyna, A. V. Zerebtzov, Yelena Borodina, T. V. Chernen'kaya, T. S. Popova
{"title":"Disorders in the Functional State of the Central Nervous System, Intestinal Peristalsis and Microbiocenosis in Experimental Barbiturate Poisoning","authors":"N. S. Tropskaya, E. Kislyakova, I. G. Vilkova, Yu. V. Gurman, O. S. Kislitsyna, A. V. Zerebtzov, Yelena Borodina, T. V. Chernen'kaya, T. S. Popova","doi":"10.33647/2074-5982-18-3-45-49","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-45-49","url":null,"abstract":"Following a single administration of sodium thiopental in high doses (85 mg/kg intraperitoneally), the animals demonstrated the absence or weakening of reflexes at the levels of the spinal cord, medulla oblongata, bridge and midbrain and cerebral cortex over the period of one day. Other signs included a pronounced hypothermia, a decrease in the respiratory rate and a violation of its rhythm, a distinct tendency to bradycardia. On days 1-3 after the administration of sodium thiopental, a restoration of the respiratory rate, heart rate, body temperature, and the functional state of the central nervous system at various levels was observed, with the exception of the cerebral cortex. In the long term, following the administration of sodium thiopental for up to 21 days, a depression of the functional state of the central nervous system at the level of the cerebral cortex, violation of coordinated propulsive peristalsis of the small intestine and intestinal microbiocenosis were detected. Hence, in experimentally simulated barbiturate poisoning, not only is the suppression of the functions of the central nervous system observed, but also significant and prolonged restructuring of the functional state of the gastrointestinal tract.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72725558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Application of an Allosteric Agonist of the Luteinizing Hormone Receptor for Reducing the Effective Dose of Gonadotropin in the Treatment of Androgen Deficiency in Rats with Type 1 Diabetes 黄体生成素受体变构激动剂在降低促性腺激素有效剂量治疗1型糖尿病大鼠雄激素缺乏中的应用
Journal Biomed Pub Date : 2022-10-17 DOI: 10.33647/2074-5982-18-3-72-78
A. Bakhtyukov, K. Derkach, V. Sorokoumov, A. Shpakov
{"title":"Application of an Allosteric Agonist of the Luteinizing Hormone Receptor for Reducing the Effective Dose of Gonadotropin in the Treatment of Androgen Deficiency in Rats with Type 1 Diabetes","authors":"A. Bakhtyukov, K. Derkach, V. Sorokoumov, A. Shpakov","doi":"10.33647/2074-5982-18-3-72-78","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-72-78","url":null,"abstract":"In type 1 diabetes mellitus, the impaired testosterone synthesis in the testes leads to androgen deficiency. The long-term application of high gonadotropin doses for its correction decreases the sensitivity of luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptors in Leydig cells to the endogenous gonadotropins. The aim of this work was to study the effect of a 3-day treatment of male Wistar rats with streptozotocin type 1 diabetes with the 5-amino-N-tert-butyl-2-(methylsulfanyl)-4-(3-(nicotinamido) phenyl)thieno[2,3-d]pyrimidine-6-carboxamide allosteric LH/hCG receptor agonist (TP03, 15 mg/kg/day) on steroidogenic effects of a relatively low-dose hCG (10 IU/rat, single dose, s.c.). Pretreatment of diabetic rats with TP03 enhanced the stimulatory effect of hCG on testosterone levels, slightly modifying its effects on the expression of steroidogenic proteins (Star, Cyp11a1, Cyp17a1) and LH/hCG receptor (Lhr) genes. Thus, in type 1 diabetes, TP03 increases the steroidogenic effect of low-dose hCG, at the same time as maintaining its effect on the gene expression of LH/hCG receptor and steroidogenesis enzymes in the testes.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82377594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Single-Nucleotide Polymorphisms in Human Serum Albumin Associated with Alzheimer's Disease 与阿尔茨海默病相关的人血清白蛋白单核苷酸多态性的评价
Journal Biomed Pub Date : 2022-10-16 DOI: 10.33647/2074-5982-18-3-14-17
E. Deryusheva, E. Litus
{"title":"Evaluation of Single-Nucleotide Polymorphisms in Human Serum Albumin Associated with Alzheimer's Disease","authors":"E. Deryusheva, E. Litus","doi":"10.33647/2074-5982-18-3-14-17","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-14-17","url":null,"abstract":"Human serum albumin (HSA) is a natural buffer for amyloid в peptide (Аβ), which is a key factor in the development of Alzheimer's disease (AD). An increase in HSA affinity to Аβ can be achieved via HSA saturation with low-molecular-weight ligands, such as serotonin or specific fatty acids. The conducted analysis of the genomic data of exomes (WES) associated with AD (ADSP database) revealed the presence of a single-nucleotide polymorphism of the HSA gene at the binding sites of ibuprofen, arachidonic and oleic acids. Research into the properties of the revealed genetic variants of HSA should be carried out to determine those variants that are susceptible to the modulatory action of HSA ligands, thus increasing its affinity to Aβ.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87734154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of GABA on the Gut Microbiota During Metabolic Stress 代谢应激时GABA对肠道微生物群的影响
Journal Biomed Pub Date : 2022-10-16 DOI: 10.33647/2074-5982-18-3-10-13
Yu. V. Gurman, N. S. Tropskaya, T. V. Chernen'kaya, T. S. Popova
{"title":"The Effect of GABA on the Gut Microbiota During Metabolic Stress","authors":"Yu. V. Gurman, N. S. Tropskaya, T. V. Chernen'kaya, T. S. Popova","doi":"10.33647/2074-5982-18-3-10-13","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-10-13","url":null,"abstract":"The effect of gamma-aminobutyric acid (GABA) on the gut microbiota was evaluated in experiments on 47 rats with metabolic stress (MS) induced by food deprivation. MS was found to be associated with changes in the qualitative and quantitative composition of the caecum microbiota, including the redistribution of opportunistic flora, the growth of pathogenic microorganisms, as well as a decreased number of lactobacilli and bifidobacteria. Daily administration of GABA at a dose of 70 mg/kg during MS led to a decrease in the number of pathogens, thus leading to the restoration of normal eubionts in the cecum.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88964907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of Bacterial Recombinant Myostatin to Induce the Synthesis of Myostatin-Specific Autoantibodies 细菌重组肌生长抑制素的制备诱导合成肌生长抑制素特异性自身抗体
Journal Biomed Pub Date : 2022-10-16 DOI: 10.33647/2074-5982-18-3-22-26
E. Koloskova, V. Ezerskiy, O. Zhukova
{"title":"Preparation of Bacterial Recombinant Myostatin to Induce the Synthesis of Myostatin-Specific Autoantibodies","authors":"E. Koloskova, V. Ezerskiy, O. Zhukova","doi":"10.33647/2074-5982-18-3-22-26","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-22-26","url":null,"abstract":"The myostatin protein, belonging to the family of growth factors, represents a potential target for therapeutic effects in muscular system pathologies. However, this protein is characterized by other beneficial properties. Polymorphisms of the myostatin gene associated with the restriction of its functional activity are useful as genetic markers of meat productivity in farm animals. Blocking the action of myostatin in productive animals can be achieved by inducing the synthesis of specific autoantibodies using recombinant myostatin, possessing sufficient immunogenicity against myostatin as an antigen. A genetic construct was created and an E. coli producer strain with a high level of expression of recombinant myostatin was obtained.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82068122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Changes in the Gut Microbiota of Mice Under the Action of Ultrasonic-induced Stress 超声应激作用下小鼠肠道菌群的变化
Journal Biomed Pub Date : 2022-10-16 DOI: 10.33647/2074-5982-18-3-18-21
S. Karabanov, A. Kibitkina
{"title":"Changes in the Gut Microbiota of Mice Under the Action of Ultrasonic-induced Stress","authors":"S. Karabanov, A. Kibitkina","doi":"10.33647/2074-5982-18-3-18-21","DOIUrl":"https://doi.org/10.33647/2074-5982-18-3-18-21","url":null,"abstract":"The effect of ultrasound-induced stress on the gut microbiota composition of C57BL/6 mice was studied. Under the action of this type of stress, the gut microbiota composition shifts towards firmicutes at the phylum level. At the family level, an increase in Lachnospiraceae by 67.43%, Rikenellaceae by 39.29%, as well as a decrease in Bacteroidaceae by 64.75% and Prevotellaceae by 38.51%. is observed. The most prominent changes under the action of stress were revealed at the genus level: out of 28 identified genera, significant changes were recorded in 13.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73142304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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